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The map label for this gene is mdtD [H]

Identifier: 115352635

GI number: 115352635

Start: 2846915

End: 2848384

Strand: Direct

Name: mdtD [H]

Synonym: Bamb_2584

Alternate gene names: 115352635

Gene position: 2846915-2848384 (Clockwise)

Preceding gene: 115352633

Following gene: 115352636

Centisome position: 80.05

GC content: 67.41

Gene sequence:

>1470_bases
ATGGCGGCTGTCCCGCGCCCCCGGTCCGCCCCCATGTTCCAACCCCCGCCCGCCGCCGCTCCCGGCGAAAAGAACCTCAC
CGTGATGCTGTGGCTCGTCGCGACGGGCTTCTTCATGCAGACGCTCGATGCGACGATCGTCAACACGGCGCTGCCGTCGA
TGGCCGTGAGTCTCGGCGAATCGCCGCTCCGGATGCAGTCGGTCGTGATCGCGTACTCGCTGACGATGGCGGTGATGATT
CCCGTTTCCGGCTGGCTCGCGGACACGTTCGGCACGCGGCGCGTGTTCTTCAGCGCGATCCTGGTGTTCTCGCTCGGCTC
GCTGCTGTGCGCGAACGCGCATACGCTGCAGCAGCTCGTCGTGTTCCGCGTCGTGCAGGGGGTGGGCGGCGCGATGCTGC
TGCCGGTCGGGCGGCTCGCCGTGCTGCGCACGTTCCCGGCCGAACGCTACCTGAGCGCGCTGTCGTTCGTCGCGATTCCC
GGGCTGATCGGGCCGCTGATCGGGCCGACGCTCGGCGGCTGGCTCGTGAAGATCGCGTCGTGGCACTGGATCTTCCTGAT
CAACGTGCCGGTCGGCGTCGCCGGCTGCATCGCGACCTTCTACTCGATGCCCGACTCGCGCAACCCGGCCGTCGGCCGCT
TCGACCTGAAGGGCTATCTGCTGCTGACGATCGGGATGGTCGCGATCTCGCTGTCGCTCGACGGGCTCGCCGATCTCGGC
ATGCAGCACGCGGCCGTGCTGGTACTGCTGATCCTGAGCCTCGCATGCTTCGTCGCGTACGGACTGTACGCGGTGCGCGC
GCCGCTGCCGATCTTCTCGCTCGAGCTGTTCAAGATCCATACGTTCAGCGTCGGCCTGCTCGGCAACCTGTTCGCGCGGA
TCGGCAGCGGCGCGATGCCGTACCTGATCCCGCTGCTGCTGCAGGTGAGCCTCGGCTATTCGGCGTTCGAGGCCGGGCTG
ATGATGCTGCCGGTCGCGGCGGCGGGGATGTTCTCGAAGCGGATCATCACGCAGCTGATCACGCGGCACGGCTACCGCAA
GGTGCTGCTCGTGAACACGATCATGGTGGGCGTGATGATGGCGAGCTTCGCGCTGATGCGCGACACGGTGCCCGTCTGGG
TGAAGGTCGTGCACCTCGCGCTGTTCGGCGGCTTCAACTCGATGCAGTTCACCGCGATGAACACGCTGACGCTGAAGGAT
CTCGGCACCGGCGGCGCGAGCAGCGGCAACAGCCTGTTCTCGCTCGTGCAGATGCTGTCGATGAGCCTTGGCGTCACCGT
CGCCGGTGCGCTGCTCGCGACCTTCACCGGGATGCTGCGCACGGTGACGCCGAGCAATACGCTGCCCGCGTTCCATGCGA
CCTTCATCTGCGTGGGGATCATCACGGCCGCGTCGGCGTGGATCTTCGCGCAACTCGCCCCCGAAATCCGCGGCCGCGCG
CAGAAGACCGACCCGTCCGAACGCGCGTGA

Upstream 100 bases:

>100_bases
TACGCCCAGTGCCGGTACGCCCGCTGCCGGTACGCCCGGTTTCATGTCCTGACGGCTGGCGGGGCCCCCCATTCTGCGTG
TTCCGGCGGCTTTGCCTACA

Downstream 100 bases:

>100_bases
CGCCCGGCGCACGCCGTCCAGATCGCCGCGATCGCCACGAGGGCGCGGCGCGCACCATGTCGGTGCGGCCATGCTGCACG
GCGCGGCAGCCGGCGCCCGC

Product: EmrB/QacA family drug resistance transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MAAVPRPRSAPMFQPPPAAAPGEKNLTVMLWLVATGFFMQTLDATIVNTALPSMAVSLGESPLRMQSVVIAYSLTMAVMI
PVSGWLADTFGTRRVFFSAILVFSLGSLLCANAHTLQQLVVFRVVQGVGGAMLLPVGRLAVLRTFPAERYLSALSFVAIP
GLIGPLIGPTLGGWLVKIASWHWIFLINVPVGVAGCIATFYSMPDSRNPAVGRFDLKGYLLLTIGMVAISLSLDGLADLG
MQHAAVLVLLILSLACFVAYGLYAVRAPLPIFSLELFKIHTFSVGLLGNLFARIGSGAMPYLIPLLLQVSLGYSAFEAGL
MMLPVAAAGMFSKRIITQLITRHGYRKVLLVNTIMVGVMMASFALMRDTVPVWVKVVHLALFGGFNSMQFTAMNTLTLKD
LGTGGASSGNSLFSLVQMLSMSLGVTVAGALLATFTGMLRTVTPSNTLPAFHATFICVGIITAASAWIFAQLAPEIRGRA
QKTDPSERA

Sequences:

>Translated_489_residues
MAAVPRPRSAPMFQPPPAAAPGEKNLTVMLWLVATGFFMQTLDATIVNTALPSMAVSLGESPLRMQSVVIAYSLTMAVMI
PVSGWLADTFGTRRVFFSAILVFSLGSLLCANAHTLQQLVVFRVVQGVGGAMLLPVGRLAVLRTFPAERYLSALSFVAIP
GLIGPLIGPTLGGWLVKIASWHWIFLINVPVGVAGCIATFYSMPDSRNPAVGRFDLKGYLLLTIGMVAISLSLDGLADLG
MQHAAVLVLLILSLACFVAYGLYAVRAPLPIFSLELFKIHTFSVGLLGNLFARIGSGAMPYLIPLLLQVSLGYSAFEAGL
MMLPVAAAGMFSKRIITQLITRHGYRKVLLVNTIMVGVMMASFALMRDTVPVWVKVVHLALFGGFNSMQFTAMNTLTLKD
LGTGGASSGNSLFSLVQMLSMSLGVTVAGALLATFTGMLRTVTPSNTLPAFHATFICVGIITAASAWIFAQLAPEIRGRA
QKTDPSERA
>Mature_488_residues
AAVPRPRSAPMFQPPPAAAPGEKNLTVMLWLVATGFFMQTLDATIVNTALPSMAVSLGESPLRMQSVVIAYSLTMAVMIP
VSGWLADTFGTRRVFFSAILVFSLGSLLCANAHTLQQLVVFRVVQGVGGAMLLPVGRLAVLRTFPAERYLSALSFVAIPG
LIGPLIGPTLGGWLVKIASWHWIFLINVPVGVAGCIATFYSMPDSRNPAVGRFDLKGYLLLTIGMVAISLSLDGLADLGM
QHAAVLVLLILSLACFVAYGLYAVRAPLPIFSLELFKIHTFSVGLLGNLFARIGSGAMPYLIPLLLQVSLGYSAFEAGLM
MLPVAAAGMFSKRIITQLITRHGYRKVLLVNTIMVGVMMASFALMRDTVPVWVKVVHLALFGGFNSMQFTAMNTLTLKDL
GTGGASSGNSLFSLVQMLSMSLGVTVAGALLATFTGMLRTVTPSNTLPAFHATFICVGIITAASAWIFAQLAPEIRGRAQ
KTDPSERA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=469, Percent_Identity=47.1215351812367, Blast_Score=422, Evalue=1e-119,
Organism=Escherichia coli, GI1788392, Length=461, Percent_Identity=48.8069414316703, Blast_Score=391, Evalue=1e-110,
Organism=Escherichia coli, GI1788710, Length=325, Percent_Identity=32.6153846153846, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1789042, Length=454, Percent_Identity=27.7533039647577, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI87081983, Length=321, Percent_Identity=31.7757009345794, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1788509, Length=136, Percent_Identity=33.0882352941176, Blast_Score=65, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6322958, Length=156, Percent_Identity=31.4102564102564, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323735, Length=253, Percent_Identity=25.6916996047431, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6325455, Length=129, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 52061; Mature: 51930

Theoretical pI: Translated: 10.44; Mature: 10.44

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAVPRPRSAPMFQPPPAAAPGEKNLTVMLWLVATGFFMQTLDATIVNTALPSMAVSLGE
CCCCCCCCCCCCCCCCCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SPLRMQSVVIAYSLTMAVMIPVSGWLADTFGTRRVFFSAILVFSLGSLLCANAHTLQQLV
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VFRVVQGVGGAMLLPVGRLAVLRTFPAERYLSALSFVAIPGLIGPLIGPTLGGWLVKIAS
HHHHHHHCCCEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
WHWIFLINVPVGVAGCIATFYSMPDSRNPAVGRFDLKGYLLLTIGMVAISLSLDGLADLG
EEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHH
MQHAAVLVLLILSLACFVAYGLYAVRAPLPIFSLELFKIHTFSVGLLGNLFARIGSGAMP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEHEEEEEHHHHHHHHHHHHHHCCCCHH
YLIPLLLQVSLGYSAFEAGLMMLPVAAAGMFSKRIITQLITRHGYRKVLLVNTIMVGVMM
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ASFALMRDTVPVWVKVVHLALFGGFNSMQFTAMNTLTLKDLGTGGASSGNSLFSLVQMLS
HHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCCCCCCCHHHHHHHHHHH
MSLGVTVAGALLATFTGMLRTVTPSNTLPAFHATFICVGIITAASAWIFAQLAPEIRGRA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCC
QKTDPSERA
CCCCCCCCC
>Mature Secondary Structure 
AAVPRPRSAPMFQPPPAAAPGEKNLTVMLWLVATGFFMQTLDATIVNTALPSMAVSLGE
CCCCCCCCCCCCCCCCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SPLRMQSVVIAYSLTMAVMIPVSGWLADTFGTRRVFFSAILVFSLGSLLCANAHTLQQLV
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VFRVVQGVGGAMLLPVGRLAVLRTFPAERYLSALSFVAIPGLIGPLIGPTLGGWLVKIAS
HHHHHHHCCCEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
WHWIFLINVPVGVAGCIATFYSMPDSRNPAVGRFDLKGYLLLTIGMVAISLSLDGLADLG
EEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHH
MQHAAVLVLLILSLACFVAYGLYAVRAPLPIFSLELFKIHTFSVGLLGNLFARIGSGAMP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEHEEEEEHHHHHHHHHHHHHHCCCCHH
YLIPLLLQVSLGYSAFEAGLMMLPVAAAGMFSKRIITQLITRHGYRKVLLVNTIMVGVMM
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ASFALMRDTVPVWVKVVHLALFGGFNSMQFTAMNTLTLKDLGTGGASSGNSLFSLVQMLS
HHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCCCCCCCHHHHHHHHHHH
MSLGVTVAGALLATFTGMLRTVTPSNTLPAFHATFICVGIITAASAWIFAQLAPEIRGRA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCC
QKTDPSERA
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA