Click here to switch to the map view.

The map label for this gene is caiA-5 [C]

Identifier: 116327188

GI number: 116327188

Start: 429182

End: 430894

Strand: Direct

Name: caiA-5 [C]

Synonym: LBL_0367

Alternate gene names: 116327188

Gene position: 429182-430894 (Clockwise)

Preceding gene: 116327183

Following gene: 116327190

Centisome position: 11.87

GC content: 41.04

Gene sequence:

>1713_bases
ATGATTCAAAACAACTACTTTTCGGATAACCAAGATATCCAGAATCATTTTGAGCACATTCTTCCCTGGACTGAAATTAT
ACTCGATTACGAAAACGAATTCCCAGACCCTTCTGACGGAGGACCGGCAAATCCATCCGAAACAAAAGAATATTATAAAA
CTCTTTTGAATACAGTGGGAGATTTAGCCGGAAATATTCTTTCTCCGCATGTAGCGAAACTCGATAGGGAAGGATTGAAA
TTTAAGGAGGGTAAAGTCGAATTTCCGCCGAAGATGCTCGAACTGGTTTCCAAAGTTATAGAAGCCGGAGTTCAAGCTTA
CGGGTTTTCGAGAAAATACGGTGAACTTGGTATACCTTGGACTGTGAAATCTTTTATTTCCGAAATTTTCTACAGAGTTG
ATACATCACTCGCCATTGCCATTGGATGTGTAAATCTCGCTGAAATTTTGGAACACCATGCGACTCGGGAAATGAAAGAG
GAATGGATTCCAAAACTTGCCGCTGGAAAATTCGTCTGTGCGATGGGACTCACCGAGCCTGATCACGGTTCTGATCTTTC
TAATCTTAGAACCAAAGCCACGAAAGATAAGAATGGAAATTGGGTGCTGAATGGAACTAAACGGTTCATTACACACGGTT
GCGGGTTCGGCGACATCCCTGCGATTTTATTGACCCTGGCACGTTCGGGAAAAATAGGTTCTGGTGCAAGGGGACTTTCG
CTTTTCCTCGTTCAAAGCAAAAATGTTCAAATTGCGGGAATTGAACGTAAACTAGGACTTCATTGTTCTCCTACTTGTGA
AGTAGTCTTCGAAAATTCTCCCGGGCTCTTGATCGGTGAAGAAGGTCTCGGACTCGTTAAATATACGATGGGAATATTGA
ATGGAGCGAGAATGGGAATCGCACAACAATCCACCGGACTTGCAACTGCAGCATATTATGAAGCTCTAAAATATACAAAG
GAAAGAATTCAATTTGGAAAACCTTTGATAGAAATTCCTGCGGTAAAAAAAATCATCGATCGAATCGAAAGGGAAATGTA
TGCGATGCGATGTCTGACTCTGGAAGGTTCCCGGGTGATGGATCGTTATTATTGGAGAACGTTTCGTCTTAAAAAACAAG
GAGCTACCGAAAGAGAAGCAAAAAACGACATCGTCGTGCACTATTGGGAAAAGATCGCAGATATACTTACGCCGATCAGC
AAATTCTATTGTTCCGAAACCTGTTTGAAAGTGGTCAGCGACGCACTTCAAATTCACGGGGGTTCTGGTTACACCGAAGA
CTATGATATCTCTAGAATCTATCGTGACGCAAGGATCACTACGATTTATGACGGAACCTCACAAATTCAAATCAACGCGT
GTATCGGTGGAATTACCTCAGGTTTGACTCATTCGTTTGGAGAATACGTTTCCGAGCTTGTAAACCGATCGGATTTTTCT
CTTACTCATAAATTATTTCGCGAATTTCAAGAGCTGGTATTCCTTTACAAAAATTTTTCAAAAAAAGAAAATAAGGACAT
ATACGCGGAAGAGGTCGTTTTTACTTGTTCCAGATTTTTGGCGGGAATCTTGCTTGAACTTTCCTGTAGAAGACTCCCGG
AAGAGAGCAAACAAGTTCGACTTAAACTCACGAAAGACTATCATCTTGATACTCTTTTTTTTCTGGAAGGTAATCTTGCA
AAACTAAAAGAAGCAAATCGAGTTTCTATCTAA

Upstream 100 bases:

>100_bases
CAAACGATCCTTTTGTTACGCTAAAAATGCAGTAGTTATTACAATTTTCCTTTTCTTGGCCTTTCCGATCTTTTATACTG
TATAAGCCTCAGGAGACTCT

Downstream 100 bases:

>100_bases
ACGAATCGTTCCCCATGCCCACCTATTCGTTGTTTAGATGTTAATAGATAGGGACAGGGCAGGGGAAGCCTTCCCCTATC
GAACGACCCGTAGGGAGTGA

Product: Acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Butyryl-CoA dehydrogenase; BCAD; SCAD [H]

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MIQNNYFSDNQDIQNHFEHILPWTEIILDYENEFPDPSDGGPANPSETKEYYKTLLNTVGDLAGNILSPHVAKLDREGLK
FKEGKVEFPPKMLELVSKVIEAGVQAYGFSRKYGELGIPWTVKSFISEIFYRVDTSLAIAIGCVNLAEILEHHATREMKE
EWIPKLAAGKFVCAMGLTEPDHGSDLSNLRTKATKDKNGNWVLNGTKRFITHGCGFGDIPAILLTLARSGKIGSGARGLS
LFLVQSKNVQIAGIERKLGLHCSPTCEVVFENSPGLLIGEEGLGLVKYTMGILNGARMGIAQQSTGLATAAYYEALKYTK
ERIQFGKPLIEIPAVKKIIDRIEREMYAMRCLTLEGSRVMDRYYWRTFRLKKQGATEREAKNDIVVHYWEKIADILTPIS
KFYCSETCLKVVSDALQIHGGSGYTEDYDISRIYRDARITTIYDGTSQIQINACIGGITSGLTHSFGEYVSELVNRSDFS
LTHKLFREFQELVFLYKNFSKKENKDIYAEEVVFTCSRFLAGILLELSCRRLPEESKQVRLKLTKDYHLDTLFFLEGNLA
KLKEANRVSI

Sequences:

>Translated_570_residues
MIQNNYFSDNQDIQNHFEHILPWTEIILDYENEFPDPSDGGPANPSETKEYYKTLLNTVGDLAGNILSPHVAKLDREGLK
FKEGKVEFPPKMLELVSKVIEAGVQAYGFSRKYGELGIPWTVKSFISEIFYRVDTSLAIAIGCVNLAEILEHHATREMKE
EWIPKLAAGKFVCAMGLTEPDHGSDLSNLRTKATKDKNGNWVLNGTKRFITHGCGFGDIPAILLTLARSGKIGSGARGLS
LFLVQSKNVQIAGIERKLGLHCSPTCEVVFENSPGLLIGEEGLGLVKYTMGILNGARMGIAQQSTGLATAAYYEALKYTK
ERIQFGKPLIEIPAVKKIIDRIEREMYAMRCLTLEGSRVMDRYYWRTFRLKKQGATEREAKNDIVVHYWEKIADILTPIS
KFYCSETCLKVVSDALQIHGGSGYTEDYDISRIYRDARITTIYDGTSQIQINACIGGITSGLTHSFGEYVSELVNRSDFS
LTHKLFREFQELVFLYKNFSKKENKDIYAEEVVFTCSRFLAGILLELSCRRLPEESKQVRLKLTKDYHLDTLFFLEGNLA
KLKEANRVSI
>Mature_570_residues
MIQNNYFSDNQDIQNHFEHILPWTEIILDYENEFPDPSDGGPANPSETKEYYKTLLNTVGDLAGNILSPHVAKLDREGLK
FKEGKVEFPPKMLELVSKVIEAGVQAYGFSRKYGELGIPWTVKSFISEIFYRVDTSLAIAIGCVNLAEILEHHATREMKE
EWIPKLAAGKFVCAMGLTEPDHGSDLSNLRTKATKDKNGNWVLNGTKRFITHGCGFGDIPAILLTLARSGKIGSGARGLS
LFLVQSKNVQIAGIERKLGLHCSPTCEVVFENSPGLLIGEEGLGLVKYTMGILNGARMGIAQQSTGLATAAYYEALKYTK
ERIQFGKPLIEIPAVKKIIDRIEREMYAMRCLTLEGSRVMDRYYWRTFRLKKQGATEREAKNDIVVHYWEKIADILTPIS
KFYCSETCLKVVSDALQIHGGSGYTEDYDISRIYRDARITTIYDGTSQIQINACIGGITSGLTHSFGEYVSELVNRSDFS
LTHKLFREFQELVFLYKNFSKKENKDIYAEEVVFTCSRFLAGILLELSCRRLPEESKQVRLKLTKDYHLDTLFFLEGNLA
KLKEANRVSI

Specific function: Has an optimum specificity for 4-carbon length fatty acyl-CoAs [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=366, Percent_Identity=30.6010928961749, Blast_Score=150, Evalue=5e-36,
Organism=Homo sapiens, GI4557233, Length=413, Percent_Identity=29.2978208232446, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI21361497, Length=404, Percent_Identity=30.4455445544554, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI4501857, Length=305, Percent_Identity=29.8360655737705, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI7656849, Length=420, Percent_Identity=26.6666666666667, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI76496475, Length=469, Percent_Identity=27.5053304904051, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI4557235, Length=478, Percent_Identity=26.9874476987448, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI187960098, Length=423, Percent_Identity=28.1323877068558, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI4557231, Length=423, Percent_Identity=28.1323877068558, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI226958412, Length=412, Percent_Identity=24.5145631067961, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI226958414, Length=350, Percent_Identity=24.2857142857143, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI4503943, Length=377, Percent_Identity=25.4641909814324, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI7669494, Length=371, Percent_Identity=25.0673854447439, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI87081958, Length=368, Percent_Identity=27.9891304347826, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI87082384, Length=288, Percent_Identity=27.4305555555556, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786223, Length=304, Percent_Identity=25.9868421052632, Blast_Score=95, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17508101, Length=419, Percent_Identity=27.2076372315036, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17533517, Length=401, Percent_Identity=28.428927680798, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71985184, Length=333, Percent_Identity=29.4294294294294, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17506239, Length=404, Percent_Identity=25.4950495049505, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17534899, Length=392, Percent_Identity=27.8061224489796, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17569725, Length=410, Percent_Identity=26.3414634146341, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17538396, Length=408, Percent_Identity=25.7352941176471, Blast_Score=108, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17534353, Length=306, Percent_Identity=28.7581699346405, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17570075, Length=377, Percent_Identity=27.5862068965517, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71985192, Length=294, Percent_Identity=29.9319727891156, Blast_Score=102, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI71990804, Length=272, Percent_Identity=27.9411764705882, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI86563381, Length=424, Percent_Identity=23.8207547169811, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI86563383, Length=424, Percent_Identity=23.8207547169811, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17551932, Length=422, Percent_Identity=25.1184834123223, Blast_Score=92, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71982178, Length=289, Percent_Identity=26.9896193771626, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17505929, Length=414, Percent_Identity=22.9468599033816, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32563615, Length=234, Percent_Identity=27.3504273504274, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21356377, Length=419, Percent_Identity=31.5035799522673, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24666513, Length=414, Percent_Identity=28.0193236714976, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24646207, Length=417, Percent_Identity=28.0575539568345, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI281363737, Length=348, Percent_Identity=29.8850574712644, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24660351, Length=387, Percent_Identity=27.906976744186, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21355753, Length=351, Percent_Identity=29.0598290598291, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI19920834, Length=246, Percent_Identity=30.4878048780488, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: =1.3.99.2 [H]

Molecular weight: Translated: 64270; Mature: 64270

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQNNYFSDNQDIQNHFEHILPWTEIILDYENEFPDPSDGGPANPSETKEYYKTLLNTVG
CCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
DLAGNILSPHVAKLDREGLKFKEGKVEFPPKMLELVSKVIEAGVQAYGFSRKYGELGIPW
HHHHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
TVKSFISEIFYRVDTSLAIAIGCVNLAEILEHHATREMKEEWIPKLAAGKFVCAMGLTEP
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEECCCCC
DHGSDLSNLRTKATKDKNGNWVLNGTKRFITHGCGFGDIPAILLTLARSGKIGSGARGLS
CCCCCHHHHHHHHCCCCCCCEEECCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEE
LFLVQSKNVQIAGIERKLGLHCSPTCEVVFENSPGLLIGEEGLGLVKYTMGILNGARMGI
EEEEECCCEEEEEEHHHCCCCCCCCEEEEEECCCCEEECCCCCHHHHHHHHHHCCHHCCC
AQQSTGLATAAYYEALKYTKERIQFGKPLIEIPAVKKIIDRIEREMYAMRCLTLEGSRVM
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
DRYYWRTFRLKKQGATEREAKNDIVVHYWEKIADILTPISKFYCSETCLKVVSDALQIHG
HHHHHHHHHHHHCCCCHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GSGYTEDYDISRIYRDARITTIYDGTSQIQINACIGGITSGLTHSFGEYVSELVNRSDFS
CCCCCCCCHHHHHHHCCEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCHH
LTHKLFREFQELVFLYKNFSKKENKDIYAEEVVFTCSRFLAGILLELSCRRLPEESKQVR
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
LKLTKDYHLDTLFFLEGNLAKLKEANRVSI
EEEECCCCCEEEEEECCCHHHHCCCCCCCC
>Mature Secondary Structure
MIQNNYFSDNQDIQNHFEHILPWTEIILDYENEFPDPSDGGPANPSETKEYYKTLLNTVG
CCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
DLAGNILSPHVAKLDREGLKFKEGKVEFPPKMLELVSKVIEAGVQAYGFSRKYGELGIPW
HHHHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
TVKSFISEIFYRVDTSLAIAIGCVNLAEILEHHATREMKEEWIPKLAAGKFVCAMGLTEP
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEECCCCC
DHGSDLSNLRTKATKDKNGNWVLNGTKRFITHGCGFGDIPAILLTLARSGKIGSGARGLS
CCCCCHHHHHHHHCCCCCCCEEECCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEE
LFLVQSKNVQIAGIERKLGLHCSPTCEVVFENSPGLLIGEEGLGLVKYTMGILNGARMGI
EEEEECCCEEEEEEHHHCCCCCCCCEEEEEECCCCEEECCCCCHHHHHHHHHHCCHHCCC
AQQSTGLATAAYYEALKYTKERIQFGKPLIEIPAVKKIIDRIEREMYAMRCLTLEGSRVM
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
DRYYWRTFRLKKQGATEREAKNDIVVHYWEKIADILTPISKFYCSETCLKVVSDALQIHG
HHHHHHHHHHHHCCCCHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GSGYTEDYDISRIYRDARITTIYDGTSQIQINACIGGITSGLTHSFGEYVSELVNRSDFS
CCCCCCCCHHHHHHHCCEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCHH
LTHKLFREFQELVFLYKNFSKKENKDIYAEEVVFTCSRFLAGILLELSCRRLPEESKQVR
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
LKLTKDYHLDTLFFLEGNLAKLKEANRVSI
EEEECCCCCEEEEEECCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8399220; 7857927 [H]