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The map label for this gene is phoR [H]

Identifier: 116329430

GI number: 116329430

Start: 3447536

End: 3448927

Strand: Direct

Name: phoR [H]

Synonym: LBL_2898

Alternate gene names: 116329430

Gene position: 3447536-3448927 (Clockwise)

Preceding gene: 116329429

Following gene: 116329431

Centisome position: 95.38

GC content: 41.95

Gene sequence:

>1392_bases
ATGAGGCGTAGCTTATTTTCAAAACTTCTTCTCAGTAACTGGTTACTTTTGCTAGTTCTTCTCGTTGTTGCGGGGACGGT
TCTTTTTGCGGAAAAGTTTGTTCATTCGGATTTTAAAATTCTTCTGTTTTCGTTTTACGTTCTTTTCGCGATGTTCGGAA
CATTTTACATGTCCTATTCGATCGCCAAAAGTGTAGCGGAGCCTTTGGATAGAATCGAAAAAAAAACAGGAGAGATCAAT
GCAGGCGACTTCGGATCCGAATTGACTCTGTCGGACATTCGAGAACTCGCAGACCTCGCTTCTTCCATCAACTTAATGTC
TACAAGACTTAAAAGCCAGTTTGTGGATCTCACGATCGAAAAAGAAAAATTCGATTCCGTTTTACAGAATTTAAAGGAAG
GTGTTTTTGCGATCGACCCCGAAAATGCCTCTATTCTTTTTCAAAACAAAAGTATCCCAGGATCTCTCATTGAACCGAAT
TCCAGGTCCAGAAAAGTCGCAGACGCAACTCGAGATCCGAGGCTCTTGGAATTCGTATCGAACCACCTCAGAGGGTCGGG
CGATTCCAAAATGGAACTGGATCTCGGACAAAATTTTTACACAATCAAAATGTACCCTCTGAAAACGAACGGTAAAACTC
TTATGTACATCGGAGTGATCAGAAATATTACCGAAGAAAAGCAGTCTCATATCATAAGAGAACAATTTGTTCAGAACGCT
TCTCACGAACTCAAGACCCCGATTACGTCCATTAAGGGATACACTGAAACGTTACTCGATCGTCTACGTCTTTCTCCCGA
AAGTCACGAGAAAAGATTTTTGGACGCAATTTCAAGAAATACAGACCGTATGGTTCGTATCGTGGCAGATATGCTCACGA
TTACTCGGATCGAAAACCAAACCAAAATTTCCGGGGAAGAGGAATTTTCCTTAAAATCTCTTGTGGAGAATTTAAGTTAT
ACGGTCGAAGGGGTTGTGTCGCCTAAAGGACAGAGGTTTCTAGTAGAGATGCCGGAGCCTCTAATGATCTCGGCCGACTG
GGTTCTTTTGGAGCATATGCTTTTGAACCTAATCTCAAATGCTTCGGCTTATTCTCCCGAAGGCAAAACGATTACACTAA
AAATCCTTCCTTTCGAATCAGATCAGGTCCAGTTTCAAGTGATCGACCAAGGAATCGGAATTCAAGACGAGGATAAAAGT
AGAATTTTCGAAAGATTTTTCCGAGTCGATAAGAATCGTTCTAGAAAAGAAGGCGGAACCGGCTTAGGCCTCTCCATCGT
AAAACATATCGTTCGTCTTCACCACGGCTCCGTAAAAGTTTTCGACAATTCAGAAGGTGGAACTATTTTTGCGGTTACGA
TTCCCATTCGTTATCAAGCCGAAATGTTCTGA

Upstream 100 bases:

>100_bases
ACCGACAGAGCCGTCGACGTAAATATTAAAAGATTACGCGATAAACTCGGAGACGAAAAGGAAAGACTCGAAACGATACG
CGGAATCGGCTATAGATTCA

Downstream 100 bases:

>100_bases
ATTCTTCTTTTCGGCAGAGATAATTTCCCAAAGATAGATCCAACTGATACGTTGAGGGATCTTATGACAATGCCCAAAGG
CTTTTCATCTTTCGGAATCA

Product: sensor histidine kinase of a two component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MRRSLFSKLLLSNWLLLLVLLVVAGTVLFAEKFVHSDFKILLFSFYVLFAMFGTFYMSYSIAKSVAEPLDRIEKKTGEIN
AGDFGSELTLSDIRELADLASSINLMSTRLKSQFVDLTIEKEKFDSVLQNLKEGVFAIDPENASILFQNKSIPGSLIEPN
SRSRKVADATRDPRLLEFVSNHLRGSGDSKMELDLGQNFYTIKMYPLKTNGKTLMYIGVIRNITEEKQSHIIREQFVQNA
SHELKTPITSIKGYTETLLDRLRLSPESHEKRFLDAISRNTDRMVRIVADMLTITRIENQTKISGEEEFSLKSLVENLSY
TVEGVVSPKGQRFLVEMPEPLMISADWVLLEHMLLNLISNASAYSPEGKTITLKILPFESDQVQFQVIDQGIGIQDEDKS
RIFERFFRVDKNRSRKEGGTGLGLSIVKHIVRLHHGSVKVFDNSEGGTIFAVTIPIRYQAEMF

Sequences:

>Translated_463_residues
MRRSLFSKLLLSNWLLLLVLLVVAGTVLFAEKFVHSDFKILLFSFYVLFAMFGTFYMSYSIAKSVAEPLDRIEKKTGEIN
AGDFGSELTLSDIRELADLASSINLMSTRLKSQFVDLTIEKEKFDSVLQNLKEGVFAIDPENASILFQNKSIPGSLIEPN
SRSRKVADATRDPRLLEFVSNHLRGSGDSKMELDLGQNFYTIKMYPLKTNGKTLMYIGVIRNITEEKQSHIIREQFVQNA
SHELKTPITSIKGYTETLLDRLRLSPESHEKRFLDAISRNTDRMVRIVADMLTITRIENQTKISGEEEFSLKSLVENLSY
TVEGVVSPKGQRFLVEMPEPLMISADWVLLEHMLLNLISNASAYSPEGKTITLKILPFESDQVQFQVIDQGIGIQDEDKS
RIFERFFRVDKNRSRKEGGTGLGLSIVKHIVRLHHGSVKVFDNSEGGTIFAVTIPIRYQAEMF
>Mature_463_residues
MRRSLFSKLLLSNWLLLLVLLVVAGTVLFAEKFVHSDFKILLFSFYVLFAMFGTFYMSYSIAKSVAEPLDRIEKKTGEIN
AGDFGSELTLSDIRELADLASSINLMSTRLKSQFVDLTIEKEKFDSVLQNLKEGVFAIDPENASILFQNKSIPGSLIEPN
SRSRKVADATRDPRLLEFVSNHLRGSGDSKMELDLGQNFYTIKMYPLKTNGKTLMYIGVIRNITEEKQSHIIREQFVQNA
SHELKTPITSIKGYTETLLDRLRLSPESHEKRFLDAISRNTDRMVRIVADMLTITRIENQTKISGEEEFSLKSLVENLSY
TVEGVVSPKGQRFLVEMPEPLMISADWVLLEHMLLNLISNASAYSPEGKTITLKILPFESDQVQFQVIDQGIGIQDEDKS
RIFERFFRVDKNRSRKEGGTGLGLSIVKHIVRLHHGSVKVFDNSEGGTIFAVTIPIRYQAEMF

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=368, Percent_Identity=30.1630434782609, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1786783, Length=228, Percent_Identity=32.8947368421053, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1786912, Length=245, Percent_Identity=31.4285714285714, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1789149, Length=224, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1790861, Length=216, Percent_Identity=32.4074074074074, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI48994928, Length=254, Percent_Identity=28.3464566929134, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1790346, Length=231, Percent_Identity=28.1385281385281, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI145693157, Length=237, Percent_Identity=27.4261603375527, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788279, Length=223, Percent_Identity=32.2869955156951, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788713, Length=291, Percent_Identity=24.3986254295533, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788393, Length=261, Percent_Identity=24.1379310344828, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87082128, Length=226, Percent_Identity=31.4159292035398, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1788549, Length=228, Percent_Identity=28.5087719298246, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87081816, Length=240, Percent_Identity=27.9166666666667, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1787894, Length=257, Percent_Identity=26.8482490272374, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790551, Length=207, Percent_Identity=30.9178743961353, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789403, Length=228, Percent_Identity=29.8245614035088, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=28.0542986425339, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790300, Length=254, Percent_Identity=26.3779527559055, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52539; Mature: 52539

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRSLFSKLLLSNWLLLLVLLVVAGTVLFAEKFVHSDFKILLFSFYVLFAMFGTFYMSYS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IAKSVAEPLDRIEKKTGEINAGDFGSELTLSDIRELADLASSINLMSTRLKSQFVDLTIE
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
KEKFDSVLQNLKEGVFAIDPENASILFQNKSIPGSLIEPNSRSRKVADATRDPRLLEFVS
HHHHHHHHHHHHCCEEEECCCCCEEEEECCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHH
NHLRGSGDSKMELDLGQNFYTIKMYPLKTNGKTLMYIGVIRNITEEKQSHIIREQFVQNA
HHHCCCCCCEEEEECCCCEEEEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCC
SHELKTPITSIKGYTETLLDRLRLSPESHEKRFLDAISRNTDRMVRIVADMLTITRIENQ
HHHHHCCHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
TKISGEEEFSLKSLVENLSYTVEGVVSPKGQRFLVEMPEPLMISADWVLLEHMLLNLISN
CCCCCCHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCEEECHHHHHHHHHHHHHHC
ASAYSPEGKTITLKILPFESDQVQFQVIDQGIGIQDEDKSRIFERFFRVDKNRSRKEGGT
CCCCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
GLGLSIVKHIVRLHHGSVKVFDNSEGGTIFAVTIPIRYQAEMF
CCCHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEEEEEECCCC
>Mature Secondary Structure
MRRSLFSKLLLSNWLLLLVLLVVAGTVLFAEKFVHSDFKILLFSFYVLFAMFGTFYMSYS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IAKSVAEPLDRIEKKTGEINAGDFGSELTLSDIRELADLASSINLMSTRLKSQFVDLTIE
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
KEKFDSVLQNLKEGVFAIDPENASILFQNKSIPGSLIEPNSRSRKVADATRDPRLLEFVS
HHHHHHHHHHHHCCEEEECCCCCEEEEECCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHH
NHLRGSGDSKMELDLGQNFYTIKMYPLKTNGKTLMYIGVIRNITEEKQSHIIREQFVQNA
HHHCCCCCCEEEEECCCCEEEEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCC
SHELKTPITSIKGYTETLLDRLRLSPESHEKRFLDAISRNTDRMVRIVADMLTITRIENQ
HHHHHCCHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
TKISGEEEFSLKSLVENLSYTVEGVVSPKGQRFLVEMPEPLMISADWVLLEHMLLNLISN
CCCCCCHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCEEECHHHHHHHHHHHHHHC
ASAYSPEGKTITLKILPFESDQVQFQVIDQGIGIQDEDKSRIFERFFRVDKNRSRKEGGT
CCCCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
GLGLSIVKHIVRLHHGSVKVFDNSEGGTIFAVTIPIRYQAEMF
CCCHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]