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The map label for this gene is lysA [H]

Identifier: 116329346

GI number: 116329346

Start: 3319164

End: 3320432

Strand: Direct

Name: lysA [H]

Synonym: LBL_2795

Alternate gene names: 116329346

Gene position: 3319164-3320432 (Clockwise)

Preceding gene: 116329341

Following gene: 116329347

Centisome position: 91.83

GC content: 43.81

Gene sequence:

>1269_bases
ATGCAACCAATAGAAAAATTAAAATTTTTGACCAAACTCCAAGTGCGCTCGATTGCACAGCAATTCGGGACCCCGATTTT
TGTGTATTCTCGGGAAGGGATAGAAAAAAGTTGCGACGCCGCACTTGCGTTTCCGAACGGCTACGGATTAACCGTACGCT
ATGCAATGAAAGCCAATTCCAATCGAACGATCCTTGAAATCATAAAACGAAAAGGAATTCAAATCGACGCAAGTTCCGAA
TACGAAGTGTTGAGAGCGATTCATTACGGATTCAAACCGGAAGAGATCATGCTTACTTCTCAAGAACTTGCAAAGAACTT
AAAAGAATTCGTGGAAAAGGGAGTGGTCTTCAACGCTTGCTCTCTACGTCAATTGGAAGCTTTTGGAAATTTATTTCCAG
GAAAAGAAGTCAGCGTTCGTTTTAACCCGGGACTAGGATCGGGACAGACCAAAAAAACGGACGTGGGCGGAAAAACTTCT
TCCTTCGGCGTTTGGCACGAGGAACTGAACAAGGTAAAGGAAATCGCTTCAAAATACAAACTCAAAATTTTTAAGATTCA
CACTCATATCGGATCCGGAAGCGATCCGGAAGCTTGGAAGGCGATTGCTCAAGTCTCTCTGGACATCGCGGCGCAATTTT
CGGAATGTAAAATCTTGAATTTAGGCGGCGGCTTTAAGGTCGGTAGAATGGAGGATGAAAAAACCACAAACTTTCAAAAA
ATCGGCAAACCCGTGGTTGAGCTCTTCCAGGAATTCGCGAAAAAACACGGAACTTCGCTTCACTTGGAGATCGAGCCGGG
TTCGTTTTTAATGGTGAATAACGGTTCCATCATATCTACGGTGGACGACGTAGTTTCCACGGGTGACGGCGGTTATACTT
TTGTAAAGATTGACGCGGGAATGGATGTAAACACAAGGCCTTCTCTGTATGCGGCAAGACATCCATTAGTCGTAGTTCCC
AAAGTAGAAACACATTCCGGTAAAACCGCAAGTTACGTATATGTGGGACATTGTTGCGAGAGTGGAGATTTATTCACGCA
AGCCGAAGGCGGCGGACCGGTCACAAGAATAACAGGAGAAGCTCAATTAGGAGATTATGTTGTAATGGAAGGGGCAGGCG
CTTATTGTTCTTCTATGTCCACAAAAAATTACAATTCTTTTCCCGAGACTGCGGAAGTTCTTGTGGACTTAGACGGAAGT
TTTCAACTCATTCGGAAACGTCAAAATCTAGAGCAAATTTTTCAGAATGAAGTCCCTATTTCTCTCTGA

Upstream 100 bases:

>100_bases
GATGAGTGATTTTACCAGCCATGATGGAAAATACCTTTTAAAAAACGGAACCTTTTAGGAGCGTGTTCTTAAAAACCATT
TAGAATTGTCCGTTTTACTT

Downstream 100 bases:

>100_bases
AAAAATTTATGTCCTGATTCTCGCCGGAGGAACCGGCACAAGGATGGGCTCGGAGATTCCAAAACAGTTTTTGGAATTTT
CCAACGAGCCCATCTTGATT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MQPIEKLKFLTKLQVRSIAQQFGTPIFVYSREGIEKSCDAALAFPNGYGLTVRYAMKANSNRTILEIIKRKGIQIDASSE
YEVLRAIHYGFKPEEIMLTSQELAKNLKEFVEKGVVFNACSLRQLEAFGNLFPGKEVSVRFNPGLGSGQTKKTDVGGKTS
SFGVWHEELNKVKEIASKYKLKIFKIHTHIGSGSDPEAWKAIAQVSLDIAAQFSECKILNLGGGFKVGRMEDEKTTNFQK
IGKPVVELFQEFAKKHGTSLHLEIEPGSFLMVNNGSIISTVDDVVSTGDGGYTFVKIDAGMDVNTRPSLYAARHPLVVVP
KVETHSGKTASYVYVGHCCESGDLFTQAEGGGPVTRITGEAQLGDYVVMEGAGAYCSSMSTKNYNSFPETAEVLVDLDGS
FQLIRKRQNLEQIFQNEVPISL

Sequences:

