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The map label for this gene is ywlC [H]

Identifier: 116328292

GI number: 116328292

Start: 1906291

End: 1907235

Strand: Direct

Name: ywlC [H]

Synonym: LBL_1627

Alternate gene names: 116328292

Gene position: 1906291-1907235 (Clockwise)

Preceding gene: 116328291

Following gene: 116328294

Centisome position: 52.74

GC content: 39.79

Gene sequence:

>945_bases
TTGCCAGAAAACAAGGTTGATACTCTTATTACGGACTCTCCTTTGGAAGCGGCGAAAATCCTGCTTGAAGGAGGGAACGT
CGTTTTTCCTACGGAAACGGTTTATGGAATCGGAGCATCCGCGTTTGACTTCAAAGCTTGTAAGAAAATCTATGAAGTTA
AAAACAGGCCTTTTGATAATCCTCTCATCCTTCACGTAGAAAACCTTTCCTCCTTAAAAACTTACGGAAATATCAGTGAA
AAAGCCGGTCTTGTATTTCAAAATTTTTCTCCCGGGCCTATTACCGGTATTTTTACAAAGAAAAATCAAGATCTTTTTAC
CGCCGGTTTGAATACGGTTGCCTTAAGAATTCCATCCAACCCAACAACTCAACTATTTTTGAATCTTTGTGGCGTTCCGG
TCGCCGCTCCATCCGCGAACCTTTCCGGAAAACCATCCTTAACAAAAATTGAATATATTTTAGAAGAGTTTTCCGGTAGA
GTGGACTGTATTTTAAAAGGAGAAGAACCAAAGATAGGAATCGAATCGACCGTAATCGATTTCAGCTCCGAACCTCCGGT
TCTCCTTCGTCCCGGTTTTGTGGATCGAAACGATCTCCTGAAAATATTGCCGGATCTTAAAGGAATCGAATCGTTTAACG
AACTGAACAAAATACCCAGAAGTCCAGGTCTCAAATATAGACATTATGCCCCCGCTTGCAAAGTCGTATTAAAGGATTCA
TTAAAGGGAATTTCTGGAAATTTTGCACAAATCGGTTTTCACTTCGAATCGGAATCAATGTTTCAGATTTTGGTTTCTTC
CAATGAAGAATATATGAAATCCATTTACTCCTTTTTCGTGGAATGCGATCGTAAGGGAATTAAGGAAGCATGGTGTGAAA
TTCCCAAAGATGGAAACGGAAAAGAAGCGTTAATCAATCGAATTTCAAAAGCCGCTTCGAAATAA

Upstream 100 bases:

>100_bases
GAAAAAGTAAAAGATCCAGTGCAAAATCCGACTGCACCCGCTACAGAACAAACCGTTCCGGAAGAAGCAAAAATGGATCG
TCAACATCATTCGGAGAAAC

Downstream 100 bases:

>100_bases
TACAGCAGGCACACATCGACTTCTCCTAAATAACGTGAGTTCGACGGCTGAAAATCTTGGCGAATCAGACGAAAAACCTA
GAATTATTTTTGGTTCCAAA

Product: Sua5 family translation factor

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MPENKVDTLITDSPLEAAKILLEGGNVVFPTETVYGIGASAFDFKACKKIYEVKNRPFDNPLILHVENLSSLKTYGNISE
KAGLVFQNFSPGPITGIFTKKNQDLFTAGLNTVALRIPSNPTTQLFLNLCGVPVAAPSANLSGKPSLTKIEYILEEFSGR
VDCILKGEEPKIGIESTVIDFSSEPPVLLRPGFVDRNDLLKILPDLKGIESFNELNKIPRSPGLKYRHYAPACKVVLKDS
LKGISGNFAQIGFHFESESMFQILVSSNEEYMKSIYSFFVECDRKGIKEAWCEIPKDGNGKEALINRISKAASK

Sequences:

>Translated_314_residues
MPENKVDTLITDSPLEAAKILLEGGNVVFPTETVYGIGASAFDFKACKKIYEVKNRPFDNPLILHVENLSSLKTYGNISE
KAGLVFQNFSPGPITGIFTKKNQDLFTAGLNTVALRIPSNPTTQLFLNLCGVPVAAPSANLSGKPSLTKIEYILEEFSGR
VDCILKGEEPKIGIESTVIDFSSEPPVLLRPGFVDRNDLLKILPDLKGIESFNELNKIPRSPGLKYRHYAPACKVVLKDS
LKGISGNFAQIGFHFESESMFQILVSSNEEYMKSIYSFFVECDRKGIKEAWCEIPKDGNGKEALINRISKAASK
>Mature_313_residues
PENKVDTLITDSPLEAAKILLEGGNVVFPTETVYGIGASAFDFKACKKIYEVKNRPFDNPLILHVENLSSLKTYGNISEK
AGLVFQNFSPGPITGIFTKKNQDLFTAGLNTVALRIPSNPTTQLFLNLCGVPVAAPSANLSGKPSLTKIEYILEEFSGRV
DCILKGEEPKIGIESTVIDFSSEPPVLLRPGFVDRNDLLKILPDLKGIESFNELNKIPRSPGLKYRHYAPACKVVLKDSL
KGISGNFAQIGFHFESESMFQILVSSNEEYMKSIYSFFVECDRKGIKEAWCEIPKDGNGKEALINRISKAASK

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable) [H]

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain [H]

Homologues:

Organism=Escherichia coli, GI87081864, Length=202, Percent_Identity=29.2079207920792, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI2367210, Length=159, Percent_Identity=27.6729559748428, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321269, Length=249, Percent_Identity=36.9477911646586, Blast_Score=151, Evalue=1e-37,
Organism=Drosophila melanogaster, GI78707274, Length=183, Percent_Identity=26.775956284153, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923 [H]

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC [H]

EC number: NA

Molecular weight: Translated: 34572; Mature: 34441

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPENKVDTLITDSPLEAAKILLEGGNVVFPTETVYGIGASAFDFKACKKIYEVKNRPFDN
CCCCCCCEEECCCCHHHHHHEEECCCEEECCCHHEECCCCHHHHHHHHHHHHHHCCCCCC
PLILHVENLSSLKTYGNISEKAGLVFQNFSPGPITGIFTKKNQDLFTAGLNTVALRIPSN
CEEEEECCHHHHHHHCCCCHHCCEEEECCCCCCEEEEEECCCCCCEEECCCEEEEEECCC
PTTQLFLNLCGVPVAAPSANLSGKPSLTKIEYILEEFSGRVDCILKGEEPKIGIESTVID
CHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEE
FSSEPPVLLRPGFVDRNDLLKILPDLKGIESFNELNKIPRSPGLKYRHYAPACKVVLKDS
CCCCCCEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
LKGISGNFAQIGFHFESESMFQILVSSNEEYMKSIYSFFVECDRKGIKEAWCEIPKDGNG
HCCCCCCEEEEEEEECCCCEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
KEALINRISKAASK
HHHHHHHHHHHHCC
>Mature Secondary Structure 
PENKVDTLITDSPLEAAKILLEGGNVVFPTETVYGIGASAFDFKACKKIYEVKNRPFDN
CCCCCCEEECCCCHHHHHHEEECCCEEECCCHHEECCCCHHHHHHHHHHHHHHCCCCCC
PLILHVENLSSLKTYGNISEKAGLVFQNFSPGPITGIFTKKNQDLFTAGLNTVALRIPSN
CEEEEECCHHHHHHHCCCCHHCCEEEECCCCCCEEEEEECCCCCCEEECCCEEEEEECCC
PTTQLFLNLCGVPVAAPSANLSGKPSLTKIEYILEEFSGRVDCILKGEEPKIGIESTVID
CHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEE
FSSEPPVLLRPGFVDRNDLLKILPDLKGIESFNELNKIPRSPGLKYRHYAPACKVVLKDS
CCCCCCEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
LKGISGNFAQIGFHFESESMFQILVSSNEEYMKSIYSFFVECDRKGIKEAWCEIPKDGNG
HCCCCCCEEEEEEEECCCCEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
KEALINRISKAASK
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]