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The map label for this gene is gyaR [H]

Identifier: 116248910

GI number: 116248910

Start: 251096

End: 252043

Strand: Reverse

Name: gyaR [H]

Synonym: pRL120240

Alternate gene names: 116248910

Gene position: 252043-251096 (Counterclockwise)

Preceding gene: 116248911

Following gene: 116248908

Centisome position: 28.97

GC content: 62.45

Gene sequence:

>948_bases
ATGAAGCCCGATGTCATCGTCGCCTATCCGCTCCGGCCCCATCAGATGGCGATGCTGGAGGAGACCTACACGCTGCACCG
GCTCGATCTCGTCAAAGGCGAAGAGCGGGATGCTCTCTTGCAACAAGCCGGCCCGATCTCTTCCGCGCTGGTCTGCAACG
GCCATGTGACGATCGACGAAGCCCTGCTTTCGAAATTGCCGGCATTAAAGCTCGCCGCCTGTTCCTCGGCTGGTTACGAC
CAGATGGATCTCGAGGCGATGACCCGGCGCGGCATCAAGCTCACCAACACATCCGAAGTGCTGTGCGACGACGTTGCCGA
CATGGCACTGCTTCTGATGCTGGCGGCACGCCGGCGCCTGCCGGAAGGCGATCGCTATGTGCGCTCCGGCGATTGGGGGC
AGAAGGGCATGATGCCGCTGACGACATCGACGTCGGGCAAGAAGGCCGGGATCGTCGGCCTCGGCCGCATAGGGATGGCG
ATTGCCAAGCGATGCGAAGCTGTCGGACTGACGATCGGCTATTATGGGAGGACGAAGAAAGCCGGCAACGATTTTGCCTA
TTTCGACGCGCCGGTAAAACTGGCGGACTGGGCCGATATCCTGATCGTCGCGACCCCCGGTGGGCCCTCGACCGAGGGGT
TGATTTCGGCGGACGTGCTGAATGCGCTCGGACCGACGGGCAGCTTCATCAACATTGCCCGCGGCACCGTGGTCGACGAA
CCTGCCTTGATCAAGGCCTTGCAGGAAAGGCGGATCGCCTCGGCCGGCATCGATGTCTACCTCAACGAACCCAATCCCGA
TCCGCGCTTCGCGGCGCTCGACAACGTTGTGCTCTATCCCCATCATGCCAGCGGCACCGAGGAAACGCGCGACAGGATGG
CGCAGTTGACGGTCGACAACCTTGCCGCCTTCTTCGCAGGCAGGCCGCTGCTGACGCCGGTCAATTGA

Upstream 100 bases:

>100_bases
CCTACACGCAGGCGCTTCTTGCCGCGAGCCTCGATCCCGATCCGGAGATCCAGGCCACCCGACGCGCCGCCCGCCAACGA
CAGGAAGGACTCGTTTCCGC

Downstream 100 bases:

>100_bases
CTCCGGCAAAGCCCGCGGCGCGGCAGATCAGACGAAGTAGTCCGGGAACTCCTTCCGCAGGTCTTCCACTTTTGCGACGG
TGCGGCTGAGATGCTCACGG

Product: putative glyoxylate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MKPDVIVAYPLRPHQMAMLEETYTLHRLDLVKGEERDALLQQAGPISSALVCNGHVTIDEALLSKLPALKLAACSSAGYD
QMDLEAMTRRGIKLTNTSEVLCDDVADMALLLMLAARRRLPEGDRYVRSGDWGQKGMMPLTTSTSGKKAGIVGLGRIGMA
IAKRCEAVGLTIGYYGRTKKAGNDFAYFDAPVKLADWADILIVATPGGPSTEGLISADVLNALGPTGSFINIARGTVVDE
PALIKALQERRIASAGIDVYLNEPNPDPRFAALDNVVLYPHHASGTEETRDRMAQLTVDNLAAFFAGRPLLTPVN

Sequences:

>Translated_315_residues
MKPDVIVAYPLRPHQMAMLEETYTLHRLDLVKGEERDALLQQAGPISSALVCNGHVTIDEALLSKLPALKLAACSSAGYD
QMDLEAMTRRGIKLTNTSEVLCDDVADMALLLMLAARRRLPEGDRYVRSGDWGQKGMMPLTTSTSGKKAGIVGLGRIGMA
IAKRCEAVGLTIGYYGRTKKAGNDFAYFDAPVKLADWADILIVATPGGPSTEGLISADVLNALGPTGSFINIARGTVVDE
PALIKALQERRIASAGIDVYLNEPNPDPRFAALDNVVLYPHHASGTEETRDRMAQLTVDNLAAFFAGRPLLTPVN
>Mature_315_residues
MKPDVIVAYPLRPHQMAMLEETYTLHRLDLVKGEERDALLQQAGPISSALVCNGHVTIDEALLSKLPALKLAACSSAGYD
QMDLEAMTRRGIKLTNTSEVLCDDVADMALLLMLAARRRLPEGDRYVRSGDWGQKGMMPLTTSTSGKKAGIVGLGRIGMA
IAKRCEAVGLTIGYYGRTKKAGNDFAYFDAPVKLADWADILIVATPGGPSTEGLISADVLNALGPTGSFINIARGTVVDE
PALIKALQERRIASAGIDVYLNEPNPDPRFAALDNVVLYPHHASGTEETRDRMAQLTVDNLAAFFAGRPLLTPVN

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=271, Percent_Identity=36.1623616236162, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI23308577, Length=250, Percent_Identity=31.6, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI4557497, Length=264, Percent_Identity=26.1363636363636, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI61743967, Length=264, Percent_Identity=26.1363636363636, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI145580578, Length=266, Percent_Identity=25.5639097744361, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI4557499, Length=266, Percent_Identity=25.5639097744361, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI145580575, Length=269, Percent_Identity=25.6505576208178, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI87082289, Length=323, Percent_Identity=35.6037151702786, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1789279, Length=268, Percent_Identity=30.2238805970149, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787645, Length=255, Percent_Identity=25.8823529411765, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17532191, Length=257, Percent_Identity=28.0155642023346, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25147481, Length=293, Percent_Identity=25.938566552901, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324055, Length=253, Percent_Identity=32.8063241106719, Blast_Score=135, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6320925, Length=236, Percent_Identity=31.3559322033898, Blast_Score=102, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6322116, Length=252, Percent_Identity=29.7619047619048, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6321253, Length=278, Percent_Identity=27.6978417266187, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=372, Percent_Identity=23.1182795698925, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28574284, Length=320, Percent_Identity=32.5, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24585514, Length=320, Percent_Identity=32.5, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI28574282, Length=320, Percent_Identity=32.5, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI45551003, Length=320, Percent_Identity=32.5, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI45552429, Length=320, Percent_Identity=32.5, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI28571528, Length=275, Percent_Identity=35.6363636363636, Blast_Score=131, Evalue=6e-31,
Organism=Drosophila melanogaster, GI28574286, Length=256, Percent_Identity=33.984375, Blast_Score=130, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24585516, Length=285, Percent_Identity=29.8245614035088, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI19921140, Length=282, Percent_Identity=28.3687943262411, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24646446, Length=241, Percent_Identity=29.045643153527, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24646448, Length=241, Percent_Identity=29.045643153527, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24646452, Length=241, Percent_Identity=29.045643153527, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24646450, Length=241, Percent_Identity=29.045643153527, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI62472511, Length=241, Percent_Identity=29.045643153527, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 33874; Mature: 33874

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPDVIVAYPLRPHQMAMLEETYTLHRLDLVKGEERDALLQQAGPISSALVCNGHVTIDE
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEECCCEEHHH
ALLSKLPALKLAACSSAGYDQMDLEAMTRRGIKLTNTSEVLCDDVADMALLLMLAARRRL
HHHHHCCCCEEEHHCCCCCCHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHCC
PEGDRYVRSGDWGQKGMMPLTTSTSGKKAGIVGLGRIGMAIAKRCEAVGLTIGYYGRTKK
CCCCCEEECCCCCCCCCEEEEECCCCCCCCEEEEHHHHHHHHHHHHHHEEEEEECCCCCC
AGNDFAYFDAPVKLADWADILIVATPGGPSTEGLISADVLNALGPTGSFINIARGTVVDE
CCCCEEEECCCEEEECCCCEEEEECCCCCCCCCEEHHHHHHHCCCCCCEEEECCCCCCCC
PALIKALQERRIASAGIDVYLNEPNPDPRFAALDNVVLYPHHASGTEETRDRMAQLTVDN
HHHHHHHHHHHHHHCCCEEEECCCCCCCCEEECCCEEEECCCCCCCHHHHHHHHHHHHHH
LAAFFAGRPLLTPVN
HHHHHCCCCCCCCCC
>Mature Secondary Structure
MKPDVIVAYPLRPHQMAMLEETYTLHRLDLVKGEERDALLQQAGPISSALVCNGHVTIDE
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEECCCEEHHH
ALLSKLPALKLAACSSAGYDQMDLEAMTRRGIKLTNTSEVLCDDVADMALLLMLAARRRL
HHHHHCCCCEEEHHCCCCCCHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHCC
PEGDRYVRSGDWGQKGMMPLTTSTSGKKAGIVGLGRIGMAIAKRCEAVGLTIGYYGRTKK
CCCCCEEECCCCCCCCCEEEEECCCCCCCCEEEEHHHHHHHHHHHHHHEEEEEECCCCCC
AGNDFAYFDAPVKLADWADILIVATPGGPSTEGLISADVLNALGPTGSFINIARGTVVDE
CCCCEEEECCCEEEECCCCEEEEECCCCCCCCCEEHHHHHHHCCCCCCEEEECCCCCCCC
PALIKALQERRIASAGIDVYLNEPNPDPRFAALDNVVLYPHHASGTEETRDRMAQLTVDN
HHHHHHHHHHHHHHCCCEEEECCCCCCCCEEECCCEEEECCCCCCCHHHHHHHHHHHHHH
LAAFFAGRPLLTPVN
HHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA