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The map label for this gene is purL

Identifier: 116327603

GI number: 116327603

Start: 966969

End: 969206

Strand: Direct

Name: purL

Synonym: LBL_0835

Alternate gene names: 116327603

Gene position: 966969-969206 (Clockwise)

Preceding gene: 116327595

Following gene: 116327604

Centisome position: 26.75

GC content: 45.93

Gene sequence:

>2238_bases
ATGGAAAAAGACGTCGTTTCCCTACAAGACGCTCTGGAACACGGACTTACCGCAGAAGAATTTCAGAAAATTCAGGAAAT
TTTGGGAAGAATTCCAAACTCCACCGAACTTGGAATTTTTTCCGCAATGTGGTCGGAGCATTGTTCTTATAAAAACTCGG
TCCTAAAATTGAAAACTCTTCCGACATCTTCGGATAAGCTACTTGCCAAAGCGGGTGAAGAGAATGCAGGCGCGATGGAT
ATCGGTGATGGGCTGGCCGTGGTTTTCAAAATCGAAAGCCACAATCACCCGACCGCAGTAGAACCGTATCAGGGTGCGGC
GACCGGTGTGGGTGGGATTATGAGAGATATCTTTACGATGGGCGCACGTCCGATCGTATCTTTGAATTCTCTTCGATTCG
GAAATCCTGACGAACCAAGAAATAAATATCTTCTTTCCCGTGCTGTAAAAGGAATCGGAGATTACGGGAACTCGCTCGGG
ATTGCGGTTTCGGGGGGAGAACTTTTTATCGACGAATGTTTTTCCAAAAACCCTCTCGTAAACGCAATGACCGTAGGAAT
CGTTCGCCACGATCAGATGGCCAGCGCGACGACCGGTGGTCAAGTTGGGAACGCGGTTTATATTGTCGGAGCTACGACAG
GAAGAGACGGAATTCACGGAGCATCTTTCGCGTCCAAAGATCTATCCAAAGAATCCGAATCCAAACGTTCCGCCGTTCAG
GTGGGGGATCCGTTTATGGAAAAACTTCTCATGGAAGCAAGCCTGGAAGCGATTCAAAAAGGGCTCTTGATCGGAATTCA
AGATATGGGTGCGGCCGGAATTTCTTGCGCGACTTCGGAAATGAGCGCCAAAGGTAAAACCGGAATGAAAATCGACCTCG
ATCTCGTTCCGTTTCGTGAAACCGGGATGAACGCCTACGAAGTGATGCTTTCCGAGTCTCAAGAAAGAATGCTCGTCGTT
CCAAAAAAAGGGAAAGAATCCGAACTCGTATCTATATTCGAAAAATGGAATCTAAATGCGGTCAGGATCGGCGAGGTTAC
CGCAGACGGATTTATCGAGATTTATATGGGTGGAAAACTGAAAGCGCATATTCCCGCCGAGTCGCTCGTGTTAGGAGGAG
GGGCGCCGCGTTACGAAAGAGAAACAAAACGGCCTTCTTATTTAGACGCGGTAAAAACTTGGAAACCGAATTCTATTTTG
GATATCACTCCGGGCGCAAATACAAAAGACGTATTACTTAATATTCTTTCTTCTTGGAATGTGTGCTCCAGAAAACCGAT
CACGGAACAATACGACAGCGAAGTCGGTCTCGTAAAACTCATAGGCCCGGGATTAGACGGAGGACTTTCCTCCATCCCGG
ACACGAACAAAGCTCTTGCGACCGCTACCGATTGTAATTCCAGATATACCTATCTTGATCCGTATAAAGGAGCGCAATTC
GCCGTTTGTGAGGCGGCTCGAAACGTTTATGTTACGGGAGCGACTCCGTACGGAGTGACCAATAATCTGAATTTTGCAAA
TCCTTATATTCCAGAAAACTATTATATGTTTTCCGAATGTATTCGAGGAATGGGAGATGCTTGTCGTTTCTTGGGGCTTC
CCGTAACCGGAGGGAACGTATCTTTTTACAACGAATCTCCCGAAGGACCGATTTTTCCAACCCCTACGATCGGGATGGTG
GGAATCCTTCAAGATAAGAAAAAATTTCTTTCCAACTTTCCGAAGGAAGTCGGAATCGAACTTGCGGTTCTTGGGAATTT
TCGTCCTTCTTTGGGAGGGAGCGAATACCTGAAAAAAATCCACGGACAAGTAAATGGGAGTATTCCCGAGATCGATATCA
AGGAGGAATTAGAACTTTGTAAACTGATTCTTTCTTTGAATGAAAAAGGGGCTCTAAAATCAGCGAGAGATCTTTCTCTC
GGAGGAATCGGAATCGCTCTTTCCAAAACGATTCTTTTTTCGGGACTCGGTATCGATGCGGAACTGATCGCTTTCAAACA
AAGCCGATTGGATCTCACCTTGTTCGGAGAAAGTTCGACTACCGTTCTTGTCGGATTTGATTCCTCTTGGAAGGAAAAAA
TCCGCGAACAAACGGAAGAGAAAGGGCTGAAATTTTATCCTGTCGGTAAAACGACTTCCTCCGAACTTTTGAAACTGAAG
GATATCGGAGTGGAAGTTTCTTTTTCGGAATTGAACGGGCCCTATGAGAAAGGTTTGGAGGTCGTATTCGCTTTATGA

Upstream 100 bases:

>100_bases
GGTTAAAACTACTAACATCTAACAACTATCCACCCCGCCTTCGAATTTTACCGGAATATTTGATTTTCAGGGTGCGACTT
AGAAAAAATACTGGCAAACG

Downstream 100 bases:

>100_bases
GAGAGGGAGCAAAACGAATGAATTTTCCGTTATTAAAGGAATTTCTTGTGATTGGCTTCGTTTGTTTTACTGCGAGTTTC
AATTGTAAAAAGAATGCGGA

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 745; Mature: 745

Protein sequence:

>745_residues
MEKDVVSLQDALEHGLTAEEFQKIQEILGRIPNSTELGIFSAMWSEHCSYKNSVLKLKTLPTSSDKLLAKAGEENAGAMD
IGDGLAVVFKIESHNHPTAVEPYQGAATGVGGIMRDIFTMGARPIVSLNSLRFGNPDEPRNKYLLSRAVKGIGDYGNSLG
IAVSGGELFIDECFSKNPLVNAMTVGIVRHDQMASATTGGQVGNAVYIVGATTGRDGIHGASFASKDLSKESESKRSAVQ
VGDPFMEKLLMEASLEAIQKGLLIGIQDMGAAGISCATSEMSAKGKTGMKIDLDLVPFRETGMNAYEVMLSESQERMLVV
PKKGKESELVSIFEKWNLNAVRIGEVTADGFIEIYMGGKLKAHIPAESLVLGGGAPRYERETKRPSYLDAVKTWKPNSIL
DITPGANTKDVLLNILSSWNVCSRKPITEQYDSEVGLVKLIGPGLDGGLSSIPDTNKALATATDCNSRYTYLDPYKGAQF
AVCEAARNVYVTGATPYGVTNNLNFANPYIPENYYMFSECIRGMGDACRFLGLPVTGGNVSFYNESPEGPIFPTPTIGMV
GILQDKKKFLSNFPKEVGIELAVLGNFRPSLGGSEYLKKIHGQVNGSIPEIDIKEELELCKLILSLNEKGALKSARDLSL
GGIGIALSKTILFSGLGIDAELIAFKQSRLDLTLFGESSTTVLVGFDSSWKEKIREQTEEKGLKFYPVGKTTSSELLKLK
DIGVEVSFSELNGPYEKGLEVVFAL

Sequences:

>Translated_745_residues
MEKDVVSLQDALEHGLTAEEFQKIQEILGRIPNSTELGIFSAMWSEHCSYKNSVLKLKTLPTSSDKLLAKAGEENAGAMD
IGDGLAVVFKIESHNHPTAVEPYQGAATGVGGIMRDIFTMGARPIVSLNSLRFGNPDEPRNKYLLSRAVKGIGDYGNSLG
IAVSGGELFIDECFSKNPLVNAMTVGIVRHDQMASATTGGQVGNAVYIVGATTGRDGIHGASFASKDLSKESESKRSAVQ
VGDPFMEKLLMEASLEAIQKGLLIGIQDMGAAGISCATSEMSAKGKTGMKIDLDLVPFRETGMNAYEVMLSESQERMLVV
PKKGKESELVSIFEKWNLNAVRIGEVTADGFIEIYMGGKLKAHIPAESLVLGGGAPRYERETKRPSYLDAVKTWKPNSIL
DITPGANTKDVLLNILSSWNVCSRKPITEQYDSEVGLVKLIGPGLDGGLSSIPDTNKALATATDCNSRYTYLDPYKGAQF
AVCEAARNVYVTGATPYGVTNNLNFANPYIPENYYMFSECIRGMGDACRFLGLPVTGGNVSFYNESPEGPIFPTPTIGMV
GILQDKKKFLSNFPKEVGIELAVLGNFRPSLGGSEYLKKIHGQVNGSIPEIDIKEELELCKLILSLNEKGALKSARDLSL
GGIGIALSKTILFSGLGIDAELIAFKQSRLDLTLFGESSTTVLVGFDSSWKEKIREQTEEKGLKFYPVGKTTSSELLKLK
DIGVEVSFSELNGPYEKGLEVVFAL
>Mature_745_residues
MEKDVVSLQDALEHGLTAEEFQKIQEILGRIPNSTELGIFSAMWSEHCSYKNSVLKLKTLPTSSDKLLAKAGEENAGAMD
IGDGLAVVFKIESHNHPTAVEPYQGAATGVGGIMRDIFTMGARPIVSLNSLRFGNPDEPRNKYLLSRAVKGIGDYGNSLG
IAVSGGELFIDECFSKNPLVNAMTVGIVRHDQMASATTGGQVGNAVYIVGATTGRDGIHGASFASKDLSKESESKRSAVQ
VGDPFMEKLLMEASLEAIQKGLLIGIQDMGAAGISCATSEMSAKGKTGMKIDLDLVPFRETGMNAYEVMLSESQERMLVV
PKKGKESELVSIFEKWNLNAVRIGEVTADGFIEIYMGGKLKAHIPAESLVLGGGAPRYERETKRPSYLDAVKTWKPNSIL
DITPGANTKDVLLNILSSWNVCSRKPITEQYDSEVGLVKLIGPGLDGGLSSIPDTNKALATATDCNSRYTYLDPYKGAQF
AVCEAARNVYVTGATPYGVTNNLNFANPYIPENYYMFSECIRGMGDACRFLGLPVTGGNVSFYNESPEGPIFPTPTIGMV
GILQDKKKFLSNFPKEVGIELAVLGNFRPSLGGSEYLKKIHGQVNGSIPEIDIKEELELCKLILSLNEKGALKSARDLSL
GGIGIALSKTILFSGLGIDAELIAFKQSRLDLTLFGESSTTVLVGFDSSWKEKIREQTEEKGLKFYPVGKTTSSELLKLK
DIGVEVSFSELNGPYEKGLEVVFAL

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Escherichia coli, GI48994899, Length=823, Percent_Identity=23.6938031591738, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17553022, Length=720, Percent_Identity=23.1944444444444, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_LEPBJ (Q04QS4)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_801504.1
- ProteinModelPortal:   Q04QS4
- STRING:   Q04QS4
- GeneID:   4410995
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_2272
- eggNOG:   COG0046
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- BioCyc:   LBOR355277:LBJ_2272-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 80359; Mature: 80359

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKDVVSLQDALEHGLTAEEFQKIQEILGRIPNSTELGIFSAMWSEHCSYKNSVLKLKTL
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEC
PTSSDKLLAKAGEENAGAMDIGDGLAVVFKIESHNHPTAVEPYQGAATGVGGIMRDIFTM
CCCCCHHHHHCCCCCCCCEECCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHC
GARPIVSLNSLRFGNPDEPRNKYLLSRAVKGIGDYGNSLGIAVSGGELFIDECFSKNPLV
CCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEHHHHCCCCCCC
NAMTVGIVRHDQMASATTGGQVGNAVYIVGATTGRDGIHGASFASKDLSKESESKRSAVQ
EEEEEEEEECCHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHEE
VGDPFMEKLLMEASLEAIQKGLLIGIQDMGAAGISCATSEMSAKGKTGMKIDLDLVPFRE
CCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEECHHHCCCCCCCCEEEEEEECCHH
TGMNAYEVMLSESQERMLVVPKKGKESELVSIFEKWNLNAVRIGEVTADGFIEIYMGGKL
HCCCHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCEE
KAHIPAESLVLGGGAPRYERETKRPSYLDAVKTWKPNSILDITPGANTKDVLLNILSSWN
EEECCHHHEEECCCCCCCCHHCCCCHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHCCC
VCSRKPITEQYDSEVGLVKLIGPGLDGGLSSIPDTNKALATATDCNSRYTYLDPYKGAQF
CCCCCCCHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCCEEECCCCCCCC
AVCEAARNVYVTGATPYGVTNNLNFANPYIPENYYMFSECIRGMGDACRFLGLPVTGGNV
CEEEHHCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHEECEECCCCE
SFYNESPEGPIFPTPTIGMVGILQDKKKFLSNFPKEVGIELAVLGNFRPSLGGSEYLKKI
EEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHCEEEEEEECCCCCCCHHHHHHHH
HGQVNGSIPEIDIKEELELCKLILSLNEKGALKSARDLSLGGIGIALSKTILFSGLGIDA
HHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCH
ELIAFKQSRLDLTLFGESSTTVLVGFDSSWKEKIREQTEEKGLKFYPVGKTTSSELLKLK
HHEEEHHCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHEEE
DIGVEVSFSELNGPYEKGLEVVFAL
CCCEEEEHHHCCCCHHCCCEEEEEC
>Mature Secondary Structure
MEKDVVSLQDALEHGLTAEEFQKIQEILGRIPNSTELGIFSAMWSEHCSYKNSVLKLKTL
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEC
PTSSDKLLAKAGEENAGAMDIGDGLAVVFKIESHNHPTAVEPYQGAATGVGGIMRDIFTM
CCCCCHHHHHCCCCCCCCEECCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHC
GARPIVSLNSLRFGNPDEPRNKYLLSRAVKGIGDYGNSLGIAVSGGELFIDECFSKNPLV
CCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEHHHHCCCCCCC
NAMTVGIVRHDQMASATTGGQVGNAVYIVGATTGRDGIHGASFASKDLSKESESKRSAVQ
EEEEEEEEECCHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHEE
VGDPFMEKLLMEASLEAIQKGLLIGIQDMGAAGISCATSEMSAKGKTGMKIDLDLVPFRE
CCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEECHHHCCCCCCCCEEEEEEECCHH
TGMNAYEVMLSESQERMLVVPKKGKESELVSIFEKWNLNAVRIGEVTADGFIEIYMGGKL
HCCCHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCEE
KAHIPAESLVLGGGAPRYERETKRPSYLDAVKTWKPNSILDITPGANTKDVLLNILSSWN
EEECCHHHEEECCCCCCCCHHCCCCHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHCCC
VCSRKPITEQYDSEVGLVKLIGPGLDGGLSSIPDTNKALATATDCNSRYTYLDPYKGAQF
CCCCCCCHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCCEEECCCCCCCC
AVCEAARNVYVTGATPYGVTNNLNFANPYIPENYYMFSECIRGMGDACRFLGLPVTGGNV
CEEEHHCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHEECEECCCCE
SFYNESPEGPIFPTPTIGMVGILQDKKKFLSNFPKEVGIELAVLGNFRPSLGGSEYLKKI
EEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHCEEEEEEECCCCCCCHHHHHHHH
HGQVNGSIPEIDIKEELELCKLILSLNEKGALKSARDLSLGGIGIALSKTILFSGLGIDA
HHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCH
ELIAFKQSRLDLTLFGESSTTVLVGFDSSWKEKIREQTEEKGLKFYPVGKTTSSELLKLK
HHEEEHHCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHEEE
DIGVEVSFSELNGPYEKGLEVVFAL
CCCEEEEHHHCCCCHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA