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The map label for this gene is ndk

Identifier: 116327010

GI number: 116327010

Start: 212961

End: 213374

Strand: Direct

Name: ndk

Synonym: LBL_0180

Alternate gene names: 116327010

Gene position: 212961-213374 (Clockwise)

Preceding gene: 116327009

Following gene: 116327011

Centisome position: 5.89

GC content: 43.72

Gene sequence:

>414_bases
ATGTCCAAAACGTTTATCATGATCAAACCCGACGGAGTAAAAAACAAACACGTCGGGAACATTCTTGCAAGGATCGAAAA
GGAAGGATTTAAAATCCTAGGTTTAAAATACCTCAAGTTGTCTCTTGAAGACGCTAAACAATTTTATAAAGTGCATTCTG
CGCGTCCGTTTTACAGCGACTTATGTAACTATATGTCTTCCGGTCCGATCGTTGCCGCTGCTCTGGAAAGAGACAACGCC
GTTCTTCATTGGAGAGAAGTGATCGGAGCGACCGATCCGAAAGAAGCGGCTGCCGGAACGATTCGTGCTTTGTATGCGGA
AAGTAAGGAAGCGAATGCGGTACACGGTTCCGATTCTGATGAAAACGCCGCTCTTGAAGTTTCCTTCTTTTTTAAGGGAA
ACGAGTTATTTTAA

Upstream 100 bases:

>100_bases
CGTAAAGGAAGTCGCAAGACATGGAAGAGACGTTAGCAATCAGGTTCCCGAAATTGTCGGCAAAGCATTACTTAAAAAAC
TCTCTCAATAAGGAAAAAAA

Downstream 100 bases:

>100_bases
AACGGTTTTTAGAGAGGAGTTCCACGATTTTTGAACTCCTCTTTTATATGATATTTCCGAATTTTTGCGACGATGAATTC
TAATCAGAGTTTAGAATATT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 137; Mature: 136

Protein sequence:

>137_residues
MSKTFIMIKPDGVKNKHVGNILARIEKEGFKILGLKYLKLSLEDAKQFYKVHSARPFYSDLCNYMSSGPIVAAALERDNA
VLHWREVIGATDPKEAAAGTIRALYAESKEANAVHGSDSDENAALEVSFFFKGNELF

Sequences:

>Translated_137_residues
MSKTFIMIKPDGVKNKHVGNILARIEKEGFKILGLKYLKLSLEDAKQFYKVHSARPFYSDLCNYMSSGPIVAAALERDNA
VLHWREVIGATDPKEAAAGTIRALYAESKEANAVHGSDSDENAALEVSFFFKGNELF
>Mature_136_residues
SKTFIMIKPDGVKNKHVGNILARIEKEGFKILGLKYLKLSLEDAKQFYKVHSARPFYSDLCNYMSSGPIVAAALERDNAV
LHWREVIGATDPKEAAAGTIRALYAESKEANAVHGSDSDENAALEVSFFFKGNELF

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=41.4814814814815, Blast_Score=116, Evalue=6e-27,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=42.6470588235294, Blast_Score=115, Evalue=8e-27,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=42.6470588235294, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=42.6470588235294, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=42.6470588235294, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=42.6470588235294, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI38045913, Length=134, Percent_Identity=41.7910447761194, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI4557797, Length=134, Percent_Identity=41.7910447761194, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI4826862, Length=134, Percent_Identity=40.2985074626866, Blast_Score=110, Evalue=3e-25,
Organism=Homo sapiens, GI37574614, Length=132, Percent_Identity=37.1212121212121, Blast_Score=97, Evalue=6e-21,
Organism=Homo sapiens, GI7019465, Length=132, Percent_Identity=37.1212121212121, Blast_Score=96, Evalue=7e-21,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=36.2962962962963, Blast_Score=83, Evalue=7e-17,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=32.5925925925926, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=31.8840579710145, Blast_Score=70, Evalue=4e-13,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=30.3703703703704, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1788866, Length=136, Percent_Identity=48.5294117647059, Blast_Score=139, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17506807, Length=134, Percent_Identity=39.5522388059701, Blast_Score=103, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322783, Length=134, Percent_Identity=39.5522388059701, Blast_Score=110, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45549037, Length=134, Percent_Identity=43.2835820895522, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=33.5820895522388, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_LEPBJ (Q04P86)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_802042.1
- ProteinModelPortal:   Q04P86
- SMR:   Q04P86
- STRING:   Q04P86
- GeneID:   4412153
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_2883
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   Q04P86
- ProtClustDB:   PRK14542
- BioCyc:   LBOR355277:LBJ_2883-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15183; Mature: 15052

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTFIMIKPDGVKNKHVGNILARIEKEGFKILGLKYLKLSLEDAKQFYKVHSARPFYSD
CCCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEEEEEEHHHHHHHHHHHCCCCHHHH
LCNYMSSGPIVAAALERDNAVLHWREVIGATDPKEAAAGTIRALYAESKEANAVHGSDSD
HHHHHCCCCEEEEEECCCCCEEEHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEECCCCCC
ENAALEVSFFFKGNELF
CCEEEEEEEEECCCCCC
>Mature Secondary Structure 
SKTFIMIKPDGVKNKHVGNILARIEKEGFKILGLKYLKLSLEDAKQFYKVHSARPFYSD
CCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEEEEEEHHHHHHHHHHHCCCCHHHH
LCNYMSSGPIVAAALERDNAVLHWREVIGATDPKEAAAGTIRALYAESKEANAVHGSDSD
HHHHHCCCCEEEEEECCCCCEEEHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEECCCCCC
ENAALEVSFFFKGNELF
CCEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA