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The map label for this gene is bioA [H]

Identifier: 116328115

GI number: 116328115

Start: 1645746

End: 1647047

Strand: Direct

Name: bioA [H]

Synonym: LBL_1413

Alternate gene names: 116328115

Gene position: 1645746-1647047 (Clockwise)

Preceding gene: 116328114

Following gene: 116328116

Centisome position: 45.53

GC content: 43.01

Gene sequence:

>1302_bases
ATGATTTGGTATCCGTTTACGCTTCAGTTCGAATCCGATCCTCCCTTAAAGATAAAGAGGGCAAAAGGAGAATTTTTGTA
TGACGAAAACGGAAACTCTTATATAGACGCTGTTTCTTCTTGGTGGGTGAGTATTCACGGACACAACCATCCTAAGATTA
TTCAAGCCGTTAAAAATCAATTGAATAAACTCGATCACGTTTTGCTCGCCGGATTTACACACGACCCGGCTGAAAAACTC
GCGAGTGAACTTTTAAAAATTACGGATGGTTTGTTTCATAGGGTTCTTTACTCGGACAACGGTTCCACCGCCGTAGAGAT
CATGATAAAACTTGCGTATCAATATTTTCAGAATACGGGGGAAACGGATCGTAGAACATTCATAAAGTTTAATGCTTCCT
ATCACGGAGATACGATAGGGGCTATGAGTGTAGGCGGAAATTCTGTGTTCAATCGGGTTTTTCAAGGGTTGATGTTTCCG
ACGAAAGAATTTTTAACTCCGAATTGTAGTTTTTGTCCGATGAAAAAAAAGCCTGACTCTTGCAACGTGGAATGTGTGGA
TCCAATTGAAGAGTTTTTTCAAAAAAATCCTAAATCCGTTGCGGGAATCGTGATCGAACCATTGATTTTGGGTTCGGGGG
GGATGATAATTTATAAAGAGGAAGTTCTTCAAAGACTCGAAAAGGTCTCCAAAAAATACGGGACTTTACTTTTGGTGGAC
GAGGTTTTTACCGGTTTTGGGAGAACCGGTTCGTTCTTCGCTTATCAAAGAGCCAAAATCCGACCCGATTTGGTGGCGAT
GGCAAAGGGATTGAGCGCCGGTGCGGCCGCGATCGCAGCGACTCTTACGACGGATAAAATTCATTCCTCGTTCGTCGCCC
CCGAGCCGGAAAAGGGGTTTTATCACGGGCATACGATGACTGGAAATCCGATTGCTTGTTCGGCGGCACTTGCTTCCATA
GAACTTCTTTTAAGGGAAGGTTATCTAGAGCAAGTCGCAAGACTGGAATTCAAACTCAGGGTCGGTCTCAAAAAAATTGC
GGAAGAGTATCCGAAAGCGGTTCGGGACTGTCGAGTTTTGGGAGCGGTTGGTGTTTTGGAATTGGAAGTAGGAAACGAAA
GCGGTTACAATTATTCGGGGAATAAGATTCTCAAGAAGAAGTTTTTAGAAAAGGGAGTGTTGCTTCGTCCTTTGGGAAAC
GTGATTTATATCACACCTCCATATAACATCAAAAATTCTTCCTTGGAAAAAGTATTTTCTGCGATCCGGGAAACACTCTC
GGAAATTTCCTATGGGAATTAG

Upstream 100 bases:

>100_bases
ATTTTTTTCTGAACTCAAAAGAAAAAATGAGTCGGGAACGTTTTCAAATCGAATGTCTTTCCCGATTCGATCAGTGCGAA
GTAATCAAGAAAATGTTCGT

Downstream 100 bases:

>100_bases
ACTTTTCAAGAAAGCTTCTTCTCTTCAATCTGTCTGAAAAGATGTACGCAACACTTAAAACAGCCGAAAAAATATTCTCC
GAAATTTCAAGCGTAATCAC

Product: adenosylmethionine-8-amino-7- oxononanoateaminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MIWYPFTLQFESDPPLKIKRAKGEFLYDENGNSYIDAVSSWWVSIHGHNHPKIIQAVKNQLNKLDHVLLAGFTHDPAEKL
ASELLKITDGLFHRVLYSDNGSTAVEIMIKLAYQYFQNTGETDRRTFIKFNASYHGDTIGAMSVGGNSVFNRVFQGLMFP
TKEFLTPNCSFCPMKKKPDSCNVECVDPIEEFFQKNPKSVAGIVIEPLILGSGGMIIYKEEVLQRLEKVSKKYGTLLLVD
EVFTGFGRTGSFFAYQRAKIRPDLVAMAKGLSAGAAAIAATLTTDKIHSSFVAPEPEKGFYHGHTMTGNPIACSAALASI
ELLLREGYLEQVARLEFKLRVGLKKIAEEYPKAVRDCRVLGAVGVLELEVGNESGYNYSGNKILKKKFLEKGVLLRPLGN
VIYITPPYNIKNSSLEKVFSAIRETLSEISYGN

Sequences:

>Translated_433_residues
MIWYPFTLQFESDPPLKIKRAKGEFLYDENGNSYIDAVSSWWVSIHGHNHPKIIQAVKNQLNKLDHVLLAGFTHDPAEKL
ASELLKITDGLFHRVLYSDNGSTAVEIMIKLAYQYFQNTGETDRRTFIKFNASYHGDTIGAMSVGGNSVFNRVFQGLMFP
TKEFLTPNCSFCPMKKKPDSCNVECVDPIEEFFQKNPKSVAGIVIEPLILGSGGMIIYKEEVLQRLEKVSKKYGTLLLVD
EVFTGFGRTGSFFAYQRAKIRPDLVAMAKGLSAGAAAIAATLTTDKIHSSFVAPEPEKGFYHGHTMTGNPIACSAALASI
ELLLREGYLEQVARLEFKLRVGLKKIAEEYPKAVRDCRVLGAVGVLELEVGNESGYNYSGNKILKKKFLEKGVLLRPLGN
VIYITPPYNIKNSSLEKVFSAIRETLSEISYGN
>Mature_433_residues
MIWYPFTLQFESDPPLKIKRAKGEFLYDENGNSYIDAVSSWWVSIHGHNHPKIIQAVKNQLNKLDHVLLAGFTHDPAEKL
ASELLKITDGLFHRVLYSDNGSTAVEIMIKLAYQYFQNTGETDRRTFIKFNASYHGDTIGAMSVGGNSVFNRVFQGLMFP
TKEFLTPNCSFCPMKKKPDSCNVECVDPIEEFFQKNPKSVAGIVIEPLILGSGGMIIYKEEVLQRLEKVSKKYGTLLLVD
EVFTGFGRTGSFFAYQRAKIRPDLVAMAKGLSAGAAAIAATLTTDKIHSSFVAPEPEKGFYHGHTMTGNPIACSAALASI
ELLLREGYLEQVARLEFKLRVGLKKIAEEYPKAVRDCRVLGAVGVLELEVGNESGYNYSGNKILKKKFLEKGVLLRPLGN
VIYITPPYNIKNSSLEKVFSAIRETLSEISYGN

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=415, Percent_Identity=27.9518072289157, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI13994255, Length=374, Percent_Identity=28.0748663101604, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI37574042, Length=414, Percent_Identity=26.8115942028986, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI284507298, Length=240, Percent_Identity=29.1666666666667, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI24119277, Length=437, Percent_Identity=25.1716247139588, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI226442705, Length=414, Percent_Identity=26.0869565217391, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI188536080, Length=391, Percent_Identity=22.2506393861893, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI38679950, Length=391, Percent_Identity=22.2506393861893, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI38679946, Length=391, Percent_Identity=22.2506393861893, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI226442709, Length=377, Percent_Identity=25.4641909814324, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1786991, Length=433, Percent_Identity=35.5658198614319, Blast_Score=267, Evalue=8e-73,
Organism=Escherichia coli, GI145693181, Length=405, Percent_Identity=31.1111111111111, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1789016, Length=423, Percent_Identity=30.2600472813239, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1789759, Length=403, Percent_Identity=28.5359801488834, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1788044, Length=399, Percent_Identity=27.0676691729323, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1787560, Length=417, Percent_Identity=27.8177458033573, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1786349, Length=340, Percent_Identity=29.1176470588235, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25144271, Length=426, Percent_Identity=26.5258215962441, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71992977, Length=446, Percent_Identity=25.3363228699552, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI32564660, Length=446, Percent_Identity=27.3542600896861, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25144274, Length=237, Percent_Identity=29.1139240506329, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17541228, Length=356, Percent_Identity=23.0337078651685, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324386, Length=462, Percent_Identity=32.2510822510823, Blast_Score=233, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6323470, Length=417, Percent_Identity=26.378896882494, Blast_Score=140, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6324432, Length=426, Percent_Identity=27.4647887323944, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321456, Length=373, Percent_Identity=23.3243967828418, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21357415, Length=415, Percent_Identity=26.5060240963855, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI28574759, Length=442, Percent_Identity=26.6968325791855, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI161085790, Length=436, Percent_Identity=25.6880733944954, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21356575, Length=444, Percent_Identity=26.5765765765766, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI281366494, Length=400, Percent_Identity=25.75, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24667139, Length=400, Percent_Identity=25.75, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24667143, Length=400, Percent_Identity=25.75, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 48190; Mature: 48190