>Translated_422_residues
MQPIEKLKFLTKLQVRSIAQQFGTPIFVYSREGIEKSCDAALAFPNGYGLTVRYAMKANSNRTILEIIKRKGIQIDASSE
YEVLRAIHYGFKPEEIMLTSQELAKNLKEFVEKGVVFNACSLRQLEAFGNLFPGKEVSVRFNPGLGSGQTKKTDVGGKTS
SFGVWHEELNKVKEIASKYKLKIFKIHTHIGSGSDPEAWKAIAQVSLDIAAQFSECKILNLGGGFKVGRMEDEKTTNFQK
IGKPVVELFQEFAKKHGTSLHLEIEPGSFLMVNNGSIISTVDDVVSTGDGGYTFVKIDAGMDVNTRPSLYAARHPLVVVP
KVETHSGKTASYVYVGHCCESGDLFTQAEGGGPVTRITGEAQLGDYVVMEGAGAYCSSMSTKNYNSFPETAEVLVDLDGS
FQLIRKRQNLEQIFQNEVPISL
>Mature_422_residues
MQPIEKLKFLTKLQVRSIAQQFGTPIFVYSREGIEKSCDAALAFPNGYGLTVRYAMKANSNRTILEIIKRKGIQIDASSE
YEVLRAIHYGFKPEEIMLTSQELAKNLKEFVEKGVVFNACSLRQLEAFGNLFPGKEVSVRFNPGLGSGQTKKTDVGGKTS
SFGVWHEELNKVKEIASKYKLKIFKIHTHIGSGSDPEAWKAIAQVSLDIAAQFSECKILNLGGGFKVGRMEDEKTTNFQK
IGKPVVELFQEFAKKHGTSLHLEIEPGSFLMVNNGSIISTVDDVVSTGDGGYTFVKIDAGMDVNTRPSLYAARHPLVVVP
KVETHSGKTASYVYVGHCCESGDLFTQAEGGGPVTRITGEAQLGDYVVMEGAGAYCSSMSTKNYNSFPETAEVLVDLDGS
FQLIRKRQNLEQIFQNEVPISL

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=409, Percent_Identity=32.7628361858191, Blast_Score=218, Evalue=8e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 46395; Mature: 46395

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPIEKLKFLTKLQVRSIAQQFGTPIFVYSREGIEKSCDAALAFPNGYGLTVRYAMKANS
CCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCEEEECCCCCCEEEEEEEECCC
NRTILEIIKRKGIQIDASSEYEVLRAIHYGFKPEEIMLTSQELAKNLKEFVEKGVVFNAC
CCHHHHHHHHCCCEEECCCHHHHHHHHHCCCCCHHEEEEHHHHHHHHHHHHHCCEEEECH
SLRQLEAFGNLFPGKEVSVRFNPGLGSGQTKKTDVGGKTSSFGVWHEELNKVKEIASKYK
HHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHE
LKIFKIHTHIGSGSDPEAWKAIAQVSLDIAAQFSECKILNLGGGFKVGRMEDEKTTNFQK
EEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCCCCCCHHH
IGKPVVELFQEFAKKHGTSLHLEIEPGSFLMVNNGSIISTVDDVVSTGDGGYTFVKIDAG
HCHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCEEEEHHHHHHCCCCCEEEEEEECC
MDVNTRPSLYAARHPLVVVPKVETHSGKTASYVYVGHCCESGDLFTQAEGGGPVTRITGE
CCCCCCCCEEECCCCEEEEEEEECCCCCEEEEEEEEEEECCCCEEEECCCCCCEEEEECC
AQLGDYVVMEGAGAYCSSMSTKNYNSFPETAEVLVDLDGSFQLIRKRQNLEQIFQNEVPI
CCCCCEEEEECCCHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCC
SL
CC
>Mature Secondary Structure
MQPIEKLKFLTKLQVRSIAQQFGTPIFVYSREGIEKSCDAALAFPNGYGLTVRYAMKANS
CCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCEEEECCCCCCEEEEEEEECCC
NRTILEIIKRKGIQIDASSEYEVLRAIHYGFKPEEIMLTSQELAKNLKEFVEKGVVFNAC
CCHHHHHHHHCCCEEECCCHHHHHHHHHCCCCCHHEEEEHHHHHHHHHHHHHCCEEEECH
SLRQLEAFGNLFPGKEVSVRFNPGLGSGQTKKTDVGGKTSSFGVWHEELNKVKEIASKYK
HHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHE
LKIFKIHTHIGSGSDPEAWKAIAQVSLDIAAQFSECKILNLGGGFKVGRMEDEKTTNFQK
EEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCCCCCCHHH
IGKPVVELFQEFAKKHGTSLHLEIEPGSFLMVNNGSIISTVDDVVSTGDGGYTFVKIDAG
HCHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCEEEEHHHHHHCCCCCEEEEEEECC
MDVNTRPSLYAARHPLVVVPKVETHSGKTASYVYVGHCCESGDLFTQAEGGGPVTRITGE
CCCCCCCCEEECCCCEEEEEEEECCCCCEEEEEEEEEEECCCCEEEECCCCCCEEEEECC
AQLGDYVVMEGAGAYCSSMSTKNYNSFPETAEVLVDLDGSFQLIRKRQNLEQIFQNEVPI
CCCCCEEEEECCCHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCC
SL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]