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The map label for this gene is esd [H]

Identifier: 116249189

GI number: 116249189

Start: 570267

End: 571103

Strand: Direct

Name: esd [H]

Synonym: pRL120525

Alternate gene names: 116249189

Gene position: 570267-571103 (Clockwise)

Preceding gene: 116249188

Following gene: 116249190

Centisome position: 65.55

GC content: 61.17

Gene sequence:

>837_bases
ATGAAGACGATCTCGACCGAAAATTCTCATGGCGGCACCCAGGGCGTTTACCTCGATCGCTCGGACGCCTGCGACTGCGA
CATGACCTTTGCGGTCTTCCTGCCGCCGCAGGCCAAAGCACGGAAGCTGCCGGTTCTATGGTACCTTTCCGGTCTGACCT
GCACCCATGCCAACGTCATGGAAAAGGGCGAGTATCGGCGTCTTGCCGCAGAACTTGGCATCATCGTCGTCTGCCCCGAC
ACCAGTCCGCGGGGCGATGCCGTCCCGGACGAAGCTGATAATTGGCAGTTCGGCAAGGGTGCCGGCTTCTACGTCGACGC
CACCGAGCCGCCGTTCGTACAGAACTATCGGATGTACAGCTACGTCGTCGATGAATTGCCGAAGCTTATCGCCGCCGAGT
TTCCGGTCGACATGGACCGACAGGGCATCTTCGGACACTCGATGGGCGGACATGGCGCGATCACGATTGCGCTCAAGAAC
CCCGGACGCTTCGGCAGCTGCTCGGCCTTCGCTCCGATCAGCCACCCCTCGGTCTCCGGTTGGTCAAAGCCGGCATTCCG
GAAATACCTCGGATCGGATGAAACGGCCTGGCGGGCATATGATGCCTGCTCGCTGATCGAAGATGGGCACCGGTTCCCCG
AATTCCTCGTCGACCAGGGGACGGCGGATAGCTTCCTGGAGGAGGGATTGCGCCCCGAAGAGCTCAGGCAAGCCTGCGAG
ACGGCCGGCATCAGCCTGCGGCTTCGCATGCAGGAAGGCTACGGCCACTCCTACTTCTTCATTTCGACATTCATGGAAGA
CCATCTGCGCTGGCACGCGCGGAGGTTGGGAGACTGA

Upstream 100 bases:

>100_bases
TCCGATGATCACCCACACAATGCCGCTCGAAGACATCAACAAGGGCTTCGAGCTGATGCACAAGGGCGAAAGCATCCGCG
GCGTGGTCGTGTACTGAGCC

Downstream 100 bases:

>100_bases
TTGCAGAGCTTGGCCGGGCATATCGCAAACGGCCCAGAAGGGGAGGAGAAACCCATGACCAGCATAGCCATACATCCGGC
AGTGGATTCAGGCTTTCGGG

Product: putative esterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MKTISTENSHGGTQGVYLDRSDACDCDMTFAVFLPPQAKARKLPVLWYLSGLTCTHANVMEKGEYRRLAAELGIIVVCPD
TSPRGDAVPDEADNWQFGKGAGFYVDATEPPFVQNYRMYSYVVDELPKLIAAEFPVDMDRQGIFGHSMGGHGAITIALKN
PGRFGSCSAFAPISHPSVSGWSKPAFRKYLGSDETAWRAYDACSLIEDGHRFPEFLVDQGTADSFLEEGLRPEELRQACE
TAGISLRLRMQEGYGHSYFFISTFMEDHLRWHARRLGD

Sequences:

>Translated_278_residues
MKTISTENSHGGTQGVYLDRSDACDCDMTFAVFLPPQAKARKLPVLWYLSGLTCTHANVMEKGEYRRLAAELGIIVVCPD
TSPRGDAVPDEADNWQFGKGAGFYVDATEPPFVQNYRMYSYVVDELPKLIAAEFPVDMDRQGIFGHSMGGHGAITIALKN
PGRFGSCSAFAPISHPSVSGWSKPAFRKYLGSDETAWRAYDACSLIEDGHRFPEFLVDQGTADSFLEEGLRPEELRQACE
TAGISLRLRMQEGYGHSYFFISTFMEDHLRWHARRLGD
>Mature_278_residues
MKTISTENSHGGTQGVYLDRSDACDCDMTFAVFLPPQAKARKLPVLWYLSGLTCTHANVMEKGEYRRLAAELGIIVVCPD
TSPRGDAVPDEADNWQFGKGAGFYVDATEPPFVQNYRMYSYVVDELPKLIAAEFPVDMDRQGIFGHSMGGHGAITIALKN
PGRFGSCSAFAPISHPSVSGWSKPAFRKYLGSDETAWRAYDACSLIEDGHRFPEFLVDQGTADSFLEEGLRPEELRQACE
TAGISLRLRMQEGYGHSYFFISTFMEDHLRWHARRLGD

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable) [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=280, Percent_Identity=52.1428571428571, Blast_Score=300, Evalue=1e-81,
Organism=Escherichia coli, GI1786551, Length=277, Percent_Identity=46.2093862815885, Blast_Score=265, Evalue=2e-72,
Organism=Escherichia coli, GI1788477, Length=278, Percent_Identity=46.7625899280576, Blast_Score=253, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI17510185, Length=278, Percent_Identity=47.841726618705, Blast_Score=256, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6322393, Length=297, Percent_Identity=39.0572390572391, Blast_Score=211, Evalue=1e-55,
Organism=Drosophila melanogaster, GI45551932, Length=280, Percent_Identity=48.2142857142857, Blast_Score=261, Evalue=4e-70,
Organism=Drosophila melanogaster, GI24648347, Length=280, Percent_Identity=48.2142857142857, Blast_Score=261, Evalue=4e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 30968; Mature: 30968

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTISTENSHGGTQGVYLDRSDACDCDMTFAVFLPPQAKARKLPVLWYLSGLTCTHANVM
CCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEECCCHHHCCCCEEEEECCCEECCHHHH
EKGEYRRLAAELGIIVVCPDTSPRGDAVPDEADNWQFGKGAGFYVDATEPPFVQNYRMYS
HCCHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHH
YVVDELPKLIAAEFPVDMDRQGIFGHSMGGHGAITIALKNPGRFGSCSAFAPISHPSVSG
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCC
WSKPAFRKYLGSDETAWRAYDACSLIEDGHRFPEFLVDQGTADSFLEEGLRPEELRQACE
CCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHCCCHHHHHHHHH
TAGISLRLRMQEGYGHSYFFISTFMEDHLRWHARRLGD
HCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTISTENSHGGTQGVYLDRSDACDCDMTFAVFLPPQAKARKLPVLWYLSGLTCTHANVM
CCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEECCCHHHCCCCEEEEECCCEECCHHHH
EKGEYRRLAAELGIIVVCPDTSPRGDAVPDEADNWQFGKGAGFYVDATEPPFVQNYRMYS
HCCHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHH
YVVDELPKLIAAEFPVDMDRQGIFGHSMGGHGAITIALKNPGRFGSCSAFAPISHPSVSG
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCC
WSKPAFRKYLGSDETAWRAYDACSLIEDGHRFPEFLVDQGTADSFLEEGLRPEELRQACE
CCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHCCCHHHHHHHHH
TAGISLRLRMQEGYGHSYFFISTFMEDHLRWHARRLGD
HCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8892832 [H]