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIWYPFTLQFESDPPLKIKRAKGEFLYDENGNSYIDAVSSWWVSIHGHNHPKIIQAVKNQ
CEEEEEEEEECCCCCEEEEECCCCEEEECCCCHHHHHHHEEEEEEECCCCHHHHHHHHHH
LNKLDHVLLAGFTHDPAEKLASELLKITDGLFHRVLYSDNGSTAVEIMIKLAYQYFQNTG
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
ETDRRTFIKFNASYHGDTIGAMSVGGNSVFNRVFQGLMFPTKEFLTPNCSFCPMKKKPDS
CCCCEEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCC
CNVECVDPIEEFFQKNPKSVAGIVIEPLILGSGGMIIYKEEVLQRLEKVSKKYGTLLLVD
CCCEECCHHHHHHHCCCCHHHHHEEEHEEECCCCEEEEHHHHHHHHHHHHHHHCCEEEEH
EVFTGFGRTGSFFAYQRAKIRPDLVAMAKGLSAGAAAIAATLTTDKIHSSFVAPEPEKGF
HHHHCCCCCCCEEEEHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCE
YHGHTMTGNPIACSAALASIELLLREGYLEQVARLEFKLRVGLKKIAEEYPKAVRDCRVL
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAVGVLELEVGNESGYNYSGNKILKKKFLEKGVLLRPLGNVIYITPPYNIKNSSLEKVFS
CCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEECCCEEEECCCCCCCCHHHHHHHH
AIRETLSEISYGN
HHHHHHHHCCCCC
>Mature Secondary Structure
MIWYPFTLQFESDPPLKIKRAKGEFLYDENGNSYIDAVSSWWVSIHGHNHPKIIQAVKNQ
CEEEEEEEEECCCCCEEEEECCCCEEEECCCCHHHHHHHEEEEEEECCCCHHHHHHHHHH
LNKLDHVLLAGFTHDPAEKLASELLKITDGLFHRVLYSDNGSTAVEIMIKLAYQYFQNTG
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
ETDRRTFIKFNASYHGDTIGAMSVGGNSVFNRVFQGLMFPTKEFLTPNCSFCPMKKKPDS
CCCCEEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCC
CNVECVDPIEEFFQKNPKSVAGIVIEPLILGSGGMIIYKEEVLQRLEKVSKKYGTLLLVD
CCCEECCHHHHHHHCCCCHHHHHEEEHEEECCCCEEEEHHHHHHHHHHHHHHHCCEEEEH
EVFTGFGRTGSFFAYQRAKIRPDLVAMAKGLSAGAAAIAATLTTDKIHSSFVAPEPEKGF
HHHHCCCCCCCEEEEHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCE
YHGHTMTGNPIACSAALASIELLLREGYLEQVARLEFKLRVGLKKIAEEYPKAVRDCRVL
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAVGVLELEVGNESGYNYSGNKILKKKFLEKGVLLRPLGNVIYITPPYNIKNSSLEKVFS
CCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEECCCEEEECCCCCCCCHHHHHHHH
AIRETLSEISYGN
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]