Click here to switch to the map view.

The map label for this gene is degU [H]

Identifier: 116329279

GI number: 116329279

Start: 3229763

End: 3230428

Strand: Direct

Name: degU [H]

Synonym: LBL_2725

Alternate gene names: 116329279

Gene position: 3229763-3230428 (Clockwise)

Preceding gene: 116329277

Following gene: 116329280

Centisome position: 89.36

GC content: 42.19

Gene sequence:

>666_bases
ATGAAACCTACTAACACAAAAATATTCTTAGTCGATGATCACGCTATTCTCAGAGAAGGGCTTAAAATGATCCTTTCCGG
ACAATTTGAAATCTGCGGCGAATCCGGAGACGCTGAAAAAGCTCTGGATCAAATCGGTAAATTGAATCCCGATTTGGTAA
TTACCGACATCTCTATGCCCGGTTTAAGCGGGATCGATCTTGTCAAAAATCTAAGAAAGCAGTATCCGAATATTCGGACC
ATTATTCTTTCCCGGCACGACAACAGAGAATACGTTCAGAAACTATTGGAATTAGGAATCAACGGTTACGTTTTGAAAGA
CGACGCCGGTAATGATCTCCTTCGCGCAATCGAAGCGGTTCACAAAGGAGAAACGTATTTAAGTCCCGGAATCACCGCTC
ATTTCCTATCCGGTTTTGTAGGTTCTGGAAAACCGGGCGAAGAAAATCAAGACGCCAAAAAAGCATTTTCTGTCCTTTCG
GATAGAGAAAGAGAAATTTTAAAACTAGTCGCCGAAGGGAATTCCAACGAATCCATCGGTAAAATTTTAGGGATTTCTCC
GGCCACGGTAAAAGTTCATCGAGCCAACATCATGAAAAAGTTGAATCTTCATAAGGTTGCGGATTTAGTTATGTATGCGA
TCCGCGCGGGTTTGATCGAATCTTAG

Upstream 100 bases:

>100_bases
TTAAACGGTAAGTTTAAGATCGAATCCTCTTCGGGAAAAGGAACTAAATTTATCGTTCGAATTCCTTTAGAAAAAACAAA
AACACATCCGCCAAAAAAAT

Downstream 100 bases:

>100_bases
ATCGAAGTTTGTAAAATCCACGACACAATTTGATAAACGAAGAATCGACAAACTAATTCCGAACAAACAACGTGTTTCGA
TATCCGTTCATTTTACTCGG

Product: receiver component of a two-component response regulator

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MKPTNTKIFLVDDHAILREGLKMILSGQFEICGESGDAEKALDQIGKLNPDLVITDISMPGLSGIDLVKNLRKQYPNIRT
IILSRHDNREYVQKLLELGINGYVLKDDAGNDLLRAIEAVHKGETYLSPGITAHFLSGFVGSGKPGEENQDAKKAFSVLS
DREREILKLVAEGNSNESIGKILGISPATVKVHRANIMKKLNLHKVADLVMYAIRAGLIES

Sequences:

>Translated_221_residues
MKPTNTKIFLVDDHAILREGLKMILSGQFEICGESGDAEKALDQIGKLNPDLVITDISMPGLSGIDLVKNLRKQYPNIRT
IILSRHDNREYVQKLLELGINGYVLKDDAGNDLLRAIEAVHKGETYLSPGITAHFLSGFVGSGKPGEENQDAKKAFSVLS
DREREILKLVAEGNSNESIGKILGISPATVKVHRANIMKKLNLHKVADLVMYAIRAGLIES
>Mature_221_residues
MKPTNTKIFLVDDHAILREGLKMILSGQFEICGESGDAEKALDQIGKLNPDLVITDISMPGLSGIDLVKNLRKQYPNIRT
IILSRHDNREYVQKLLELGINGYVLKDDAGNDLLRAIEAVHKGETYLSPGITAHFLSGFVGSGKPGEENQDAKKAFSVLS
DREREILKLVAEGNSNESIGKILGISPATVKVHRANIMKKLNLHKVADLVMYAIRAGLIES

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=219, Percent_Identity=32.8767123287671, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1788222, Length=216, Percent_Identity=28.2407407407407, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1790102, Length=198, Percent_Identity=33.8383838383838, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1786747, Length=215, Percent_Identity=29.3023255813954, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788712, Length=208, Percent_Identity=29.8076923076923, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI1787473, Length=188, Percent_Identity=34.0425531914894, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI1788546, Length=214, Percent_Identity=30.8411214953271, Blast_Score=90, Evalue=9e-20,
Organism=Escherichia coli, GI1789937, Length=201, Percent_Identity=25.8706467661692, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24241; Mature: 24241

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPTNTKIFLVDDHAILREGLKMILSGQFEICGESGDAEKALDQIGKLNPDLVITDISMP
CCCCCCEEEEEECHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCCEEEEECCCC
GLSGIDLVKNLRKQYPNIRTIILSRHDNREYVQKLLELGINGYVLKDDAGNDLLRAIEAV
CCCHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHH
HKGETYLSPGITAHFLSGFVGSGKPGEENQDAKKAFSVLSDREREILKLVAEGNSNESIG
HCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
KILGISPATVKVHRANIMKKLNLHKVADLVMYAIRAGLIES
HHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKPTNTKIFLVDDHAILREGLKMILSGQFEICGESGDAEKALDQIGKLNPDLVITDISMP
CCCCCCEEEEEECHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCCEEEEECCCC
GLSGIDLVKNLRKQYPNIRTIILSRHDNREYVQKLLELGINGYVLKDDAGNDLLRAIEAV
CCCHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHH
HKGETYLSPGITAHFLSGFVGSGKPGEENQDAKKAFSVLSDREREILKLVAEGNSNESIG
HCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
KILGISPATVKVHRANIMKKLNLHKVADLVMYAIRAGLIES
HHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]