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The map label for this gene is hbpA [H]

Identifier: 116249100

GI number: 116249100

Start: 467024

End: 468634

Strand: Reverse

Name: hbpA [H]

Synonym: pRL120434

Alternate gene names: 116249100

Gene position: 468634-467024 (Counterclockwise)

Preceding gene: 116249103

Following gene: 116249099

Centisome position: 53.86

GC content: 58.04

Gene sequence:

>1611_bases
ATGATCTTCCGCACGGCAATCCTTGCAGTATCTGCTACGTTTGCAATGATGACGGCAAACGCAAGCGGAGCGCTGGCTGC
GGGTACGTTGCGCATCGGGATGACTGCCTCCGATATTCCCCTGACGACTGGCCAAACTGACCAAGGGGGCGAGGGTCAGC
GGTTCATGGGCTATACCGTCTACAATTCGCTCATCGAATGGGATCTGACGAGCGCAGACAAGCCTTCGAGCCTGATACCG
AGCCTTGCGGTCTCCTGGGACGTCGACGCGACTGATAAAACGAAATGGGTATTCAAGCTTCGTGATGGGGTGAAGTTTCA
TGATGGCAGCGCCTTTGACGCGAATGCCGTTGTATGGAATCTCGACAAGATCCTGAAGCAGGATGCCCCACAGTTCGACA
AGCGTCAGTCCGCGCAAGGCAAATCACGCATTCCGGCCGTTGCCTCCTACAAGGTCATCGATCCGCTCACGGTCGAAATT
ACCACCAAGACACCGGATGCCACCCTGCCCTATCAGATCAGCTGGATCCTGATATCATCGCCGACGAACTGGGAAGCCCA
GAACAAGAGCTGGGACGCGGTTGCCCAGAAACCCTCCGGCACCGGCCCATGGAAAATGGAAAGTGGTTTCACCCCGCGCG
AGCGCGTCGAGCTGACGCCGAACAAGGACTACTGGGACAAGAAGCGCGTACCACAGCTCGACAAGCTGATTCTAATCCCG
CTGCCTGAACCGAACACCCGCGTCGCCGCGCTTCGGTCCGGCCAGGTCGACTGGATCGAAGCACCGGCTCCAGATTCCGT
CAGCTCGCTGAAGGACGCAGGCTTCAAGATCATCACCAACTCCTATCCGCACAACTGGACCTGGCATTTCTCTCGTGTCG
AGGGTTCGCCGTGGAATGACATTCGCGTTCGCAAGGCGGCAAACCTTGCGGTCGATCGCGACGGCCTGAACGAACTGCTC
GGCGGCCTGTCGATCCCGGCGCAGGGCTATCTGCCGCCTGGCCACCAGTGGTTCGGCAACCCGACGTTCAAGCTGAGCTA
CAATGTCGAAGAGGCAAAGAAGCTGATGGCTGAGGCCGGTTTCGGTCCGGACAAGCCCATCACGACCAAAGTCATCATCT
CGTCCTCCGGCTCGGGCCAGATGCTGCCGTTGCAGATGAACGAATACATCCAGCAGACGCTGGCTGAAATCGGCATCAAG
ATCGAATACGAGGTCGCTGACTGGAACACCGTCATCAACATTTGGCGTGCCGGTGCTAAGGATCCGAGCGCCAAGGGTGC
GACGGCGATCAACTACAGTTACTTCATCCAGGATCCCTTCACCGCGCTGATCCGCCAGTCGCAATGCAACCTCGCACCAC
CGAACGGTACCAACTGGGGTTACTATTGCGACCCTGAGATGGATGCCCTCTTCGACAAGGTGCGCACGACCTTCGACGCT
GCCGAACAGGACAAGGTGCTTCAGCAGATCCACGAGAAATACGTGAACGAAGCCCTGTTCCTCATGGTGACCCATGACGT
CAACCCGCGTGCCATGACCGGCAAGATCAAGGGCTTCGTCCAGGCACAGAACTGGTTCCAGGACTTCTCCACCATCAGCA
TGGACCCCTGA

Upstream 100 bases:

>100_bases
CTTCTCTTCTTTCGACTGGGCAGACGCTCAGCGGCAGCAAAAAAGAGGGAACAGAATGACGCATAGGGACACTCACATTT
CCCGTAGCCAGCGAATGACC

Downstream 100 bases:

>100_bases
TCCAACGCATGGGCCTGCGCGCCGGCACGCCGGCGCGCAGTTCATTATGCCCGATCCGAACAATATTGTGAGGAAACCAT
GCTGGCCTATGCCTTGAAAC

Product: putative substrate-binding component of ABC transporter

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Hemin-binding lipoprotein [H]

Number of amino acids: Translated: 536; Mature: 536

Protein sequence:

>536_residues
MIFRTAILAVSATFAMMTANASGALAAGTLRIGMTASDIPLTTGQTDQGGEGQRFMGYTVYNSLIEWDLTSADKPSSLIP
SLAVSWDVDATDKTKWVFKLRDGVKFHDGSAFDANAVVWNLDKILKQDAPQFDKRQSAQGKSRIPAVASYKVIDPLTVEI
TTKTPDATLPYQISWILISSPTNWEAQNKSWDAVAQKPSGTGPWKMESGFTPRERVELTPNKDYWDKKRVPQLDKLILIP
LPEPNTRVAALRSGQVDWIEAPAPDSVSSLKDAGFKIITNSYPHNWTWHFSRVEGSPWNDIRVRKAANLAVDRDGLNELL
GGLSIPAQGYLPPGHQWFGNPTFKLSYNVEEAKKLMAEAGFGPDKPITTKVIISSSGSGQMLPLQMNEYIQQTLAEIGIK
IEYEVADWNTVINIWRAGAKDPSAKGATAINYSYFIQDPFTALIRQSQCNLAPPNGTNWGYYCDPEMDALFDKVRTTFDA
AEQDKVLQQIHEKYVNEALFLMVTHDVNPRAMTGKIKGFVQAQNWFQDFSTISMDP

Sequences:

>Translated_536_residues
MIFRTAILAVSATFAMMTANASGALAAGTLRIGMTASDIPLTTGQTDQGGEGQRFMGYTVYNSLIEWDLTSADKPSSLIP
SLAVSWDVDATDKTKWVFKLRDGVKFHDGSAFDANAVVWNLDKILKQDAPQFDKRQSAQGKSRIPAVASYKVIDPLTVEI
TTKTPDATLPYQISWILISSPTNWEAQNKSWDAVAQKPSGTGPWKMESGFTPRERVELTPNKDYWDKKRVPQLDKLILIP
LPEPNTRVAALRSGQVDWIEAPAPDSVSSLKDAGFKIITNSYPHNWTWHFSRVEGSPWNDIRVRKAANLAVDRDGLNELL
GGLSIPAQGYLPPGHQWFGNPTFKLSYNVEEAKKLMAEAGFGPDKPITTKVIISSSGSGQMLPLQMNEYIQQTLAEIGIK
IEYEVADWNTVINIWRAGAKDPSAKGATAINYSYFIQDPFTALIRQSQCNLAPPNGTNWGYYCDPEMDALFDKVRTTFDA
AEQDKVLQQIHEKYVNEALFLMVTHDVNPRAMTGKIKGFVQAQNWFQDFSTISMDP
>Mature_536_residues
MIFRTAILAVSATFAMMTANASGALAAGTLRIGMTASDIPLTTGQTDQGGEGQRFMGYTVYNSLIEWDLTSADKPSSLIP
SLAVSWDVDATDKTKWVFKLRDGVKFHDGSAFDANAVVWNLDKILKQDAPQFDKRQSAQGKSRIPAVASYKVIDPLTVEI
TTKTPDATLPYQISWILISSPTNWEAQNKSWDAVAQKPSGTGPWKMESGFTPRERVELTPNKDYWDKKRVPQLDKLILIP
LPEPNTRVAALRSGQVDWIEAPAPDSVSSLKDAGFKIITNSYPHNWTWHFSRVEGSPWNDIRVRKAANLAVDRDGLNELL
GGLSIPAQGYLPPGHQWFGNPTFKLSYNVEEAKKLMAEAGFGPDKPITTKVIISSSGSGQMLPLQMNEYIQQTLAEIGIK
IEYEVADWNTVINIWRAGAKDPSAKGATAINYSYFIQDPFTALIRQSQCNLAPPNGTNWGYYCDPEMDALFDKVRTTFDA
AEQDKVLQQIHEKYVNEALFLMVTHDVNPRAMTGKIKGFVQAQNWFQDFSTISMDP

Specific function: Important role in heme acquisition or metabolism [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=557, Percent_Identity=22.0825852782765, Blast_Score=113, Evalue=4e-26,
Organism=Escherichia coli, GI1787052, Length=499, Percent_Identity=24.8496993987976, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1787495, Length=545, Percent_Identity=23.8532110091743, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1787762, Length=474, Percent_Identity=24.6835443037975, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789887, Length=372, Percent_Identity=27.6881720430108, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789397, Length=444, Percent_Identity=22.972972972973, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787551, Length=480, Percent_Identity=22.7083333333333, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI87081878, Length=375, Percent_Identity=22.6666666666667, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 59541; Mature: 59541

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFRTAILAVSATFAMMTANASGALAAGTLRIGMTASDIPLTTGQTDQGGEGQRFMGYTV
CCCHHHHHHHHHEEEEEECCCCCCEEEEEEEEECEECCCCCCCCCCCCCCCCCEEEEHHH
YNSLIEWDLTSADKPSSLIPSLAVSWDVDATDKTKWVFKLRDGVKFHDGSAFDANAVVWN
HHHHHHCCCCCCCCCCHHCCCEEEEECCCCCCCCEEEEEECCCCEECCCCCCCCCEEEEC
LDKILKQDAPQFDKRQSAQGKSRIPAVASYKVIDPLTVEITTKTPDATLPYQISWILISS
HHHHHHCCCCCHHHHHCCCCCCCCCCEEEEEEECCEEEEEEECCCCCCCCEEEEEEEEEC
PTNWEAQNKSWDAVAQKPSGTGPWKMESGFTPRERVELTPNKDYWDKKRVPQLDKLILIP
CCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCHHEEEECCCCCCCCCCCCCCCCCEEEEE
LPEPNTRVAALRSGQVDWIEAPAPDSVSSLKDAGFKIITNSYPHNWTWHFSRVEGSPWND
CCCCCCEEEEEECCCEEEEECCCCCCHHHHHHCCEEEEECCCCCCEEEEEEECCCCCCCC
IRVRKAANLAVDRDGLNELLGGLSIPAQGYLPPGHQWFGNPTFKLSYNVEEAKKLMAEAG
EEEEECCCCEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHCC
FGPDKPITTKVIISSSGSGQMLPLQMNEYIQQTLAEIGIKIEYEVADWNTVINIWRAGAK
CCCCCCCEEEEEEECCCCCCEEEEHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCC
DPSAKGATAINYSYFIQDPFTALIRQSQCNLAPPNGTNWGYYCDPEMDALFDKVRTTFDA
CCCCCCCEEEEEEEEECCHHHHHHHHCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHCH
AEQDKVLQQIHEKYVNEALFLMVTHDVNPRAMTGKIKGFVQAQNWFQDFSTISMDP
HHHHHHHHHHHHHHHCCEEEEEEEECCCCCEEECHHHHEEHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIFRTAILAVSATFAMMTANASGALAAGTLRIGMTASDIPLTTGQTDQGGEGQRFMGYTV
CCCHHHHHHHHHEEEEEECCCCCCEEEEEEEEECEECCCCCCCCCCCCCCCCCEEEEHHH
YNSLIEWDLTSADKPSSLIPSLAVSWDVDATDKTKWVFKLRDGVKFHDGSAFDANAVVWN
HHHHHHCCCCCCCCCCHHCCCEEEEECCCCCCCCEEEEEECCCCEECCCCCCCCCEEEEC
LDKILKQDAPQFDKRQSAQGKSRIPAVASYKVIDPLTVEITTKTPDATLPYQISWILISS
HHHHHHCCCCCHHHHHCCCCCCCCCCEEEEEEECCEEEEEEECCCCCCCCEEEEEEEEEC
PTNWEAQNKSWDAVAQKPSGTGPWKMESGFTPRERVELTPNKDYWDKKRVPQLDKLILIP
CCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCHHEEEECCCCCCCCCCCCCCCCCEEEEE
LPEPNTRVAALRSGQVDWIEAPAPDSVSSLKDAGFKIITNSYPHNWTWHFSRVEGSPWND
CCCCCCEEEEEECCCEEEEECCCCCCHHHHHHCCEEEEECCCCCCEEEEEEECCCCCCCC
IRVRKAANLAVDRDGLNELLGGLSIPAQGYLPPGHQWFGNPTFKLSYNVEEAKKLMAEAG
EEEEECCCCEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHCC
FGPDKPITTKVIISSSGSGQMLPLQMNEYIQQTLAEIGIKIEYEVADWNTVINIWRAGAK
CCCCCCCEEEEEEECCCCCCEEEEHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCC
DPSAKGATAINYSYFIQDPFTALIRQSQCNLAPPNGTNWGYYCDPEMDALFDKVRTTFDA
CCCCCCCEEEEEEEEECCHHHHHHHHCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHCH
AEQDKVLQQIHEKYVNEALFLMVTHDVNPRAMTGKIKGFVQAQNWFQDFSTISMDP
HHHHHHHHHHHHHHHCCEEEEEEEECCCCCEEECHHHHEEHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339409; 7542800; 2041470 [H]