Click here to switch to the map view.

The map label for this gene is acdA [H]

Identifier: 116327038

GI number: 116327038

Start: 253038

End: 254201

Strand: Direct

Name: acdA [H]

Synonym: LBL_0211

Alternate gene names: 116327038

Gene position: 253038-254201 (Clockwise)

Preceding gene: 116327037

Following gene: 116327039

Centisome position: 7.0

GC content: 46.31

Gene sequence:

>1164_bases
ATGGAATTTGCCCTTTCTAGTGAACAGAAAGAATTGCGTGATCTCGCCAGAAAATTTGCTAAAGAAGAAGTTCGTCCAAA
AGCGGAACATCACGATCGTACGGGAGAATACCCCCTTGCAATCTTAAAAAAAGCCTGGGAAATCGGGCTCATGAATCTTC
ATATAGAATCCAGATTCAATGGGGCCGATATGTCCGAACTGGACGGTGTGGTCATCGGAGAAGAACTTTTTTGGGGATGT
TCCGGTGTGGCGACCGCAATTCTTGCAAACAACCTTGCGTTGGCTCCTGTTATTCTCGGGGCAAGTGATAGAATCAAAAA
AGAATTCATTCAACCGATGACGGAGGAATTTAAACTCGCGGCTTATGCGGTGACCGAACCGGGTGCGGGATCGGACGTCG
CGGCAATTCGTACCTCCGCAAAAAAAGTCGGGGACGAATATATCATCAACGGTTCCAAAATGTGGATCACGAATGCCGGA
TATGCAGATTGGCTTTTCGTTCTTGCAAAAACCGATCCTTCCGCAGGTCATAAAGGAATTACCGGATTTATCGTAGATGC
AAAATCTCCCGGAATCATCGTAGGGAAAAAAGAAATCAACATGGGGCAGAAATGCTCCGACACGCGTGCGATCACATTCG
AAGACGTGAAAGTTCCCTCGTGGCAGATGATTGGGAGAGAGGGAGAGGGTTTTAAAATTGCAATGGGGGCTTTTGACCGC
ACTCGTCCTGGAGTTGCGATTGGAGCTGTCGGGGTTGCGCGTGCTGCAATGGAACATTCCGTTAACTATGCAAATACTCG
TAGTACTTTCGGTCGTCCGATTATGGATAACCAAGGAATCTCTTTTATGATCGCGGAAATGGCCCGTGACATCGAAGCCG
GAAGACTTCTTTGTTATCAAGCGGCTTGGATAATTGATAACGGATTCAGGAATACATACCAAGCATCGATCGCAAAAATG
TTCTGTGCGGATATGTGCATGAAAGTTTGCACGGACGCCGTCCAAGTTCTCGGCGGATACGGATTTAACACGGAATATCC
GGTTGAAAAGTTAATGAGAGATGCGAAAATTTTTCAAATCTACGAAGGCACTTCTCAAATTCAAAGAATGATCGTTTCTC
GTTTTCTTGCTGATGGAAAGGGAATCGAGGGACCGAACTCCTGA

Upstream 100 bases:

>100_bases
GGCCGTACCGGAAAATAAAATCCCGGCATCGACGATCCCAAGCGGGGGAATGCCAGGAACCATTGGATGAGTTCAATTTC
GACCAAGGTGTACTATAAAA

Downstream 100 bases:

>100_bases
AAGAGTTTTCTCTCACATTCGAGGAGTTCTCCGCGCTTGCAGAACGCGGGAATTTAATTCCTGTTTTTAAACAGGTTTTT
CTAGATATGGAAACTCCGGT

Product: Acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MEFALSSEQKELRDLARKFAKEEVRPKAEHHDRTGEYPLAILKKAWEIGLMNLHIESRFNGADMSELDGVVIGEELFWGC
SGVATAILANNLALAPVILGASDRIKKEFIQPMTEEFKLAAYAVTEPGAGSDVAAIRTSAKKVGDEYIINGSKMWITNAG
YADWLFVLAKTDPSAGHKGITGFIVDAKSPGIIVGKKEINMGQKCSDTRAITFEDVKVPSWQMIGREGEGFKIAMGAFDR
TRPGVAIGAVGVARAAMEHSVNYANTRSTFGRPIMDNQGISFMIAEMARDIEAGRLLCYQAAWIIDNGFRNTYQASIAKM
FCADMCMKVCTDAVQVLGGYGFNTEYPVEKLMRDAKIFQIYEGTSQIQRMIVSRFLADGKGIEGPNS

Sequences:

>Translated_387_residues
MEFALSSEQKELRDLARKFAKEEVRPKAEHHDRTGEYPLAILKKAWEIGLMNLHIESRFNGADMSELDGVVIGEELFWGC
SGVATAILANNLALAPVILGASDRIKKEFIQPMTEEFKLAAYAVTEPGAGSDVAAIRTSAKKVGDEYIINGSKMWITNAG
YADWLFVLAKTDPSAGHKGITGFIVDAKSPGIIVGKKEINMGQKCSDTRAITFEDVKVPSWQMIGREGEGFKIAMGAFDR
TRPGVAIGAVGVARAAMEHSVNYANTRSTFGRPIMDNQGISFMIAEMARDIEAGRLLCYQAAWIIDNGFRNTYQASIAKM
FCADMCMKVCTDAVQVLGGYGFNTEYPVEKLMRDAKIFQIYEGTSQIQRMIVSRFLADGKGIEGPNS
>Mature_387_residues
MEFALSSEQKELRDLARKFAKEEVRPKAEHHDRTGEYPLAILKKAWEIGLMNLHIESRFNGADMSELDGVVIGEELFWGC
SGVATAILANNLALAPVILGASDRIKKEFIQPMTEEFKLAAYAVTEPGAGSDVAAIRTSAKKVGDEYIINGSKMWITNAG
YADWLFVLAKTDPSAGHKGITGFIVDAKSPGIIVGKKEINMGQKCSDTRAITFEDVKVPSWQMIGREGEGFKIAMGAFDR
TRPGVAIGAVGVARAAMEHSVNYANTRSTFGRPIMDNQGISFMIAEMARDIEAGRLLCYQAAWIIDNGFRNTYQASIAKM
FCADMCMKVCTDAVQVLGGYGFNTEYPVEKLMRDAKIFQIYEGTSQIQRMIVSRFLADGKGIEGPNS

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI187960098, Length=375, Percent_Identity=57.0666666666667, Blast_Score=451, Evalue=1e-127,
Organism=Homo sapiens, GI4557231, Length=375, Percent_Identity=57.0666666666667, Blast_Score=451, Evalue=1e-127,
Organism=Homo sapiens, GI4557233, Length=373, Percent_Identity=37.5335120643432, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI7656849, Length=373, Percent_Identity=35.9249329758713, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI4501859, Length=372, Percent_Identity=33.8709677419355, Blast_Score=248, Evalue=7e-66,
Organism=Homo sapiens, GI226958412, Length=382, Percent_Identity=31.9371727748691, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI226958414, Length=340, Percent_Identity=31.1764705882353, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=31.5508021390374, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI21361497, Length=365, Percent_Identity=32.0547945205479, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI4557235, Length=380, Percent_Identity=31.8421052631579, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI76496475, Length=380, Percent_Identity=31.8421052631579, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI4503943, Length=377, Percent_Identity=24.4031830238727, Blast_Score=121, Evalue=9e-28,
Organism=Homo sapiens, GI7669494, Length=365, Percent_Identity=23.8356164383562, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI211971008, Length=402, Percent_Identity=25.6218905472637, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI48976061, Length=402, Percent_Identity=25.6218905472637, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI38505218, Length=280, Percent_Identity=26.7857142857143, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1786223, Length=377, Percent_Identity=31.2997347480106, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI87081958, Length=380, Percent_Identity=29.7368421052632, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI87082384, Length=289, Percent_Identity=24.9134948096886, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17570075, Length=379, Percent_Identity=53.2981530343008, Blast_Score=416, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=50.9234828496042, Blast_Score=403, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17534899, Length=379, Percent_Identity=52.5065963060686, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17508101, Length=374, Percent_Identity=35.5614973262032, Blast_Score=251, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI17533517, Length=374, Percent_Identity=35.8288770053476, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17506239, Length=364, Percent_Identity=33.5164835164835, Blast_Score=231, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=32.6259946949602, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI71990804, Length=292, Percent_Identity=33.9041095890411, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI71985184, Length=356, Percent_Identity=30.6179775280899, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17551932, Length=362, Percent_Identity=30.1104972375691, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17505929, Length=362, Percent_Identity=29.5580110497238, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71982178, Length=273, Percent_Identity=31.1355311355311, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71985192, Length=321, Percent_Identity=28.9719626168224, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI17534353, Length=374, Percent_Identity=27.2727272727273, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=33.195020746888, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI32563615, Length=240, Percent_Identity=31.25, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17562446, Length=276, Percent_Identity=26.0869565217391, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17531913, Length=177, Percent_Identity=28.2485875706215, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI86563381, Length=289, Percent_Identity=24.5674740484429, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI86563383, Length=289, Percent_Identity=24.5674740484429, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24660351, Length=375, Percent_Identity=55.4666666666667, Blast_Score=427, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24646207, Length=378, Percent_Identity=39.4179894179894, Blast_Score=277, Evalue=9e-75,
Organism=Drosophila melanogaster, GI21356377, Length=371, Percent_Identity=37.7358490566038, Blast_Score=256, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24666513, Length=371, Percent_Identity=33.6927223719677, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI21355753, Length=379, Percent_Identity=32.9815303430079, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI281363737, Length=388, Percent_Identity=30.4123711340206, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI19920834, Length=379, Percent_Identity=27.1767810026385, Blast_Score=135, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42430; Mature: 42430

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFALSSEQKELRDLARKFAKEEVRPKAEHHDRTGEYPLAILKKAWEIGLMNLHIESRFN
CCCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHCEEEEEEECCCC
GADMSELDGVVIGEELFWGCSGVATAILANNLALAPVILGASDRIKKEFIQPMTEEFKLA
CCCHHHCCCEEECHHHHHCHHHHHHHHHHCCCEEEHEEECCCHHHHHHHHHHHHHHHEEE
AYAVTEPGAGSDVAAIRTSAKKVGDEYIINGSKMWITNAGYADWLFVLAKTDPSAGHKGI
EEEEECCCCCCCHHHHHHHHHHCCCCEEECCCEEEEECCCCCEEEEEEEECCCCCCCCCC
TGFIVDAKSPGIIVGKKEINMGQKCSDTRAITFEDVKVPSWQMIGREGEGFKIAMGAFDR
EEEEEECCCCCEEEEHHHCCCCCCCCCCCEEEEECCCCCCHHHCCCCCCCEEEEECCCCC
TRPGVAIGAVGVARAAMEHSVNYANTRSTFGRPIMDNQGISFMIAEMARDIEAGRLLCYQ
CCCCEEEHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCEEEEEE
AAWIIDNGFRNTYQASIAKMFCADMCMKVCTDAVQVLGGYGFNTEYPVEKLMRDAKIFQI
EEHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEE
YEGTSQIQRMIVSRFLADGKGIEGPNS
ECCHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MEFALSSEQKELRDLARKFAKEEVRPKAEHHDRTGEYPLAILKKAWEIGLMNLHIESRFN
CCCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHCEEEEEEECCCC
GADMSELDGVVIGEELFWGCSGVATAILANNLALAPVILGASDRIKKEFIQPMTEEFKLA
CCCHHHCCCEEECHHHHHCHHHHHHHHHHCCCEEEHEEECCCHHHHHHHHHHHHHHHEEE
AYAVTEPGAGSDVAAIRTSAKKVGDEYIINGSKMWITNAGYADWLFVLAKTDPSAGHKGI
EEEEECCCCCCCHHHHHHHHHHCCCCEEECCCEEEEECCCCCEEEEEEEECCCCCCCCCC
TGFIVDAKSPGIIVGKKEINMGQKCSDTRAITFEDVKVPSWQMIGREGEGFKIAMGAFDR
EEEEEECCCCCEEEEHHHCCCCCCCCCCCEEEEECCCCCCHHHCCCCCCCEEEEECCCCC
TRPGVAIGAVGVARAAMEHSVNYANTRSTFGRPIMDNQGISFMIAEMARDIEAGRLLCYQ
CCCCEEEHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCEEEEEE
AAWIIDNGFRNTYQASIAKMFCADMCMKVCTDAVQVLGGYGFNTEYPVEKLMRDAKIFQI
EEHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEE
YEGTSQIQRMIVSRFLADGKGIEGPNS
ECCHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]