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The map label for this gene is creC [H]

Identifier: 116328025

GI number: 116328025

Start: 1549414

End: 1550751

Strand: Direct

Name: creC [H]

Synonym: LBL_1320

Alternate gene names: 116328025

Gene position: 1549414-1550751 (Clockwise)

Preceding gene: 116328024

Following gene: 116328026

Centisome position: 42.87

GC content: 37.37

Gene sequence:

>1338_bases
ATGGAAACCGTGGAGGAATCTTTAAACGATACGGCGTATCTTTTAGTCTCTTTATTGGAAAGTGAACTATTTCAAAGAAA
CGTTTCCTTGGAAAAAACGAGCGAGCGTGTGTTTTCTCCTATATTAAGAATCTCTAAAGAAAAAAAATTAAATTCTAAAA
TTTTCGAAATCACCAAGAAAAAGATGGATTTACAATTGTATGTGGTTGACGAGCGTGGAATCGTAATCTACGATTCGGAA
GGAATTAGAAAGGGACTCGATTATTCCAAAAAGAACGACGTATATCTCACCTTACAAGGGAAATACGGAGCTAGGTCTAG
TCCCTTAACGATTTCAGAATCCGATAAAGGATTGTTTATCGCAGCCCCGATCCGAAAAAACGGAAAAATCATCGGCGCGG
TTACGGTAATCAAACCCAAAAAAAGTTTGATTCCTTTTATCGAATCAACCCGAAAAAAATTTTGGAATCTGAGTTTGTAT
GTGGCTCTTTCCATAATCGTTTTGTTTATTAGCATTTTATATTTTTTGTTTTCACCGATTCGAAAATTATCCGAATATGT
TTCGGCTCTAAGGTTTCAAAAGCGGGTTCCTTTTCCGAAAATCAGCGTGCCCGAAATACGAGGATTGGGAGAGGAAATGG
ACAGATTGTTTCGGGAACTTGCGGGGAAGGAATACGTGGAAAATTATGTACAATCCATGACTCACGAGATCAAGAGTCCT
TTATCCTCTTTACTTGCTTCTTCGGAGTTGATTATCGAAAACCCGGATCGATTGGAATTTTTAATTTCTAATATTCAATT
GGAAGGAAAAAGAATCCAAACGATTTTAGAGAAACTTTTAGAACTCAGTTCTTTGGAAAATCAATCTCAGTTGGAAAAAA
CTTCGAATCTCAATTTACAAGACTTGGTTCGAGAGACGGTTGTTTCTTCTATTTCGGAAGCCGTTCGAAAAAAAATAAAA
CTAAAAGAGTTAACCGAGGCCGTATGGGTGGAAGGAAATTCTTTCTTTTTAGGAATGGCTCTTCGGAATTTAGTTCAGAA
CGCATTGGATTTTTCAAACTCGGGATCTGAAATTACGGTTCGTTGCGGTAAAAAAAACGGATTTCCCTTTTTAGAAGTGG
AAGACTCCGGTTCTGGAATTCCATTGTATGCTTTGGAAAGAATTTTTGAGAAATTCTATTCTTTGCCTCGTCCTGACACT
GGACGTAAAAGTTCCGGATTGGGTTTGGCATTTGTAAGAGAGATCGCAAAATTACACGATGCGGATTTGCAAGTAAAAAA
CGGAACTTCAATGGGTGTAGTCGCTCGGATTTGTTTCAAAAAAAAATTTCAACAATAG

Upstream 100 bases:

>100_bases
TGAGTCTTTGGATACGAATTGTAATCGGTTTTTTTTTGCCTTTTTTGCGGGTTATTATTACTTCGTGGATAAAATCGAGG
ATTCGATTCGACCGCGTTAT

Downstream 100 bases:

>100_bases
AACCGGTTTTTAGCTACGGATTTTAACGGCAAATTCTTTGTCCCAATATAGAATTTCTTTCAAAATTCAGGTTGTTTAAT
AAGGATCAGTAAGTGCGAGT

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
METVEESLNDTAYLLVSLLESELFQRNVSLEKTSERVFSPILRISKEKKLNSKIFEITKKKMDLQLYVVDERGIVIYDSE
GIRKGLDYSKKNDVYLTLQGKYGARSSPLTISESDKGLFIAAPIRKNGKIIGAVTVIKPKKSLIPFIESTRKKFWNLSLY
VALSIIVLFISILYFLFSPIRKLSEYVSALRFQKRVPFPKISVPEIRGLGEEMDRLFRELAGKEYVENYVQSMTHEIKSP
LSSLLASSELIIENPDRLEFLISNIQLEGKRIQTILEKLLELSSLENQSQLEKTSNLNLQDLVRETVVSSISEAVRKKIK
LKELTEAVWVEGNSFFLGMALRNLVQNALDFSNSGSEITVRCGKKNGFPFLEVEDSGSGIPLYALERIFEKFYSLPRPDT
GRKSSGLGLAFVREIAKLHDADLQVKNGTSMGVVARICFKKKFQQ

Sequences:

>Translated_445_residues
METVEESLNDTAYLLVSLLESELFQRNVSLEKTSERVFSPILRISKEKKLNSKIFEITKKKMDLQLYVVDERGIVIYDSE
GIRKGLDYSKKNDVYLTLQGKYGARSSPLTISESDKGLFIAAPIRKNGKIIGAVTVIKPKKSLIPFIESTRKKFWNLSLY
VALSIIVLFISILYFLFSPIRKLSEYVSALRFQKRVPFPKISVPEIRGLGEEMDRLFRELAGKEYVENYVQSMTHEIKSP
LSSLLASSELIIENPDRLEFLISNIQLEGKRIQTILEKLLELSSLENQSQLEKTSNLNLQDLVRETVVSSISEAVRKKIK
LKELTEAVWVEGNSFFLGMALRNLVQNALDFSNSGSEITVRCGKKNGFPFLEVEDSGSGIPLYALERIFEKFYSLPRPDT
GRKSSGLGLAFVREIAKLHDADLQVKNGTSMGVVARICFKKKFQQ
>Mature_445_residues
METVEESLNDTAYLLVSLLESELFQRNVSLEKTSERVFSPILRISKEKKLNSKIFEITKKKMDLQLYVVDERGIVIYDSE
GIRKGLDYSKKNDVYLTLQGKYGARSSPLTISESDKGLFIAAPIRKNGKIIGAVTVIKPKKSLIPFIESTRKKFWNLSLY
VALSIIVLFISILYFLFSPIRKLSEYVSALRFQKRVPFPKISVPEIRGLGEEMDRLFRELAGKEYVENYVQSMTHEIKSP
LSSLLASSELIIENPDRLEFLISNIQLEGKRIQTILEKLLELSSLENQSQLEKTSNLNLQDLVRETVVSSISEAVRKKIK
LKELTEAVWVEGNSFFLGMALRNLVQNALDFSNSGSEITVRCGKKNGFPFLEVEDSGSGIPLYALERIFEKFYSLPRPDT
GRKSSGLGLAFVREIAKLHDADLQVKNGTSMGVVARICFKKKFQQ

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=445, Percent_Identity=32.8089887640449, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI1789403, Length=288, Percent_Identity=29.1666666666667, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786783, Length=204, Percent_Identity=28.4313725490196, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=26.9406392694064, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87082128, Length=290, Percent_Identity=25.1724137931034, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI145693157, Length=213, Percent_Identity=22.5352112676056, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788393, Length=326, Percent_Identity=22.6993865030675, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI48994928, Length=215, Percent_Identity=23.7209302325581, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1788279, Length=276, Percent_Identity=25, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50490; Mature: 50490

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METVEESLNDTAYLLVSLLESELFQRNVSLEKTSERVFSPILRISKEKKLNSKIFEITKK
CCCHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KMDLQLYVVDERGIVIYDSEGIRKGLDYSKKNDVYLTLQGKYGARSSPLTISESDKGLFI
CCCEEEEEEECCCEEEECCCCHHHCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCEEE
AAPIRKNGKIIGAVTVIKPKKSLIPFIESTRKKFWNLSLYVALSIIVLFISILYFLFSPI
ECCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKLSEYVSALRFQKRVPFPKISVPEIRGLGEEMDRLFRELAGKEYVENYVQSMTHEIKSP
HHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
LSSLLASSELIIENPDRLEFLISNIQLEGKRIQTILEKLLELSSLENQSQLEKTSNLNLQ
HHHHHCCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHH
DLVRETVVSSISEAVRKKIKLKELTEAVWVEGNSFFLGMALRNLVQNALDFSNSGSEITV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEHHHHHHHHHHHHHCCCCCCCEEEE
RCGKKNGFPFLEVEDSGSGIPLYALERIFEKFYSLPRPDTGRKSSGLGLAFVREIAKLHD
EECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCC
ADLQVKNGTSMGVVARICFKKKFQQ
CCEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
METVEESLNDTAYLLVSLLESELFQRNVSLEKTSERVFSPILRISKEKKLNSKIFEITKK
CCCHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KMDLQLYVVDERGIVIYDSEGIRKGLDYSKKNDVYLTLQGKYGARSSPLTISESDKGLFI
CCCEEEEEEECCCEEEECCCCHHHCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCEEE
AAPIRKNGKIIGAVTVIKPKKSLIPFIESTRKKFWNLSLYVALSIIVLFISILYFLFSPI
ECCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKLSEYVSALRFQKRVPFPKISVPEIRGLGEEMDRLFRELAGKEYVENYVQSMTHEIKSP
HHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
LSSLLASSELIIENPDRLEFLISNIQLEGKRIQTILEKLLELSSLENQSQLEKTSNLNLQ
HHHHHCCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHH
DLVRETVVSSISEAVRKKIKLKELTEAVWVEGNSFFLGMALRNLVQNALDFSNSGSEITV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEHHHHHHHHHHHHHCCCCCCCEEEE
RCGKKNGFPFLEVEDSGSGIPLYALERIFEKFYSLPRPDTGRKSSGLGLAFVREIAKLHD
EECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCC
ADLQVKNGTSMGVVARICFKKKFQQ
CCEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]