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The map label for this gene is pepP [H]

Identifier: 116328646

GI number: 116328646

Start: 2350113

End: 2351402

Strand: Reverse

Name: pepP [H]

Synonym: LBL_2012

Alternate gene names: 116328646

Gene position: 2351402-2350113 (Counterclockwise)

Preceding gene: 116328647

Following gene: 116328644

Centisome position: 65.06

GC content: 41.94

Gene sequence:

>1290_bases
ATGACCCATGCCCTTTATAGAGAAAGAATCGCTGAAGTTCAGAAAAAGCTCAAAGACGGAGAGGTTTTGATCGTTTTTGC
GGCTTCTCATTTAATCCGAAATCGAGACGTGGACTATAAATTTCGTCAGGATTCCGATTACTATTATCTCACCGGTCTTG
ACGAATCCGATGGGATTATAATATTAAAAAATTCTTATAAATCTATATTTGTTCTTCCCAAGGATAAGGAAAAGGAGATT
TGGACCGGGATTAGAGTCGGAAAAGAAAGAGCAAAAGAACTTTTAAGGCTTGACGAGTCGTTTGATACGACGGAATGGGA
ATCAAAACTGGATGAGATTCTCCTCAATCAACATACTTTATATCATTTTTTCGGAAAAAATCTAGTTCGGGATACGAGAC
TCATCGAATGGATTTATTCCCTCAATCAAAGATCCAGGGAGGGAAAATTCGGACCGAGGAGAATCGAGTCTCCCGATTTT
TTACATTGGATGCGTATGTTCAAGTCTCCGATGGAGATTGATGCGCTTCGAGAGTCCGCTAGAATTACCGCTTTGGGCCA
CGAAAGGCTTATGAGAGAATCCAGACCCGGTATGTACGAATACGAACTTGAAGCCATTTTAGAATCCGAATATTTGAAAC
ACGGAGCCTGGGGAGGAGGTTACGGACATATAGTCGCCGGCGGAAAGAATGCTACAATTCTACACTATACATCTAACAAC
TGTAAGTTGAACGACGGCGAACTCGTTCTTGTGGACAGCGGTGCTGAAAAAGGATATTATACCGCGGACGTTACTCGAAA
TTTTCCCGTGGGTAAAAAATTTTCTTCCGAACAAAAAGCGGTGTATGAAGTCGTTTTAAAGGCTCAAAAGGAGGCCGTGT
CCAACACAAAAGAAGGAGTCGAGTTCGTCGCGATTCATGAACAGGCTGTTAGAACACTCGTGGAAGGTTTGAAAGATCTA
GGTTTATTACGAGGTTCGACCGACTCCGTCTTAGAACAAGGAACATTCAAAAAATATTATATGCATAGGACCAGTCATTA
TTTGGGAATGGACGTTCACGACGTGGGCACTTATTATCAGAACGGGGCCTCTAAAAAATTAGAAAGTGGTCAGGTGATTA
CGATCGAACCCGGACTTTATTTCGATCCTAACGACCTTGAAATTCCGGAAAAATTCCGAGGGATCGGAGTTCGAATCGAA
GACGATGTTCTTGTACAGGGTTCCAATCCTTTGAATCTGACTTCTATGATTCCGAAGGAAATAGACGAGATAGAGTCTAG
AAAGAATTGA

Upstream 100 bases:

>100_bases
GCGGAAAGGTTTGTCCGGAAGGACATTTTCGTTGTATGAAGGAGCAGAATGTGGACAAAATGTTTGAAGCGGCGATCCAA
TTGGAAAGAGGAAATGTAAA

Downstream 100 bases:

>100_bases
CGTCCCATTGCTTTTCTTGCAGATCGAATTTTTCTGTTGCAAAACGATGGAAATCCGAACGTGCAGTCGGATTCCGATCC
TAAACAACGTGAGTTCGATA

Product: Xaa-Pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MTHALYRERIAEVQKKLKDGEVLIVFAASHLIRNRDVDYKFRQDSDYYYLTGLDESDGIIILKNSYKSIFVLPKDKEKEI
WTGIRVGKERAKELLRLDESFDTTEWESKLDEILLNQHTLYHFFGKNLVRDTRLIEWIYSLNQRSREGKFGPRRIESPDF
LHWMRMFKSPMEIDALRESARITALGHERLMRESRPGMYEYELEAILESEYLKHGAWGGGYGHIVAGGKNATILHYTSNN
CKLNDGELVLVDSGAEKGYYTADVTRNFPVGKKFSSEQKAVYEVVLKAQKEAVSNTKEGVEFVAIHEQAVRTLVEGLKDL
GLLRGSTDSVLEQGTFKKYYMHRTSHYLGMDVHDVGTYYQNGASKKLESGQVITIEPGLYFDPNDLEIPEKFRGIGVRIE
DDVLVQGSNPLNLTSMIPKEIDEIESRKN

Sequences:

>Translated_429_residues
MTHALYRERIAEVQKKLKDGEVLIVFAASHLIRNRDVDYKFRQDSDYYYLTGLDESDGIIILKNSYKSIFVLPKDKEKEI
WTGIRVGKERAKELLRLDESFDTTEWESKLDEILLNQHTLYHFFGKNLVRDTRLIEWIYSLNQRSREGKFGPRRIESPDF
LHWMRMFKSPMEIDALRESARITALGHERLMRESRPGMYEYELEAILESEYLKHGAWGGGYGHIVAGGKNATILHYTSNN
CKLNDGELVLVDSGAEKGYYTADVTRNFPVGKKFSSEQKAVYEVVLKAQKEAVSNTKEGVEFVAIHEQAVRTLVEGLKDL
GLLRGSTDSVLEQGTFKKYYMHRTSHYLGMDVHDVGTYYQNGASKKLESGQVITIEPGLYFDPNDLEIPEKFRGIGVRIE
DDVLVQGSNPLNLTSMIPKEIDEIESRKN
>Mature_428_residues
THALYRERIAEVQKKLKDGEVLIVFAASHLIRNRDVDYKFRQDSDYYYLTGLDESDGIIILKNSYKSIFVLPKDKEKEIW
TGIRVGKERAKELLRLDESFDTTEWESKLDEILLNQHTLYHFFGKNLVRDTRLIEWIYSLNQRSREGKFGPRRIESPDFL
HWMRMFKSPMEIDALRESARITALGHERLMRESRPGMYEYELEAILESEYLKHGAWGGGYGHIVAGGKNATILHYTSNNC
KLNDGELVLVDSGAEKGYYTADVTRNFPVGKKFSSEQKAVYEVVLKAQKEAVSNTKEGVEFVAIHEQAVRTLVEGLKDLG
LLRGSTDSVLEQGTFKKYYMHRTSHYLGMDVHDVGTYYQNGASKKLESGQVITIEPGLYFDPNDLEIPEKFRGIGVRIED
DVLVQGSNPLNLTSMIPKEIDEIESRKN

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=442, Percent_Identity=32.1266968325792, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI149589008, Length=469, Percent_Identity=28.5714285714286, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI260593665, Length=296, Percent_Identity=33.7837837837838, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI260593663, Length=463, Percent_Identity=26.5658747300216, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1789275, Length=427, Percent_Identity=37.9391100702576, Blast_Score=321, Evalue=5e-89,
Organism=Escherichia coli, GI1788728, Length=269, Percent_Identity=29.7397769516729, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790282, Length=290, Percent_Identity=27.2413793103448, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17508215, Length=440, Percent_Identity=30, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71989583, Length=269, Percent_Identity=34.9442379182156, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6320922, Length=436, Percent_Identity=29.8165137614679, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6321118, Length=427, Percent_Identity=27.1662763466042, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI19920384, Length=396, Percent_Identity=33.0808080808081, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI21357079, Length=457, Percent_Identity=31.5098468271335, Blast_Score=196, Evalue=3e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 49312; Mature: 49180

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHALYRERIAEVQKKLKDGEVLIVFAASHLIRNRDVDYKFRQDSDYYYLTGLDESDGII
CCHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHCCCCCEEEECCCCEEEEEECCCCCCEE
ILKNSYKSIFVLPKDKEKEIWTGIRVGKERAKELLRLDESFDTTEWESKLDEILLNQHTL
EEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHH
YHFFGKNLVRDTRLIEWIYSLNQRSREGKFGPRRIESPDFLHWMRMFKSPMEIDALRESA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCC
RITALGHERLMRESRPGMYEYELEAILESEYLKHGAWGGGYGHIVAGGKNATILHYTSNN
CEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEECCC
CKLNDGELVLVDSGAEKGYYTADVTRNFPVGKKFSSEQKAVYEVVLKAQKEAVSNTKEGV
CEECCCCEEEEECCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCC
EFVAIHEQAVRTLVEGLKDLGLLRGSTDSVLEQGTFKKYYMHRTSHYLGMDVHDVGTYYQ
EEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHH
NGASKKLESGQVITIEPGLYFDPNDLEIPEKFRGIGVRIEDDVLVQGSNPLNLTSMIPKE
CCCCCCCCCCCEEEECCCCEECCCCCCCCHHHCCCCEEEECCEEEECCCCCCHHHHHHHH
IDEIESRKN
HHHHHHCCC
>Mature Secondary Structure 
THALYRERIAEVQKKLKDGEVLIVFAASHLIRNRDVDYKFRQDSDYYYLTGLDESDGII
CHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHCCCCCEEEECCCCEEEEEECCCCCCEE
ILKNSYKSIFVLPKDKEKEIWTGIRVGKERAKELLRLDESFDTTEWESKLDEILLNQHTL
EEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHH
YHFFGKNLVRDTRLIEWIYSLNQRSREGKFGPRRIESPDFLHWMRMFKSPMEIDALRESA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCC
RITALGHERLMRESRPGMYEYELEAILESEYLKHGAWGGGYGHIVAGGKNATILHYTSNN
CEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEECCC
CKLNDGELVLVDSGAEKGYYTADVTRNFPVGKKFSSEQKAVYEVVLKAQKEAVSNTKEGV
CEECCCCEEEEECCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCC
EFVAIHEQAVRTLVEGLKDLGLLRGSTDSVLEQGTFKKYYMHRTSHYLGMDVHDVGTYYQ
EEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHH
NGASKKLESGQVITIEPGLYFDPNDLEIPEKFRGIGVRIEDDVLVQGSNPLNLTSMIPKE
CCCCCCCCCCCEEEECCCCEECCCCCCCCHHHCCCCEEEECCEEEECCCCCCHHHHHHHH
IDEIESRKN
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]