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The map label for this gene is zraS [C]

Identifier: 116249381

GI number: 116249381

Start: 786746

End: 788422

Strand: Direct

Name: zraS [C]

Synonym: pRL120719

Alternate gene names: 116249381

Gene position: 786746-788422 (Clockwise)

Preceding gene: 116249380

Following gene: 116249384

Centisome position: 90.43

GC content: 63.33

Gene sequence:

>1677_bases
ATGAACCCCGTCAACATCCTCCTCGTCGACGACCAACCGGCAAAGCTCCTGAGTTACGAGGTCATTCTCGAAGAGCTCCA
AGAAAACCTCATCAAGGCGCAATCCGCTCGCGAAGCCTTCGAGCACCTATTGCGCACCGAAATCGCGGTGATCCTCGTCG
ATGTCTGCATGCCCGAACAGGATGGGTTCGAGCTCGTCAGCATGATCCGGCAGCATCCGCGCTATCAGAACACGCCGATC
ATCTTCGTTTCCGCCGTCATGCTGGCGGAACCGGACCGGCTGCGCGGCTATGCGGTGGGCGCGGTCGACTACGTTTCCGT
CCCGATCGTACCCGAAGTGCTGAGAGCCAAGGTGCGGGTCTTTGCCGATCTCTACAGGAAGACGAGGGAACTCGAACGCC
TGAACGTTGAGCTGGAGGCGCGCGTTCACCAACGCACCGCCGAGCTCGAGGCCTCGGCAGCGCAGTTGCGTGAGCTCAAC
GAGGAGCTCGAGCACCGGATCGATCAACGGACGCGGGAGCGCGAAGAAGCGCTCGCACAACTGTTCGAGGCGCAAAAACT
CGACACGATCGGCCACCTGACGGGCGGCGTGGCGCACGACTTCAATAACCTCCTGATGGCAGTTCTCGGCAGCCTCAACC
TTCTGAAGAAGCGGCTTCCGGCCGATGAACGCAGCGAACGCCTGGTGACGAATGCGATCCAGGCGGCCGAGCGCGGCACG
GCGCTGACCCAGCGCCTGCTTGCCTTCGCACGCCGCCAGGAGCTCAAGCCGCAGGCAGTCGACTTCTTCAGGCTGTTCGA
AAACGTCGAGGATCTTCTCGCCAAGGCGGTGGGGCCGCGCATCGAAATCCGCAAAAGCATCCCGGCGGATCTGGCGCCCC
TCCTAGTCGACAGCAACCAACTGGAACTGGCGCTGCTTAACCTGTTCGTCAATGCGCGGGATGCGCTCGAAAGCGGCGGA
GCCGTGACGGTGGCCGCGGCGGCAGCCGAAGACGCCCGGCCGGCCGGCCTCGCGGGCGGAAATTACATCAGGATTTCGGT
TTCGGACGATGGCGAGGGGATGGACGAGGCAACGGTCTCGCGTGCCGCCGAACCGTTTTTCACCACCAAAGGGGTCGGCA
AGGGCACCGGTCTCGGCCTGTCGATGGTGCACGGCCTGGCAGCGCAATCCGGCGGCTCGATCCAGATATCGAGCGTCAGG
GGCAAGGGCACGACCGTTTCGCTGTGGCTGCCCGTTGCCGAGACATTCGTCAAGGTGCAGCCTCCCGTCGAGCCTCCGGC
GACGGAGCCTTTGAAACCGGCGTCGCGGCCGCTTGCCATTCTGGTGGTCGACGACGACGCTCTTGTGAGGACGGGAACCG
TGGCGATGCTGGAGGATCTCGGGCACCTGCCGCAGGAAGCGTCTTCCGCTTCCCAGGCTTTGGAATTCTTTGCCGACGGA
CAGGGTTGCGATCTCGTCATCACCGATCATGCCATGCCGGGCATGACGGGCGCCGAGCTTGCACGTCACCTTCGCTCCTC
CTTTCCAGGCCTGCCCATCATCCTAGCCTCGGGCTACGCCGAGTTTTCCGAAGACCATGGCCTCGGCCGGATGCTGCGGA
TGAAGAAGCCATTCACGCAGGAACAGCTTCAGGCAGCGATGGATCAGGCGCTCTCGGGCAAAGTCGCGGCGGCTTGA

Upstream 100 bases:

>100_bases
TGCCTGGAAGCGGGCGCGTCCGACTATCTGGCGAAGCCGGTCAATACCGAACAGCTTCTGTCGGCTCTTCGCATGTGGTT
GCATCGCTGAGGATCTGGCC

Downstream 100 bases:

>100_bases
CGATCGAAGTGGGGATGTACTGGGTGTGTTGCGTTCTGGGCCAGTTCTAACCCTCGTCGCTTTCAAACTGCCGCCCGGCA
TAGAGGATGCGGAGGACAAC

Product: two-component histidine kinase/response regulator motif-containing protein

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MNPVNILLVDDQPAKLLSYEVILEELQENLIKAQSAREAFEHLLRTEIAVILVDVCMPEQDGFELVSMIRQHPRYQNTPI
IFVSAVMLAEPDRLRGYAVGAVDYVSVPIVPEVLRAKVRVFADLYRKTRELERLNVELEARVHQRTAELEASAAQLRELN
EELEHRIDQRTREREEALAQLFEAQKLDTIGHLTGGVAHDFNNLLMAVLGSLNLLKKRLPADERSERLVTNAIQAAERGT
ALTQRLLAFARRQELKPQAVDFFRLFENVEDLLAKAVGPRIEIRKSIPADLAPLLVDSNQLELALLNLFVNARDALESGG
AVTVAAAAAEDARPAGLAGGNYIRISVSDDGEGMDEATVSRAAEPFFTTKGVGKGTGLGLSMVHGLAAQSGGSIQISSVR
GKGTTVSLWLPVAETFVKVQPPVEPPATEPLKPASRPLAILVVDDDALVRTGTVAMLEDLGHLPQEASSASQALEFFADG
QGCDLVITDHAMPGMTGAELARHLRSSFPGLPIILASGYAEFSEDHGLGRMLRMKKPFTQEQLQAAMDQALSGKVAAA

Sequences:

>Translated_558_residues
MNPVNILLVDDQPAKLLSYEVILEELQENLIKAQSAREAFEHLLRTEIAVILVDVCMPEQDGFELVSMIRQHPRYQNTPI
IFVSAVMLAEPDRLRGYAVGAVDYVSVPIVPEVLRAKVRVFADLYRKTRELERLNVELEARVHQRTAELEASAAQLRELN
EELEHRIDQRTREREEALAQLFEAQKLDTIGHLTGGVAHDFNNLLMAVLGSLNLLKKRLPADERSERLVTNAIQAAERGT
ALTQRLLAFARRQELKPQAVDFFRLFENVEDLLAKAVGPRIEIRKSIPADLAPLLVDSNQLELALLNLFVNARDALESGG
AVTVAAAAAEDARPAGLAGGNYIRISVSDDGEGMDEATVSRAAEPFFTTKGVGKGTGLGLSMVHGLAAQSGGSIQISSVR
GKGTTVSLWLPVAETFVKVQPPVEPPATEPLKPASRPLAILVVDDDALVRTGTVAMLEDLGHLPQEASSASQALEFFADG
QGCDLVITDHAMPGMTGAELARHLRSSFPGLPIILASGYAEFSEDHGLGRMLRMKKPFTQEQLQAAMDQALSGKVAAA
>Mature_558_residues
MNPVNILLVDDQPAKLLSYEVILEELQENLIKAQSAREAFEHLLRTEIAVILVDVCMPEQDGFELVSMIRQHPRYQNTPI
IFVSAVMLAEPDRLRGYAVGAVDYVSVPIVPEVLRAKVRVFADLYRKTRELERLNVELEARVHQRTAELEASAAQLRELN
EELEHRIDQRTREREEALAQLFEAQKLDTIGHLTGGVAHDFNNLLMAVLGSLNLLKKRLPADERSERLVTNAIQAAERGT
ALTQRLLAFARRQELKPQAVDFFRLFENVEDLLAKAVGPRIEIRKSIPADLAPLLVDSNQLELALLNLFVNARDALESGG
AVTVAAAAAEDARPAGLAGGNYIRISVSDDGEGMDEATVSRAAEPFFTTKGVGKGTGLGLSMVHGLAAQSGGSIQISSVR
GKGTTVSLWLPVAETFVKVQPPVEPPATEPLKPASRPLAILVVDDDALVRTGTVAMLEDLGHLPQEASSASQALEFFADG
QGCDLVITDHAMPGMTGAELARHLRSSFPGLPIILASGYAEFSEDHGLGRMLRMKKPFTQEQLQAAMDQALSGKVAAA

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=245, Percent_Identity=33.0612244897959, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1788549, Length=284, Percent_Identity=27.4647887323944, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI48994928, Length=373, Percent_Identity=28.1501340482574, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1788713, Length=373, Percent_Identity=26.5415549597855, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI87081816, Length=182, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 60693; Mature: 60693

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPVNILLVDDQPAKLLSYEVILEELQENLIKAQSAREAFEHLLRTEIAVILVDVCMPEQ
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DGFELVSMIRQHPRYQNTPIIFVSAVMLAEPDRLRGYAVGAVDYVSVPIVPEVLRAKVRV
CCHHHHHHHHHCCCCCCCCEEEEEHHHHCCCHHHCCEEECCHHHEECCCHHHHHHHHHHH
FADLYRKTRELERLNVELEARVHQRTAELEASAAQLRELNEELEHRIDQRTREREEALAQ
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFEAQKLDTIGHLTGGVAHDFNNLLMAVLGSLNLLKKRLPADERSERLVTNAIQAAERGT
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
ALTQRLLAFARRQELKPQAVDFFRLFENVEDLLAKAVGPRIEIRKSIPADLAPLLVDSNQ
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEHHCCCCHHHHHHCCCCC
LELALLNLFVNARDALESGGAVTVAAAAAEDARPAGLAGGNYIRISVSDDGEGMDEATVS
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHH
RAAEPFFTTKGVGKGTGLGLSMVHGLAAQSGGSIQISSVRGKGTTVSLWLPVAETFVKVQ
HCCCCCEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEHHHHHEECC
PPVEPPATEPLKPASRPLAILVVDDDALVRTGTVAMLEDLGHLPQEASSASQALEFFADG
CCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
QGCDLVITDHAMPGMTGAELARHLRSSFPGLPIILASGYAEFSEDHGLGRMLRMKKPFTQ
CCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHCCCHHHHHHHCCCCCH
EQLQAAMDQALSGKVAAA
HHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNPVNILLVDDQPAKLLSYEVILEELQENLIKAQSAREAFEHLLRTEIAVILVDVCMPEQ
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DGFELVSMIRQHPRYQNTPIIFVSAVMLAEPDRLRGYAVGAVDYVSVPIVPEVLRAKVRV
CCHHHHHHHHHCCCCCCCCEEEEEHHHHCCCHHHCCEEECCHHHEECCCHHHHHHHHHHH
FADLYRKTRELERLNVELEARVHQRTAELEASAAQLRELNEELEHRIDQRTREREEALAQ
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFEAQKLDTIGHLTGGVAHDFNNLLMAVLGSLNLLKKRLPADERSERLVTNAIQAAERGT
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
ALTQRLLAFARRQELKPQAVDFFRLFENVEDLLAKAVGPRIEIRKSIPADLAPLLVDSNQ
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEHHCCCCHHHHHHCCCCC
LELALLNLFVNARDALESGGAVTVAAAAAEDARPAGLAGGNYIRISVSDDGEGMDEATVS
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHH
RAAEPFFTTKGVGKGTGLGLSMVHGLAAQSGGSIQISSVRGKGTTVSLWLPVAETFVKVQ
HCCCCCEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEHHHHHEECC
PPVEPPATEPLKPASRPLAILVVDDDALVRTGTVAMLEDLGHLPQEASSASQALEFFADG
CCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
QGCDLVITDHAMPGMTGAELARHLRSSFPGLPIILASGYAEFSEDHGLGRMLRMKKPFTQ
CCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHCCCHHHHHHHCCCCCH
EQLQAAMDQALSGKVAAA
HHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA