Click here to switch to the map view.

The map label for this gene is argE [H]

Identifier: 116249298

GI number: 116249298

Start: 689820

End: 690941

Strand: Reverse

Name: argE [H]

Synonym: pRL120633

Alternate gene names: 116249298

Gene position: 690941-689820 (Counterclockwise)

Preceding gene: 116249300

Following gene: 116249297

Centisome position: 79.42

GC content: 67.74

Gene sequence:

>1122_bases
ATGCAGGCCATTGAAATTCTCGAAAGGCTCGTCGGCTTCCCCTCCGTCGTCGGCACGCCGAACCGCGAGATCGTCGCATG
GATTCGGCACTATCTGCAAAGCCACGGCGCCGTCGTGACGGAGCTCCCCGGCCCGGAGGGCGACCGGTCGAACCTCTTCG
CCACGATCGGCCCGAAGGGGGAGCCGGGCTATATCCTCTCAGGCCATATGGACGTGGTCCCCGCCGCCGAAGGCGGCTGG
ACCAGCGATCCGTTTCGGCTGCGCGCCGAAGCGGACCGCCTCTACGGTCGCGGCGCCACCGACATGAAGGGTTTCCTGGC
CGCCGTTCTCGCCGCCGTCCCAGTGCTGGCGGAAACACCGCTTCGCCGCCCCGTCCACCTTGCCTTTTCCTATGACGAGG
AAGCCGGCTGCCGCGGCGTGCCGCACATGATCGCCCGCCTGCCGGAGCTCTGCGCAACTCCGCTTGGCGCGATCATCGGC
GAGCCGAGCGGCATGCGGGCGATCCGCGCCCACAAAGGCAAGGCCGCGGCCCGGCTGACGGTCAAGGGCCGGTCCGGCCA
CTCCTCGCGCCCGGACCAGGGACTGAACGCAATCCATGCCATTACCGACGTCCTGGCTTGCGCTCGCGCCGAAGCCGAAC
GGCTCACGCGCGGCCCTTTCGAGCATGTTTTCGAACCGCCCTACTCCTCCCTTCAGGTCGGCACGCTGAAGGGCGGCCAG
GCGGTCAACATCATTCCCGACACCTGCGAGGCCGAGTTCGAAGCGCGGGCTATTTCCGGCGTCGATCCGATCACGCTTCT
GGCGCCGCTCCGGGCAGCGGCCGAGGGACTATCGCAGCTTGGCTTTCAGGTGGAATGGCGCGAACTCAGCGCCTATCCGG
CACTTTCGCTTGCCGCCGATGCGCCTCTTGCAACTCTGCTCCGCGAACTGACCGGTCTCGAGCCGCTCGCCGCCGTCAGC
TATGGCACCGAGGCCGGGCTTTTTCAGCGCGCAGGCATCGATGCAATCATCTGCGGACCCGGCGACATCGGCCGCGCCCA
CAAGCCGGACGAATTCATCCTCGCCGGCGAACTGCTCGCCTGCCAGGCGATGATCGAGGCACTCGGCCGCCGTTGCGCCT
GA

Upstream 100 bases:

>100_bases
GAAATGTCACCTCCCTCAGCCCAGTTGCAAACACCTCTAACATCTCGCTGGGCCGAATTGTCGTTTCCGTCGGCGGCAGG
GCATGCTTGTGAGGTCGGAG

Downstream 100 bases:

>100_bases
TGACATGATCGAGGAACCGACGCCATGACCTTTCTCTTCAATTCCGATGTGAAGCGCGGCGCCATATTCGCCGAAGCCTT
CGCGCGCGAACTGCCCGACA

Product: acetylornithine deacetylase

Products: NA

Alternate protein names: AO; Acetylornithinase; N-acetylornithinase; NAO [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MQAIEILERLVGFPSVVGTPNREIVAWIRHYLQSHGAVVTELPGPEGDRSNLFATIGPKGEPGYILSGHMDVVPAAEGGW
TSDPFRLRAEADRLYGRGATDMKGFLAAVLAAVPVLAETPLRRPVHLAFSYDEEAGCRGVPHMIARLPELCATPLGAIIG
EPSGMRAIRAHKGKAAARLTVKGRSGHSSRPDQGLNAIHAITDVLACARAEAERLTRGPFEHVFEPPYSSLQVGTLKGGQ
AVNIIPDTCEAEFEARAISGVDPITLLAPLRAAAEGLSQLGFQVEWRELSAYPALSLAADAPLATLLRELTGLEPLAAVS
YGTEAGLFQRAGIDAIICGPGDIGRAHKPDEFILAGELLACQAMIEALGRRCA

Sequences:

>Translated_373_residues
MQAIEILERLVGFPSVVGTPNREIVAWIRHYLQSHGAVVTELPGPEGDRSNLFATIGPKGEPGYILSGHMDVVPAAEGGW
TSDPFRLRAEADRLYGRGATDMKGFLAAVLAAVPVLAETPLRRPVHLAFSYDEEAGCRGVPHMIARLPELCATPLGAIIG
EPSGMRAIRAHKGKAAARLTVKGRSGHSSRPDQGLNAIHAITDVLACARAEAERLTRGPFEHVFEPPYSSLQVGTLKGGQ
AVNIIPDTCEAEFEARAISGVDPITLLAPLRAAAEGLSQLGFQVEWRELSAYPALSLAADAPLATLLRELTGLEPLAAVS
YGTEAGLFQRAGIDAIICGPGDIGRAHKPDEFILAGELLACQAMIEALGRRCA
>Mature_373_residues
MQAIEILERLVGFPSVVGTPNREIVAWIRHYLQSHGAVVTELPGPEGDRSNLFATIGPKGEPGYILSGHMDVVPAAEGGW
TSDPFRLRAEADRLYGRGATDMKGFLAAVLAAVPVLAETPLRRPVHLAFSYDEEAGCRGVPHMIARLPELCATPLGAIIG
EPSGMRAIRAHKGKAAARLTVKGRSGHSSRPDQGLNAIHAITDVLACARAEAERLTRGPFEHVFEPPYSSLQVGTLKGGQ
AVNIIPDTCEAEFEARAISGVDPITLLAPLRAAAEGLSQLGFQVEWRELSAYPALSLAADAPLATLLRELTGLEPLAAVS
YGTEAGLFQRAGIDAIICGPGDIGRAHKPDEFILAGELLACQAMIEALGRRCA

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. ArgE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501901, Length=237, Percent_Identity=31.2236286919831, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1790395, Length=362, Percent_Identity=32.3204419889503, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI1788816, Length=379, Percent_Identity=27.4406332453826, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1789236, Length=329, Percent_Identity=23.7082066869301, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17551016, Length=382, Percent_Identity=28.0104712041885, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17563146, Length=159, Percent_Identity=28.9308176100629, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24649212, Length=319, Percent_Identity=26.6457680250784, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010169
- InterPro:   IPR001261
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.16 [H]

Molecular weight: Translated: 39520; Mature: 39520

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00759 ARGE_DAPE_CPG2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAIEILERLVGFPSVVGTPNREIVAWIRHYLQSHGAVVTELPGPEGDRSNLFATIGPKG
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEECCCC
EPGYILSGHMDVVPAAEGGWTSDPFRLRAEADRLYGRGATDMKGFLAAVLAAVPVLAETP
CCCEEEECCCEEEECCCCCCCCCCEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
LRRPVHLAFSYDEEAGCRGVPHMIARLPELCATPLGAIIGEPSGMRAIRAHKGKAAARLT
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHCCCCCEEEEE
VKGRSGHSSRPDQGLNAIHAITDVLACARAEAERLTRGPFEHVFEPPYSSLQVGTLKGGQ
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEEECCCC
AVNIIPDTCEAEFEARAISGVDPITLLAPLRAAAEGLSQLGFQVEWRELSAYPALSLAAD
EEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHCCCCCHHHHCC
APLATLLRELTGLEPLAAVSYGTEAGLFQRAGIDAIICGPGDIGRAHKPDEFILAGELLA
CCHHHHHHHHHCCCHHHHHHCCCCCCHHHHCCCCEEEECCCCCCCCCCCCCEEEHHHHHH
CQAMIEALGRRCA
HHHHHHHHHHCCC
>Mature Secondary Structure
MQAIEILERLVGFPSVVGTPNREIVAWIRHYLQSHGAVVTELPGPEGDRSNLFATIGPKG
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEECCCC
EPGYILSGHMDVVPAAEGGWTSDPFRLRAEADRLYGRGATDMKGFLAAVLAAVPVLAETP
CCCEEEECCCEEEECCCCCCCCCCEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
LRRPVHLAFSYDEEAGCRGVPHMIARLPELCATPLGAIIGEPSGMRAIRAHKGKAAARLT
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHCCCCCEEEEE
VKGRSGHSSRPDQGLNAIHAITDVLACARAEAERLTRGPFEHVFEPPYSSLQVGTLKGGQ
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEEECCCC
AVNIIPDTCEAEFEARAISGVDPITLLAPLRAAAEGLSQLGFQVEWRELSAYPALSLAAD
EEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHCCCCCHHHHCC
APLATLLRELTGLEPLAAVSYGTEAGLFQRAGIDAIICGPGDIGRAHKPDEFILAGELLA
CCHHHHHHHHHCCCHHHHHHCCCCCCHHHHCCCCEEEECCCCCCCCCCCCCEEEHHHHHH
CQAMIEALGRRCA
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10692366 [H]