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The map label for this gene is hutH [H]

Identifier: 116249411

GI number: 116249411

Start: 815377

End: 816882

Strand: Direct

Name: hutH [H]

Synonym: pRL120749

Alternate gene names: 116249411

Gene position: 815377-816882 (Clockwise)

Preceding gene: 116249410

Following gene: 116249412

Centisome position: 93.72

GC content: 63.55

Gene sequence:

>1506_bases
GTGAGCGCCACCAATTCTCCGTCGATCATCTTCAGCGCGGCGCCGCCGACGATCGAGGACATCGCAGCAATTGCCCGTCG
TCACGCAAGGATCGAGGTATCCGCCGAGGTCGAGGCCCGGATTGTGGCCGCGCGCGCCGTCGTCGACCGCTATACGGAAA
GCGACCTGCCGGTCTATGGCCTGACGACGGGACTTGGAGCGGGGGTCGATACACGACTTGCAACGGAAGATCTGGTGGCG
TTCCAGCTGCGTGTGCCGCAAGCCCGCGCGGTCGGCGTTGGAGAGCCGCTTGCCCGGGAATCCGTGCGGGCGATGATGGC
CGTCAGGGCCGCCGGCATGGCGGCGGGCGGTACCGGCGTTTCGCTGAAAGTCTTCCAGGGTCTGATTGCCGCCATCAATG
CAGGTGTGCATCCCGTCGTCCCGTCATTGGGCTCGATCGGTGCGGCGGATTTGGCGCCGCTTGCCCATATGAGCCGGGGC
CTCCTGGGCTTCGGTGAGATCGAGCTTGGCGGCGAAGTGCTGCCGGCCGCCATCGCCCTTGACAGGGCCGGCCTGAAGCC
CCTCGAATTCGCGCCGAAGGACGGGCATGCGCTTGTTGTGGCCAACAGCCTCTCCATCGGCCTCGCCTGCTTGACGCTTG
TGGATATCGAGCGGCTCTTCGATTGGTCCCTGAAGGCGATTGCCATTAGTTTCGAAGCGTTCCGGGCCAATGTCAGTGCC
TTCGACGACCGCGCACTGGCTGCAAGACCGGCCTTTGGGCAGCGCCGCGTCGCCGCTCAGCTGATGGAGCTTCTTTCGGG
CAGCTCCTTGCTTACCGCCGATGCAGCAAGGCGTCTGCAGGATCCTTTGAGCTACCGCTGCACGCCGCAGGTCTGGGGCG
CGTTGAGGCATGCGATCGATGAGGCAAGGCAGGCGACTGACATAGAGCTCGTCAGTTCCAGCGACAATCCTGTCGTGATC
GCATCCGAAGGCGTCATTCTTTCGCACGGCAATTTCGACATGACCGCCTTTGTGCTCGCCTGGGAAAGGCTGGGGCAGGC
GATGGCGCATTGTGCGGCAGGCACCGCCTATCGGATCATGAAGATCATGTCGCCCGGCATGTCCGACCTCCCACGCTTTC
TGACCCCGATGGGCCAGAGCCGTACTGGTTTTGCGACCGTGCAAAAGACCGTCTCGGCCATGGAAGCCGAAATCCGCCAC
CTGGCCATGCCGGTTTCGCTTTCGCCCATTCCTGTCGCCGATGGCGTCGAAGACCAGGCATCGATGGCTCCGAGCGTTTT
GGCAAAGGCGCAGGCGATCGTCGAGCGCCTGCGCTATCTGGTCGCCATCGAACTGATTGCTTCGGTGCAGGCCGTCGAGC
TCAGAGGCGTCTCGGGCGAATTGGGCAAAGGATCGGCGCAAGCCTATGCCTTTGTCCGCACCCACGTCCCGGCGCTTGAA
GAGGATCGCGCGCAAGGGCCGGATTTTGCGACAATTGCCGCATTGATCGGGCTTGGCCCGCAATAA

Upstream 100 bases:

>100_bases
TGACCTGCGCGCTGTTATACTATCCCGGCGCGCAATACCGGCTGGAAGCACGGTCCACCAAGGGTCCCTCCAGGCCCGTC
GCCATTCTCGGAGAGAAACA

Downstream 100 bases:

>100_bases
GCCGGTTCGCCACTGCCCCGGCAAGAAGGGCAGGGCGCCGACCGGTCATGCTGACGGTTATTCCGGGGAATGCCGTCAGT
CCGTTCATTGAAAAGTCAAC

Product: putative histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MSATNSPSIIFSAAPPTIEDIAAIARRHARIEVSAEVEARIVAARAVVDRYTESDLPVYGLTTGLGAGVDTRLATEDLVA
FQLRVPQARAVGVGEPLARESVRAMMAVRAAGMAAGGTGVSLKVFQGLIAAINAGVHPVVPSLGSIGAADLAPLAHMSRG
LLGFGEIELGGEVLPAAIALDRAGLKPLEFAPKDGHALVVANSLSIGLACLTLVDIERLFDWSLKAIAISFEAFRANVSA
FDDRALAARPAFGQRRVAAQLMELLSGSSLLTADAARRLQDPLSYRCTPQVWGALRHAIDEARQATDIELVSSSDNPVVI
ASEGVILSHGNFDMTAFVLAWERLGQAMAHCAAGTAYRIMKIMSPGMSDLPRFLTPMGQSRTGFATVQKTVSAMEAEIRH
LAMPVSLSPIPVADGVEDQASMAPSVLAKAQAIVERLRYLVAIELIASVQAVELRGVSGELGKGSAQAYAFVRTHVPALE
EDRAQGPDFATIAALIGLGPQ

Sequences:

>Translated_501_residues
MSATNSPSIIFSAAPPTIEDIAAIARRHARIEVSAEVEARIVAARAVVDRYTESDLPVYGLTTGLGAGVDTRLATEDLVA
FQLRVPQARAVGVGEPLARESVRAMMAVRAAGMAAGGTGVSLKVFQGLIAAINAGVHPVVPSLGSIGAADLAPLAHMSRG
LLGFGEIELGGEVLPAAIALDRAGLKPLEFAPKDGHALVVANSLSIGLACLTLVDIERLFDWSLKAIAISFEAFRANVSA
FDDRALAARPAFGQRRVAAQLMELLSGSSLLTADAARRLQDPLSYRCTPQVWGALRHAIDEARQATDIELVSSSDNPVVI
ASEGVILSHGNFDMTAFVLAWERLGQAMAHCAAGTAYRIMKIMSPGMSDLPRFLTPMGQSRTGFATVQKTVSAMEAEIRH
LAMPVSLSPIPVADGVEDQASMAPSVLAKAQAIVERLRYLVAIELIASVQAVELRGVSGELGKGSAQAYAFVRTHVPALE
EDRAQGPDFATIAALIGLGPQ
>Mature_500_residues
SATNSPSIIFSAAPPTIEDIAAIARRHARIEVSAEVEARIVAARAVVDRYTESDLPVYGLTTGLGAGVDTRLATEDLVAF
QLRVPQARAVGVGEPLARESVRAMMAVRAAGMAAGGTGVSLKVFQGLIAAINAGVHPVVPSLGSIGAADLAPLAHMSRGL
LGFGEIELGGEVLPAAIALDRAGLKPLEFAPKDGHALVVANSLSIGLACLTLVDIERLFDWSLKAIAISFEAFRANVSAF
DDRALAARPAFGQRRVAAQLMELLSGSSLLTADAARRLQDPLSYRCTPQVWGALRHAIDEARQATDIELVSSSDNPVVIA
SEGVILSHGNFDMTAFVLAWERLGQAMAHCAAGTAYRIMKIMSPGMSDLPRFLTPMGQSRTGFATVQKTVSAMEAEIRHL
AMPVSLSPIPVADGVEDQASMAPSVLAKAQAIVERLRYLVAIELIASVQAVELRGVSGELGKGSAQAYAFVRTHVPALEE
DRAQGPDFATIAALIGLGPQ

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=481, Percent_Identity=30.977130977131, Blast_Score=218, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI17567831, Length=493, Percent_Identity=32.657200811359, Blast_Score=208, Evalue=5e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 52545; Mature: 52414

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATNSPSIIFSAAPPTIEDIAAIARRHARIEVSAEVEARIVAARAVVDRYTESDLPVYG
CCCCCCCCEEEECCCCCHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHHCCCCCCEEE
LTTGLGAGVDTRLATEDLVAFQLRVPQARAVGVGEPLARESVRAMMAVRAAGMAAGGTGV
ECCCCCCCCCCHHHHHHHHEEEEECCCHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
SLKVFQGLIAAINAGVHPVVPSLGSIGAADLAPLAHMSRGLLGFGEIELGGEVLPAAIAL
HHHHHHHHHHHHCCCCCHHCCCCCCCCCHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHH
DRAGLKPLEFAPKDGHALVVANSLSIGLACLTLVDIERLFDWSLKAIAISFEAFRANVSA
HHCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHEEEHHHHHCCHHH
FDDRALAARPAFGQRRVAAQLMELLSGSSLLTADAARRLQDPLSYRCTPQVWGALRHAID
CCCCHHHCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
EARQATDIELVSSSDNPVVIASEGVILSHGNFDMTAFVLAWERLGQAMAHCAAGTAYRIM
HHHCCCCEEEEECCCCCEEEEECCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHH
KIMSPGMSDLPRFLTPMGQSRTGFATVQKTVSAMEAEIRHLAMPVSLSPIPVADGVEDQA
HHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
SMAPSVLAKAQAIVERLRYLVAIELIASVQAVELRGVSGELGKGSAQAYAFVRTHVPALE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHEEEHHHCCCCCH
EDRAQGPDFATIAALIGLGPQ
HHHCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
SATNSPSIIFSAAPPTIEDIAAIARRHARIEVSAEVEARIVAARAVVDRYTESDLPVYG
CCCCCCCEEEECCCCCHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHHCCCCCCEEE
LTTGLGAGVDTRLATEDLVAFQLRVPQARAVGVGEPLARESVRAMMAVRAAGMAAGGTGV
ECCCCCCCCCCHHHHHHHHEEEEECCCHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
SLKVFQGLIAAINAGVHPVVPSLGSIGAADLAPLAHMSRGLLGFGEIELGGEVLPAAIAL
HHHHHHHHHHHHCCCCCHHCCCCCCCCCHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHH
DRAGLKPLEFAPKDGHALVVANSLSIGLACLTLVDIERLFDWSLKAIAISFEAFRANVSA
HHCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHEEEHHHHHCCHHH
FDDRALAARPAFGQRRVAAQLMELLSGSSLLTADAARRLQDPLSYRCTPQVWGALRHAID
CCCCHHHCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
EARQATDIELVSSSDNPVVIASEGVILSHGNFDMTAFVLAWERLGQAMAHCAAGTAYRIM
HHHCCCCEEEEECCCCCEEEEECCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHH
KIMSPGMSDLPRFLTPMGQSRTGFATVQKTVSAMEAEIRHLAMPVSLSPIPVADGVEDQA
HHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
SMAPSVLAKAQAIVERLRYLVAIELIASVQAVELRGVSGELGKGSAQAYAFVRTHVPALE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHEEEHHHCCCCCH
EDRAQGPDFATIAALIGLGPQ
HHHCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA