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The map label for this gene is tdcB [H]

Identifier: 116491981

GI number: 116491981

Start: 198620

End: 199675

Strand: Direct

Name: tdcB [H]

Synonym: PEPE_0167

Alternate gene names: 116491981

Gene position: 198620-199675 (Clockwise)

Preceding gene: 116491980

Following gene: 116491982

Centisome position: 10.84

GC content: 41.19

Gene sequence:

>1056_bases
ATGTTAGTAGAGAAAGAACCCAGAAACCAAGTTGTAGCAGCAACCGATAATTTATTAAATCTAAACCAGATTGAAGAAGC
CCGCGAGGTTATTAAAAAATATGCGCGTCGGACACCATTAGTTAAGTCCATGTTTTTGAGCAACAACGTTGTCCATGGGG
ATGTCTATTTAAAATTAGAGAATATGCAATTAACCGGTTCTTTTAAATTTAGAGGGGCGAATAACAAAATTAACCACTTG
AATGAAGAAGAAAAACAACGAGGCGTAATTACAGCTTCAGCTGGAAATCATGCACAAGGAGTAGCTTTGACCGGTAAGTT
GCTGGGAATTAAAACTACGGTAGTGATGCCGGATGAGGCGCCCCAAATGAAGCGCGATGCAACCCGAGGATATGGAGCGG
AAGTAGATATTCATGGCGCAACTTTTGATGACGCTCACGAATGGATGCGAGAAAGAGCTGAAAAAGAAGGAAAAACCATT
GTAGATCCGTTTAATGATGCTTTAATTTGTGCTGGACAAGGAACTATCGGTTTGGAAATTCTAGAAGATTTAGTGGATGT
AGAAACCGTTGTAGTTCCAGTCGGGGGCGGTGGTCTAATTTCAGGAATCGCCACGGCTTTAAAATCAATCAATCCTTCAA
TTCATATCGTCGGAGTTCAATCGGAAAATGTGCATGGCATGAAGGCGTCTGTTGATGCAGGCAAAATTGTTAAACATCAC
CAAGATTTTACGCTAGCAGACGGAACTGATGTAGCAACCCCAGGTAATATTACATTTGGGATTGTTTCCAAACTAGTGGA
TGAGATTGTCTTGGTTAGTGAAGAAGAAATTTCAAAAGCGATGAAAGATTTAATGCAGAGAACCAAGGTGGTTGCTGAAG
GAGCAGGAGCATTGCCAACGGCCGCTTTAGAAGCAGGTAAGATTGATCCAAAATGGACTAAAGATAAGAAGGTTGTAGCT
TTAGTTTCCGGTGGAAATGTGGATCTACAGCGAGTTTCACAGATTATTGATCACTTCTTTACTCCTGTTGATACGCATAA
AGGTGCCATTGGGTAA

Upstream 100 bases:

>100_bases
GGGATTAACCTGTATGAAGGAAAAATTACTAATCAAGGTTTGGCAGACTCCTTGAATCTTCCATATACTGAACTGAAACT
ATAAAAAGGGGGTGGCGTTG

Downstream 100 bases:

>100_bases
TTAATATTTTGTGAGTGAAAGAGGGAATCAAATTGGCAAAAAATAAGGAGCAAAAAAGCGGTAAACATGTACCGTATGTC
ACTAAAAAGCAACGAGGTGG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MLVEKEPRNQVVAATDNLLNLNQIEEAREVIKKYARRTPLVKSMFLSNNVVHGDVYLKLENMQLTGSFKFRGANNKINHL
NEEEKQRGVITASAGNHAQGVALTGKLLGIKTTVVMPDEAPQMKRDATRGYGAEVDIHGATFDDAHEWMRERAEKEGKTI
VDPFNDALICAGQGTIGLEILEDLVDVETVVVPVGGGGLISGIATALKSINPSIHIVGVQSENVHGMKASVDAGKIVKHH
QDFTLADGTDVATPGNITFGIVSKLVDEIVLVSEEEISKAMKDLMQRTKVVAEGAGALPTAALEAGKIDPKWTKDKKVVA
LVSGGNVDLQRVSQIIDHFFTPVDTHKGAIG

Sequences:

>Translated_351_residues
MLVEKEPRNQVVAATDNLLNLNQIEEAREVIKKYARRTPLVKSMFLSNNVVHGDVYLKLENMQLTGSFKFRGANNKINHL
NEEEKQRGVITASAGNHAQGVALTGKLLGIKTTVVMPDEAPQMKRDATRGYGAEVDIHGATFDDAHEWMRERAEKEGKTI
VDPFNDALICAGQGTIGLEILEDLVDVETVVVPVGGGGLISGIATALKSINPSIHIVGVQSENVHGMKASVDAGKIVKHH
QDFTLADGTDVATPGNITFGIVSKLVDEIVLVSEEEISKAMKDLMQRTKVVAEGAGALPTAALEAGKIDPKWTKDKKVVA
LVSGGNVDLQRVSQIIDHFFTPVDTHKGAIG
>Mature_351_residues
MLVEKEPRNQVVAATDNLLNLNQIEEAREVIKKYARRTPLVKSMFLSNNVVHGDVYLKLENMQLTGSFKFRGANNKINHL
NEEEKQRGVITASAGNHAQGVALTGKLLGIKTTVVMPDEAPQMKRDATRGYGAEVDIHGATFDDAHEWMRERAEKEGKTI
VDPFNDALICAGQGTIGLEILEDLVDVETVVVPVGGGGLISGIATALKSINPSIHIVGVQSENVHGMKASVDAGKIVKHH
QDFTLADGTDVATPGNITFGIVSKLVDEIVLVSEEEISKAMKDLMQRTKVVAEGAGALPTAALEAGKIDPKWTKDKKVVA
LVSGGNVDLQRVSQIIDHFFTPVDTHKGAIG

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=317, Percent_Identity=33.7539432176656, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI19923959, Length=312, Percent_Identity=28.525641025641, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI33469958, Length=273, Percent_Identity=27.8388278388278, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1789505, Length=315, Percent_Identity=53.6507936507937, Blast_Score=291, Evalue=4e-80,
Organism=Escherichia coli, GI1790207, Length=303, Percent_Identity=39.2739273927393, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71991565, Length=310, Percent_Identity=41.9354838709677, Blast_Score=198, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17537387, Length=334, Percent_Identity=37.4251497005988, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17508781, Length=325, Percent_Identity=29.5384615384615, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322631, Length=313, Percent_Identity=39.9361022364217, Blast_Score=196, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6320930, Length=301, Percent_Identity=36.8770764119601, Blast_Score=166, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6319788, Length=282, Percent_Identity=27.6595744680851, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321594, Length=313, Percent_Identity=28.1150159744409, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI21355833, Length=310, Percent_Identity=41.2903225806452, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24645328, Length=213, Percent_Identity=41.3145539906103, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 37777; Mature: 37777

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00165 DEHYDRATASE_SER_THR ; PS00995 TCP1_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVEKEPRNQVVAATDNLLNLNQIEEAREVIKKYARRTPLVKSMFLSNNVVHGDVYLKLE
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEEEEEEEEE
NMQLTGSFKFRGANNKINHLNEEEKQRGVITASAGNHAQGVALTGKLLGIKTTVVMPDEA
CEEEEEEEEEECCCCCCCCCCHHHHHCCEEEECCCCCCCCEEEEEEEEEEEEEEECCCCC
PQMKRDATRGYGAEVDIHGATFDDAHEWMRERAEKEGKTIVDPFNDALICAGQGTIGLEI
CHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEECCCCCEEEEECCCCCHHHH
LEDLVDVETVVVPVGGGGLISGIATALKSINPSIHIVGVQSENVHGMKASVDAGKIVKHH
HHHHHCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCCHHHHHHHC
QDFTLADGTDVATPGNITFGIVSKLVDEIVLVSEEEISKAMKDLMQRTKVVAEGAGALPT
CCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCH
AALEAGKIDPKWTKDKKVVALVSGGNVDLQRVSQIIDHFFTPVDTHKGAIG
HHHHCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MLVEKEPRNQVVAATDNLLNLNQIEEAREVIKKYARRTPLVKSMFLSNNVVHGDVYLKLE
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEEEEEEEEE
NMQLTGSFKFRGANNKINHLNEEEKQRGVITASAGNHAQGVALTGKLLGIKTTVVMPDEA
CEEEEEEEEEECCCCCCCCCCHHHHHCCEEEECCCCCCCCEEEEEEEEEEEEEEECCCCC
PQMKRDATRGYGAEVDIHGATFDDAHEWMRERAEKEGKTIVDPFNDALICAGQGTIGLEI
CHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEECCCCCEEEEECCCCCHHHH
LEDLVDVETVVVPVGGGGLISGIATALKSINPSIHIVGVQSENVHGMKASVDAGKIVKHH
HHHHHCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCCHHHHHHHC
QDFTLADGTDVATPGNITFGIVSKLVDEIVLVSEEEISKAMKDLMQRTKVVAEGAGALPT
CCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCH
AALEAGKIDPKWTKDKKVVALVSGGNVDLQRVSQIIDHFFTPVDTHKGAIG
HHHHCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA