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The map label for this gene is creB [H]

Identifier: 116328024

GI number: 116328024

Start: 1548648

End: 1549316

Strand: Direct

Name: creB [H]

Synonym: LBL_1319

Alternate gene names: 116328024

Gene position: 1548648-1549316 (Clockwise)

Preceding gene: 116328018

Following gene: 116328025

Centisome position: 42.85

GC content: 42.75

Gene sequence:

>669_bases
ATGCGTACGATTTTACTCACGGAAGACGAACCGGGGATTCGAGATACGATTCGAGTCGTTTTAGAATCGGAAGGTTTTAA
AATGATCTCCGCGATGACCGGTAAGGAATGTCTTTCACTTTTAAAAGAATCTCCCGATCTGTTGGTATTGGATGTAGGAC
TTCCGGACGGAAACGGTTTTGAAATTTTGAAAGAGCTGAGAAAGAAAAACTCCATCCCGGTCATTTTACTGACCGCTAGG
GAATCGGAACTGGACCGGGTTCTCGGTTTGGAACTAGGCGCGGACGATTATATGGTAAAACCGTTTAGTCCTAGAGAGTT
GGTCGCTAGAATCAAAGCCGTTTTGAGGAGATACGACGGAAGCTCCGAAAAGAAACGAACCGAGTTTTTAACGGACGAGG
ATCGTAAGATTATTTATTATTACGGAAAATCTTTAACTTTGACTCCTTACGAATACAAAACACTTCTTTTATTTTTAAAG
CGACCCGGAAAAATTTTCACTCGGGAAGAAATTATGGACAGTGTTTGGACGGAACCGGAAGAGAGTTTTGATCGGGCCGT
GGATACTGTAATCAAAAACATTCGATCCAGGTTGAAGGAAATTCGACCGGATACGGATCCGATAGAAACTAGACGAGCCC
AAGGTTACGGATTGAAGGAAATAGTATGA

Upstream 100 bases:

>100_bases
TGCTTGAAATTCGGATGCCGGTCATTCTAAGATATTTTCGAGATAGCTTCTAGACAAAAACTTCTTTTCGTAAAAGAAGA
GTCGAATTTTCATTTATTGT

Downstream 100 bases:

>100_bases
GTCTTTGGATACGAATTGTAATCGGTTTTTTTTTGCCTTTTTTGCGGGTTATTATTACTTCGTGGATAAAATCGAGGATT
CGATTCGACCGCGTTATATG

Product: sensor protein of a two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MRTILLTEDEPGIRDTIRVVLESEGFKMISAMTGKECLSLLKESPDLLVLDVGLPDGNGFEILKELRKKNSIPVILLTAR
ESELDRVLGLELGADDYMVKPFSPRELVARIKAVLRRYDGSSEKKRTEFLTDEDRKIIYYYGKSLTLTPYEYKTLLLFLK
RPGKIFTREEIMDSVWTEPEESFDRAVDTVIKNIRSRLKEIRPDTDPIETRRAQGYGLKEIV

Sequences:

>Translated_222_residues
MRTILLTEDEPGIRDTIRVVLESEGFKMISAMTGKECLSLLKESPDLLVLDVGLPDGNGFEILKELRKKNSIPVILLTAR
ESELDRVLGLELGADDYMVKPFSPRELVARIKAVLRRYDGSSEKKRTEFLTDEDRKIIYYYGKSLTLTPYEYKTLLLFLK
RPGKIFTREEIMDSVWTEPEESFDRAVDTVIKNIRSRLKEIRPDTDPIETRRAQGYGLKEIV
>Mature_222_residues
MRTILLTEDEPGIRDTIRVVLESEGFKMISAMTGKECLSLLKESPDLLVLDVGLPDGNGFEILKELRKKNSIPVILLTAR
ESELDRVLGLELGADDYMVKPFSPRELVARIKAVLRRYDGSSEKKRTEFLTDEDRKIIYYYGKSLTLTPYEYKTLLLFLK
RPGKIFTREEIMDSVWTEPEESFDRAVDTVIKNIRSRLKEIRPDTDPIETRRAQGYGLKEIV

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=43.9461883408072, Blast_Score=190, Evalue=5e-50,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=42.2907488986784, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1788394, Length=218, Percent_Identity=35.3211009174312, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=39.1891891891892, Blast_Score=143, Evalue=7e-36,
Organism=Escherichia coli, GI1786911, Length=205, Percent_Identity=33.1707317073171, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=35.3982300884956, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=36.1990950226244, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=31.858407079646, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=34.703196347032, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=35, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=35.4260089686099, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1787375, Length=217, Percent_Identity=30.4147465437788, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=32.15859030837, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=28.1385281385281, Blast_Score=85, Evalue=3e-18,
Organism=Escherichia coli, GI1788550, Length=148, Percent_Identity=31.0810810810811, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1790299, Length=129, Percent_Identity=28.6821705426357, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25591; Mature: 25591

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTILLTEDEPGIRDTIRVVLESEGFKMISAMTGKECLSLLKESPDLLVLDVGLPDGNGF
CCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCH
EILKELRKKNSIPVILLTARESELDRVLGLELGADDYMVKPFSPRELVARIKAVLRRYDG
HHHHHHHHCCCCCEEEEECCHHHHHHHHHHEECCCCCEECCCCHHHHHHHHHHHHHHCCC
SSEKKRTEFLTDEDRKIIYYYGKSLTLTPYEYKTLLLFLKRPGKIFTREEIMDSVWTEPE
CCHHHHHHCCCCCCCEEEEEECCEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCH
ESFDRAVDTVIKNIRSRLKEIRPDTDPIETRRAQGYGLKEIV
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHCC
>Mature Secondary Structure
MRTILLTEDEPGIRDTIRVVLESEGFKMISAMTGKECLSLLKESPDLLVLDVGLPDGNGF
CCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCH
EILKELRKKNSIPVILLTARESELDRVLGLELGADDYMVKPFSPRELVARIKAVLRRYDG
HHHHHHHHCCCCCEEEEECCHHHHHHHHHHEECCCCCEECCCCHHHHHHHHHHHHHHCCC
SSEKKRTEFLTDEDRKIIYYYGKSLTLTPYEYKTLLLFLKRPGKIFTREEIMDSVWTEPE
CCHHHHHHCCCCCCCEEEEEECCEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCH
ESFDRAVDTVIKNIRSRLKEIRPDTDPIETRRAQGYGLKEIV
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503 [H]