BacMap

Definition	Leptospira borgpetersenii serovar Hardjo-bovis L550 chromosome 1, complete sequence.
Accession	NC_008508
Length	3,614,446

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The map label for this gene is lolD-2 [H]

Identifier: 116327123

GI number: 116327123

Start: 354798

End: 355472

Strand: Direct

Name: lolD-2 [H]

Synonym: LBL_0299

Alternate gene names: 116327123

Gene position: 354798-355472 (Clockwise)

Preceding gene: 116327122

Following gene: 116327124

Centisome position: 9.82

GC content: 43.7

Gene sequence:

>675_bases
GTGAGTCTGATTAAAGTAAGAAATCTGGTAAAAAATTACCGTATTCTCGATAAGGAATTTAAGATTCTGGATCACTTGGA
TCTGGACGTGGAAGAAGGTGAGATCGTTTCCGTGGAAGGAAAATCCGGTATCGGAAAGTCCACTCTTTTGAACATTTTAG
GTTCTATGGATTCCTCCGATGCGGGCGAGGTCAACGTTTGCGGAGTTTCACTGGATCAAATTTCCGAAACCGGAAAAGAA
AAATTTAGAGCTGAAAAGGTTGCCTTTATCTTTCAGCACCATCTTCTGCTTCCGGATTTTACCGCGCTGGAAAATGTAAG
TATTCCTCTTTTGATCAACGGAGTTCAGCCGGGGAAGGCGTGGCAACTTTCGATTGAAATGTTGGACCGGGTTGGTCTTA
AGGATCGTCATGATAACTTTCCTTCTCAACTTTCCGGCGGAGAAAGTGCTAGAGTTGGAGTTGCAAGGGCGCTCGTAGCC
GGAAAAAAGCTTATTCTTGCGGATGAGCCTACGGGTAATTTGGATCGGGAAAATTCTCGCAATCTGATGGCGTTGATTTT
AGAGCTGCAAAAAGAATTTCGTTTTTCGATCGTTATCGTCACACATGATATGGAACTTGCTTCTTTGGCTCATAAAAGAA
ATCAAATGGCGGGTGGCAAGCTGCAGCCGATTTAA

Upstream 100 bases:

>100_bases
GTGACTACTGCCGCTACGATTTTATCCGGAATCGCGGGTTATTTTCCCGCAAGATGGGCCGCCGGTCTTAATCCAGTGGA
TACGATAAGGAACGACTAAC

Downstream 100 bases:

>100_bases
AGTGTGTTCTATGGAAGAAAAAAATAGGATTTCACAACCTTTGAGTTGAATCATCGGGCCCGAAGGTTCGTACTTATATT
CTTGTCGGATTTCTATTGGA

Product: lipoprotein releasing system, LolD ATPase component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MSLIKVRNLVKNYRILDKEFKILDHLDLDVEEGEIVSVEGKSGIGKSTLLNILGSMDSSDAGEVNVCGVSLDQISETGKE
KFRAEKVAFIFQHHLLLPDFTALENVSIPLLINGVQPGKAWQLSIEMLDRVGLKDRHDNFPSQLSGGESARVGVARALVA
GKKLILADEPTGNLDRENSRNLMALILELQKEFRFSIVIVTHDMELASLAHKRNQMAGGKLQPI

Sequences:

>Translated_224_residues
MSLIKVRNLVKNYRILDKEFKILDHLDLDVEEGEIVSVEGKSGIGKSTLLNILGSMDSSDAGEVNVCGVSLDQISETGKE
KFRAEKVAFIFQHHLLLPDFTALENVSIPLLINGVQPGKAWQLSIEMLDRVGLKDRHDNFPSQLSGGESARVGVARALVA
GKKLILADEPTGNLDRENSRNLMALILELQKEFRFSIVIVTHDMELASLAHKRNQMAGGKLQPI
>Mature_223_residues
SLIKVRNLVKNYRILDKEFKILDHLDLDVEEGEIVSVEGKSGIGKSTLLNILGSMDSSDAGEVNVCGVSLDQISETGKEK
FRAEKVAFIFQHHLLLPDFTALENVSIPLLINGVQPGKAWQLSIEMLDRVGLKDRHDNFPSQLSGGESARVGVARALVAG
KKLILADEPTGNLDRENSRNLMALILELQKEFRFSIVIVTHDMELASLAHKRNQMAGGKLQPI

Specific function: Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-de

COG id: COG1136

COG function: function code V; ABC-type antimicrobial peptide transport system, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI116734710, Length=220, Percent_Identity=30.4545454545455, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI153792144, Length=220, Percent_Identity=29.0909090909091, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI27262624, Length=223, Percent_Identity=29.5964125560538, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI27262626, Length=223, Percent_Identity=29.5964125560538, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI105990541, Length=211, Percent_Identity=29.3838862559242, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI21536376, Length=211, Percent_Identity=28.436018957346, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI47078218, Length=224, Percent_Identity=29.0178571428571, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI45446740, Length=224, Percent_Identity=29.0178571428571, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI27436953, Length=221, Percent_Identity=27.1493212669683, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI42741659, Length=192, Percent_Identity=30.7291666666667, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI27477115, Length=186, Percent_Identity=26.8817204301075, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI9961252, Length=189, Percent_Identity=29.1005291005291, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI9961250, Length=189, Percent_Identity=29.1005291005291, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI4505771, Length=189, Percent_Identity=29.1005291005291, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI150417984, Length=214, Percent_Identity=27.5700934579439, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI87081834, Length=219, Percent_Identity=42.9223744292237, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1786703, Length=221, Percent_Identity=38.0090497737557, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1787105, Length=219, Percent_Identity=36.5296803652968, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI1786398, Length=204, Percent_Identity=34.8039215686275, Blast_Score=130, Evalue=7e-32,
Organism=Escherichia coli, GI1788225, Length=212, Percent_Identity=36.7924528301887, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1787029, Length=212, Percent_Identity=34.4339622641509, Blast_Score=123, Evalue=8e-30,
Organism=Escherichia coli, GI1789873, Length=188, Percent_Identity=37.7659574468085, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1788761, Length=209, Percent_Identity=31.5789473684211, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1789672, Length=213, Percent_Identity=30.9859154929577, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1786563, Length=185, Percent_Identity=34.5945945945946, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1789963, Length=235, Percent_Identity=34.0425531914894, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1787089, Length=185, Percent_Identity=34.0540540540541, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1789032, Length=180, Percent_Identity=32.7777777777778, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI145693107, Length=236, Percent_Identity=31.3559322033898, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI87081791, Length=221, Percent_Identity=31.6742081447964, Blast_Score=103, Evalue=8e-24,
Organism=Escherichia coli, GI87081709, Length=202, Percent_Identity=30.1980198019802, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787164, Length=183, Percent_Identity=35.5191256830601, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787712, Length=192, Percent_Identity=30.2083333333333, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1786872, Length=208, Percent_Identity=33.6538461538462, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1789962, Length=215, Percent_Identity=30.2325581395349, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1788506, Length=231, Percent_Identity=32.034632034632, Blast_Score=97, Evalue=6e-22,
Organism=Escherichia coli, GI48994883, Length=212, Percent_Identity=30.188679245283, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1790544, Length=221, Percent_Identity=31.6742081447964, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1787370, Length=187, Percent_Identity=29.4117647058824, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1787548, Length=238, Percent_Identity=28.5714285714286, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787547, Length=210, Percent_Identity=31.4285714285714, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082267, Length=223, Percent_Identity=30.0448430493274, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI48994997, Length=215, Percent_Identity=31.1627906976744, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1790534, Length=210, Percent_Identity=32.3809523809524, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1790467, Length=223, Percent_Identity=29.1479820627803, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI1789891, Length=189, Percent_Identity=31.7460317460317, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1786253, Length=224, Percent_Identity=28.125, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789586, Length=191, Percent_Identity=33.5078534031414, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1786698, Length=196, Percent_Identity=32.1428571428571, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787500, Length=195, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1788644, Length=200, Percent_Identity=31, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1788450, Length=195, Percent_Identity=30.2564102564103, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788053, Length=201, Percent_Identity=29.8507462686567, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1788210, Length=205, Percent_Identity=31.7073170731707, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787758, Length=187, Percent_Identity=28.3422459893048, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI48994943, Length=218, Percent_Identity=24.7706422018349, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1789864, Length=204, Percent_Identity=26.4705882352941, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1786319, Length=192, Percent_Identity=28.6458333333333, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1786345, Length=219, Percent_Identity=27.3972602739726, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790739, Length=197, Percent_Identity=30.4568527918782, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1790162, Length=218, Percent_Identity=27.0642201834862, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1788165, Length=190, Percent_Identity=27.3684210526316, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790190, Length=199, Percent_Identity=28.643216080402, Blast_Score=66, Evalue=1e-12,
Organism=Escherichia coli, GI1789991, Length=219, Percent_Identity=26.9406392694064, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787759, Length=217, Percent_Identity=24.4239631336406, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1786803, Length=199, Percent_Identity=25.1256281407035, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790525, Length=206, Percent_Identity=27.6699029126214, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787112, Length=195, Percent_Identity=28.7179487179487, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI87081782, Length=191, Percent_Identity=26.7015706806283, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI193202349, Length=207, Percent_Identity=31.4009661835749, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI115533608, Length=200, Percent_Identity=26.5, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17541710, Length=193, Percent_Identity=31.0880829015544, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17510237, Length=208, Percent_Identity=25.9615384615385, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71983510, Length=205, Percent_Identity=25.3658536585366, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71983516, Length=205, Percent_Identity=25.3658536585366, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71983523, Length=204, Percent_Identity=25.4901960784314, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17565586, Length=234, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI193211017, Length=186, Percent_Identity=28.494623655914, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI193211015, Length=186, Percent_Identity=28.494623655914, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71996809, Length=186, Percent_Identity=28.494623655914, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71992290, Length=185, Percent_Identity=30.2702702702703, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI212646699, Length=187, Percent_Identity=27.807486631016, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17558664, Length=195, Percent_Identity=27.6923076923077, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17567269, Length=172, Percent_Identity=31.9767441860465, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6319856, Length=194, Percent_Identity=27.319587628866, Blast_Score=75, Evalue=7e-15,
Organism=Drosophila melanogaster, GI28574150, Length=222, Percent_Identity=28.3783783783784, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI116007328, Length=222, Percent_Identity=28.3783783783784, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI19920532, Length=204, Percent_Identity=28.921568627451, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24580930, Length=204, Percent_Identity=28.921568627451, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24650853, Length=229, Percent_Identity=27.9475982532751, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24650855, Length=229, Percent_Identity=27.9475982532751, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281362751, Length=229, Percent_Identity=27.9475982532751, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24666092, Length=203, Percent_Identity=24.1379310344828, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24643674, Length=207, Percent_Identity=25.6038647342995, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161076682, Length=199, Percent_Identity=29.6482412060301, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161076684, Length=199, Percent_Identity=29.6482412060301, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24581617, Length=199, Percent_Identity=29.6482412060301, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24581615, Length=199, Percent_Identity=29.6482412060301, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI85725262, Length=200, Percent_Identity=26, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24582014, Length=228, Percent_Identity=26.7543859649123, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24582012, Length=228, Percent_Identity=26.7543859649123, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24648314, Length=202, Percent_Identity=27.7227722772277, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR015854
- InterPro:   IPR003593
- InterPro:   IPR011924 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 24708; Mature: 24577

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLIKVRNLVKNYRILDKEFKILDHLDLDVEEGEIVSVEGKSGIGKSTLLNILGSMDSSD
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCC
AGEVNVCGVSLDQISETGKEKFRAEKVAFIFQHHLLLPDFTALENVSIPLLINGVQPGKA
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCEEEEECCCCCCE
WQLSIEMLDRVGLKDRHDNFPSQLSGGESARVGVARALVAGKKLILADEPTGNLDRENSR
EEEHHHHHHHCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCC
NLMALILELQKEFRFSIVIVTHDMELASLAHKRNQMAGGKLQPI
HHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SLIKVRNLVKNYRILDKEFKILDHLDLDVEEGEIVSVEGKSGIGKSTLLNILGSMDSSD
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCC
AGEVNVCGVSLDQISETGKEKFRAEKVAFIFQHHLLLPDFTALENVSIPLLINGVQPGKA
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCEEEEECCCCCCE
WQLSIEMLDRVGLKDRHDNFPSQLSGGESARVGVARALVAGKKLILADEPTGNLDRENSR
EEEHHHHHHHCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCC
NLMALILELQKEFRFSIVIVTHDMELASLAHKRNQMAGGKLQPI
HHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA