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The map label for this gene is pgsA-1 [H]

Identifier: 116328777

GI number: 116328777

Start: 2525137

End: 2525883

Strand: Reverse

Name: pgsA-1 [H]

Synonym: LBL_2152

Alternate gene names: 116328777

Gene position: 2525883-2525137 (Counterclockwise)

Preceding gene: 116328778

Following gene: 116328776

Centisome position: 69.88

GC content: 42.3

Gene sequence:

>747_bases
ATGAACAAAGCAATTTTCAATATTCCTAATATTCTCACGATGCTTCGCGTTGTGGCGGTTCCTTTTTTCGTATGGTTTTT
GTTCCAGAAAGAATTGGAATATCATATCGCCGCTCTTGTGCTTTTTTCCGCTGCTTCTCTCACCGATTTGATCGACGGTT
ATCTTGCCAGAAAATGGAATCAGGAAACCGAGTTCGGTAAATTTCTGGATCCTCTCGCCGACAAGATCGTCGTAACGGGT
TGTTTTATTACGTTTATATTTTTGCAGGAACAGATCGAGTTTTGGATGGTTTGTCTGATCATAGGGCGGGATATGCTTAT
CACGAGTCTTCGTTATTTGGCGATCCGACAAGGGCAGTCGATCCGAACTACCATGCTCGGGAAGGTCAAGACGGTATTTC
AGATGGGAGCGATTCTTTTGATCCTCGTATTTTTTATTCTGGTTTCGAGCAAAAAAAGAATTTTGATCAACGAGGCTTAT
GCTTCCGGAAAGGCGAACGGCCTCACAGTGTTTGAAATCGCCACGGGGAATGCGATTTACTTTTTCCAAAATCTGAATAA
AAATACCGGACTTGGAGACGTTATTTTTGGTTTGGGAGCTTTCGTTCCTTATTGGGGGATGCTCGTTACTACCGCGATCA
CCGTGATTTCCGGAATTCGATATCTCATTACCAATAATAAGGTTCTTCGACCTTCCCATATCAAAAGGATGTTTCAGAAA
AATGGAACCAAGAGCAATCGTTCTTAA

Upstream 100 bases:

>100_bases
TCGTGTATGTGGACGATATTTCCTTAATTCCGGGTATGATCGGAAAAATACGGATCGATTCCTTTTATGAATACGATATG
AACGGAACCTGGATTTCTAA

Downstream 100 bases:

>100_bases
ACTGATCGAACATAAACATATCAGTGTCGAAGAGGCCGAATTCTTTATGAATCGTGTGATGAAGGGAGAGGTTTCCGAAA
TTCTTCTTTCCTCTTTCGTG

Product: CDP-diacylglycerol--glycerol-3-phosphate 3- phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MNKAIFNIPNILTMLRVVAVPFFVWFLFQKELEYHIAALVLFSAASLTDLIDGYLARKWNQETEFGKFLDPLADKIVVTG
CFITFIFLQEQIEFWMVCLIIGRDMLITSLRYLAIRQGQSIRTTMLGKVKTVFQMGAILLILVFFILVSSKKRILINEAY
ASGKANGLTVFEIATGNAIYFFQNLNKNTGLGDVIFGLGAFVPYWGMLVTTAITVISGIRYLITNNKVLRPSHIKRMFQK
NGTKSNRS

Sequences:

>Translated_248_residues
MNKAIFNIPNILTMLRVVAVPFFVWFLFQKELEYHIAALVLFSAASLTDLIDGYLARKWNQETEFGKFLDPLADKIVVTG
CFITFIFLQEQIEFWMVCLIIGRDMLITSLRYLAIRQGQSIRTTMLGKVKTVFQMGAILLILVFFILVSSKKRILINEAY
ASGKANGLTVFEIATGNAIYFFQNLNKNTGLGDVIFGLGAFVPYWGMLVTTAITVISGIRYLITNNKVLRPSHIKRMFQK
NGTKSNRS
>Mature_248_residues
MNKAIFNIPNILTMLRVVAVPFFVWFLFQKELEYHIAALVLFSAASLTDLIDGYLARKWNQETEFGKFLDPLADKIVVTG
CFITFIFLQEQIEFWMVCLIIGRDMLITSLRYLAIRQGQSIRTTMLGKVKTVFQMGAILLILVFFILVSSKKRILINEAY
ASGKANGLTVFEIATGNAIYFFQNLNKNTGLGDVIFGLGAFVPYWGMLVTTAITVISGIRYLITNNKVLRPSHIKRMFQK
NGTKSNRS

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=120, Percent_Identity=35.8333333333333, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI10092647, Length=120, Percent_Identity=35.8333333333333, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1788220, Length=143, Percent_Identity=40.5594405594406, Blast_Score=107, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320059, Length=171, Percent_Identity=32.1637426900585, Blast_Score=72, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24650130, Length=156, Percent_Identity=28.2051282051282, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24650126, Length=156, Percent_Identity=28.2051282051282, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24650128, Length=156, Percent_Identity=28.2051282051282, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 28103; Mature: 28103

Theoretical pI: Translated: 10.40; Mature: 10.40

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKAIFNIPNILTMLRVVAVPFFVWFLFQKELEYHIAALVLFSAASLTDLIDGYLARKWN
CCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QETEFGKFLDPLADKIVVTGCFITFIFLQEQIEFWMVCLIIGRDMLITSLRYLAIRQGQS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
IRTTMLGKVKTVFQMGAILLILVFFILVSSKKRILINEAYASGKANGLTVFEIATGNAIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHCCCCCCCEEEEEEECCCEEE
FFQNLNKNTGLGDVIFGLGAFVPYWGMLVTTAITVISGIRYLITNNKVLRPSHIKRMFQK
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHH
NGTKSNRS
CCCCCCCC
>Mature Secondary Structure
MNKAIFNIPNILTMLRVVAVPFFVWFLFQKELEYHIAALVLFSAASLTDLIDGYLARKWN
CCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QETEFGKFLDPLADKIVVTGCFITFIFLQEQIEFWMVCLIIGRDMLITSLRYLAIRQGQS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
IRTTMLGKVKTVFQMGAILLILVFFILVSSKKRILINEAYASGKANGLTVFEIATGNAIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHCCCCCCCEEEEEEECCCEEE
FFQNLNKNTGLGDVIFGLGAFVPYWGMLVTTAITVISGIRYLITNNKVLRPSHIKRMFQK
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHH
NGTKSNRS
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]