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The map label for this gene is rnd [H]

Identifier: 116329422

GI number: 116329422

Start: 3442437

End: 3443603

Strand: Direct

Name: rnd [H]

Synonym: LBL_2890

Alternate gene names: 116329422

Gene position: 3442437-3443603 (Clockwise)

Preceding gene: 116329420

Following gene: 116329423

Centisome position: 95.24

GC content: 37.79

Gene sequence:

>1167_bases
ATGCAAATAAATTCCGATTACATAGTCGTAGATACAATTCGAAGCCTACAACTCGTTCTCATCACTCTGAGTCAGGCCGA
TTCCATCTCCATCGATACGGAGTCCTCCGGTTATTATACCTATTTCTCAAAGGTCTGTCTGATCCAAATTTCGGCTAAGG
GAAAAAATTATATCATCGATCCTTTGAAATTACAAAATTTAGATGGCCTTGGAAATTTATTTGAAGATAAAAAAATCCTA
AAGATATTCCATTCCGCCATTGATGATATTAAAGCCCTTAAAAAAGACTTCGGTTTTAAATTTCATAACATCGCGGATAC
CGGATTCAGTTCCCGTCTTTTAGATCACGAACAATATTCTTTAACTTATCTTGTGGATTATTATCATAAGATAAAACTTT
CCAAAAAAGAACAAAAATCTAATTGGGAAAAACGACCTCTTGAAAAAAGTCAACTTCAATACGCGGCTTTAGATACGGTT
TATCTAGAAACGATTTGGGAAAAAATGAAGGAAGAACTTACCAAGAGAAATCTTTACGAAGAAGCGTTTTCCGAATTTGA
AAAGATCGCATCCGAAGAACCGGGCGCCGAAGGAAATTCCATCTCCATGGATAAGTTCCCCGAGATTTTGGAATACAGCG
CCGATGAAAGAAGATTTATATACGACACGTTGGTTTTTAGGGACGATAAATCTAGAAAGTTAAACAAAGCTCCTTTTCGG
GTATTCAACAACGAAAAGGTAATTCTTCTCGTAAAGTCAAGAAGAGACATGGCAAAGTTAACCGAAATTGTCGGTAAAAA
AGACGCGGAAAGTTTATTTCGGATTTATGCGAATCCAAGCGGACCTCCGATTCAAAAATCCGAGCTTTTTAAAAAACCGG
GTGAAAACTTGACGAACGAAGAAGGCGAACGTTTCAAACGTCTGAGAATTTGGAGAGAAACGATCATGTCCATCAGAAGA
ATGAGTCATCAGATGATGCCTTCGAACAAAATGATCGCGGAGTTGGCCCAAAGAAATCCGAAAACTTTAGACGAGTTGAG
AGAGATGAATCTTTTCTCAGAGTGGAAAGTGATTCACTACGGCCCCTCTATTTTGGCCGCATTAGAAAATGTACCTTACG
AATCGAATATCAAGGGACTCATTCCGATAAATAAAAAATTCGAATAG

Upstream 100 bases:

>100_bases
TTTTGGTTTGTCATCCTGGGCTTGTCTTCTTACTCTGGATTTATCGGGAATTCGACTCATTCTCTGCCTCTTAAGCTCAA
AATCTCAGGTCGCGTTTTTC

Downstream 100 bases:

>100_bases
AAATATTTAACTCTTCCAATGCAGGTGAAAAAATGAGATTTGATTTTCAGTCGCTCAAAAATCGACTTGCAGTTCCTCAG
AAAATTTTTACCGGAATTCC

Product: ribonuclease III

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MQINSDYIVVDTIRSLQLVLITLSQADSISIDTESSGYYTYFSKVCLIQISAKGKNYIIDPLKLQNLDGLGNLFEDKKIL
KIFHSAIDDIKALKKDFGFKFHNIADTGFSSRLLDHEQYSLTYLVDYYHKIKLSKKEQKSNWEKRPLEKSQLQYAALDTV
YLETIWEKMKEELTKRNLYEEAFSEFEKIASEEPGAEGNSISMDKFPEILEYSADERRFIYDTLVFRDDKSRKLNKAPFR
VFNNEKVILLVKSRRDMAKLTEIVGKKDAESLFRIYANPSGPPIQKSELFKKPGENLTNEEGERFKRLRIWRETIMSIRR
MSHQMMPSNKMIAELAQRNPKTLDELREMNLFSEWKVIHYGPSILAALENVPYESNIKGLIPINKKFE

Sequences:

>Translated_388_residues
MQINSDYIVVDTIRSLQLVLITLSQADSISIDTESSGYYTYFSKVCLIQISAKGKNYIIDPLKLQNLDGLGNLFEDKKIL
KIFHSAIDDIKALKKDFGFKFHNIADTGFSSRLLDHEQYSLTYLVDYYHKIKLSKKEQKSNWEKRPLEKSQLQYAALDTV
YLETIWEKMKEELTKRNLYEEAFSEFEKIASEEPGAEGNSISMDKFPEILEYSADERRFIYDTLVFRDDKSRKLNKAPFR
VFNNEKVILLVKSRRDMAKLTEIVGKKDAESLFRIYANPSGPPIQKSELFKKPGENLTNEEGERFKRLRIWRETIMSIRR
MSHQMMPSNKMIAELAQRNPKTLDELREMNLFSEWKVIHYGPSILAALENVPYESNIKGLIPINKKFE
>Mature_388_residues
MQINSDYIVVDTIRSLQLVLITLSQADSISIDTESSGYYTYFSKVCLIQISAKGKNYIIDPLKLQNLDGLGNLFEDKKIL
KIFHSAIDDIKALKKDFGFKFHNIADTGFSSRLLDHEQYSLTYLVDYYHKIKLSKKEQKSNWEKRPLEKSQLQYAALDTV
YLETIWEKMKEELTKRNLYEEAFSEFEKIASEEPGAEGNSISMDKFPEILEYSADERRFIYDTLVFRDDKSRKLNKAPFR
VFNNEKVILLVKSRRDMAKLTEIVGKKDAESLFRIYANPSGPPIQKSELFKKPGENLTNEEGERFKRLRIWRETIMSIRR
MSHQMMPSNKMIAELAQRNPKTLDELREMNLFSEWKVIHYGPSILAALENVPYESNIKGLIPINKKFE

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI50301240, Length=156, Percent_Identity=35.8974358974359, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI4505917, Length=156, Percent_Identity=35.8974358974359, Blast_Score=102, Evalue=9e-22,
Organism=Escherichia coli, GI1788105, Length=184, Percent_Identity=26.6304347826087, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17531757, Length=181, Percent_Identity=31.4917127071823, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI32564304, Length=100, Percent_Identity=33, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324574, Length=184, Percent_Identity=34.7826086956522, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI161078302, Length=174, Percent_Identity=34.4827586206897, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 45324; Mature: 45324

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQINSDYIVVDTIRSLQLVLITLSQADSISIDTESSGYYTYFSKVCLIQISAKGKNYIID
CCCCCCEEEEEHHHHHEEEEEEECCCCCEEEECCCCCCHHEEEEEEEEEEECCCCCEEEC
PLKLQNLDGLGNLFEDKKILKIFHSAIDDIKALKKDFGFKFHNIADTGFSSRLLDHEQYS
CHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHCCHHHH
LTYLVDYYHKIKLSKKEQKSNWEKRPLEKSQLQYAALDTVYLETIWEKMKEELTKRNLYE
HHHHHHHHHHHHCCCHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAFSEFEKIASEEPGAEGNSISMDKFPEILEYSADERRFIYDTLVFRDDKSRKLNKAPFR
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEHHHEEECCCCCCCCCCCCE
VFNNEKVILLVKSRRDMAKLTEIVGKKDAESLFRIYANPSGPPIQKSELFKKPGENLTNE
EECCCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCH
EGERFKRLRIWRETIMSIRRMSHQMMPSNKMIAELAQRNPKTLDELREMNLFSEWKVIHY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHCCHHHCCEEEEE
GPSILAALENVPYESNIKGLIPINKKFE
CHHHHHHHHCCCCCCCCCEEECCCCCCC
>Mature Secondary Structure
MQINSDYIVVDTIRSLQLVLITLSQADSISIDTESSGYYTYFSKVCLIQISAKGKNYIID
CCCCCCEEEEEHHHHHEEEEEEECCCCCEEEECCCCCCHHEEEEEEEEEEECCCCCEEEC
PLKLQNLDGLGNLFEDKKILKIFHSAIDDIKALKKDFGFKFHNIADTGFSSRLLDHEQYS
CHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHCCHHHH
LTYLVDYYHKIKLSKKEQKSNWEKRPLEKSQLQYAALDTVYLETIWEKMKEELTKRNLYE
HHHHHHHHHHHHCCCHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAFSEFEKIASEEPGAEGNSISMDKFPEILEYSADERRFIYDTLVFRDDKSRKLNKAPFR
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEHHHEEECCCCCCCCCCCCE
VFNNEKVILLVKSRRDMAKLTEIVGKKDAESLFRIYANPSGPPIQKSELFKKPGENLTNE
EECCCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCH
EGERFKRLRIWRETIMSIRRMSHQMMPSNKMIAELAQRNPKTLDELREMNLFSEWKVIHY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHCCHHHCCEEEEE
GPSILAALENVPYESNIKGLIPINKKFE
CHHHHHHHHCCCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]