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The map label for this gene is lpxK [H]

Identifier: 116327211

GI number: 116327211

Start: 466366

End: 467409

Strand: Reverse

Name: lpxK [H]

Synonym: LBL_0399

Alternate gene names: 116327211

Gene position: 467409-466366 (Counterclockwise)

Preceding gene: 116327212

Following gene: 116327210

Centisome position: 12.93

GC content: 39.08

Gene sequence:

>1044_bases
ATGAAATCGTTTAATCCTCTTTCACTTTTGCACGCCGCCTTGTTTCCGATTCTTTATGTGCTTTCCTTTATTTATCGTAT
TCTCTTTTTATTCGATCAAAAGCTTACCGAAAAGAAAAAACTTTCCGGAGCTTTTGTTATCAGCGTCGGAAATATTTCCA
TGGGCGGAACCGGAAAGACCCCGTTTTCGATTTATCTCGCAAAACTGATCCATAAAAAATTTCCCGAAAAAAAGATCGTT
CTTTTGTCCAGAGGTTACGGTGCGACGGGATCCAAACATGGACATAGAGTTTCACGACGATCCTCTCCAAGGGAGGCTGG
AGACGAACCTCTTCTTTTAAAAAAACATCTTCCGTTTGCCGAGGTTTGGATCGGAAGAGATAGACATTCCACTTATCTCC
GTTTTAAGGAAGAATTGAAAATGAAGGAAAATTCGATCGTAATTTTGGACGACGGATTTCAGCATCACGCTTTGAAAAGG
GACGTGGATATCGTTTTATTGGATTCGAGTAGAATTTGCAAGGAACATTTTTTGATCCCTGCAGGAAGTCTGAGAGAACC
GATTTCTTCTCTACTAAGGGCGGATTGGATCGTATTCTCAAAGTACGAACTTTCCGCGGAGAGGATCGTGCAGAATATTC
AAAAGAAGTTCTCGAAAAGAATTCTTCGTTTTTCTTTGGAGCCGGATAAACTTTTATCCCCCGATTTGCAAATGGATTCT
CCGAAAATATTCTACGATAAAAAAGTGTATGCGTTTACCGGAATCGGAAATCCGGAAATTTTTTTTTCGATGATTCGAAA
ATTTCAACCGGTCAAATTGGAAACCAGAACGTTTCGAGATCATCATTCTTATACGATTGAAGATGAAAACGTTCTGAATA
CGATTGCGAGTAGTTACGATTATCTCGTTTGCACCGAAAAGGATTTCATCAAAATTTCGAAATCCCCGAAAAATTTAAGA
ATTCTTCTCTTAGAAAGTAAACTCGATAAGGAAGAAAAGCTCGGTTCTTTTCTCAAGAAGAGGCTTATGTCGGAAACGTT
TTGA

Upstream 100 bases:

>100_bases
ATGCGGAACTGATCCGACTTGACGGTAAATATAAAAAGCTCTACGACATCCAGTTTGTCGAATTCTCGGAAAGTGTATAA
TGTAAAAAACATTCTTGCTT

Downstream 100 bases:

>100_bases
TTCTTTTAAGGACAAATTTTACCTGTTCCGGATGCGACCAAAAAATCTCTTAGAGTAACCGGAATTTGTATTTTAAGCAA
GGCTAAAGTATTCTTGAAAT

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKSFNPLSLLHAALFPILYVLSFIYRILFLFDQKLTEKKKLSGAFVISVGNISMGGTGKTPFSIYLAKLIHKKFPEKKIV
LLSRGYGATGSKHGHRVSRRSSPREAGDEPLLLKKHLPFAEVWIGRDRHSTYLRFKEELKMKENSIVILDDGFQHHALKR
DVDIVLLDSSRICKEHFLIPAGSLREPISSLLRADWIVFSKYELSAERIVQNIQKKFSKRILRFSLEPDKLLSPDLQMDS
PKIFYDKKVYAFTGIGNPEIFFSMIRKFQPVKLETRTFRDHHSYTIEDENVLNTIASSYDYLVCTEKDFIKISKSPKNLR
ILLLESKLDKEEKLGSFLKKRLMSETF

