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The map label for this gene is thyX [H]

Identifier: 116327812

GI number: 116327812

Start: 1266824

End: 1268398

Strand: Direct

Name: thyX [H]

Synonym: LBL_1079

Alternate gene names: 116327812

Gene position: 1266824-1268398 (Clockwise)

Preceding gene: 116327811

Following gene: 116327813

Centisome position: 35.05

GC content: 43.17

Gene sequence:

>1575_bases
ATGTCAGCCCAAAAACCGATCGTTTCACTTTTGGATCATAGCAAGGATCCATTCAATCTTTCCATTGCTACGGCAAGGAC
CTGCTATTCTTCTAAAGGAATTCTTCTCCCTTCCGATATGGTTGCGTCGGAAAAATCCATTGAAATTCGGGATAAAGTAG
CTAAGTCCACGAAAAAGGCCGGACACCTTACCACTCGTCAGCATCCACAATTTATCTTTACTTTGGATAAGGTTTCTAGA
CAATTCGTGTGGTCTTTTTTGCATTCTCATCCGTTTTATAATTCCGAACAAGTTTCCCAGAGATATGTGGAAGTCAAAAA
GGAGAATTACTACGTTCCCCCCGAGTTAAACGGAAAACTTTTAGAACTTTATCTGGATGCGGTGGATTTTGCAAGTCAGG
CTTACTTTTCCTACACGGAAATCTTACATCCTTTTATTCAGGAAGAATACTTTCGGATCTACAAAGCCCGTGCCAATTAT
CCTGATAAGTGGCAGATTCCGATCAAAAAAAAATGTCTGGAAGTAGCGCGTTATCTGCTACCGCTTGGAACCTACACGTA
TCTCTATCATTCCATCAACGGGCTTACACTACATCGTTATTACAGACTGATGAATTCCTACGACGTTCCGCAGGAACAAA
GAGCCGTGGTCACGGAAATGGTCGATCAGGTTCGAGCGGTCGATCCTTTGTATGCGGATGAGATGGATGATCCGATTCCT
CTTGAAGAAACGACCGAGTATCGTTACTTCGATTCCGTATTCGGTTCCGGCAAGAGAGAGTTTCATCCGAAAGTCTCGGC
GAACTTCGTAAAAGAATTCGATCAAGAACTTGGAACGAGATATTCCAGACTCGTTTCTTATTCTTCCAACGGTCCAGAGA
TTTTGGCGCAATCCGTCCGTTCTATATTAGGAATTCCTAAATCTTCTCTCGGCGATCAGGATGCTATAGATCTGGTTTTA
AATCCTACAAAAAACGGACATCTAACCTCTACTCTCAATGAAAACTCTATGAGTCCGATTTCCAGAGCCTTATTTAACGT
TCAATATTCCTTCCAAAAAAGAATCTCACACACAGCCGATAGTCAGGATCAAAGACATAGAATGGTTCCCGGTGGAAGAC
CGGTTCTCATGTCTCAGTATGCGGGAGTTCCGGATTATATCACTCCTTTCGTGGTTCAAAAATATCCTGAACTCAAAGAA
AAATACGACGCGACTCATACTCGAGTTTTCGAGAAGTTGAATCGTTTTTTGGATGCGGGAGGTTCTCCGGAATACGGCAC
TTATCTGTTACCGAACAGTTTTCCGATTCGTTTTTACGAAAGCGGAGACCTTCTCAATCTACATCATAAATGGAGATCCA
GAACCTGTTACAACGCTCAGGAGGAAATTTTCCAAGCCTCGGTGGAGGAACTCACGGACGTGATGAAGGTTCATCCAGGG
ATCGCAAAGTGGATTAAGGCTCCTTGTTGGATTCGCCTTCAAGGAGAAGTAAAACCTTATTGCCCGGAAGGGGATCATTA
TTGCGGAACCCAGGTTTGGAAAAGGGAATTATCCGAATACTCGAGAGTGATTTAA

Upstream 100 bases:

>100_bases
GTCGCTCGATAAGCAGAAATCCGCCGAAAAAAGAGTTTTCGATGAGCTTTCTCATCTTAGGATAGCCTATAGGGGACATA
GTCCCGTTCGGAGATTCCCG

Downstream 100 bases:

>100_bases
GATCTTATTGTAAACCGAATTATCCAGAAGAGTTCGGCGGCACGTTTGCTTTGAACCTTAGAGCATACGAGAACAAAAGA
TCTTTTTTGCAAAGTTAAGG

Product: thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 524; Mature: 523

Protein sequence:

>524_residues
MSAQKPIVSLLDHSKDPFNLSIATARTCYSSKGILLPSDMVASEKSIEIRDKVAKSTKKAGHLTTRQHPQFIFTLDKVSR
QFVWSFLHSHPFYNSEQVSQRYVEVKKENYYVPPELNGKLLELYLDAVDFASQAYFSYTEILHPFIQEEYFRIYKARANY
PDKWQIPIKKKCLEVARYLLPLGTYTYLYHSINGLTLHRYYRLMNSYDVPQEQRAVVTEMVDQVRAVDPLYADEMDDPIP
LEETTEYRYFDSVFGSGKREFHPKVSANFVKEFDQELGTRYSRLVSYSSNGPEILAQSVRSILGIPKSSLGDQDAIDLVL
NPTKNGHLTSTLNENSMSPISRALFNVQYSFQKRISHTADSQDQRHRMVPGGRPVLMSQYAGVPDYITPFVVQKYPELKE
KYDATHTRVFEKLNRFLDAGGSPEYGTYLLPNSFPIRFYESGDLLNLHHKWRSRTCYNAQEEIFQASVEELTDVMKVHPG
IAKWIKAPCWIRLQGEVKPYCPEGDHYCGTQVWKRELSEYSRVI

Sequences:

>Translated_524_residues
MSAQKPIVSLLDHSKDPFNLSIATARTCYSSKGILLPSDMVASEKSIEIRDKVAKSTKKAGHLTTRQHPQFIFTLDKVSR
QFVWSFLHSHPFYNSEQVSQRYVEVKKENYYVPPELNGKLLELYLDAVDFASQAYFSYTEILHPFIQEEYFRIYKARANY
PDKWQIPIKKKCLEVARYLLPLGTYTYLYHSINGLTLHRYYRLMNSYDVPQEQRAVVTEMVDQVRAVDPLYADEMDDPIP
LEETTEYRYFDSVFGSGKREFHPKVSANFVKEFDQELGTRYSRLVSYSSNGPEILAQSVRSILGIPKSSLGDQDAIDLVL
NPTKNGHLTSTLNENSMSPISRALFNVQYSFQKRISHTADSQDQRHRMVPGGRPVLMSQYAGVPDYITPFVVQKYPELKE
KYDATHTRVFEKLNRFLDAGGSPEYGTYLLPNSFPIRFYESGDLLNLHHKWRSRTCYNAQEEIFQASVEELTDVMKVHPG
IAKWIKAPCWIRLQGEVKPYCPEGDHYCGTQVWKRELSEYSRVI
>Mature_523_residues
SAQKPIVSLLDHSKDPFNLSIATARTCYSSKGILLPSDMVASEKSIEIRDKVAKSTKKAGHLTTRQHPQFIFTLDKVSRQ
FVWSFLHSHPFYNSEQVSQRYVEVKKENYYVPPELNGKLLELYLDAVDFASQAYFSYTEILHPFIQEEYFRIYKARANYP
DKWQIPIKKKCLEVARYLLPLGTYTYLYHSINGLTLHRYYRLMNSYDVPQEQRAVVTEMVDQVRAVDPLYADEMDDPIPL
EETTEYRYFDSVFGSGKREFHPKVSANFVKEFDQELGTRYSRLVSYSSNGPEILAQSVRSILGIPKSSLGDQDAIDLVLN
PTKNGHLTSTLNENSMSPISRALFNVQYSFQKRISHTADSQDQRHRMVPGGRPVLMSQYAGVPDYITPFVVQKYPELKEK
YDATHTRVFEKLNRFLDAGGSPEYGTYLLPNSFPIRFYESGDLLNLHHKWRSRTCYNAQEEIFQASVEELTDVMKVHPGI
AKWIKAPCWIRLQGEVKPYCPEGDHYCGTQVWKRELSEYSRVI

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 60663; Mature: 60532

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQKPIVSLLDHSKDPFNLSIATARTCYSSKGILLPSDMVASEKSIEIRDKVAKSTKKA
CCCCHHHHHHHHCCCCCCEEEEHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHH
GHLTTRQHPQFIFTLDKVSRQFVWSFLHSHPFYNSEQVSQRYVEVKKENYYVPPELNGKL
CCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEECCCCCCCHH
LELYLDAVDFASQAYFSYTEILHPFIQEEYFRIYKARANYPDKWQIPIKKKCLEVARYLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
PLGTYTYLYHSINGLTLHRYYRLMNSYDVPQEQRAVVTEMVDQVRAVDPLYADEMDDPIP
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCC
LEETTEYRYFDSVFGSGKREFHPKVSANFVKEFDQELGTRYSRLVSYSSNGPEILAQSVR
CCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
SILGIPKSSLGDQDAIDLVLNPTKNGHLTSTLNENSMSPISRALFNVQYSFQKRISHTAD
HHHCCCCCCCCCCCCEEEEECCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
SQDQRHRMVPGGRPVLMSQYAGVPDYITPFVVQKYPELKEKYDATHTRVFEKLNRFLDAG
CCHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHCHHHHHHHCHHHHHHHHHHHHHHCCC
GSPEYGTYLLPNSFPIRFYESGDLLNLHHKWRSRTCYNAQEEIFQASVEELTDVMKVHPG
CCCCCCEEECCCCCCEEEECCCCEEEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCC
IAKWIKAPCWIRLQGEVKPYCPEGDHYCGTQVWKRELSEYSRVI
HHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAQKPIVSLLDHSKDPFNLSIATARTCYSSKGILLPSDMVASEKSIEIRDKVAKSTKKA
CCCHHHHHHHHCCCCCCEEEEHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHH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HHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]