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The map label for this gene is fadE25 [H]

Identifier: 116329092

GI number: 116329092

Start: 2977868

End: 2979031

Strand: Reverse

Name: fadE25 [H]

Synonym: LBL_2512

Alternate gene names: 116329092

Gene position: 2979031-2977868 (Counterclockwise)

Preceding gene: 116329093

Following gene: 116329091

Centisome position: 82.42

GC content: 46.31

Gene sequence:

>1164_bases
ATGTATCAGGAATTTACCGAACAACAGCTCGAAATCAGAGACCAGATCCGTAATTTCGTGAAAAAAGAAATCACACATGA
AGTTGCAAGTCACTGGGACGAAGAAAATAAACATCCCGAAGAACTCATCAATCGTATGAGAAAAGAATTGGGAGTCAACG
GTTTGACCATCCCCGAAGAATACGGCGGTTGGGGACTTGGTTCTGTGGAACAGTGCCTCGTCACTGAAGAACTTTCCAGA
GGATGTCTCGGAATTTCTCTTTGTTTTGGTTATACAGGTCTTGGGATTCTTCCTATTTTGAAAGGGGCTTCTCACGAGCA
AAAAAAGAAGTGGTTACAACCAGTCATAGACGGAGAGTATGGAATCTCTTTCTGTCTTTCCGAGCCGGGTGCGGGATCCG
ACGTTCCGGGCATGAGTACGACTGCCGTTAAAAAAGGCGATAAGTGGGTCATCAACGGAACGAAACAATGGATCACCGGT
GGTGGTAGTGCCGGTGCTTATACTGTATTTGCCTATACCGATAAGGGAAGAGGGACCAGAGGGGTGAGTTGTTTCTATGT
GAAAAGAGATACGCCGGGGCTGACCGTCGGTAAAAAAGAAGACAAACTCGGAATCCGTGCTTCGGATACTCGTCAGATCA
TCTTTGAAGATTGTGCCGTGGAAGAAGCGAACATGATCGGAAGGGAAAACTTAGGGTTTATCTACGCGCTTCAAACTCTA
AACGCTTCTCGTCCTTACGTTGCGGCGATGGGAGTAGGTGTCTCTCAAGCGGCTCTTGATTATGCTTCCAAATATGCAAG
ACAAAGGGAGCAATTCGGATCCAAGATTTCCAGCTTTCAAGCTGTTCAGCACATGCTTGCGGATATGTCCATCGGTTTGG
AAACTTCTCGTCAAGTTACGTATCTTGCGGCGAGAATGGCCGATGCCGATGATCCGAGACTTCCCAAGTATTCCGCAATT
GCAAAAGCTCACGCTTCTGAGACTGCGATGAAATGCGCTCTGGATGCGGTTCAAATTTTCGGCGGATACGGTTATACAAA
AGAATATCCTGTCGAAAAATTGATGAGAGATGCGAAAATCCTTTGTATTTTCGAAGGAACTACTCAGATCCAGAAAAACG
AGATCGCGGCTTACGTGATTCGTGAAGCGGCGTCCGCTAAATAA

Upstream 100 bases:

>100_bases
ACGAGTGAAGCGCCGATTTTTTCTCCCGTATTTTGATTTGATCTAATCATGGAGAAAAAAAAAGTAGGATCAGAACACTC
TCGTAAGAAGGGAAAAACCG

Downstream 100 bases:

>100_bases
GAATATTAGAATTTTCAAAAATGCGTTTTACACAATGGGACGTGTTTGAAAATTACGGGGATTAGAAAAAAGTTTTCGAG
AACCCGTGACTGAATTAAAA

Product: Acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MYQEFTEQQLEIRDQIRNFVKKEITHEVASHWDEENKHPEELINRMRKELGVNGLTIPEEYGGWGLGSVEQCLVTEELSR
GCLGISLCFGYTGLGILPILKGASHEQKKKWLQPVIDGEYGISFCLSEPGAGSDVPGMSTTAVKKGDKWVINGTKQWITG
GGSAGAYTVFAYTDKGRGTRGVSCFYVKRDTPGLTVGKKEDKLGIRASDTRQIIFEDCAVEEANMIGRENLGFIYALQTL
NASRPYVAAMGVGVSQAALDYASKYARQREQFGSKISSFQAVQHMLADMSIGLETSRQVTYLAARMADADDPRLPKYSAI
AKAHASETAMKCALDAVQIFGGYGYTKEYPVEKLMRDAKILCIFEGTTQIQKNEIAAYVIREAASAK

Sequences:

>Translated_387_residues
MYQEFTEQQLEIRDQIRNFVKKEITHEVASHWDEENKHPEELINRMRKELGVNGLTIPEEYGGWGLGSVEQCLVTEELSR
GCLGISLCFGYTGLGILPILKGASHEQKKKWLQPVIDGEYGISFCLSEPGAGSDVPGMSTTAVKKGDKWVINGTKQWITG
GGSAGAYTVFAYTDKGRGTRGVSCFYVKRDTPGLTVGKKEDKLGIRASDTRQIIFEDCAVEEANMIGRENLGFIYALQTL
NASRPYVAAMGVGVSQAALDYASKYARQREQFGSKISSFQAVQHMLADMSIGLETSRQVTYLAARMADADDPRLPKYSAI
AKAHASETAMKCALDAVQIFGGYGYTKEYPVEKLMRDAKILCIFEGTTQIQKNEIAAYVIREAASAK
>Mature_387_residues
MYQEFTEQQLEIRDQIRNFVKKEITHEVASHWDEENKHPEELINRMRKELGVNGLTIPEEYGGWGLGSVEQCLVTEELSR
GCLGISLCFGYTGLGILPILKGASHEQKKKWLQPVIDGEYGISFCLSEPGAGSDVPGMSTTAVKKGDKWVINGTKQWITG
GGSAGAYTVFAYTDKGRGTRGVSCFYVKRDTPGLTVGKKEDKLGIRASDTRQIIFEDCAVEEANMIGRENLGFIYALQTL
NASRPYVAAMGVGVSQAALDYASKYARQREQFGSKISSFQAVQHMLADMSIGLETSRQVTYLAARMADADDPRLPKYSAI
AKAHASETAMKCALDAVQIFGGYGYTKEYPVEKLMRDAKILCIFEGTTQIQKNEIAAYVIREAASAK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI187960098, Length=376, Percent_Identity=44.4148936170213, Blast_Score=303, Evalue=2e-82,
Organism=Homo sapiens, GI4557231, Length=376, Percent_Identity=44.4148936170213, Blast_Score=302, Evalue=3e-82,
Organism=Homo sapiens, GI4557233, Length=384, Percent_Identity=42.1875, Blast_Score=298, Evalue=5e-81,
Organism=Homo sapiens, GI4501859, Length=381, Percent_Identity=39.6325459317585, Blast_Score=264, Evalue=9e-71,
Organism=Homo sapiens, GI226958412, Length=373, Percent_Identity=37.2654155495979, Blast_Score=242, Evalue=5e-64,
Organism=Homo sapiens, GI226958414, Length=367, Percent_Identity=37.874659400545, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI21361497, Length=386, Percent_Identity=36.5284974093264, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI7656849, Length=378, Percent_Identity=33.0687830687831, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI76496475, Length=371, Percent_Identity=33.9622641509434, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI4557235, Length=371, Percent_Identity=33.9622641509434, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI4501857, Length=381, Percent_Identity=30.9711286089239, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI4503943, Length=379, Percent_Identity=30.8707124010554, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI7669494, Length=357, Percent_Identity=31.6526610644258, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI38505218, Length=397, Percent_Identity=26.1964735516373, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI48976061, Length=387, Percent_Identity=23.5142118863049, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI211971008, Length=387, Percent_Identity=23.5142118863049, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI87081958, Length=368, Percent_Identity=30.4347826086957, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1786223, Length=376, Percent_Identity=28.4574468085106, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI87082384, Length=322, Percent_Identity=23.9130434782609, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=44.6194225721785, Blast_Score=303, Evalue=9e-83,
Organism=Caenorhabditis elegans, GI17570075, Length=384, Percent_Identity=41.9270833333333, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17534899, Length=381, Percent_Identity=44.3569553805774, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17508101, Length=378, Percent_Identity=38.6243386243386, Blast_Score=257, Evalue=8e-69,
Organism=Caenorhabditis elegans, GI17506239, Length=379, Percent_Identity=38.2585751978892, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17538396, Length=372, Percent_Identity=38.4408602150538, Blast_Score=250, Evalue=7e-67,
Organism=Caenorhabditis elegans, GI17533517, Length=365, Percent_Identity=34.7945205479452, Blast_Score=227, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI71990804, Length=279, Percent_Identity=37.9928315412186, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=40.4347826086956, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71985184, Length=374, Percent_Identity=30.2139037433155, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17551932, Length=369, Percent_Identity=29.2682926829268, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17505929, Length=386, Percent_Identity=28.7564766839378, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI71982178, Length=278, Percent_Identity=31.6546762589928, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17531909, Length=245, Percent_Identity=33.469387755102, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71985192, Length=306, Percent_Identity=29.0849673202614, Blast_Score=130, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17534353, Length=376, Percent_Identity=26.8617021276596, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17562446, Length=356, Percent_Identity=26.685393258427, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17531913, Length=183, Percent_Identity=31.1475409836066, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI86563381, Length=265, Percent_Identity=25.6603773584906, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI86563383, Length=265, Percent_Identity=26.0377358490566, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24660351, Length=371, Percent_Identity=47.7088948787062, Blast_Score=315, Evalue=4e-86,
Organism=Drosophila melanogaster, GI21356377, Length=382, Percent_Identity=42.4083769633508, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24646207, Length=378, Percent_Identity=38.6243386243386, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24666513, Length=374, Percent_Identity=38.7700534759358, Blast_Score=237, Evalue=9e-63,
Organism=Drosophila melanogaster, GI21355753, Length=371, Percent_Identity=37.7358490566038, Blast_Score=225, Evalue=4e-59,
Organism=Drosophila melanogaster, GI281363737, Length=345, Percent_Identity=34.4927536231884, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI19920834, Length=379, Percent_Identity=28.4960422163588, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42627; Mature: 42627

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQEFTEQQLEIRDQIRNFVKKEITHEVASHWDEENKHPEELINRMRKELGVNGLTIPEE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHH
YGGWGLGSVEQCLVTEELSRGCLGISLCFGYTGLGILPILKGASHEQKKKWLQPVIDGEY
HCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHCCCCC
GISFCLSEPGAGSDVPGMSTTAVKKGDKWVINGTKQWITGGGSAGAYTVFAYTDKGRGTR
CEEEEECCCCCCCCCCCCCHHHCCCCCEEEECCCHHEECCCCCCCEEEEEEEECCCCCCC
GVSCFYVKRDTPGLTVGKKEDKLGIRASDTRQIIFEDCAVEEANMIGRENLGFIYALQTL
CEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEC
NASRPYVAAMGVGVSQAALDYASKYARQREQFGSKISSFQAVQHMLADMSIGLETSRQVT
CCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
YLAARMADADDPRLPKYSAIAKAHASETAMKCALDAVQIFGGYGYTKEYPVEKLMRDAKI
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCEE
LCIFEGTTQIQKNEIAAYVIREAASAK
EEEECCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYQEFTEQQLEIRDQIRNFVKKEITHEVASHWDEENKHPEELINRMRKELGVNGLTIPEE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHH
YGGWGLGSVEQCLVTEELSRGCLGISLCFGYTGLGILPILKGASHEQKKKWLQPVIDGEY
HCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHCCCCC
GISFCLSEPGAGSDVPGMSTTAVKKGDKWVINGTKQWITGGGSAGAYTVFAYTDKGRGTR
CEEEEECCCCCCCCCCCCCHHHCCCCCEEEECCCHHEECCCCCCCEEEEEEEECCCCCCC
GVSCFYVKRDTPGLTVGKKEDKLGIRASDTRQIIFEDCAVEEANMIGRENLGFIYALQTL
CEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEC
NASRPYVAAMGVGVSQAALDYASKYARQREQFGSKISSFQAVQHMLADMSIGLETSRQVT
CCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
YLAARMADADDPRLPKYSAIAKAHASETAMKCALDAVQIFGGYGYTKEYPVEKLMRDAKI
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCEE
LCIFEGTTQIQKNEIAAYVIREAASAK
EEEECCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]