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The map label for this gene is mutL [H]

Identifier: 116328839

GI number: 116328839

Start: 2610908

End: 2612698

Strand: Reverse

Name: mutL [H]

Synonym: LBL_2218

Alternate gene names: 116328839

Gene position: 2612698-2610908 (Counterclockwise)

Preceding gene: 116328842

Following gene: 116328838

Centisome position: 72.28

GC content: 44.67

Gene sequence:

>1791_bases
ATGGGAAAAATTCAGGAACTCAGTCCGGAACTCATCAATCAAATTGCCGCGGGGGAAGTCATTGAATCCGCTCATTCCGT
CGTCAAAGAATTGATGGAAAATTCCATGGATGCGGGTGCGACTCAGATGGATATCGAGTCCAAGGACGGAGGTCTTTCTC
TTTTACGCATCACCGATAACGGTTCCGGAATCGATCCGGAAGATATAGAACCCGCTTTGAAAAGACATGCTACGAGTAAG
ATTCGGGATTACGGGGATTTAGAAAACGTGCTCAGCTACGGGTTTCGAGGGGAAGCTTTGGCTTCCATCGCATCAGTGTC
CCGCCTAACGTTGGAAAGTGGAATCAAGAATCAAAAGACTGCTTGGAAAATTTGTTCGATCGGGGGAAAAATTTCCGAAA
AAGAAGAAATTCCAGGATTTGTCGGAACAAAAATACTTGTGGAGGAATTATTTTTTAACACTCCTGTCCGTAGAAAGTTT
TTGAAATCGGTCCGTTCCGAAGATAAGAAAATCCGCGACCGGGTCACGACGCAGGCGCTCGCAAGACATGATGTACGTTT
TCGTCTTTTTCAGGACGGAAAGGAAGTATTTGTACTTCCTTCCAGAGAAAATAAAAAGGATCGGATCGTCGATTTATTTG
GGGAGAATTTTCGGGATCATCTTCTCGAAGTGAGTCTCGAACGCGGAGGACTGAATGCGACCGGTTATATCAGCGATCCC
GATTTTTATAAGTCCAATCGAACCGGACAATTCGTATTCGTCAACGGAAGGCCTGTGGAAATCAAATACGGTTCCACTCT
ATTAAAAAAAGCTTATGATGAATTGCTTCCTCCGAACGGACATCCGTATTGTTTTTTATTTTTTGAAATCGATCCTTCGA
GGGTGGACGTGAACGTTCATCCGGCTAAAAAAGAGATCCGCTTTTTGGACGAAGAAGGGTTCAACGGATTTTTTTTAACG
TTAATTCAAAAGGAACTCCGCTCCAGCACTCCGGTTAGTTTTTTGGAACTCAAAAAACGTCTTTTGAGACCGACTCCGGA
AACTTTCAAAACGAGTTCGCTCTATCAAGCTCATTCTTCCTCTCGTTCGGGTGAAAGTCCTCTGCTCAGCCGTGAACTTT
TTACCGAGGTTCCGAGGCAGGAAGGATTCGATTTGGATCGGATGGGACCGGGGGCGTCCCTTTCCGCGCTTACGGATAAC
GTCGTAAAACATTCTTCCTTTGTTCCTAAAAAACATTTCGGAGTTTTGTTCGAGACCTTTATTCTCGCGGAAGCGGAAGA
CGGTTTTTATATCATCGATCAGCATACCGCTCACGAAAGAATTCGCTACGAGGAGGTTTTGCGTAAACTCGAAAAGAAAA
ACTACGGAATTCAGCCGCTTTTGACTCCGATCCGAATCGACGTTTCCAAACAGGAACAAGAGGACATCTTAAATCGAAAA
AAAGAATATGAGGAAGTTGGAATATTCTTGGATCCTCTCGGAGAGGATAGCGTAGTTCTGCGGGAAATTCCCGCTTACAT
GGAACCGGGAGAGGAAAAGGAAATCATACTCGATTTTTTAAACCGAACCGAAGGGAAGGAGACCACCGAACCCGAGTTAT
ACGATTTGATGGCAAAATGTGTGGCTTGTAGATCCGCTATCAAAAAAGGGGATCATCTTTCCGATCCGATTCTGGCGGAA
ATTTTAAACAGACTGAGTTATTGCGAAAATCCTTCCCGTTGTCCGCACGGAAGACCCACCCTGGTAAAGTTGAGCAGAGA
TGACCTCGAAAGAATGTTCCACAGAAAATAA

Upstream 100 bases:

>100_bases
GATCGTATCCTGATAAGATAAGTTGAACCCTGATATTTTAAAAAATTCATAGATCCCGTCCTTGACAGACTTAGTCAAAG
TTCCGACATTGGAACCATCC

Downstream 100 bases:

>100_bases
GGAAGTTTCCGGTAAGGAACCGGACCGAGTCGTAAGAAAATTATTCCGTCAAACATTAGTCGGAATCGCGATTCTCGTTT
TAGGAGTTGTGTTCCTCGCG

Product: DNA mismatch repair ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 596; Mature: 595

Protein sequence:

>596_residues
MGKIQELSPELINQIAAGEVIESAHSVVKELMENSMDAGATQMDIESKDGGLSLLRITDNGSGIDPEDIEPALKRHATSK
IRDYGDLENVLSYGFRGEALASIASVSRLTLESGIKNQKTAWKICSIGGKISEKEEIPGFVGTKILVEELFFNTPVRRKF
LKSVRSEDKKIRDRVTTQALARHDVRFRLFQDGKEVFVLPSRENKKDRIVDLFGENFRDHLLEVSLERGGLNATGYISDP
DFYKSNRTGQFVFVNGRPVEIKYGSTLLKKAYDELLPPNGHPYCFLFFEIDPSRVDVNVHPAKKEIRFLDEEGFNGFFLT
LIQKELRSSTPVSFLELKKRLLRPTPETFKTSSLYQAHSSSRSGESPLLSRELFTEVPRQEGFDLDRMGPGASLSALTDN
VVKHSSFVPKKHFGVLFETFILAEAEDGFYIIDQHTAHERIRYEEVLRKLEKKNYGIQPLLTPIRIDVSKQEQEDILNRK
KEYEEVGIFLDPLGEDSVVLREIPAYMEPGEEKEIILDFLNRTEGKETTEPELYDLMAKCVACRSAIKKGDHLSDPILAE
ILNRLSYCENPSRCPHGRPTLVKLSRDDLERMFHRK

Sequences:

>Translated_596_residues
MGKIQELSPELINQIAAGEVIESAHSVVKELMENSMDAGATQMDIESKDGGLSLLRITDNGSGIDPEDIEPALKRHATSK
IRDYGDLENVLSYGFRGEALASIASVSRLTLESGIKNQKTAWKICSIGGKISEKEEIPGFVGTKILVEELFFNTPVRRKF
LKSVRSEDKKIRDRVTTQALARHDVRFRLFQDGKEVFVLPSRENKKDRIVDLFGENFRDHLLEVSLERGGLNATGYISDP
DFYKSNRTGQFVFVNGRPVEIKYGSTLLKKAYDELLPPNGHPYCFLFFEIDPSRVDVNVHPAKKEIRFLDEEGFNGFFLT
LIQKELRSSTPVSFLELKKRLLRPTPETFKTSSLYQAHSSSRSGESPLLSRELFTEVPRQEGFDLDRMGPGASLSALTDN
VVKHSSFVPKKHFGVLFETFILAEAEDGFYIIDQHTAHERIRYEEVLRKLEKKNYGIQPLLTPIRIDVSKQEQEDILNRK
KEYEEVGIFLDPLGEDSVVLREIPAYMEPGEEKEIILDFLNRTEGKETTEPELYDLMAKCVACRSAIKKGDHLSDPILAE
ILNRLSYCENPSRCPHGRPTLVKLSRDDLERMFHRK
>Mature_595_residues
GKIQELSPELINQIAAGEVIESAHSVVKELMENSMDAGATQMDIESKDGGLSLLRITDNGSGIDPEDIEPALKRHATSKI
RDYGDLENVLSYGFRGEALASIASVSRLTLESGIKNQKTAWKICSIGGKISEKEEIPGFVGTKILVEELFFNTPVRRKFL
KSVRSEDKKIRDRVTTQALARHDVRFRLFQDGKEVFVLPSRENKKDRIVDLFGENFRDHLLEVSLERGGLNATGYISDPD
FYKSNRTGQFVFVNGRPVEIKYGSTLLKKAYDELLPPNGHPYCFLFFEIDPSRVDVNVHPAKKEIRFLDEEGFNGFFLTL
IQKELRSSTPVSFLELKKRLLRPTPETFKTSSLYQAHSSSRSGESPLLSRELFTEVPRQEGFDLDRMGPGASLSALTDNV
VKHSSFVPKKHFGVLFETFILAEAEDGFYIIDQHTAHERIRYEEVLRKLEKKNYGIQPLLTPIRIDVSKQEQEDILNRKK
EYEEVGIFLDPLGEDSVVLREIPAYMEPGEEKEIILDFLNRTEGKETTEPELYDLMAKCVACRSAIKKGDHLSDPILAEI
LNRLSYCENPSRCPHGRPTLVKLSRDDLERMFHRK

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=322, Percent_Identity=37.888198757764, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI4505913, Length=328, Percent_Identity=30.1829268292683, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI310128478, Length=328, Percent_Identity=30.1829268292683, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI4505911, Length=326, Percent_Identity=30.6748466257669, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI189458898, Length=326, Percent_Identity=30.6748466257669, Blast_Score=135, Evalue=2e-31,
Organism=Homo sapiens, GI189458896, Length=318, Percent_Identity=30.188679245283, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI91992162, Length=262, Percent_Identity=34.3511450381679, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI91992160, Length=262, Percent_Identity=34.3511450381679, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI263191589, Length=226, Percent_Identity=35.3982300884956, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI310128480, Length=292, Percent_Identity=27.7397260273973, Blast_Score=106, Evalue=6e-23,
Organism=Escherichia coli, GI1790612, Length=338, Percent_Identity=42.0118343195266, Blast_Score=248, Evalue=6e-67,
Organism=Caenorhabditis elegans, GI71991825, Length=323, Percent_Identity=36.8421052631579, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17562796, Length=402, Percent_Identity=26.1194029850746, Blast_Score=128, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323819, Length=317, Percent_Identity=37.8548895899054, Blast_Score=212, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6324247, Length=356, Percent_Identity=32.3033707865169, Blast_Score=144, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6325093, Length=173, Percent_Identity=32.9479768786127, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323063, Length=198, Percent_Identity=28.7878787878788, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17136968, Length=316, Percent_Identity=34.1772151898734, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17136970, Length=393, Percent_Identity=28.2442748091603, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 67763; Mature: 67632

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKIQELSPELINQIAAGEVIESAHSVVKELMENSMDAGATQMDIESKDGGLSLLRITDN
CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEEEECC
GSGIDPEDIEPALKRHATSKIRDYGDLENVLSYGFRGEALASIASVSRLTLESGIKNQKT
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCH
AWKICSIGGKISEKEEIPGFVGTKILVEELFFNTPVRRKFLKSVRSEDKKIRDRVTTQAL
HHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ARHDVRFRLFQDGKEVFVLPSRENKKDRIVDLFGENFRDHLLEVSLERGGLNATGYISDP
HHHCCEEEEEECCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCC
DFYKSNRTGQFVFVNGRPVEIKYGSTLLKKAYDELLPPNGHPYCFLFFEIDPSRVDVNVH
CHHCCCCCCCEEEECCEEEEEECCHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEC
PAKKEIRFLDEEGFNGFFLTLIQKELRSSTPVSFLELKKRLLRPTPETFKTSSLYQAHSS
CCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
SRSGESPLLSRELFTEVPRQEGFDLDRMGPGASLSALTDNVVKHSSFVPKKHFGVLFETF
CCCCCCCHHHHHHHHHCCHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
ILAEAEDGFYIIDQHTAHERIRYEEVLRKLEKKNYGIQPLLTPIRIDVSKQEQEDILNRK
HHEECCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHHHH
KEYEEVGIFLDPLGEDSVVLREIPAYMEPGEEKEIILDFLNRTEGKETTEPELYDLMAKC
HHHHHCCEEECCCCCCCHHHHHCCHHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
VACRSAIKKGDHLSDPILAEILNRLSYCENPSRCPHGRPTLVKLSRDDLERMFHRK
HHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECHHHHHHHHCCC
>Mature Secondary Structure 
GKIQELSPELINQIAAGEVIESAHSVVKELMENSMDAGATQMDIESKDGGLSLLRITDN
CCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEEEECC
GSGIDPEDIEPALKRHATSKIRDYGDLENVLSYGFRGEALASIASVSRLTLESGIKNQKT
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCH
AWKICSIGGKISEKEEIPGFVGTKILVEELFFNTPVRRKFLKSVRSEDKKIRDRVTTQAL
HHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ARHDVRFRLFQDGKEVFVLPSRENKKDRIVDLFGENFRDHLLEVSLERGGLNATGYISDP
HHHCCEEEEEECCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCC
DFYKSNRTGQFVFVNGRPVEIKYGSTLLKKAYDELLPPNGHPYCFLFFEIDPSRVDVNVH
CHHCCCCCCCEEEECCEEEEEECCHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEC
PAKKEIRFLDEEGFNGFFLTLIQKELRSSTPVSFLELKKRLLRPTPETFKTSSLYQAHSS
CCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
SRSGESPLLSRELFTEVPRQEGFDLDRMGPGASLSALTDNVVKHSSFVPKKHFGVLFETF
CCCCCCCHHHHHHHHHCCHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
ILAEAEDGFYIIDQHTAHERIRYEEVLRKLEKKNYGIQPLLTPIRIDVSKQEQEDILNRK
HHEECCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHHHH
KEYEEVGIFLDPLGEDSVVLREIPAYMEPGEEKEIILDFLNRTEGKETTEPELYDLMAKC
HHHHHCCEEECCCCCCCHHHHHCCHHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
VACRSAIKKGDHLSDPILAEILNRLSYCENPSRCPHGRPTLVKLSRDDLERMFHRK
HHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA