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The map label for this gene is argH [H]

Identifier: 115352527

GI number: 115352527

Start: 2730541

End: 2732013

Strand: Direct

Name: argH [H]

Synonym: Bamb_2476

Alternate gene names: 115352527

Gene position: 2730541-2732013 (Clockwise)

Preceding gene: 115352526

Following gene: 115352528

Centisome position: 76.78

GC content: 67.82

Gene sequence:

>1473_bases
ATGTTAGAATTGCAGGATTCCCTCGGCGGCGCACGCCGCCCAACTCCCCTTCGAAGAATCGCCATGACGTCCCAACTGCA
CAAAAAGGGCGAGGCCTGGTCGGCCCGCTTCTCGGAACCGATGTCGGAGCTGGTCAAGCGCTACACGTCGTCGGTGTTTT
TCGACAAGCGCCTCGCGCTCGTCGACATCGCCGGCTCGCTCGCGCACGCGAGCATGCTCGCGGCGCAGAAGATCATCAGC
ACCGACGACCTCGCCGCGATCGAACGCGGGATGACGCAGATCAAGGGCGAGATCGAGCGCGGCGAATTCGAATGGCAGCT
GGATCTCGAGGACGTCCACCTGAACATCGAGGCGCGCCTGACCGCGCTGATCGGCGATGCGGGCAAGCGTCTGCACACGG
GCCGCTCGCGCAACGACCAGGTCGCGACCGACATCCGTCTGTGGCTGCGCGGCGAGATCGACCGCATCGGCGGCCTGCTG
AACGACCTGCGCGGCGCGCTGATCGACCTCGCGGAGAAGAACGCCGACACGATCATGCCGGGCTTCACGCACCTGCAGGT
CGCGCAGCCGGTCACGTTCGGCCATCACCTGCTCGCGTACGTCGAGATGTTCACGCGCGACGCGGAACGCATGCGCGACT
GCCGCACCCGCGTGAACCGCCTGCCGCTCGGCGCGGCCGCGCTCGCGGGCACCAGCTACCCGATCGACCGTCACGCCGTC
GCGAAGACGCTCGGCTTCGACGGCATCTGCGCGAACTCGCTCGACGCGGTGTCGGATCGCGACTTCGCGATCGAATTCGC
GGCGGCATCCGCGCTCGTGATGACGCACGTGTCGCGCTTCTCCGAGGAACTCGTGCTGTGGATGAGCCCGCGCGTCGGCT
TCATCGACATCGCCGATCGCTTCTGCACCGGCAGCTCGATCATGCCGCAGAAGAAGAACCCGGACGTGCCCGAGCTCGCG
CGCGGCAAGACGGGCCGCGTGAACGGCCACCTGATGGCGCTCCTCACGCTGATGAAGGGCCAGCCGCTCGCGTACAACAA
GGACAACCAGGAAGACAAGGAACCGCTGTTCGACACGGTCGACACCGTCGCCGACACGCTGCGGATCTTCGCCGAGATGG
TCGCGGGCATCACCGTGAAGCCGGACGCGATGCGCGCGGCCGCGCTGCAGGGCTTCTCGACCGCCACCGACCTCGCCGAC
TACCTCGTGAAGCGCGGGCTGCCGTTCCGCGACGCGCACGAAGCGGTCGCGCACGCGGTGCGGATCTGCGACGACCGCGG
GATCGACCTCGCCGACCTGACGCTCGACGAAATGAAGCAGGAGCTGCCGAACGTCGCGCACCTGATCGGCGACGACGTGT
TCGGCTACCTGACGCTCGAAGGTTCGGTCGCAAGCCGCAACCACGCGGGCGGCACCGCGCCCGACCAGGTGCGTGCGGCG
GTCAAGGCTGCCCGCGCCGCGCTCGGCACGTAA

Upstream 100 bases:

>100_bases
GTACCAGCGCCCCGACGACGGCACGCTGCCGCGGATCGGCCCGCTGACCTGCGGCCCGCGGTGATCCGCGGCCGGCGCGC
GCCGGCCGTCAGCCCCGCGA

Downstream 100 bases:

>100_bases
GCCCGTCGTCCCGGACGGACGCCTCCGGCGTCCGTCTTTCATTCGGGCGGCCGCCGCGCCGCCCATTGCCTGCCCCGCTT
CCCGGATACCGCCGATGACC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MLELQDSLGGARRPTPLRRIAMTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHASMLAAQKIIS
TDDLAAIERGMTQIKGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLL
NDLRGALIDLAEKNADTIMPGFTHLQVAQPVTFGHHLLAYVEMFTRDAERMRDCRTRVNRLPLGAAALAGTSYPIDRHAV
AKTLGFDGICANSLDAVSDRDFAIEFAAASALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELA
RGKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLAD
YLVKRGLPFRDAHEAVAHAVRICDDRGIDLADLTLDEMKQELPNVAHLIGDDVFGYLTLEGSVASRNHAGGTAPDQVRAA
VKAARAALGT

Sequences:

>Translated_490_residues
MLELQDSLGGARRPTPLRRIAMTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHASMLAAQKIIS
TDDLAAIERGMTQIKGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLL
NDLRGALIDLAEKNADTIMPGFTHLQVAQPVTFGHHLLAYVEMFTRDAERMRDCRTRVNRLPLGAAALAGTSYPIDRHAV
AKTLGFDGICANSLDAVSDRDFAIEFAAASALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELA
RGKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLAD
YLVKRGLPFRDAHEAVAHAVRICDDRGIDLADLTLDEMKQELPNVAHLIGDDVFGYLTLEGSVASRNHAGGTAPDQVRAA
VKAARAALGT
>Mature_490_residues
MLELQDSLGGARRPTPLRRIAMTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHASMLAAQKIIS
TDDLAAIERGMTQIKGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLL
NDLRGALIDLAEKNADTIMPGFTHLQVAQPVTFGHHLLAYVEMFTRDAERMRDCRTRVNRLPLGAAALAGTSYPIDRHAV
AKTLGFDGICANSLDAVSDRDFAIEFAAASALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELA
RGKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLAD
YLVKRGLPFRDAHEAVAHAVRICDDRGIDLADLTLDEMKQELPNVAHLIGDDVFGYLTLEGSVASRNHAGGTAPDQVRAA
VKAARAALGT

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=461, Percent_Identity=39.6963123644252, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI68303542, Length=461, Percent_Identity=39.6963123644252, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI68303547, Length=461, Percent_Identity=37.527114967462, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI68303549, Length=461, Percent_Identity=37.0932754880694, Blast_Score=311, Evalue=1e-84,
Organism=Escherichia coli, GI1790398, Length=458, Percent_Identity=44.5414847161572, Blast_Score=397, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6321806, Length=459, Percent_Identity=40.5228758169935, Blast_Score=334, Evalue=2e-92,
Organism=Drosophila melanogaster, GI221473854, Length=457, Percent_Identity=38.2932166301969, Blast_Score=309, Evalue=2e-84,
Organism=Drosophila melanogaster, GI78706858, Length=457, Percent_Identity=38.2932166301969, Blast_Score=309, Evalue=2e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 53634; Mature: 53634

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELQDSLGGARRPTPLRRIAMTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLAL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDIAGSLAHASMLAAQKIISTDDLAAIERGMTQIKGEIERGEFEWQLDLEDVHLNIEARL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHEEEEHHHHH
TALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLNDLRGALIDLAEKNADTIMP
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GFTHLQVAQPVTFGHHLLAYVEMFTRDAERMRDCRTRVNRLPLGAAALAGTSYPIDRHAV
CCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHH
AKTLGFDGICANSLDAVSDRDFAIEFAAASALVMTHVSRFSEELVLWMSPRVGFIDIADR
HHHHCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEHHHH
FCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTV
HCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
DTVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAV
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
RICDDRGIDLADLTLDEMKQELPNVAHLIGDDVFGYLTLEGSVASRNHAGGTAPDQVRAA
HHHCCCCCCHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHH
VKAARAALGT
HHHHHHHCCC
>Mature Secondary Structure
MLELQDSLGGARRPTPLRRIAMTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLAL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDIAGSLAHASMLAAQKIISTDDLAAIERGMTQIKGEIERGEFEWQLDLEDVHLNIEARL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHEEEEHHHHH
TALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLNDLRGALIDLAEKNADTIMP
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GFTHLQVAQPVTFGHHLLAYVEMFTRDAERMRDCRTRVNRLPLGAAALAGTSYPIDRHAV
CCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHH
AKTLGFDGICANSLDAVSDRDFAIEFAAASALVMTHVSRFSEELVLWMSPRVGFIDIADR
HHHHCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEHHHH
FCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTV
HCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
DTVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAV
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
RICDDRGIDLADLTLDEMKQELPNVAHLIGDDVFGYLTLEGSVASRNHAGGTAPDQVRAA
HHHCCCCCCHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHH
VKAARAALGT
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA