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The map label for this gene is ribAB [H]

Identifier: 116328769

GI number: 116328769

Start: 2516443

End: 2517648

Strand: Reverse

Name: ribAB [H]

Synonym: LBL_2144

Alternate gene names: 116328769

Gene position: 2517648-2516443 (Counterclockwise)

Preceding gene: 116328770

Following gene: 116328768

Centisome position: 69.66

GC content: 42.79

Gene sequence:

>1206_bases
ATGATTCAACCCATTGAGAATGCAATCGAAGAAATCAAGTCCGGGAGAATGATTATTCTTGTGGATTCGGAAGACCGGGA
GAATGAGGGAGACCTTGTTGTTGCAGCTGAATTTGCGGATAAGGAAAAAATCAATTTTATGGCTACGTTTGGCCGTGGTC
TGATTTGTATACCAATGGAAGCAGAGCGTCTCAAAAAACTCGGACTCAACAGAATGGTAGACGATTACTCTTTGGGAGAC
AAACACGGAACTGCGTTTACGGTTTCGGTTGATGCGAAGTATGGAACTTCTACCGGAATCTCTGCACAAGATAGAGCGAT
TACGGTGCAAACTCTTTTGGATGATAAAACTGTGTCTGCTGATTTGATGCGTCCTGGACATTTGTTTCCTCTTCAGGCCG
TTCCGGGTGGGGTTTTAAGAAGGGCGGGGCACACCGAAGCGGCTGTTGATTTATCGAAACTTGCTCGTTTGTATCCTGCG
GGTGTTATTTGTGAAATTATGAACGATGACGGGACTATGGCTCGTCTTCCTGATCTGGAAAAATTTGCAGAGAAACATGG
ACTGAATATTTATACGATCGAAGATTTGATTCGTTATCGAAGGGCGAAGGAAAATTTGATTCGCCTTGAAGTGGAATCCA
AATTACCCACCGAATACGGCGACTTTACAATCCGAGCGTATTCAACTCTTATCGACGATAAGATTCATGTCGCTCTCATC
AAAGGTGACATCAAAAAAGAAGAAACCACGATGGTCCGTGTTCATAGCGAGTGTCTGACCGGAGACATTTTTTCGAGTAA
CAGATGCGATTGTGGTCCGCAACTGCATTCCGCTTTGGAAATGATTTCCAAAGAAGGAAAGGGCGTGCTTCTTTACATGA
GGCAGGAAGGAAGAGGAATCGGTCTGATCAATAAATTAAAGGCTTATAATATTCAAGATAAAGGATATGATACCGTCGAA
GCAAATGAAAAACTAGGCTTTGCTCCGGATTTGAGAGATTACGGAATCGGAGCCCAAATTCTGAGAGAGATCGGTATTGG
TAAAATGAAAATTTTAACGAACAATCCTCGTAAGATTGTCGGTTTGGACGGTTACGGTTTGGAAGTTGTAGAAAGGGTTC
CGATCGAAATTCAACCGGGCTCGGACAATCATAATTATCTGATGACCAAAAAATTAAAACTTGGACACATGCTTGGTCTT
GGTTAA

Upstream 100 bases:

>100_bases
GCCTAAACGTTATATCATTTTCGACGAGTTCATGATAAGTTCGATATTTAAGTTTCTGTAGCCAAATTTCAGTCCAATAG
AAGAGATGGTAAGAAGATCT

Downstream 100 bases:

>100_bases
ACTTAAATCCCGTCGAGCGCCAATAGAAGCGAGACGGCTTGAGTTAACGCGACCTACAAGTTGAGTTGGAATCGTAAGAA
TCTAAAACGCACATTTTTCA

Product: bifunctional 3,4-dihydroxy-2-butanone 4- phosphate synthase/GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MIQPIENAIEEIKSGRMIILVDSEDRENEGDLVVAAEFADKEKINFMATFGRGLICIPMEAERLKKLGLNRMVDDYSLGD
KHGTAFTVSVDAKYGTSTGISAQDRAITVQTLLDDKTVSADLMRPGHLFPLQAVPGGVLRRAGHTEAAVDLSKLARLYPA
GVICEIMNDDGTMARLPDLEKFAEKHGLNIYTIEDLIRYRRAKENLIRLEVESKLPTEYGDFTIRAYSTLIDDKIHVALI
KGDIKKEETTMVRVHSECLTGDIFSSNRCDCGPQLHSALEMISKEGKGVLLYMRQEGRGIGLINKLKAYNIQDKGYDTVE
ANEKLGFAPDLRDYGIGAQILREIGIGKMKILTNNPRKIVGLDGYGLEVVERVPIEIQPGSDNHNYLMTKKLKLGHMLGL
G

Sequences:

>Translated_401_residues
MIQPIENAIEEIKSGRMIILVDSEDRENEGDLVVAAEFADKEKINFMATFGRGLICIPMEAERLKKLGLNRMVDDYSLGD
KHGTAFTVSVDAKYGTSTGISAQDRAITVQTLLDDKTVSADLMRPGHLFPLQAVPGGVLRRAGHTEAAVDLSKLARLYPA
GVICEIMNDDGTMARLPDLEKFAEKHGLNIYTIEDLIRYRRAKENLIRLEVESKLPTEYGDFTIRAYSTLIDDKIHVALI
KGDIKKEETTMVRVHSECLTGDIFSSNRCDCGPQLHSALEMISKEGKGVLLYMRQEGRGIGLINKLKAYNIQDKGYDTVE
ANEKLGFAPDLRDYGIGAQILREIGIGKMKILTNNPRKIVGLDGYGLEVVERVPIEIQPGSDNHNYLMTKKLKLGHMLGL
G
>Mature_401_residues
MIQPIENAIEEIKSGRMIILVDSEDRENEGDLVVAAEFADKEKINFMATFGRGLICIPMEAERLKKLGLNRMVDDYSLGD
KHGTAFTVSVDAKYGTSTGISAQDRAITVQTLLDDKTVSADLMRPGHLFPLQAVPGGVLRRAGHTEAAVDLSKLARLYPA
GVICEIMNDDGTMARLPDLEKFAEKHGLNIYTIEDLIRYRRAKENLIRLEVESKLPTEYGDFTIRAYSTLIDDKIHVALI
KGDIKKEETTMVRVHSECLTGDIFSSNRCDCGPQLHSALEMISKEGKGVLLYMRQEGRGIGLINKLKAYNIQDKGYDTVE
ANEKLGFAPDLRDYGIGAQILREIGIGKMKILTNNPRKIVGLDGYGLEVVERVPIEIQPGSDNHNYLMTKKLKLGHMLGL
G

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=187, Percent_Identity=51.3368983957219, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1789420, Length=200, Percent_Identity=47, Blast_Score=196, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6320695, Length=205, Percent_Identity=44.8780487804878, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6319438, Length=170, Percent_Identity=45.8823529411765, Blast_Score=132, Evalue=9e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 44494; Mature: 44494

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQPIENAIEEIKSGRMIILVDSEDRENEGDLVVAAEFADKEKINFMATFGRGLICIPME
CCCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEECC
AERLKKLGLNRMVDDYSLGDKHGTAFTVSVDAKYGTSTGISAQDRAITVQTLLDDKTVSA
HHHHHHCCHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCHH
DLMRPGHLFPLQAVPGGVLRRAGHTEAAVDLSKLARLYPAGVICEIMNDDGTMARLPDLE
HHCCCCCEEEHHCCCCHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEECCCCHH
KFAEKHGLNIYTIEDLIRYRRAKENLIRLEVESKLPTEYGDFTIRAYSTLIDDKIHVALI
HHHHHHCCEEEEHHHHHHHHHHHCCEEEEEECCCCCCCCCCEEEEEEHHHHCCCEEEEEE
KGDIKKEETTMVRVHSECLTGDIFSSNRCDCGPQLHSALEMISKEGKGVLLYMRQEGRGI
ECCCCCCCCEEEEEEHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCC
GLINKLKAYNIQDKGYDTVEANEKLGFAPDLRDYGIGAQILREIGIGKMKILTNNPRKIV
CEEHHHEEECCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHCCCEEEEEECCCCEEE
GLDGYGLEVVERVPIEIQPGSDNHNYLMTKKLKLGHMLGLG
EECCCCHHHHEECCEEEECCCCCCCEEEEEEEEHHHHCCCC
>Mature Secondary Structure
MIQPIENAIEEIKSGRMIILVDSEDRENEGDLVVAAEFADKEKINFMATFGRGLICIPME
CCCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEECC
AERLKKLGLNRMVDDYSLGDKHGTAFTVSVDAKYGTSTGISAQDRAITVQTLLDDKTVSA
HHHHHHCCHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCHH
DLMRPGHLFPLQAVPGGVLRRAGHTEAAVDLSKLARLYPAGVICEIMNDDGTMARLPDLE
HHCCCCCEEEHHCCCCHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEECCCCHH
KFAEKHGLNIYTIEDLIRYRRAKENLIRLEVESKLPTEYGDFTIRAYSTLIDDKIHVALI
HHHHHHCCEEEEHHHHHHHHHHHCCEEEEEECCCCCCCCCCEEEEEEHHHHCCCEEEEEE
KGDIKKEETTMVRVHSECLTGDIFSSNRCDCGPQLHSALEMISKEGKGVLLYMRQEGRGI
ECCCCCCCCEEEEEEHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCC
GLINKLKAYNIQDKGYDTVEANEKLGFAPDLRDYGIGAQILREIGIGKMKILTNNPRKIV
CEEHHHEEECCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHCCCEEEEEECCCCEEE
GLDGYGLEVVERVPIEIQPGSDNHNYLMTKKLKLGHMLGLG
EECCCCHHHHEECCEEEECCCCCCCEEEEEEEEHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA