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The map label for this gene is pdxB [H]

Identifier: 116327293

GI number: 116327293

Start: 529150

End: 530172

Strand: Reverse

Name: pdxB [H]

Synonym: LBL_0482

Alternate gene names: 116327293

Gene position: 530172-529150 (Counterclockwise)

Preceding gene: 116327296

Following gene: 116327257

Centisome position: 14.67

GC content: 40.18

Gene sequence:

>1023_bases
GTGCGACAAAAAAGACCAATCCTCTATTACCCGGAAGGAATCACGGGAGCTAAAGAAATTTTTTCGACTTTTGAAAAGTT
AGAAGTAAAATCGTATTCGATCAATCAAATCGGAGACTTGTCTCGCAACGAACCCGAAATTCTGATCGCAAACACGAGAC
TCAAAATAAACCGGGAATGTATCTTAAATTTCCCTTCAGTGAAAATTTTTGCGACCGTAAGTTCCGGAACGGATCACGTA
GATTTTAATATTCTCAAAAAATCAGGAAAAATCTTTTTGAACGCACCCGGTTGTAACGCCGGTTCGGTTGCGGAATACTG
TTATGCCGGCCTCTTGAATCGATTCGACAAAGCAGAATTAAAAACCGTCAAGGTCGGAATAATCGGACATGGAAATACGG
GAAAAGAATTTTATAAAATTCTAATATCTCAAGGAATCGACTGTATCTTTTACGACCCATTTTACAGGACGGAATCATCT
CCTTTGAAAGAAGTTTTAAGTCGCCCCGTCGTCAGTTACCACGTACCTTTGATTGAAAAAGGTATAGAACCGACATTTCA
TTCTGTCACCGATTCTTTGATAGATTCCCTAACGCCGGGAACCGTTTTTATCAATACGAGTCGAGGGGAAATCCTCTCTC
CGGGCGCTTTTAACCGATTGATTGCAAGAAACGATATATTCAAAATTTTAGATGTGTTTGACCCGGAGCCTCCATCGGAG
GAAAAAGGGAAAATGCTCGCGGAAGTAGATCATTCGATTTTTACCCCCCATATCGCCGGTTATAGTCAGTTGGGAAGAAT
CAGTGGAACTTACCGAATCGCCGAAAAATTATCTATTTTATACCAAGATCATCCCTTACCACCGTTGAAATCCTTCTTAC
AAACCTCCGGAGAATTTAAAACCTCCACTTTCTTAAAAAAAGAAGACCAGCTTTTAAGGGAAGCCTGGAGAAAAGGAGAT
CAAAGTTATTTTGAAAGAAGAAGGAATTCATATCCTGTAAGATTGGATTGGGGATTGGTTTGA

Upstream 100 bases:

>100_bases
TGTAGAGATTTCATGGACTTGTGATTTTTAAAAAAATCTTTCTTAAAGCAAATCTTTTTTGTTTTTTCCGAGAAAGCGCT
TCAGATGAAATGACAAATTA

Downstream 100 bases:

>100_bases
TTTTGTATTATCAACTTTTCAAATTCTTTAAAAAAGTTTACTCACCCCATTTTTATTCGGCTCTTGCAGATATAAAACCA
TCATCACATATTCCGTAATA

Product: phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MRQKRPILYYPEGITGAKEIFSTFEKLEVKSYSINQIGDLSRNEPEILIANTRLKINRECILNFPSVKIFATVSSGTDHV
DFNILKKSGKIFLNAPGCNAGSVAEYCYAGLLNRFDKAELKTVKVGIIGHGNTGKEFYKILISQGIDCIFYDPFYRTESS
PLKEVLSRPVVSYHVPLIEKGIEPTFHSVTDSLIDSLTPGTVFINTSRGEILSPGAFNRLIARNDIFKILDVFDPEPPSE
EKGKMLAEVDHSIFTPHIAGYSQLGRISGTYRIAEKLSILYQDHPLPPLKSFLQTSGEFKTSTFLKKEDQLLREAWRKGD
QSYFERRRNSYPVRLDWGLV

Sequences:

>Translated_340_residues
MRQKRPILYYPEGITGAKEIFSTFEKLEVKSYSINQIGDLSRNEPEILIANTRLKINRECILNFPSVKIFATVSSGTDHV
DFNILKKSGKIFLNAPGCNAGSVAEYCYAGLLNRFDKAELKTVKVGIIGHGNTGKEFYKILISQGIDCIFYDPFYRTESS
PLKEVLSRPVVSYHVPLIEKGIEPTFHSVTDSLIDSLTPGTVFINTSRGEILSPGAFNRLIARNDIFKILDVFDPEPPSE
EKGKMLAEVDHSIFTPHIAGYSQLGRISGTYRIAEKLSILYQDHPLPPLKSFLQTSGEFKTSTFLKKEDQLLREAWRKGD
QSYFERRRNSYPVRLDWGLV
>Mature_340_residues
MRQKRPILYYPEGITGAKEIFSTFEKLEVKSYSINQIGDLSRNEPEILIANTRLKINRECILNFPSVKIFATVSSGTDHV
DFNILKKSGKIFLNAPGCNAGSVAEYCYAGLLNRFDKAELKTVKVGIIGHGNTGKEFYKILISQGIDCIFYDPFYRTESS
PLKEVLSRPVVSYHVPLIEKGIEPTFHSVTDSLIDSLTPGTVFINTSRGEILSPGAFNRLIARNDIFKILDVFDPEPPSE
EKGKMLAEVDHSIFTPHIAGYSQLGRISGTYRIAEKLSILYQDHPLPPLKSFLQTSGEFKTSTFLKKEDQLLREAWRKGD
QSYFERRRNSYPVRLDWGLV

Specific function: Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=272, Percent_Identity=25.3676470588235, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1788660, Length=357, Percent_Identity=30.2521008403361, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1789279, Length=240, Percent_Identity=29.1666666666667, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR020921
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.290 [H]

Molecular weight: Translated: 38455; Mature: 38455

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQKRPILYYPEGITGAKEIFSTFEKLEVKSYSINQIGDLSRNEPEILIANTRLKINREC
CCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCEEEEECEEEECHHE
ILNFPSVKIFATVSSGTDHVDFNILKKSGKIFLNAPGCNAGSVAEYCYAGLLNRFDKAEL
EECCCCEEEEEEECCCCCCEEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCE
KTVKVGIIGHGNTGKEFYKILISQGIDCIFYDPFYRTESSPLKEVLSRPVVSYHVPLIEK
EEEEEEEEECCCCHHHHHHHHHHCCCCEEEECCHHCCCCHHHHHHHHCCHHEEECHHHHC
GIEPTFHSVTDSLIDSLTPGTVFINTSRGEILSPGAFNRLIARNDIFKILDVFDPEPPSE
CCCCHHHHHHHHHHHHCCCCEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCH
EKGKMLAEVDHSIFTPHIAGYSQLGRISGTYRIAEKLSILYQDHPLPPLKSFLQTSGEFK
HHCCHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCH
TSTFLKKEDQLLREAWRKGDQSYFERRRNSYPVRLDWGLV
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEECCCC
>Mature Secondary Structure
MRQKRPILYYPEGITGAKEIFSTFEKLEVKSYSINQIGDLSRNEPEILIANTRLKINREC
CCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCEEEEECEEEECHHE
ILNFPSVKIFATVSSGTDHVDFNILKKSGKIFLNAPGCNAGSVAEYCYAGLLNRFDKAEL
EECCCCEEEEEEECCCCCCEEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCE
KTVKVGIIGHGNTGKEFYKILISQGIDCIFYDPFYRTESSPLKEVLSRPVVSYHVPLIEK
EEEEEEEEECCCCHHHHHHHHHHCCCCEEEECCHHCCCCHHHHHHHHCCHHEEECHHHHC
GIEPTFHSVTDSLIDSLTPGTVFINTSRGEILSPGAFNRLIARNDIFKILDVFDPEPPSE
CCCCHHHHHHHHHHHHCCCCEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCH
EKGKMLAEVDHSIFTPHIAGYSQLGRISGTYRIAEKLSILYQDHPLPPLKSFLQTSGEFK
HHCCHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCH
TSTFLKKEDQLLREAWRKGDQSYFERRRNSYPVRLDWGLV
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA