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The map label for this gene is ubiE [H]

Identifier: 116332571

GI number: 116332571

Start: 164800

End: 165534

Strand: Reverse

Name: ubiE [H]

Synonym: LBJ_4143

Alternate gene names: 116332571

Gene position: 165534-164800 (Counterclockwise)

Preceding gene: 116332574

Following gene: 116332569

Centisome position: 55.22

GC content: 37.55

Gene sequence:

>735_bases
ATGTTTCAAATGCCTCATGTTGATACCAAAGCGGATTTTGTTCGAAAGAACTTTAACAAGATCGCGAATAAATACGATCG
ATTCAATGATTGGAATAGCTTTTTGCTTCATCGGATTTGGAAAAACCGGCTAGTTCGTGAAATTGAAGAAAATCTTTCTG
ACCGCTTACATGTGATGGATCTTTGCTGTGGAACCGGAGATATTTCAGTACGTCTGGGAAATTCTCCTCGGATCGATCAT
ATTACCTGTGTGGATTTTTCAGAAAACATGCTCGAAATCGCAAAAACTCGACTTAAAAAACAAATCGAAAAGGGTCGAAT
CCATTTCGAGCTAGGAGATGCGACAGAACTCAAAAATTTTCAGGATTTTCAGTTTCATGCGGTTTCAATCGGCTTCGGTC
TCCGCAATGTAGATAATCTCTCTAAAGCGGTTAGGGAAATTCTCAGAATTTTAAAACCAGGGGGATTATTTCTCAATTTG
GACGTTGGTAAGGTTAAAAATCCTTGGATTCGTTGGATCGCAGATTTTTATTTCTTTAAAATAGTTCCGATTCTCGGTTA
TATTCTTTGGGGTGGGAAGAACGAAATGTTTGATTATCTTCCGGTTTCTTCCATTGTATATCCAGATCAAGAAAATCTAA
AGTTGATTCTTGAAAAACTGGGTTTTCAAGAGGTGCGATATAAGAATTTTGTTTTCGGAAATGTGGTTTTGCATATCGCA
AAGAAACCCCTTTGA

Upstream 100 bases:

>100_bases
AATTCTAACCACTCGCAACTCGAAACGTCCGTTTGCAATCGGATTTCTATAAAACACTTCTTGCCATCGGTAAACGCTTT
CAAATCATTTCATTAAAGTT

Downstream 100 bases:

>100_bases
AATGCATAAAAATTACCTAAAATTCCGTTGAATCCCTAAAAAAGTTTTGTTGAAAACGAAAAAATCTCCTATAATTCCTT
CCCCGAATGGTATTTAAGAT

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MFQMPHVDTKADFVRKNFNKIANKYDRFNDWNSFLLHRIWKNRLVREIEENLSDRLHVMDLCCGTGDISVRLGNSPRIDH
ITCVDFSENMLEIAKTRLKKQIEKGRIHFELGDATELKNFQDFQFHAVSIGFGLRNVDNLSKAVREILRILKPGGLFLNL
DVGKVKNPWIRWIADFYFFKIVPILGYILWGGKNEMFDYLPVSSIVYPDQENLKLILEKLGFQEVRYKNFVFGNVVLHIA
KKPL

Sequences:

>Translated_244_residues
MFQMPHVDTKADFVRKNFNKIANKYDRFNDWNSFLLHRIWKNRLVREIEENLSDRLHVMDLCCGTGDISVRLGNSPRIDH
ITCVDFSENMLEIAKTRLKKQIEKGRIHFELGDATELKNFQDFQFHAVSIGFGLRNVDNLSKAVREILRILKPGGLFLNL
DVGKVKNPWIRWIADFYFFKIVPILGYILWGGKNEMFDYLPVSSIVYPDQENLKLILEKLGFQEVRYKNFVFGNVVLHIA
KKPL
>Mature_244_residues
MFQMPHVDTKADFVRKNFNKIANKYDRFNDWNSFLLHRIWKNRLVREIEENLSDRLHVMDLCCGTGDISVRLGNSPRIDH
ITCVDFSENMLEIAKTRLKKQIEKGRIHFELGDATELKNFQDFQFHAVSIGFGLRNVDNLSKAVREILRILKPGGLFLNL
DVGKVKNPWIRWIADFYFFKIVPILGYILWGGKNEMFDYLPVSSIVYPDQENLKLILEKLGFQEVRYKNFVFGNVVLHIA
KKPL

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=271, Percent_Identity=30.6273062730627, Blast_Score=130, Evalue=8e-31,
Organism=Escherichia coli, GI48994983, Length=238, Percent_Identity=33.1932773109244, Blast_Score=128, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17557039, Length=228, Percent_Identity=32.4561403508772, Blast_Score=127, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6323526, Length=251, Percent_Identity=28.2868525896414, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24641702, Length=251, Percent_Identity=33.8645418326693, Blast_Score=151, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 28621; Mature: 28621

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS01183 UBIE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQMPHVDTKADFVRKNFNKIANKYDRFNDWNSFLLHRIWKNRLVREIEENLSDRLHVMD
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LCCGTGDISVRLGNSPRIDHITCVDFSENMLEIAKTRLKKQIEKGRIHFELGDATELKNF
HHCCCCCEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHCCC
QDFQFHAVSIGFGLRNVDNLSKAVREILRILKPGGLFLNLDVGKVKNPWIRWIADFYFFK
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHH
IVPILGYILWGGKNEMFDYLPVSSIVYPDQENLKLILEKLGFQEVRYKNFVFGNVVLHIA
HHHHHHHHHCCCCCCCHHHCCCCCEECCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
KKPL
CCCC
>Mature Secondary Structure
MFQMPHVDTKADFVRKNFNKIANKYDRFNDWNSFLLHRIWKNRLVREIEENLSDRLHVMD
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LCCGTGDISVRLGNSPRIDHITCVDFSENMLEIAKTRLKKQIEKGRIHFELGDATELKNF
HHCCCCCEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHCCC
QDFQFHAVSIGFGLRNVDNLSKAVREILRILKPGGLFLNLDVGKVKNPWIRWIADFYFFK
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHH
IVPILGYILWGGKNEMFDYLPVSSIVYPDQENLKLILEKLGFQEVRYKNFVFGNVVLHIA
HHHHHHHHHCCCCCCCHHHCCCCCEECCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
KKPL
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA