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The map label for this gene is dsbD [H]

Identifier: 116327794

GI number: 116327794

Start: 1238373

End: 1239746

Strand: Direct

Name: dsbD [H]

Synonym: LBL_1057

Alternate gene names: 116327794

Gene position: 1238373-1239746 (Clockwise)

Preceding gene: 116327789

Following gene: 116327797

Centisome position: 34.26

GC content: 42.14

Gene sequence:

>1374_bases
GTGCTACTGAAAATCCATCAATATAAGAATTTTCTAATTCGTTTTGCGATTTTGAGCGCCCTTTTTTTGGGATTACCTCT
TTCCGCGGAAACTCTTTCCGGCTCTTGGTTTTCCGGGATTCGAAAGTCCATTTCGGAAGGAATTTCCAGTGGAACTTTTG
ACTGGACTTCCGGATTTCTTCTGATCGCAGGTGGGGTCCTCGCAAGTCTTTTACCCTGCGTATATCCATTGTATCCGATT
ACGGTCGGAATCGTAAGGGCTAGGGGGGAAGGTTCTCCTAGAATTTTACATCCTGCGATTTATTATTTCGGTTTGATCAC
AATCTATGCTTCTTTCGGGCTAATCGCTGGACTTTCGGGAGGGGCGTTTAACGTAATCTTACGTTACCCGATCGTTAATC
TTGCGCTTTCCGTTCTTATTTTTCTATTGGCTTTGGGATCCTTGGATTTGATTCATCTTCCTTTTTTTCAATCCAAGGAA
GTAAAAACCGTACAAGGATGTGGCGGAACTTTTTTCCTGGGAATGGGCGCTGGACTTCTTTCTTCTCCCTGTGTCGGTCC
GGTCGTGGTCGCGATTCTTTTACGGATCACGGTTGATTCCGGTGCGATCTCGGTTGATTCCGTGCTTCTCGCCGTGTTTA
AGATGTTTTTATTCGGAGTTGGTTTGGGATTTCCATTTCTAATGATCGGGGTCTTCGGTTTGAGTCTTCCTAAGTCTGGA
AAATGGATGCGTTGGATCCAGTGGGTTTTAGGAATTTTTGTATTATATTTTTCTTATGCGTATTTTCAGAAATCCCTTTT
GGGTTGGGAAATCTCCGATTCTTTGATCCCTTTGTCCGCGTTTGGAATTTTATTCCTGCTTCTTTGCATTTACTTTTTTC
TACCGGAAGAATGGGACCGTTACGTGAGAATGAAAAAGACCCTCTTTCTCGGAGGAGTGGTTTTGTCTGCGGTTGGACTG
GTGATTCTTTTTACACAGAACTTAAGAGGAAGCAATTCGGTTTCTGCGATGGAAATAGAAACAAGGGGAAATCTTTCCTG
GTTTCGATCTACCTCTAAGGCTTATAAAGAGGCCGCAATCACGGGGAAAAAAATGTTTGTCGATTTTTATGCGGATTGGT
GCACGAATTGCAACGCGTTCGAAGAACTTACACAAAGTGATTCTGTTTTGAATGAGGCTTTACAAGGTGTTGTTCTTTTG
AAGATTAAGGATCAGGATCCTATTTTTGAAACCTATGTAAAAGATTCTCGTTTCGAGGAATTGAAGATTGGGCTTCCGTT
TTTTGTAATTTTAGATGCAGAAGGGAATCTTTTGTATAAGAATACGGATTATCAAGATACGGAGACTATGATCCAAACGC
TCAAACAACCCTGA

Upstream 100 bases:

>100_bases
CAAGTTTAGGGGCTATTTCATTTGGAAACGGGTTGACTCCTGATTTTTTAGAAGAAGCATAGTTCTCGCGACGAAGTTTC
ATTTTTTGGTCTTTTAATTT

Downstream 100 bases:

>100_bases
AAAATTCGCTCGTTGGGCTACAGAACGGCTTGATAAAACAATATGAGTTCGGCGTAAGAAAGTCGGAGTCTGTCTCAAAT
GTAAGAAACTCCCACATTCA

Product: protein-disulfide reductase

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MLLKIHQYKNFLIRFAILSALFLGLPLSAETLSGSWFSGIRKSISEGISSGTFDWTSGFLLIAGGVLASLLPCVYPLYPI
TVGIVRARGEGSPRILHPAIYYFGLITIYASFGLIAGLSGGAFNVILRYPIVNLALSVLIFLLALGSLDLIHLPFFQSKE
VKTVQGCGGTFFLGMGAGLLSSPCVGPVVVAILLRITVDSGAISVDSVLLAVFKMFLFGVGLGFPFLMIGVFGLSLPKSG
KWMRWIQWVLGIFVLYFSYAYFQKSLLGWEISDSLIPLSAFGILFLLLCIYFFLPEEWDRYVRMKKTLFLGGVVLSAVGL
VILFTQNLRGSNSVSAMEIETRGNLSWFRSTSKAYKEAAITGKKMFVDFYADWCTNCNAFEELTQSDSVLNEALQGVVLL
KIKDQDPIFETYVKDSRFEELKIGLPFFVILDAEGNLLYKNTDYQDTETMIQTLKQP

Sequences:

>Translated_457_residues
MLLKIHQYKNFLIRFAILSALFLGLPLSAETLSGSWFSGIRKSISEGISSGTFDWTSGFLLIAGGVLASLLPCVYPLYPI
TVGIVRARGEGSPRILHPAIYYFGLITIYASFGLIAGLSGGAFNVILRYPIVNLALSVLIFLLALGSLDLIHLPFFQSKE
VKTVQGCGGTFFLGMGAGLLSSPCVGPVVVAILLRITVDSGAISVDSVLLAVFKMFLFGVGLGFPFLMIGVFGLSLPKSG
KWMRWIQWVLGIFVLYFSYAYFQKSLLGWEISDSLIPLSAFGILFLLLCIYFFLPEEWDRYVRMKKTLFLGGVVLSAVGL
VILFTQNLRGSNSVSAMEIETRGNLSWFRSTSKAYKEAAITGKKMFVDFYADWCTNCNAFEELTQSDSVLNEALQGVVLL
KIKDQDPIFETYVKDSRFEELKIGLPFFVILDAEGNLLYKNTDYQDTETMIQTLKQP
>Mature_457_residues
MLLKIHQYKNFLIRFAILSALFLGLPLSAETLSGSWFSGIRKSISEGISSGTFDWTSGFLLIAGGVLASLLPCVYPLYPI
TVGIVRARGEGSPRILHPAIYYFGLITIYASFGLIAGLSGGAFNVILRYPIVNLALSVLIFLLALGSLDLIHLPFFQSKE
VKTVQGCGGTFFLGMGAGLLSSPCVGPVVVAILLRITVDSGAISVDSVLLAVFKMFLFGVGLGFPFLMIGVFGLSLPKSG
KWMRWIQWVLGIFVLYFSYAYFQKSLLGWEISDSLIPLSAFGILFLLLCIYFFLPEEWDRYVRMKKTLFLGGVVLSAVGL
VILFTQNLRGSNSVSAMEIETRGNLSWFRSTSKAYKEAAITGKKMFVDFYADWCTNCNAFEELTQSDSVLNEALQGVVLL
KIKDQDPIFETYVKDSRFEELKIGLPFFVILDAEGNLLYKNTDYQDTETMIQTLKQP

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=418, Percent_Identity=28.9473684210526, Blast_Score=123, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 50554; Mature: 50554

Theoretical pI: Translated: 8.08; Mature: 8.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKIHQYKNFLIRFAILSALFLGLPLSAETLSGSWFSGIRKSISEGISSGTFDWTSGFL
CEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHCCCCCCHHCCHH
LIAGGVLASLLPCVYPLYPITVGIVRARGEGSPRILHPAIYYFGLITIYASFGLIAGLSG
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GAFNVILRYPIVNLALSVLIFLLALGSLDLIHLPFFQSKEVKTVQGCGGTFFLGMGAGLL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHCCCCEEEHHCCCHHH
SSPCVGPVVVAILLRITVDSGAISVDSVLLAVFKMFLFGVGLGFPFLMIGVFGLSLPKSG
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KWMRWIQWVLGIFVLYFSYAYFQKSLLGWEISDSLIPLSAFGILFLLLCIYFFLPEEWDR
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHH
YVRMKKTLFLGGVVLSAVGLVILFTQNLRGSNSVSAMEIETRGNLSWFRSTSKAYKEAAI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
TGKKMFVDFYADWCTNCNAFEELTQSDSVLNEALQGVVLLKIKDQDPIFETYVKDSRFEE
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHCCCCHHH
LKIGLPFFVILDAEGNLLYKNTDYQDTETMIQTLKQP
EECCCCEEEEEECCCCEEEECCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MLLKIHQYKNFLIRFAILSALFLGLPLSAETLSGSWFSGIRKSISEGISSGTFDWTSGFL
CEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHCCCCCCHHCCHH
LIAGGVLASLLPCVYPLYPITVGIVRARGEGSPRILHPAIYYFGLITIYASFGLIAGLSG
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GAFNVILRYPIVNLALSVLIFLLALGSLDLIHLPFFQSKEVKTVQGCGGTFFLGMGAGLL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHCCCCEEEHHCCCHHH
SSPCVGPVVVAILLRITVDSGAISVDSVLLAVFKMFLFGVGLGFPFLMIGVFGLSLPKSG
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KWMRWIQWVLGIFVLYFSYAYFQKSLLGWEISDSLIPLSAFGILFLLLCIYFFLPEEWDR
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHH
YVRMKKTLFLGGVVLSAVGLVILFTQNLRGSNSVSAMEIETRGNLSWFRSTSKAYKEAAI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
TGKKMFVDFYADWCTNCNAFEELTQSDSVLNEALQGVVLLKIKDQDPIFETYVKDSRFEE
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHCCCCHHH
LKIGLPFFVILDAEGNLLYKNTDYQDTETMIQTLKQP
EECCCCEEEEEECCCCEEEECCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA