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The map label for this gene is gyrA [H]

Identifier: 116491824

GI number: 116491824

Start: 6279

End: 8810

Strand: Direct

Name: gyrA [H]

Synonym: PEPE_0006

Alternate gene names: 116491824

Gene position: 6279-8810 (Clockwise)

Preceding gene: 116491823

Following gene: 116491825

Centisome position: 0.34

GC content: 41.31

Gene sequence:

>2532_bases
TTGTCAGAAGAATTGTCAGGACGAATTACAGATGTCAATTTAAGTAGTCAAATGCGTACATCATTCTTGGATTATGCCAT
GAGTGTTATTGTTGCGCGTGCTTTACCTGACGTTCGGGATGGACTAAAACCCGTCCATCGTCGTATTTTATACGGGATGA
ATGAGTTAGGAGTTACACCTGAAAAGCCATATAAGAAGTCAGCTAGAATCGTTGGGGATGTTATGGGTAAGTATCATCCT
CATGGTGACTCTGCAATTTATGAATCAATGGTCCGGATGGCCCAAGACTTTAGTTACCGTTACATGCTTGTTGATGGACA
TGGTAACTTTGGATCTGTCGATGGGGATGGCGCTGCTGCTATGCGTTATACCGAAGCTCGAATGAGTAAAATTACATTGG
AAATGCTACGTGATATCAATAAAAATACCGTGGATTTCCAAGAAAACTATGATGGAACGGAACGCGAACCATCAATTTTA
CCAGCACGTTTCCCAAACTTATTAGTTAACGGAGCAACTGGGATTGCCGTGGGGATGACGACGAATATTCCACCACATAA
TTTGTCAGAAGTCATCAGCGCTATCCATATTTTGATGAATAACGAAGATGCAACAACCGCCGACTTGATGGAAGCTGTCC
CTGGGCCAGACTTCCCAACCGGTGGAATTGTGATGGGTAAATCGGGAATCCGTAAGGCATATGAGACTGGACACGGTACG
ATTATTTTACGGGCGAAAGTTGATATTGAGACTGAAAAAAATGGTCGCGAACGCATTGTGGCTACAGAATTACCATACAT
GGTCAATAAGGCTAAATTGATCGAACGCATTGCTGAATTAGCTCGTGATAAACGAATTGAAGGAATTACTGATGTAAATG
ATGAATCCGATCGTGATGGACTTCGAGTTGTCATTGATGTTCGTCGTGATGTCAGTGCATCTGTAGTTTTGAATAATCTT
TACAAGATGACATTAATGCAAACGACCTTTGGATTTAATATGTTGGCCATCGTTAATGGTGCTCCTAAAGTATTAGGCCT
AAAGGAAATTTTGCAACACTATCTTGTTCATCAAGAAGAAGTTATTCGTCGACGGACTGAATTTGATTTGAAGAAGGCTG
AAGCAAGGGCGCACATCTTAGAAGGTTTGCGGATTGCTTTGGACCACATCGATGAAATTATTGCGATTATTCGTAATTCA
CAAACGGCTGAGGTTGCTAAAGATAAATTGATGAATAACTATTCATTATCAAGTAAGCAAGCTCAAGCAATCTTGGATAT
GCGTTTGGTGCGTTTGACAGGACTAGAACGTGAAAAGGTTGAAGACGAGTACAACAAGGTCATGGCAGCAATTACGGATT
ACCGTGATATTTTAGCTCACCGTGAACGAATTAACGAAATCATTTACAAAGAGTTACTTGAAATTCAAGAGCGCTTTGGG
GATGAACGTCGGACAGAATTGATGGTCGGTGAAGTTCTTAGCCTTGAAGATGAAGACTTAATCGAAGAAGAAGATGTCAT
GGTTACTTTAACCCATAATGGTTACATTAAGCGAATGGCTACGTCTGAATTTAAGACGCAAAATCGCGGTGGTCGAGGAA
TCCAAGGGATGGGTGTTCATGATGACGACTTTATCGAACATCTGGTTTCAACTTCAACCCATGATGTACTCTTATTCTTC
ACCAATGCCGGTAAGGTTTACCGGATGAAAGGTTACGAAATCCCTGAATATAGCCGAACCGCTAAGGGAATTCCAGTAAT
TAACTTGCTTGGAATTAGTAGCGGAGAAAATATTCAGGCTGTAATCAATATTGGACGTGATAACGGTGATGAAGATAATG
AAAATCGTTACCTCTTCTTTACAACGTTAAACGGTGTGACAAAACGAACACCGGTTGCTGAATTCCTAAATATCCGCAGC
AATGGGCTTAAGGCCATTAGCTTGAAGGAAAATGATGAAGTAATTAACGTGGTTATTACCGATGGCGAGCAAAACATTAT
TATCGGAACGCATAACGGATACGCGGTAAGCTTTAAAGAAGCAGATGTGCGTTCAATGGGACGTTCTGCTACTGGGGTTC
GCGGAATTCGTTTACGAGATGAAGATTATGTCGTCGGTTCAGCAATCTTGAAACCTGAAAGCAAGGTCTTGGTTATTACT
GAAAAGGGTTATGGAAAACAAACTCCGGCTAGTGAATACCCAATTAAAGGCCGCGGCGGTAAAGGGATTAAGACTGCGAA
TATCACCGAAAAGAATGGTCCATTAGCTGGATTAGTAACGGTAGAAGGAACGGAAGATGTTATGTTGATTACGGATCGTG
GGGTTATGATTCGTTTCGACGTTAATAATGTTTCAACTACAGGTCGGGCGACCTTAGGGGTTCACGTAATCAAGACGGAT
GAAAATTCTAAAGTTGCTACAATGGCAATTGTTGATGAAGCACCAGTTGATGATGAAAACCAGACTCAAACTCCAGCAAC
TGAAGCAGCAGAAACTGAAAGTGTAACTGTTGAAGAAAGTTCTGAAGAATAA

Upstream 100 bases:

>100_bases
TCGTAAATTCATTGAAGAGAACGCTGTGTTTGTTAAAAACTTGGATATCTAAAAAGATTATTAAAAGTTAGACAGCCCAA
AAAATAAGGGGGAAAACGAA

Downstream 100 bases:

>100_bases
ATTTAATTAAAAAAGCTGATTGAAGTGATTTTTCACTTTTTAATCAGCTTTTTTAATTAATAAAATGAATTAGAAAATTT
TGGTGTATTTATCATTTGTA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 843; Mature: 842

Protein sequence:

>843_residues
MSEELSGRITDVNLSSQMRTSFLDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPEKPYKKSARIVGDVMGKYHP
HGDSAIYESMVRMAQDFSYRYMLVDGHGNFGSVDGDGAAAMRYTEARMSKITLEMLRDINKNTVDFQENYDGTEREPSIL
PARFPNLLVNGATGIAVGMTTNIPPHNLSEVISAIHILMNNEDATTADLMEAVPGPDFPTGGIVMGKSGIRKAYETGHGT
IILRAKVDIETEKNGRERIVATELPYMVNKAKLIERIAELARDKRIEGITDVNDESDRDGLRVVIDVRRDVSASVVLNNL
YKMTLMQTTFGFNMLAIVNGAPKVLGLKEILQHYLVHQEEVIRRRTEFDLKKAEARAHILEGLRIALDHIDEIIAIIRNS
QTAEVAKDKLMNNYSLSSKQAQAILDMRLVRLTGLEREKVEDEYNKVMAAITDYRDILAHRERINEIIYKELLEIQERFG
DERRTELMVGEVLSLEDEDLIEEEDVMVTLTHNGYIKRMATSEFKTQNRGGRGIQGMGVHDDDFIEHLVSTSTHDVLLFF
TNAGKVYRMKGYEIPEYSRTAKGIPVINLLGISSGENIQAVINIGRDNGDEDNENRYLFFTTLNGVTKRTPVAEFLNIRS
NGLKAISLKENDEVINVVITDGEQNIIIGTHNGYAVSFKEADVRSMGRSATGVRGIRLRDEDYVVGSAILKPESKVLVIT
EKGYGKQTPASEYPIKGRGGKGIKTANITEKNGPLAGLVTVEGTEDVMLITDRGVMIRFDVNNVSTTGRATLGVHVIKTD
ENSKVATMAIVDEAPVDDENQTQTPATEAAETESVTVEESSEE

Sequences:

>Translated_843_residues
MSEELSGRITDVNLSSQMRTSFLDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPEKPYKKSARIVGDVMGKYHP
HGDSAIYESMVRMAQDFSYRYMLVDGHGNFGSVDGDGAAAMRYTEARMSKITLEMLRDINKNTVDFQENYDGTEREPSIL
PARFPNLLVNGATGIAVGMTTNIPPHNLSEVISAIHILMNNEDATTADLMEAVPGPDFPTGGIVMGKSGIRKAYETGHGT
IILRAKVDIETEKNGRERIVATELPYMVNKAKLIERIAELARDKRIEGITDVNDESDRDGLRVVIDVRRDVSASVVLNNL
YKMTLMQTTFGFNMLAIVNGAPKVLGLKEILQHYLVHQEEVIRRRTEFDLKKAEARAHILEGLRIALDHIDEIIAIIRNS
QTAEVAKDKLMNNYSLSSKQAQAILDMRLVRLTGLEREKVEDEYNKVMAAITDYRDILAHRERINEIIYKELLEIQERFG
DERRTELMVGEVLSLEDEDLIEEEDVMVTLTHNGYIKRMATSEFKTQNRGGRGIQGMGVHDDDFIEHLVSTSTHDVLLFF
TNAGKVYRMKGYEIPEYSRTAKGIPVINLLGISSGENIQAVINIGRDNGDEDNENRYLFFTTLNGVTKRTPVAEFLNIRS
NGLKAISLKENDEVINVVITDGEQNIIIGTHNGYAVSFKEADVRSMGRSATGVRGIRLRDEDYVVGSAILKPESKVLVIT
EKGYGKQTPASEYPIKGRGGKGIKTANITEKNGPLAGLVTVEGTEDVMLITDRGVMIRFDVNNVSTTGRATLGVHVIKTD
ENSKVATMAIVDEAPVDDENQTQTPATEAAETESVTVEESSEE
>Mature_842_residues
SEELSGRITDVNLSSQMRTSFLDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPEKPYKKSARIVGDVMGKYHPH
GDSAIYESMVRMAQDFSYRYMLVDGHGNFGSVDGDGAAAMRYTEARMSKITLEMLRDINKNTVDFQENYDGTEREPSILP
ARFPNLLVNGATGIAVGMTTNIPPHNLSEVISAIHILMNNEDATTADLMEAVPGPDFPTGGIVMGKSGIRKAYETGHGTI
ILRAKVDIETEKNGRERIVATELPYMVNKAKLIERIAELARDKRIEGITDVNDESDRDGLRVVIDVRRDVSASVVLNNLY
KMTLMQTTFGFNMLAIVNGAPKVLGLKEILQHYLVHQEEVIRRRTEFDLKKAEARAHILEGLRIALDHIDEIIAIIRNSQ
TAEVAKDKLMNNYSLSSKQAQAILDMRLVRLTGLEREKVEDEYNKVMAAITDYRDILAHRERINEIIYKELLEIQERFGD
ERRTELMVGEVLSLEDEDLIEEEDVMVTLTHNGYIKRMATSEFKTQNRGGRGIQGMGVHDDDFIEHLVSTSTHDVLLFFT
NAGKVYRMKGYEIPEYSRTAKGIPVINLLGISSGENIQAVINIGRDNGDEDNENRYLFFTTLNGVTKRTPVAEFLNIRSN
GLKAISLKENDEVINVVITDGEQNIIIGTHNGYAVSFKEADVRSMGRSATGVRGIRLRDEDYVVGSAILKPESKVLVITE
KGYGKQTPASEYPIKGRGGKGIKTANITEKNGPLAGLVTVEGTEDVMLITDRGVMIRFDVNNVSTTGRATLGVHVIKTDE
NSKVATMAIVDEAPVDDENQTQTPATEAAETESVTVEESSEE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=179, Percent_Identity=30.1675977653631, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI19913408, Length=321, Percent_Identity=24.9221183800623, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1788562, Length=852, Percent_Identity=48.3568075117371, Blast_Score=819, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=744, Percent_Identity=35.4838709677419, Blast_Score=417, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17535065, Length=177, Percent_Identity=31.638418079096, Blast_Score=77, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=176, Percent_Identity=31.25, Blast_Score=75, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=175, Percent_Identity=33.1428571428571, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17136538, Length=179, Percent_Identity=29.608938547486, Blast_Score=76, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 93736; Mature: 93605

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEELSGRITDVNLSSQMRTSFLDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTP
CCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHCCCCC
EKPYKKSARIVGDVMGKYHPHGDSAIYESMVRMAQDFSYRYMLVDGHGNFGSVDGDGAAA
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCHH
MRYTEARMSKITLEMLRDINKNTVDFQENYDGTEREPSILPARFPNLLVNGATGIAVGMT
HHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEE
TNIPPHNLSEVISAIHILMNNEDATTADLMEAVPGPDFPTGGIVMGKSGIRKAYETGHGT
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHCCCCE
IILRAKVDIETEKNGRERIVATELPYMVNKAKLIERIAELARDKRIEGITDVNDESDRDG
EEEEEEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
LRVVIDVRRDVSASVVLNNLYKMTLMQTTFGFNMLAIVNGAPKVLGLKEILQHYLVHQEE
CEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCHHH
VIRRRTEFDLKKAEARAHILEGLRIALDHIDEIIAIIRNSQTAEVAKDKLMNNYSLSSKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHH
AQAILDMRLVRLTGLEREKVEDEYNKVMAAITDYRDILAHRERINEIIYKELLEIQERFG
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DERRTELMVGEVLSLEDEDLIEEEDVMVTLTHNGYIKRMATSEFKTQNRGGRGIQGMGVH
CHHHHHHHHHHHHCCCCHHCCCCCCEEEEEECCCEEEEHHHHHHHHCCCCCCCCCCCCCC
DDDFIEHLVSTSTHDVLLFFTNAGKVYRMKGYEIPEYSRTAKGIPVINLLGISSGENIQA
CHHHHHHHHCCCCCEEEEEEECCCEEEEECCCCCCCHHHHCCCCCEEEEEECCCCCCEEE
VINIGRDNGDEDNENRYLFFTTLNGVTKRTPVAEFLNIRSNGLKAISLKENDEVINVVIT
EEEECCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHCCCCEEEEEECCCCCEEEEEEE
DGEQNIIIGTHNGYAVSFKEADVRSMGRSATGVRGIRLRDEDYVVGSAILKPESKVLVIT
CCCCEEEEECCCCEEEEEECCHHHHCCCCCCCEEEEEECCCCEEEEHEEECCCCCEEEEE
EKGYGKQTPASEYPIKGRGGKGIKTANITEKNGPLAGLVTVEGTEDVMLITDRGVMIRFD
ECCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCEEEEEEECCCCCEEEEECCCEEEEEE
VNNVSTTGRATLGVHVIKTDENSKVATMAIVDEAPVDDENQTQTPATEAAETESVTVEES
CCCCCCCCCEEEEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCC
SEE
CCC
>Mature Secondary Structure 
SEELSGRITDVNLSSQMRTSFLDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTP
CCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHCCCCC
EKPYKKSARIVGDVMGKYHPHGDSAIYESMVRMAQDFSYRYMLVDGHGNFGSVDGDGAAA
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCHH
MRYTEARMSKITLEMLRDINKNTVDFQENYDGTEREPSILPARFPNLLVNGATGIAVGMT
HHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEE
TNIPPHNLSEVISAIHILMNNEDATTADLMEAVPGPDFPTGGIVMGKSGIRKAYETGHGT
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHCCCCE
IILRAKVDIETEKNGRERIVATELPYMVNKAKLIERIAELARDKRIEGITDVNDESDRDG
EEEEEEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
LRVVIDVRRDVSASVVLNNLYKMTLMQTTFGFNMLAIVNGAPKVLGLKEILQHYLVHQEE
CEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCHHH
VIRRRTEFDLKKAEARAHILEGLRIALDHIDEIIAIIRNSQTAEVAKDKLMNNYSLSSKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHH
AQAILDMRLVRLTGLEREKVEDEYNKVMAAITDYRDILAHRERINEIIYKELLEIQERFG
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DERRTELMVGEVLSLEDEDLIEEEDVMVTLTHNGYIKRMATSEFKTQNRGGRGIQGMGVH
CHHHHHHHHHHHHCCCCHHCCCCCCEEEEEECCCEEEEHHHHHHHHCCCCCCCCCCCCCC
DDDFIEHLVSTSTHDVLLFFTNAGKVYRMKGYEIPEYSRTAKGIPVINLLGISSGENIQA
CHHHHHHHHCCCCCEEEEEEECCCEEEEECCCCCCCHHHHCCCCCEEEEEECCCCCCEEE
VINIGRDNGDEDNENRYLFFTTLNGVTKRTPVAEFLNIRSNGLKAISLKENDEVINVVIT
EEEECCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHCCCCEEEEEECCCCCEEEEEEE
DGEQNIIIGTHNGYAVSFKEADVRSMGRSATGVRGIRLRDEDYVVGSAILKPESKVLVIT
CCCCEEEEECCCCEEEEEECCHHHHCCCCCCCEEEEEECCCCEEEEHEEECCCCCEEEEE
EKGYGKQTPASEYPIKGRGGKGIKTANITEKNGPLAGLVTVEGTEDVMLITDRGVMIRFD
ECCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCEEEEEEECCCCCEEEEECCCEEEEEE
VNNVSTTGRATLGVHVIKTDENSKVATMAIVDEAPVDDENQTQTPATEAAETESVTVEES
CCCCCCCCCEEEEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCC
SEE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]