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The map label for this gene is phoR [H]

Identifier: 116332656

GI number: 116332656

Start: 268778

End: 271093

Strand: Reverse

Name: phoR [H]

Synonym: LBJ_4237

Alternate gene names: 116332656

Gene position: 271093-268778 (Counterclockwise)

Preceding gene: 116332659

Following gene: 116332655

Centisome position: 90.44

GC content: 42.01

Gene sequence:

>2316_bases
CTGTCTTCTGTGATCGAAATCGCCATCACATCCAGAATTTCTGCGTTTCCGATTTTATATGCCAAATCTAGGGGCTTTTT
TGAAAAAGAGGGAATTCAGGTACAAATTCGGGTTTTGGAAAACTACGACGCGATTCTTGCATTTTTAAGTTCCGGAAAGA
TAGAAGTCGGGGAAATACCGTTTACGACTTGGTTGGATTTACATTTAAAAAAGACCGTACCAAACAAATCTATTTTTCGG
GGAATGATTCTTTCGAGAATGATCCACTCGTTTTATTCCAAATACAATTCCAGTATGGATTCGATTTTGGAAGGGACCCC
GTATTTAATACCGGTTCTACAGAATACATCCGTCGATAAGTTATTGGCCCAAGAATTCATGAGGTCCAGCCGTTTTCGTA
AAAAAATTTCCTATACCTTCGTGTATTCCAGATCCTATCTTTTAGAGTATGAGTTTGCACAGACCACGACTCTCGGACTT
ATCGGATCGGTTCAAGAGTCTCACTTTTTAAATAACGGATTCAGAATTTCGGAGGGACGGGATTTACCTCCGTACCGACT
TCCGGTTAACATGCTCGCGTTTAACGGTAGATTTGCGAAGACCTATCCGGATCGAATCAATAAACTTCAGAGCGCTTTGT
TCCGAGCGATTCAATCCTTGATCGAAAATACGAGCGATACTACGGAGCATGTGATTCAGGAAAACATTCCGGAATTCAAG
ATAGAACCGGAACAACTGCATTACTTTTACAAACAGCCTTCGCAGGATCTGCAGGAGATTCTTTCTCCGGTTGCCGCTTT
GGAGGAATTGGAATACTTGGGAAGAATTTACTGGAGATCCATAAAACATCTAACCGATCCTCCGCCGGTTCTTTTGGAAG
CCCTCGACTTGGCCGCTAAGGATCCGATTCCGATTTATCCTGCCGCTTTGAAAACCAAAAAAACCGTTCTTATGGAGGAG
CAGTTTAACCGTGAGGATGAATCCAATCGCTTATTGGAAATAACGGGGGACCGAAGAGAACTCGGGGATTTGGTTTCCGA
CGTTCACAATCTCGTTTTGAACATTTATAATTCCAAAAAAGGCGTAAGATTGCCGGTATTACCTCTCAAAGGGACCGCAT
CCGCGATCAGAACAGGTATCAACTCCATATTGGATTTTTTATTTCAAGAAATCCGCACTCAAGAGATTAAAGCATTAGCA
ATCGATAATGTTCTAATGATGCAGGGACTTGAGATGGATAAGAGGAATATGGAACTCCAGTTTTCGGACGATCGATTCAA
CTATCTCTTTGAGTTTTCCCCGATTCCGGTGATTTTGTTGGATTCTGTGTCGGGGGCATTGATTGCGGGAAATTATAATT
TCCGAAGTCTTACCAGTTATAGCAAGGATAACATTCATAGTTTGAGACTGGAGGATTTGTTTCCCGGTTTGGAGGAGATG
GGCGATTGGTCCTCCCCGACAAAATCTCCGGAGACGATGCTTCGTGTGGATCAAGTGAAGATGAAGTTGAGAGACAAGTC
CGAAATGGATGTTTCTTTGAGTATCACTGCGTTGTTCGAAAGGGCGAGAAAAATCTATCAGGTTCATATCTTGTATGATT
CTGAGAAAAAAGAAACGGAACAGGCCAAACACGAATTCATTTCGAATATCAGTCACGAGTTACGTTCCCCTATGACAAAT
ATTCAGGGTTATTTCGAACTTTTGAGGGCGGAAATCAATACTTTCTTATCCAAGGATCAAAGCGGGATGTTGAATGTGAT
CGAAAAGAATATAAAACGTCTGAATCATCTCATTGAAAATCTTTTAAAATTCGAGGAAGTTCAGGGAGAAGACAACTCTG
GTCTTGTTGAAAACTTCGATCCGGCTCTGGTAATCGAGGAGGTAGTTTATTCAAACGAACCTTCTGCAAAAGAGAAAGGA
TTGAGTGTAGAGCTTAATCTGATCAAAAAGCTGAAAGTTCGTGGGATCCGTTTTGAATTTTCTCAAGTGATAACGAATCT
TTTCGTAAATGCGATCAAGTATACGGAAAAGGGAAAAATCGAGATGACGATGATTGAGTCCGGCGAGGGGACGATAGAAA
TCAACATCAAGGATACGGGAGTCGGGATCGATCCGAAGTATGTCGAAAAGGTATTCGAGCGATTTTTCCGAGTTCCGAAT
GATCGAAACAAAAGAGTCAGAGGTACCGGATTGGGGCTTCCGATTTCCAGAACCATTCTCCACAAAATGAACGGGGAAAT
TACCCTTGAATCCAGAGTAGGGGGAGGAAGTAACTTCAAAATTTCCCTCCCGTTACAATCATCGGATTCCAAATGA

Upstream 100 bases:

>100_bases
ATTATGTCTCTCGGAACATTTTCCCCACGGGAAGATCTTTTTTTACCTTTTTGAGAAATTTTCAAGGGGGTTCTTGAAAA
ATCTATACTGCTTGTGAATA

Downstream 100 bases:

>100_bases
GTAGAAAAGAAATATATTCAATTATCATAATTTTCTTAATCTTTTCGGTTTGTTTCTTTTTTTTCAATGAAGAAGTCGTA
AAAGATTCTTCTGAGAATGA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 771; Mature: 770

Protein sequence:

>771_residues
MSSVIEIAITSRISAFPILYAKSRGFFEKEGIQVQIRVLENYDAILAFLSSGKIEVGEIPFTTWLDLHLKKTVPNKSIFR
GMILSRMIHSFYSKYNSSMDSILEGTPYLIPVLQNTSVDKLLAQEFMRSSRFRKKISYTFVYSRSYLLEYEFAQTTTLGL
IGSVQESHFLNNGFRISEGRDLPPYRLPVNMLAFNGRFAKTYPDRINKLQSALFRAIQSLIENTSDTTEHVIQENIPEFK
IEPEQLHYFYKQPSQDLQEILSPVAALEELEYLGRIYWRSIKHLTDPPPVLLEALDLAAKDPIPIYPAALKTKKTVLMEE
QFNREDESNRLLEITGDRRELGDLVSDVHNLVLNIYNSKKGVRLPVLPLKGTASAIRTGINSILDFLFQEIRTQEIKALA
IDNVLMMQGLEMDKRNMELQFSDDRFNYLFEFSPIPVILLDSVSGALIAGNYNFRSLTSYSKDNIHSLRLEDLFPGLEEM
GDWSSPTKSPETMLRVDQVKMKLRDKSEMDVSLSITALFERARKIYQVHILYDSEKKETEQAKHEFISNISHELRSPMTN
IQGYFELLRAEINTFLSKDQSGMLNVIEKNIKRLNHLIENLLKFEEVQGEDNSGLVENFDPALVIEEVVYSNEPSAKEKG
LSVELNLIKKLKVRGIRFEFSQVITNLFVNAIKYTEKGKIEMTMIESGEGTIEINIKDTGVGIDPKYVEKVFERFFRVPN
DRNKRVRGTGLGLPISRTILHKMNGEITLESRVGGGSNFKISLPLQSSDSK

Sequences:

>Translated_771_residues
MSSVIEIAITSRISAFPILYAKSRGFFEKEGIQVQIRVLENYDAILAFLSSGKIEVGEIPFTTWLDLHLKKTVPNKSIFR
GMILSRMIHSFYSKYNSSMDSILEGTPYLIPVLQNTSVDKLLAQEFMRSSRFRKKISYTFVYSRSYLLEYEFAQTTTLGL
IGSVQESHFLNNGFRISEGRDLPPYRLPVNMLAFNGRFAKTYPDRINKLQSALFRAIQSLIENTSDTTEHVIQENIPEFK
IEPEQLHYFYKQPSQDLQEILSPVAALEELEYLGRIYWRSIKHLTDPPPVLLEALDLAAKDPIPIYPAALKTKKTVLMEE
QFNREDESNRLLEITGDRRELGDLVSDVHNLVLNIYNSKKGVRLPVLPLKGTASAIRTGINSILDFLFQEIRTQEIKALA
IDNVLMMQGLEMDKRNMELQFSDDRFNYLFEFSPIPVILLDSVSGALIAGNYNFRSLTSYSKDNIHSLRLEDLFPGLEEM
GDWSSPTKSPETMLRVDQVKMKLRDKSEMDVSLSITALFERARKIYQVHILYDSEKKETEQAKHEFISNISHELRSPMTN
IQGYFELLRAEINTFLSKDQSGMLNVIEKNIKRLNHLIENLLKFEEVQGEDNSGLVENFDPALVIEEVVYSNEPSAKEKG
LSVELNLIKKLKVRGIRFEFSQVITNLFVNAIKYTEKGKIEMTMIESGEGTIEINIKDTGVGIDPKYVEKVFERFFRVPN
DRNKRVRGTGLGLPISRTILHKMNGEITLESRVGGGSNFKISLPLQSSDSK
>Mature_770_residues
SSVIEIAITSRISAFPILYAKSRGFFEKEGIQVQIRVLENYDAILAFLSSGKIEVGEIPFTTWLDLHLKKTVPNKSIFRG
MILSRMIHSFYSKYNSSMDSILEGTPYLIPVLQNTSVDKLLAQEFMRSSRFRKKISYTFVYSRSYLLEYEFAQTTTLGLI
GSVQESHFLNNGFRISEGRDLPPYRLPVNMLAFNGRFAKTYPDRINKLQSALFRAIQSLIENTSDTTEHVIQENIPEFKI
EPEQLHYFYKQPSQDLQEILSPVAALEELEYLGRIYWRSIKHLTDPPPVLLEALDLAAKDPIPIYPAALKTKKTVLMEEQ
FNREDESNRLLEITGDRRELGDLVSDVHNLVLNIYNSKKGVRLPVLPLKGTASAIRTGINSILDFLFQEIRTQEIKALAI
DNVLMMQGLEMDKRNMELQFSDDRFNYLFEFSPIPVILLDSVSGALIAGNYNFRSLTSYSKDNIHSLRLEDLFPGLEEMG
DWSSPTKSPETMLRVDQVKMKLRDKSEMDVSLSITALFERARKIYQVHILYDSEKKETEQAKHEFISNISHELRSPMTNI
QGYFELLRAEINTFLSKDQSGMLNVIEKNIKRLNHLIENLLKFEEVQGEDNSGLVENFDPALVIEEVVYSNEPSAKEKGL
SVELNLIKKLKVRGIRFEFSQVITNLFVNAIKYTEKGKIEMTMIESGEGTIEINIKDTGVGIDPKYVEKVFERFFRVPND
RNKRVRGTGLGLPISRTILHKMNGEITLESRVGGGSNFKISLPLQSSDSK

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=238, Percent_Identity=33.1932773109244, Blast_Score=116, Evalue=6e-27,
Organism=Escherichia coli, GI145693157, Length=231, Percent_Identity=30.7359307359307, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1786600, Length=243, Percent_Identity=27.5720164609054, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI87082128, Length=237, Percent_Identity=29.957805907173, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1788713, Length=234, Percent_Identity=27.7777777777778, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI87081816, Length=242, Percent_Identity=28.5123966942149, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788549, Length=227, Percent_Identity=28.6343612334802, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1786912, Length=262, Percent_Identity=30.1526717557252, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1788393, Length=236, Percent_Identity=25.4237288135593, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI48994928, Length=246, Percent_Identity=27.2357723577236, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI1786783, Length=242, Percent_Identity=26.4462809917355, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1787894, Length=224, Percent_Identity=28.125, Blast_Score=88, Evalue=3e-18,
Organism=Escherichia coli, GI1790346, Length=225, Percent_Identity=29.7777777777778, Blast_Score=87, Evalue=5e-18,
Organism=Escherichia coli, GI1790436, Length=260, Percent_Identity=26.9230769230769, Blast_Score=80, Evalue=6e-16,
Organism=Escherichia coli, GI1790861, Length=226, Percent_Identity=26.5486725663717, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1789808, Length=225, Percent_Identity=26.6666666666667, Blast_Score=66, Evalue=9e-12,
Organism=Escherichia coli, GI1789403, Length=223, Percent_Identity=26.457399103139, Blast_Score=63, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=77, Percent_Identity=44.1558441558442, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 88224; Mature: 88092

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSVIEIAITSRISAFPILYAKSRGFFEKEGIQVQIRVLENYDAILAFLSSGKIEVGEIP
CCCEEEEHHHCCCCCCEEEEECCCCCCCCCCCEEEEEEECCHHHHHHHHHCCCEEECCCC
FTTWLDLHLKKTVPNKSIFRGMILSRMIHSFYSKYNSSMDSILEGTPYLIPVLQNTSVDK
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEEECCCCHHH
LLAQEFMRSSRFRKKISYTFVYSRSYLLEYEFAQTTTLGLIGSVQESHFLNNGFRISEGR
HHHHHHHHHHHHHHHHEEEEEEECEEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEECCCC
DLPPYRLPVNMLAFNGRFAKTYPDRINKLQSALFRAIQSLIENTSDTTEHVIQENIPEFK
CCCCCCCCEEEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCC
IEPEQLHYFYKQPSQDLQEILSPVAALEELEYLGRIYWRSIKHLTDPPPVLLEALDLAAK
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
DPIPIYPAALKTKKTVLMEEQFNREDESNRLLEITGDRRELGDLVSDVHNLVLNIYNSKK
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCC
GVRLPVLPLKGTASAIRTGINSILDFLFQEIRTQEIKALAIDNVLMMQGLEMDKRNMELQ
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
FSDDRFNYLFEFSPIPVILLDSVSGALIAGNYNFRSLTSYSKDNIHSLRLEDLFPGLEEM
ECCCCCCEEEEECCCCEEEEECCCCEEEECCCCCHHHCCCCCCCHHEEEHHHHCCCHHHH
GDWSSPTKSPETMLRVDQVKMKLRDKSEMDVSLSITALFERARKIYQVHILYDSEKKETE
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHEEEEEEEECCCHHHHH
QAKHEFISNISHELRSPMTNIQGYFELLRAEINTFLSKDQSGMLNVIEKNIKRLNHLIEN
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LLKFEEVQGEDNSGLVENFDPALVIEEVVYSNEPSAKEKGLSVELNLIKKLKVRGIRFEF
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHCCCEEEEHHHHHHHHCCCCHHH
SQVITNLFVNAIKYTEKGKIEMTMIESGEGTIEINIKDTGVGIDPKYVEKVFERFFRVPN
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCC
DRNKRVRGTGLGLPISRTILHKMNGEITLESRVGGGSNFKISLPLQSSDSK
CCCCEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCCC
>Mature Secondary Structure 
SSVIEIAITSRISAFPILYAKSRGFFEKEGIQVQIRVLENYDAILAFLSSGKIEVGEIP
CCEEEEHHHCCCCCCEEEEECCCCCCCCCCCEEEEEEECCHHHHHHHHHCCCEEECCCC
FTTWLDLHLKKTVPNKSIFRGMILSRMIHSFYSKYNSSMDSILEGTPYLIPVLQNTSVDK
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEEECCCCHHH
LLAQEFMRSSRFRKKISYTFVYSRSYLLEYEFAQTTTLGLIGSVQESHFLNNGFRISEGR
HHHHHHHHHHHHHHHHEEEEEEECEEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEECCCC
DLPPYRLPVNMLAFNGRFAKTYPDRINKLQSALFRAIQSLIENTSDTTEHVIQENIPEFK
CCCCCCCCEEEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCC
IEPEQLHYFYKQPSQDLQEILSPVAALEELEYLGRIYWRSIKHLTDPPPVLLEALDLAAK
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
DPIPIYPAALKTKKTVLMEEQFNREDESNRLLEITGDRRELGDLVSDVHNLVLNIYNSKK
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCC
GVRLPVLPLKGTASAIRTGINSILDFLFQEIRTQEIKALAIDNVLMMQGLEMDKRNMELQ
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
FSDDRFNYLFEFSPIPVILLDSVSGALIAGNYNFRSLTSYSKDNIHSLRLEDLFPGLEEM
ECCCCCCEEEEECCCCEEEEECCCCEEEECCCCCHHHCCCCCCCHHEEEHHHHCCCHHHH
GDWSSPTKSPETMLRVDQVKMKLRDKSEMDVSLSITALFERARKIYQVHILYDSEKKETE
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHEEEEEEEECCCHHHHH
QAKHEFISNISHELRSPMTNIQGYFELLRAEINTFLSKDQSGMLNVIEKNIKRLNHLIEN
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LLKFEEVQGEDNSGLVENFDPALVIEEVVYSNEPSAKEKGLSVELNLIKKLKVRGIRFEF
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHCCCEEEEHHHHHHHHCCCCHHH
SQVITNLFVNAIKYTEKGKIEMTMIESGEGTIEINIKDTGVGIDPKYVEKVFERFFRVPN
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCC
DRNKRVRGTGLGLPISRTILHKMNGEITLESRVGGGSNFKISLPLQSSDSK
CCCCEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]