Click here to switch to the map view.

The map label for this gene is hsaA [H]

Identifier: 116248887

GI number: 116248887

Start: 225046

End: 226278

Strand: Reverse

Name: hsaA [H]

Synonym: pRL120217

Alternate gene names: 116248887

Gene position: 226278-225046 (Counterclockwise)

Preceding gene: 116248888

Following gene: 116248886

Centisome position: 26.01

GC content: 63.26

Gene sequence:

>1233_bases
ATGAACAATACAGCCGCCCTGTTTCCCGCCTCGGCGCGGGTCAAGACCGCATGTCTTGCAGATCGCATCGCCCCGCTGCT
GGACGAAATCCGTGCCGGCGCGCGCGATACCGAAAAATCCGGCCGCGTGCCGGCCCGCTCTATCGATCTGCTGCGCTCCG
CCGGCTATTTCGATATCGTCAAACCGGCCCGCTTTGGCGGCGACGAAGGATCCTTTGCCGAGCTTGTCGATGCAAATATC
GAACTGTCGTCGGCCTGCGCCTCCACCGGCTGGGTTGCCGGCCTCCTTTCCGCACATCAATGGCTCCTTGCCATGTTCGA
TGAAAGGGTTCAGCAGGAGGTGTGGGGCAGCGATCCGGATGCGCTGCTCTGCGGTTCCTATGCGCCGGTTCGCATGGCTG
AACGCACCGAGGGTGGTTTCCGGCTATCCGGCGATTGGGCCTTTGCGAGCGGATGCGAAAATGCCCAATGGGCGCTCTGT
GCGGCGATCATTCCGCCAAACGGCGAGGGTGAGCGTCCTGTGCCGGCGTTCCTTCTGGTTCCCGCCAGCGACTATACCAT
CGCCGAGACCTGGGACGTGGTCGGCCTCGCGGGCACCGGCTCAAAAAGCCTGATCCTCAAGGATGTCTTCGTTCCCGAAT
ACCGCATTCTGAGCTTTCCGGATGCGACCTCCGGCAGGACACCGGGCGGACGTGGCTACAAGGGTATCGGGCTTTTCAAC
ATTCCGCTCCTCATGGGGGTTCCGTTCTGCCTCGGCAGCGCAGCCGTCGGTGCGGCGAAGGGCGCACTGGATAGTTATAT
CGACCAGATCGGGACACGTGTGACACGGGGTGCAGTTGCCGGTGGCAACAACAAGATCGCGGAGTTTCCGACGATCCAGC
TTCGCGTGGCGGAAGCCTCGGCATCGGTGGATGCCGCCCGCGAAATCATTCTGCGCGATATTGCCCGGGCGCAGCAACTG
GCCCAGGCCCGCGAGGATGGCACCGGCGAGATCACCGAGGAAGATCGGATTCTGGCCCGCCGCAGCCAGTCCTTTGCGGT
CAGCCTAGCGCTTCGCGCCGTCGAAGCGCTCAATGCATCGACAGGCGGTCTCGGCCTCCAGATGTCCAACCCCGTCCAGC
GGGCATGGCGCGATGCAAATGCCGTCGGGCGCCACATTTCCATGAACTGGGATGCCGTCGGCACCATGGCCGGCCAGCAA
CTGCTCGGTCTTCCGCCCAAGGGACAATTCTGA

Upstream 100 bases:

>100_bases
ACACGCCATTCCGACGACACCATCGCGCTGATGTACGAGAATTCGAAATATTGCGCGCCACAGCACGCGCTTCCTGCATC
CCAGAACTGAAGGTAGTTCC

Downstream 100 bases:

>100_bases
TCCGCCATCCTCAGCATTTCGATTCAAGACAGGAAAGAGAGCATATCGTGCAAGGCAAGATCGCGCTTGAAGAACATTTC
GCCATTCCCGAGACACTGCA

Product: putative dehydrogenase/hydroxylase

Products: NA

Alternate protein names: 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-hydroxylase [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MNNTAALFPASARVKTACLADRIAPLLDEIRAGARDTEKSGRVPARSIDLLRSAGYFDIVKPARFGGDEGSFAELVDANI
ELSSACASTGWVAGLLSAHQWLLAMFDERVQQEVWGSDPDALLCGSYAPVRMAERTEGGFRLSGDWAFASGCENAQWALC
AAIIPPNGEGERPVPAFLLVPASDYTIAETWDVVGLAGTGSKSLILKDVFVPEYRILSFPDATSGRTPGGRGYKGIGLFN
IPLLMGVPFCLGSAAVGAAKGALDSYIDQIGTRVTRGAVAGGNNKIAEFPTIQLRVAEASASVDAAREIILRDIARAQQL
AQAREDGTGEITEEDRILARRSQSFAVSLALRAVEALNASTGGLGLQMSNPVQRAWRDANAVGRHISMNWDAVGTMAGQQ
LLGLPPKGQF

Sequences:

>Translated_410_residues
MNNTAALFPASARVKTACLADRIAPLLDEIRAGARDTEKSGRVPARSIDLLRSAGYFDIVKPARFGGDEGSFAELVDANI
ELSSACASTGWVAGLLSAHQWLLAMFDERVQQEVWGSDPDALLCGSYAPVRMAERTEGGFRLSGDWAFASGCENAQWALC
AAIIPPNGEGERPVPAFLLVPASDYTIAETWDVVGLAGTGSKSLILKDVFVPEYRILSFPDATSGRTPGGRGYKGIGLFN
IPLLMGVPFCLGSAAVGAAKGALDSYIDQIGTRVTRGAVAGGNNKIAEFPTIQLRVAEASASVDAAREIILRDIARAQQL
AQAREDGTGEITEEDRILARRSQSFAVSLALRAVEALNASTGGLGLQMSNPVQRAWRDANAVGRHISMNWDAVGTMAGQQ
LLGLPPKGQF
>Mature_410_residues
MNNTAALFPASARVKTACLADRIAPLLDEIRAGARDTEKSGRVPARSIDLLRSAGYFDIVKPARFGGDEGSFAELVDANI
ELSSACASTGWVAGLLSAHQWLLAMFDERVQQEVWGSDPDALLCGSYAPVRMAERTEGGFRLSGDWAFASGCENAQWALC
AAIIPPNGEGERPVPAFLLVPASDYTIAETWDVVGLAGTGSKSLILKDVFVPEYRILSFPDATSGRTPGGRGYKGIGLFN
IPLLMGVPFCLGSAAVGAAKGALDSYIDQIGTRVTRGAVAGGNNKIAEFPTIQLRVAEASASVDAAREIILRDIARAQQL
AQAREDGTGEITEEDRILARRSQSFAVSLALRAVEALNASTGGLGLQMSNPVQRAWRDANAVGRHISMNWDAVGTMAGQQ
LLGLPPKGQF

Specific function: Catalyzes the o-hydroxylation of 3-hydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy- 9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FADH(2)-utilizing monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013107
- InterPro:   IPR006092
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF08028 Acyl-CoA_dh_2; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 43394; Mature: 43394

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNTAALFPASARVKTACLADRIAPLLDEIRAGARDTEKSGRVPARSIDLLRSAGYFDIV
CCCCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHCCCCEECC
KPARFGGDEGSFAELVDANIELSSACASTGWVAGLLSAHQWLLAMFDERVQQEVWGSDPD
CHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ALLCGSYAPVRMAERTEGGFRLSGDWAFASGCENAQWALCAAIIPPNGEGERPVPAFLLV
EEEECCCCCCCHHHCCCCCEEEECCEEECCCCCCCCEEEEEEEECCCCCCCCCCCEEEEE
PASDYTIAETWDVVGLAGTGSKSLILKDVFVPEYRILSFPDATSGRTPGGRGYKGIGLFN
CCCCCEEEECCCEEEEECCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCEEEE
IPLLMGVPFCLGSAAVGAAKGALDSYIDQIGTRVTRGAVAGGNNKIAEFPTIQLRVAEAS
CHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCCCCEEECCEEEEEEECCC
ASVDAAREIILRDIARAQQLAQAREDGTGEITEEDRILARRSQSFAVSLALRAVEALNAS
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHCCC
TGGLGLQMSNPVQRAWRDANAVGRHISMNWDAVGTMAGQQLLGLPPKGQF
CCCCCEEECCHHHHHHHHHHHHCCEEECCCHHHHHHHCHHHCCCCCCCCC
>Mature Secondary Structure
MNNTAALFPASARVKTACLADRIAPLLDEIRAGARDTEKSGRVPARSIDLLRSAGYFDIV
CCCCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHCCCCEECC
KPARFGGDEGSFAELVDANIELSSACASTGWVAGLLSAHQWLLAMFDERVQQEVWGSDPD
CHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ALLCGSYAPVRMAERTEGGFRLSGDWAFASGCENAQWALCAAIIPPNGEGERPVPAFLLV
EEEECCCCCCCHHHCCCCCEEEECCEEECCCCCCCCEEEEEEEECCCCCCCCCCCEEEEE
PASDYTIAETWDVVGLAGTGSKSLILKDVFVPEYRILSFPDATSGRTPGGRGYKGIGLFN
CCCCCEEEECCCEEEEECCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCEEEE
IPLLMGVPFCLGSAAVGAAKGALDSYIDQIGTRVTRGAVAGGNNKIAEFPTIQLRVAEAS
CHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCCCCEEECCEEEEEEECCC
ASVDAAREIILRDIARAQQLAQAREDGTGEITEEDRILARRSQSFAVSLALRAVEALNAS
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHCCC
TGGLGLQMSNPVQRAWRDANAVGRHISMNWDAVGTMAGQQLLGLPPKGQF
CCCCCEEECCHHHHHHHHHHHHCCEEECCCHHHHHHHCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA