Click here to switch to the map view.

The map label for this gene is mutY [H]

Identifier: 116328197

GI number: 116328197

Start: 1778289

End: 1779407

Strand: Direct

Name: mutY [H]

Synonym: LBL_1521

Alternate gene names: 116328197

Gene position: 1778289-1779407 (Clockwise)

Preceding gene: 116328196

Following gene: 116328198

Centisome position: 49.2

GC content: 40.3

Gene sequence:

>1119_bases
GTGAAATTTAAAATAAATCCAAAACTTCTGATCGAACTCAGAGAAAATTTGCTTTCTTGGTTTCAAAAAAACAAAAGAAA
GCTTCCTTTTCGAATCAACAAAAATGCCTATCGAATTTGGGTGAGCGAGATCATGCTTCAGCAGACTCGGGTCGCCGCGA
TGCTTCCAATTTACGAAACATTCTTAAAAAGATTTCCGGATCCGAAAGCTCTGCAAGACGCATCAGAAGAAGAGGTGATG
AAATATTGGAAAGGACTCGGTTATTATTCGCGAGCTCGAAATTTAAAAAAGGGAGCGGAGCTTCTCGTTGAAAAATACGA
AGGTCGTTTTCCCGAAGATTATGAAGAGGCTCTTTCGATTCCCGGAGTGGGAAGTTATACAGCCTCCGCTGTTTTGTCAA
TCGCTTATGGGAAACCTTATGCCGTTTTGGACGGGAATGTGAAACGCGTATTATCGAGATTGTTTCTGATCGAATCAGAT
CCTAATTCAAATTCTACCAATCAGGTTCTTGCAGACCTAGCTCAAAAATTTTTAACGCCTGGCGACCCTGGGAATCATAA
CGAAGCGATGATGGAATTGGGTGCGCTTGTTTGTATTCCAGTTCCAAATTGTTCCGCGTGTCCATTCGAAAATCATTGTG
AAGCAAAAGGAGCCGGAAAAGAAAAGGAGATTCCGGTAACAAAATCAGTGGAAAATTGGGTGGATTTAGACCTCAACTTT
CTTTTTTTGAAATCATCCGGTCGTATCCTTTTGGTGAAATACACAACTCGAAGATTTTTCAAGACAATCTATTCCTTGCC
GTTTCGATTGGAAGGGAAACATCCTTATGAAAAGGATGAGTGGGCGGAAGAATTATTCGCCGATTCCGGAGTGATACAGA
ATTCTCTGAGATCAAGGCATTCCATCACGAATCATCGGATTCGATTGAAGTTCAGCGAACTTGATGAAAAGAACGTTGTT
CGAATCGAAAAAAGTCTTCAAAAGAGAAAGGATATCCAATTTAAATGGGTAAACGAATCGGATCTCAAGGAAGAATTCCC
ATCTTCTATATCCGGAAAATTGATCAGGCTTAGAAATAAAAACAAAAAACAACCGGAGCTTCCGGTGGAAAATTTATGA

Upstream 100 bases:

>100_bases
CTTAGTGAAATCTTATTTATTTCAGTAAAGAAGATGAAAACAAGATTTACCTTCGTTCAGCGTACCATTCCATGTAAAGA
AATTCATTTCCCTTACGACA

Downstream 100 bases:

>100_bases
AACTTCGATCCACAGCGGAATTCGTAAAGGAATTACAAAAGCAAAAGGAACTTCTCGTCATAGAAGAGGAAGTAAATCCA
GTATTAGAATTAGCTGAAAT

Product: A/G-specific DNA glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MKFKINPKLLIELRENLLSWFQKNKRKLPFRINKNAYRIWVSEIMLQQTRVAAMLPIYETFLKRFPDPKALQDASEEEVM
KYWKGLGYYSRARNLKKGAELLVEKYEGRFPEDYEEALSIPGVGSYTASAVLSIAYGKPYAVLDGNVKRVLSRLFLIESD
PNSNSTNQVLADLAQKFLTPGDPGNHNEAMMELGALVCIPVPNCSACPFENHCEAKGAGKEKEIPVTKSVENWVDLDLNF
LFLKSSGRILLVKYTTRRFFKTIYSLPFRLEGKHPYEKDEWAEELFADSGVIQNSLRSRHSITNHRIRLKFSELDEKNVV
RIEKSLQKRKDIQFKWVNESDLKEEFPSSISGKLIRLRNKNKKQPELPVENL

Sequences:

>Translated_372_residues
MKFKINPKLLIELRENLLSWFQKNKRKLPFRINKNAYRIWVSEIMLQQTRVAAMLPIYETFLKRFPDPKALQDASEEEVM
KYWKGLGYYSRARNLKKGAELLVEKYEGRFPEDYEEALSIPGVGSYTASAVLSIAYGKPYAVLDGNVKRVLSRLFLIESD
PNSNSTNQVLADLAQKFLTPGDPGNHNEAMMELGALVCIPVPNCSACPFENHCEAKGAGKEKEIPVTKSVENWVDLDLNF
LFLKSSGRILLVKYTTRRFFKTIYSLPFRLEGKHPYEKDEWAEELFADSGVIQNSLRSRHSITNHRIRLKFSELDEKNVV
RIEKSLQKRKDIQFKWVNESDLKEEFPSSISGKLIRLRNKNKKQPELPVENL
>Mature_372_residues
MKFKINPKLLIELRENLLSWFQKNKRKLPFRINKNAYRIWVSEIMLQQTRVAAMLPIYETFLKRFPDPKALQDASEEEVM
KYWKGLGYYSRARNLKKGAELLVEKYEGRFPEDYEEALSIPGVGSYTASAVLSIAYGKPYAVLDGNVKRVLSRLFLIESD
PNSNSTNQVLADLAQKFLTPGDPGNHNEAMMELGALVCIPVPNCSACPFENHCEAKGAGKEKEIPVTKSVENWVDLDLNF
LFLKSSGRILLVKYTTRRFFKTIYSLPFRLEGKHPYEKDEWAEELFADSGVIQNSLRSRHSITNHRIRLKFSELDEKNVV
RIEKSLQKRKDIQFKWVNESDLKEEFPSSISGKLIRLRNKNKKQPELPVENL

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=238, Percent_Identity=42.436974789916, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI115298654, Length=238, Percent_Identity=42.436974789916, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI115298652, Length=238, Percent_Identity=42.436974789916, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI115298650, Length=238, Percent_Identity=42.436974789916, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI6912520, Length=238, Percent_Identity=42.436974789916, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI190358497, Length=238, Percent_Identity=42.436974789916, Blast_Score=200, Evalue=2e-51,
Organism=Escherichia coli, GI1789331, Length=258, Percent_Identity=37.984496124031, Blast_Score=197, Evalue=7e-52,
Organism=Escherichia coli, GI1787920, Length=151, Percent_Identity=32.4503311258278, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 43011; Mature: 43011

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFKINPKLLIELRENLLSWFQKNKRKLPFRINKNAYRIWVSEIMLQQTRVAAMLPIYET
CCEECCHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
FLKRFPDPKALQDASEEEVMKYWKGLGYYSRARNLKKGAELLVEKYEGRFPEDYEEALSI
HHHHCCCCHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCC
PGVGSYTASAVLSIAYGKPYAVLDGNVKRVLSRLFLIESDPNSNSTNQVLADLAQKFLTP
CCCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHCCC
GDPGNHNEAMMELGALVCIPVPNCSACPFENHCEAKGAGKEKEIPVTKSVENWVDLDLNF
CCCCCCHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHCHHHHHCCCEEE
LFLKSSGRILLVKYTTRRFFKTIYSLPFRLEGKHPYEKDEWAEELFADSGVIQNSLRSRH
EEEECCCCEEEEEHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHH
SITNHRIRLKFSELDEKNVVRIEKSLQKRKDIQFKWVNESDLKEEFPSSISGKLIRLRNK
CCCCCEEEEEEHHCCCCHHHHHHHHHHHHHCCEEEECCHHHHHHHCCCCCCCCEEEECCC
NKKQPELPVENL
CCCCCCCCCCCC
>Mature Secondary Structure
MKFKINPKLLIELRENLLSWFQKNKRKLPFRINKNAYRIWVSEIMLQQTRVAAMLPIYET
CCEECCHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
FLKRFPDPKALQDASEEEVMKYWKGLGYYSRARNLKKGAELLVEKYEGRFPEDYEEALSI
HHHHCCCCHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCC
PGVGSYTASAVLSIAYGKPYAVLDGNVKRVLSRLFLIESDPNSNSTNQVLADLAQKFLTP
CCCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHCCC
GDPGNHNEAMMELGALVCIPVPNCSACPFENHCEAKGAGKEKEIPVTKSVENWVDLDLNF
CCCCCCHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHCHHHHHCCCEEE
LFLKSSGRILLVKYTTRRFFKTIYSLPFRLEGKHPYEKDEWAEELFADSGVIQNSLRSRH
EEEECCCCEEEEEHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHH
SITNHRIRLKFSELDEKNVVRIEKSLQKRKDIQFKWVNESDLKEEFPSSISGKLIRLRNK
CCCCCEEEEEEHHCCCCHHHHHHHHHHHHHCCEEEECCHHHHHHHCCCCCCCCEEEECCC
NKKQPELPVENL
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]