Sequences:

>Translated_347_residues
MKSFNPLSLLHAALFPILYVLSFIYRILFLFDQKLTEKKKLSGAFVISVGNISMGGTGKTPFSIYLAKLIHKKFPEKKIV
LLSRGYGATGSKHGHRVSRRSSPREAGDEPLLLKKHLPFAEVWIGRDRHSTYLRFKEELKMKENSIVILDDGFQHHALKR
DVDIVLLDSSRICKEHFLIPAGSLREPISSLLRADWIVFSKYELSAERIVQNIQKKFSKRILRFSLEPDKLLSPDLQMDS
PKIFYDKKVYAFTGIGNPEIFFSMIRKFQPVKLETRTFRDHHSYTIEDENVLNTIASSYDYLVCTEKDFIKISKSPKNLR
ILLLESKLDKEEKLGSFLKKRLMSETF
>Mature_347_residues
MKSFNPLSLLHAALFPILYVLSFIYRILFLFDQKLTEKKKLSGAFVISVGNISMGGTGKTPFSIYLAKLIHKKFPEKKIV
LLSRGYGATGSKHGHRVSRRSSPREAGDEPLLLKKHLPFAEVWIGRDRHSTYLRFKEELKMKENSIVILDDGFQHHALKR
DVDIVLLDSSRICKEHFLIPAGSLREPISSLLRADWIVFSKYELSAERIVQNIQKKFSKRILRFSLEPDKLLSPDLQMDS
PKIFYDKKVYAFTGIGNPEIFFSMIRKFQPVKLETRTFRDHHSYTIEDENVLNTIASSYDYLVCTEKDFIKISKSPKNLR
ILLLESKLDKEEKLGSFLKKRLMSETF

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=329, Percent_Identity=27.355623100304, Blast_Score=103, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 40180; Mature: 40180

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: PS00136 SUBTILASE_ASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSFNPLSLLHAALFPILYVLSFIYRILFLFDQKLTEKKKLSGAFVISVGNISMGGTGKT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEECCCCCC
PFSIYLAKLIHKKFPEKKIVLLSRGYGATGSKHGHRVSRRSSPREAGDEPLLLKKHLPFA
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHH
EVWIGRDRHSTYLRFKEELKMKENSIVILDDGFQHHALKRDVDIVLLDSSRICKEHFLIP
HHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHCCCEEEEECCCHHHHHHCCCC
AGSLREPISSLLRADWIVFSKYELSAERIVQNIQKKFSKRILRFSLEPDKLLSPDLQMDS
CCHHHHHHHHHHHHHHEEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCC
PKIFYDKKVYAFTGIGNPEIFFSMIRKFQPVKLETRTFRDHHSYTIEDENVLNTIASSYD
CCEEECCEEEEEECCCCHHHHHHHHHHCCCCEEEHHHHHCCCCEEECCHHHHHHHHCCCC
YLVCTEKDFIKISKSPKNLRILLLESKLDKEEKLGSFLKKRLMSETF
EEEECCCCCEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKSFNPLSLLHAALFPILYVLSFIYRILFLFDQKLTEKKKLSGAFVISVGNISMGGTGKT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEECCCCCC
PFSIYLAKLIHKKFPEKKIVLLSRGYGATGSKHGHRVSRRSSPREAGDEPLLLKKHLPFA
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHH
EVWIGRDRHSTYLRFKEELKMKENSIVILDDGFQHHALKRDVDIVLLDSSRICKEHFLIP
HHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHCCCEEEEECCCHHHHHHCCCC
AGSLREPISSLLRADWIVFSKYELSAERIVQNIQKKFSKRILRFSLEPDKLLSPDLQMDS
CCHHHHHHHHHHHHHHEEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCC
PKIFYDKKVYAFTGIGNPEIFFSMIRKFQPVKLETRTFRDHHSYTIEDENVLNTIASSYD
CCEEECCEEEEEECCCCHHHHHHHHHHCCCCEEEHHHHHCCCCEEECCHHHHHHHHCCCC
YLVCTEKDFIKISKSPKNLRILLLESKLDKEEKLGSFLKKRLMSETF
EEEECCCCCEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA