Click here to switch to the map view.

The map label for this gene is ggt [H]

Identifier: 116249004

GI number: 116249004

Start: 360063

End: 361673

Strand: Direct

Name: ggt [H]

Synonym: pRL120335

Alternate gene names: 116249004

Gene position: 360063-361673 (Clockwise)

Preceding gene: 116249003

Following gene: 116249005

Centisome position: 41.39

GC content: 60.83

Gene sequence:

>1611_bases
ATGAGAAATGCAACGATCGTAGCGCCTCAGCCGGAGGCAGTCGAAGCCGGTGCGGAAGTTCTCGAACGCGGCGGCAATGC
CATCGACGCAGCACTCGCCTGTGCTTTCGTCCAGGGCGTGGTCGACCCGCAGATGGCCGGCATCGGCGGCTTCGGCTCCA
TGCATGTCTATATGCCGAAAAAGGGTGTGCACGAGATCCTCGAATTTTATGCGCGCGCGCCGTTGAAGGCTGCGCCGGAC
ATGTGGCTCGACAAGATCAAGCACCAGAGCCGCGACGGCTTCGGCTACGTGCTTGAAGGCAATATATCCGATATCGGCTA
CCTTGCCGTCTGCACCCCCGGCTCGCTCAAGGGTTATGAGACTGCGCTGCGCGACTACGGCACCTTCGATTGGGCCGATC
TCATCAAGCCGGCTATCCGCCTTGCCCGTAACGGTTTCATGATCCGAAACCATATGCACTGGTATTGGGCCAAGGACCAG
TCGAATGACGGTTTTGCCAACACGCTCGACAAGCTGCGCTTTTCTGAAACGGGCCGGAAAGTCTATTTCCACGACGACGG
CACGCTCAAGAATGTCGGCGACCTGCTTGTCAACAAGGACATGGGAGAGACGCTCGAACGCATCGCGCGAAGCGGCGGCT
CGGACATTTTCTATCACGGCGAACTGGCCGAACAGATCGCCGGCGATTTCAAGGCAAATGGCGGCTTGATCGATCGGCAG
GATCTGGCGCGTTACGAATTGTCGAAGGTAGAGCCGGTTTGGGGCGACTACCGCGACCACCGCATCGCCACCTCGCCTCC
ACCAGGCTCGGGCTTCCCGATGCTGGAACTCCTGCATATCATGGAGCAGTTCGATGTCGGCTCGCTGCAGCATGGCAGCG
CCGATCATGTCCGCATCCTGTTCGAAGCGATGAAGCGGATGACGATCGACAAGGACGCGCATATGGGTGATCCCGCCTAT
GTCGACGTGCCCTATGAAAAGCTGCTGTCGAAAGAGCATGCAAAGGCCCATGCCCGCGCGATCAAGGCGGGCGAGATCGC
CAGTGTTTCGCGTCTTGATAGCTCGCAGCGCGACACCACCCACATCTCGGTAATCGACAAGGACGGCAATGCCGTCGCGA
TGACCCACACCCTCGGCAGTCCCTCGGGTGCGATCACCGACGGCCTCGGCTTCATGTACAATGGCACGATGAGCCGCTTT
AATCCGCTTCCCGGCAAGCCCGGCTCCATCGCGCCCGGCAAGCGGCGTCCCAGCTCGGCAGCGCCGACGATCGTCTTCAA
GGGCGACGAGCCCAGCATCGTCATTGGAGCGCCAGGCGGCAGCTATATCGCGCCGGCCGTTGCGCAATGCCTGATGAACA
TGATCGATTTCGACATGTCCGTGCTCGAAGCCGTCTCGGCGCCGAGGATCGTAGGGGTGTCGAACACGATCGACATCTGC
AATCGCATTCGACACTCTGTCGAAGACGAGCTGCGGGCGCAGGGTTACCAGGTGGCGCGGTCGCCGCAGACATACGCGTT
CGCCGCAGTCCACGCGATCAAGATTGACGGCGGCATCTCGAAAGGCGCTGCCGATCCGCAGCGTGACGGGATGGCGATCT
CCGTCGGCTAG

Upstream 100 bases:

>100_bases
TAACGTTCGATCGTGTTCCGGGCGTCTCTCACGACCGGATGAGAGTTCTCGGTCACGTCAAGGCCTTCCTGGCAAAGGTG
CTGGAGGAGCGGCGCGCGAA

Downstream 100 bases:

>100_bases
TGCATGTCGCGCAAAAGTGTGCAGCGGTTTTGCGGCAACGACATGCGTAAAAACAAAGACGTCGATTCAAAGTGTTACAG
CGTCTTTTGCGGCTCTCGGA

Product: putative acylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 536; Mature: 536

Protein sequence:

>536_residues
MRNATIVAPQPEAVEAGAEVLERGGNAIDAALACAFVQGVVDPQMAGIGGFGSMHVYMPKKGVHEILEFYARAPLKAAPD
MWLDKIKHQSRDGFGYVLEGNISDIGYLAVCTPGSLKGYETALRDYGTFDWADLIKPAIRLARNGFMIRNHMHWYWAKDQ
SNDGFANTLDKLRFSETGRKVYFHDDGTLKNVGDLLVNKDMGETLERIARSGGSDIFYHGELAEQIAGDFKANGGLIDRQ
DLARYELSKVEPVWGDYRDHRIATSPPPGSGFPMLELLHIMEQFDVGSLQHGSADHVRILFEAMKRMTIDKDAHMGDPAY
VDVPYEKLLSKEHAKAHARAIKAGEIASVSRLDSSQRDTTHISVIDKDGNAVAMTHTLGSPSGAITDGLGFMYNGTMSRF
NPLPGKPGSIAPGKRRPSSAAPTIVFKGDEPSIVIGAPGGSYIAPAVAQCLMNMIDFDMSVLEAVSAPRIVGVSNTIDIC
NRIRHSVEDELRAQGYQVARSPQTYAFAAVHAIKIDGGISKGAADPQRDGMAISVG

Sequences:

>Translated_536_residues
MRNATIVAPQPEAVEAGAEVLERGGNAIDAALACAFVQGVVDPQMAGIGGFGSMHVYMPKKGVHEILEFYARAPLKAAPD
MWLDKIKHQSRDGFGYVLEGNISDIGYLAVCTPGSLKGYETALRDYGTFDWADLIKPAIRLARNGFMIRNHMHWYWAKDQ
SNDGFANTLDKLRFSETGRKVYFHDDGTLKNVGDLLVNKDMGETLERIARSGGSDIFYHGELAEQIAGDFKANGGLIDRQ
DLARYELSKVEPVWGDYRDHRIATSPPPGSGFPMLELLHIMEQFDVGSLQHGSADHVRILFEAMKRMTIDKDAHMGDPAY
VDVPYEKLLSKEHAKAHARAIKAGEIASVSRLDSSQRDTTHISVIDKDGNAVAMTHTLGSPSGAITDGLGFMYNGTMSRF
NPLPGKPGSIAPGKRRPSSAAPTIVFKGDEPSIVIGAPGGSYIAPAVAQCLMNMIDFDMSVLEAVSAPRIVGVSNTIDIC
NRIRHSVEDELRAQGYQVARSPQTYAFAAVHAIKIDGGISKGAADPQRDGMAISVG
>Mature_536_residues
MRNATIVAPQPEAVEAGAEVLERGGNAIDAALACAFVQGVVDPQMAGIGGFGSMHVYMPKKGVHEILEFYARAPLKAAPD
MWLDKIKHQSRDGFGYVLEGNISDIGYLAVCTPGSLKGYETALRDYGTFDWADLIKPAIRLARNGFMIRNHMHWYWAKDQ
SNDGFANTLDKLRFSETGRKVYFHDDGTLKNVGDLLVNKDMGETLERIARSGGSDIFYHGELAEQIAGDFKANGGLIDRQ
DLARYELSKVEPVWGDYRDHRIATSPPPGSGFPMLELLHIMEQFDVGSLQHGSADHVRILFEAMKRMTIDKDAHMGDPAY
VDVPYEKLLSKEHAKAHARAIKAGEIASVSRLDSSQRDTTHISVIDKDGNAVAMTHTLGSPSGAITDGLGFMYNGTMSRF
NPLPGKPGSIAPGKRRPSSAAPTIVFKGDEPSIVIGAPGGSYIAPAVAQCLMNMIDFDMSVLEAVSAPRIVGVSNTIDIC
NRIRHSVEDELRAQGYQVARSPQTYAFAAVHAIKIDGGISKGAADPQRDGMAISVG

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI153266885, Length=552, Percent_Identity=25.3623188405797, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI153266901, Length=553, Percent_Identity=25.3164556962025, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI73915092, Length=559, Percent_Identity=27.3703041144902, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI73915090, Length=559, Percent_Identity=27.3703041144902, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI73915096, Length=559, Percent_Identity=27.3703041144902, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI73915094, Length=559, Percent_Identity=27.3703041144902, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI113429324, Length=559, Percent_Identity=26.654740608229, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI153266907, Length=552, Percent_Identity=23.9130434782609, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI113429326, Length=556, Percent_Identity=26.4388489208633, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI109148539, Length=512, Percent_Identity=25, Blast_Score=112, Evalue=8e-25,
Organism=Escherichia coli, GI1789856, Length=482, Percent_Identity=35.8921161825726, Blast_Score=275, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI193208247, Length=509, Percent_Identity=27.8978388998035, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI193208245, Length=496, Percent_Identity=28.4274193548387, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17542894, Length=557, Percent_Identity=28.5457809694794, Blast_Score=173, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17506189, Length=506, Percent_Identity=28.8537549407115, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI212646519, Length=518, Percent_Identity=27.4131274131274, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI72000294, Length=518, Percent_Identity=27.4131274131274, Blast_Score=159, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6323330, Length=498, Percent_Identity=26.9076305220884, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI161077496, Length=548, Percent_Identity=25.3649635036496, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI161077880, Length=495, Percent_Identity=27.0707070707071, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI161077878, Length=495, Percent_Identity=27.0707070707071, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24642670, Length=496, Percent_Identity=27.0161290322581, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24642666, Length=496, Percent_Identity=27.0161290322581, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI45551474, Length=495, Percent_Identity=27.0707070707071, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI18859741, Length=530, Percent_Identity=25.8490566037736, Blast_Score=133, Evalue=4e-31,
Organism=Drosophila melanogaster, GI18859893, Length=536, Percent_Identity=25.5597014925373, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 58089; Mature: 58089

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNATIVAPQPEAVEAGAEVLERGGNAIDAALACAFVQGVVDPQMAGIGGFGSMHVYMPK
CCCCEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHCCCCCCCCEEEEECH
KGVHEILEFYARAPLKAAPDMWLDKIKHQSRDGFGYVLEGNISDIGYLAVCTPGSLKGYE
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEECCCCCCHHH
TALRDYGTFDWADLIKPAIRLARNGFMIRNHMHWYWAKDQSNDGFANTLDKLRFSETGRK
HHHHHCCCCCHHHHHHHHHHHHHCCEEEECCEEEEEECCCCCCCHHHHHHHHHHHCCCCE
VYFHDDGTLKNVGDLLVNKDMGETLERIARSGGSDIFYHGELAEQIAGDFKANGGLIDRQ
EEECCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECHHHHHHHHCCCCCCCCCCCHH
DLARYELSKVEPVWGDYRDHRIATSPPPGSGFPMLELLHIMEQFDVGSLQHGSADHVRIL
HHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHH
FEAMKRMTIDKDAHMGDPAYVDVPYEKLLSKEHAKAHARAIKAGEIASVSRLDSSQRDTT
HHHHHHHCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCE
HISVIDKDGNAVAMTHTLGSPSGAITDGLGFMYNGTMSRFNPLPGKPGSIAPGKRRPSSA
EEEEEECCCCEEEEEEECCCCCCCHHCCCCCEECCCHHHCCCCCCCCCCCCCCCCCCCCC
APTIVFKGDEPSIVIGAPGGSYIAPAVAQCLMNMIDFDMSVLEAVSAPRIVGVSNTIDIC
CCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHH
NRIRHSVEDELRAQGYQVARSPQTYAFAAVHAIKIDGGISKGAADPQRDGMAISVG
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure
MRNATIVAPQPEAVEAGAEVLERGGNAIDAALACAFVQGVVDPQMAGIGGFGSMHVYMPK
CCCCEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHCCCCCCCCEEEEECH
KGVHEILEFYARAPLKAAPDMWLDKIKHQSRDGFGYVLEGNISDIGYLAVCTPGSLKGYE
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEECCCCCCHHH
TALRDYGTFDWADLIKPAIRLARNGFMIRNHMHWYWAKDQSNDGFANTLDKLRFSETGRK
HHHHHCCCCCHHHHHHHHHHHHHCCEEEECCEEEEEECCCCCCCHHHHHHHHHHHCCCCE
VYFHDDGTLKNVGDLLVNKDMGETLERIARSGGSDIFYHGELAEQIAGDFKANGGLIDRQ
EEECCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECHHHHHHHHCCCCCCCCCCCHH
DLARYELSKVEPVWGDYRDHRIATSPPPGSGFPMLELLHIMEQFDVGSLQHGSADHVRIL
HHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHH
FEAMKRMTIDKDAHMGDPAYVDVPYEKLLSKEHAKAHARAIKAGEIASVSRLDSSQRDTT
HHHHHHHCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCE
HISVIDKDGNAVAMTHTLGSPSGAITDGLGFMYNGTMSRFNPLPGKPGSIAPGKRRPSSA
EEEEEECCCCEEEEEEECCCCCCCHHCCCCCEECCCHHHCCCCCCCCCCCCCCCCCCCCC
APTIVFKGDEPSIVIGAPGGSYIAPAVAQCLMNMIDFDMSVLEAVSAPRIVGVSNTIDIC
CCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHH
NRIRHSVEDELRAQGYQVARSPQTYAFAAVHAIKIDGGISKGAADPQRDGMAISVG
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]