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The map label for this gene is uvrA [H]

Identifier: 115352050

GI number: 115352050

Start: 2194430

End: 2196715

Strand: Direct

Name: uvrA [H]

Synonym: Bamb_1999

Alternate gene names: 115352050

Gene position: 2194430-2196715 (Clockwise)

Preceding gene: 115352049

Following gene: 115352051

Centisome position: 61.7

GC content: 58.18

Gene sequence:

>2286_bases
ATGAGCCCCGTACACACCCCGTACCAGGACATGGAGATCATCGGCGCGCGCAACAACAACCTACGCAGCGTTACCGTGAA
GGTTCCCAAGCACTGCATCACAGTGTTCACCGGTGTGTCCGGCTCAGGAAAGTCCTCATTGGTGTTTGACACGATCGCGG
CTGAATCCCAGCGTCAGCTCAACGAAAGCCACAGTGCGTTCGTGCGACATCGTCTGCCGCACTACGGCCAACCGCAGGCC
GATGCCTTGCGCAATTTGCCCGCATCCATCGTGGTTGATCAGAAGCCGCTGGGCGGCAATGCGCGCTCGACAGTGGGGAC
GGCCACCGACATACAACCTTTGCTGCGGCTATTATTCTCGCGCCTGGGCGAGCCATTCGTGGGCTATTCCAATGTGTTTT
CGTTCAATCACCCGCAGGGGATGTGCCCGACCTGCCAGGGGCTGGGCATGGTCGACGAGCTTGACCTCGATCTCCTGTTC
GACCGCAACAGGTCCCTGAACCAAGGAGCAATCCGGTTTCCTACGTTCGCCCGCGGCACATTCCGCTGGAAGCGCTACGC
TTACTCAGGCTTGTTTGATTGCGACAAACCACTCGCCGACTACACCTCGGACGAATGGCAAATTTTGCTGTATGCAGACG
ATCTTGCCGTGAGCAATCCGCTGCCCGGATGGCCATCATCGGCGCGATTTCAGGGCGTCGTTCCGCGCTTTCGTCGAGCC
TATCTGGATCATGAGCCCAGTCGCCTGACCCAGGCAGAACGTGAAGGGCTCGCTCATGTCATCACTCGCCAACGGTGCCA
AGCTTGTGGTGGCACCCGCCTCAATCCGACCATCCTCTCTTGCAAGATTAAGGGAAAATCCATCGCGGACTGCACCAGTC
TGGAGATATCCGATCTGCTGATCTTCATCCGGACGATAGATTCGGAAGCCATCGCTACGGTGCTGACAGCCATTGTTGAG
AGGCTGGAGCAGATGCGCGCTATCGGCCTGGACTATCTCAGTCTGGGCCGTGAAACCGCGAGCCTATCGGGCGGCGAGTC
CCAGCGCGTGAAGATGGTTCGCCATCTTGGCAGCAGTCTGGCCGACATCGCCTACATCTTCGATGAACCCAGCGTTGGAC
TGCATCCAAGCGATGTTCACCAACTCAACACGTTGTTGCGTAGCCTGCGTGACAAAGGTAATACAGTCCTGGTGGTGGAG
CACGATCCAGATGTCATCGCCATTGCCGATCATGTGGTGGATATGGGGCCGGGCGCCGGGAAGGATGGCGGCCATGTGGT
GTACCAAGGCGATTACGCAGGTTTGCAGCAGGCCGATACCCTGACGGGGCGTTGCCTGCAACGGGTTGCGCCGATGAAAC
GCGAGCCGCGCTCTGCTACGGGACAGATCGCCTTGCAACGCCTTTCGCTGCACAACCTGCGAGATGTCAGCGTATCCATA
CCTACCGGTGTTCTGACGGTAGTGACGGGTGTCGCTGGCTCCGGCAAGAGCACGCTTGTCAACCGCCTACTGCTCCGCCA
TTGCCCGGATGCCATCCTGATCGATCAGAGAGGTTTGGGAGGAACGCGGCGCTCGTCTGTCTCAAGCTATATCGGTGTGC
TTGACAAGATTCGCTCAGGCTTCGCGCAAGCCAGCGACCAGCCCGCCAGCTTGTTCAGCAATAACGCCCAGGGGGCTTGC
CCAGCCTGCAAAGGGCTGGGCTTAGTCCAGACCGACTTGGCTTTCATGGACAGCGTGGAAACGCCTTGTGATGCCTGCAG
TACTACAGGATTCAACGAGGCGGCACGGGCGATTACCTGGATGGGCTGCAATATTGCCCAAGTGCTCGCATTCTCTGCGG
AACAGGCGCTGCGGCATTTCCAATCCTGCCAAGACATCGTTGAGCCATTGCACCGACTCTCCAATGTCGGATTGGGCTAT
CTAGCGTTGGGACAGCGACTAAACACTCTGTCAGGCGGTGAGCGCCAACGTCTGAAACTGGCATCCCGATTGGCTGAAGT
AAGCAGCTTGTATGTTCTTGACGAGCCGACGTCTGGTCTGCATATGTCCGATGTTGATCGGTTGCTTGCCATCCTTGATG
ACCTCACGCAGCGGGGTGCCACCGTCATCGTGGTCGAACACAACCTGGATGTCATGGCCCATGCTGACTGGTTGATCGAG
ATGGGCCCAGGCGCAGGCAAGAAAGGCGGAAAAGTCATCTTCGAGGGTTTGCCTACGGCAATGATCAGCGCCCCGGAATC
TGTAACGGGGCCATTCCTTTGGCGCCATTTGAATGGGCAACTGTGA

Upstream 100 bases:

>100_bases
TGGCGGCACTGACGCCTGGTGAGCAGGCCATGTTCACGGAGCTTTGCGAGAAAGCCAGCGCTGCATTGACCTCCCATGCC
TCCGAACAGGGGACACGCGC

Downstream 100 bases:

>100_bases
GGTGACGCATGGAACTTCGGCACCTGCGTTGCTTCCTTGCCGTCGCCGAAGAGCTGCATTTCGCCCGTGCGGCGGAGAAA
TTGCATGTCGAGCAATCGCC

Product: ABC transporter-like protein

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 761; Mature: 760

Protein sequence:

>761_residues
MSPVHTPYQDMEIIGARNNNLRSVTVKVPKHCITVFTGVSGSGKSSLVFDTIAAESQRQLNESHSAFVRHRLPHYGQPQA
DALRNLPASIVVDQKPLGGNARSTVGTATDIQPLLRLLFSRLGEPFVGYSNVFSFNHPQGMCPTCQGLGMVDELDLDLLF
DRNRSLNQGAIRFPTFARGTFRWKRYAYSGLFDCDKPLADYTSDEWQILLYADDLAVSNPLPGWPSSARFQGVVPRFRRA
YLDHEPSRLTQAEREGLAHVITRQRCQACGGTRLNPTILSCKIKGKSIADCTSLEISDLLIFIRTIDSEAIATVLTAIVE
RLEQMRAIGLDYLSLGRETASLSGGESQRVKMVRHLGSSLADIAYIFDEPSVGLHPSDVHQLNTLLRSLRDKGNTVLVVE
HDPDVIAIADHVVDMGPGAGKDGGHVVYQGDYAGLQQADTLTGRCLQRVAPMKREPRSATGQIALQRLSLHNLRDVSVSI
PTGVLTVVTGVAGSGKSTLVNRLLLRHCPDAILIDQRGLGGTRRSSVSSYIGVLDKIRSGFAQASDQPASLFSNNAQGAC
PACKGLGLVQTDLAFMDSVETPCDACSTTGFNEAARAITWMGCNIAQVLAFSAEQALRHFQSCQDIVEPLHRLSNVGLGY
LALGQRLNTLSGGERQRLKLASRLAEVSSLYVLDEPTSGLHMSDVDRLLAILDDLTQRGATVIVVEHNLDVMAHADWLIE
MGPGAGKKGGKVIFEGLPTAMISAPESVTGPFLWRHLNGQL

Sequences:

>Translated_761_residues
MSPVHTPYQDMEIIGARNNNLRSVTVKVPKHCITVFTGVSGSGKSSLVFDTIAAESQRQLNESHSAFVRHRLPHYGQPQA
DALRNLPASIVVDQKPLGGNARSTVGTATDIQPLLRLLFSRLGEPFVGYSNVFSFNHPQGMCPTCQGLGMVDELDLDLLF
DRNRSLNQGAIRFPTFARGTFRWKRYAYSGLFDCDKPLADYTSDEWQILLYADDLAVSNPLPGWPSSARFQGVVPRFRRA
YLDHEPSRLTQAEREGLAHVITRQRCQACGGTRLNPTILSCKIKGKSIADCTSLEISDLLIFIRTIDSEAIATVLTAIVE
RLEQMRAIGLDYLSLGRETASLSGGESQRVKMVRHLGSSLADIAYIFDEPSVGLHPSDVHQLNTLLRSLRDKGNTVLVVE
HDPDVIAIADHVVDMGPGAGKDGGHVVYQGDYAGLQQADTLTGRCLQRVAPMKREPRSATGQIALQRLSLHNLRDVSVSI
PTGVLTVVTGVAGSGKSTLVNRLLLRHCPDAILIDQRGLGGTRRSSVSSYIGVLDKIRSGFAQASDQPASLFSNNAQGAC
PACKGLGLVQTDLAFMDSVETPCDACSTTGFNEAARAITWMGCNIAQVLAFSAEQALRHFQSCQDIVEPLHRLSNVGLGY
LALGQRLNTLSGGERQRLKLASRLAEVSSLYVLDEPTSGLHMSDVDRLLAILDDLTQRGATVIVVEHNLDVMAHADWLIE
MGPGAGKKGGKVIFEGLPTAMISAPESVTGPFLWRHLNGQL
>Mature_760_residues
SPVHTPYQDMEIIGARNNNLRSVTVKVPKHCITVFTGVSGSGKSSLVFDTIAAESQRQLNESHSAFVRHRLPHYGQPQAD
ALRNLPASIVVDQKPLGGNARSTVGTATDIQPLLRLLFSRLGEPFVGYSNVFSFNHPQGMCPTCQGLGMVDELDLDLLFD
RNRSLNQGAIRFPTFARGTFRWKRYAYSGLFDCDKPLADYTSDEWQILLYADDLAVSNPLPGWPSSARFQGVVPRFRRAY
LDHEPSRLTQAEREGLAHVITRQRCQACGGTRLNPTILSCKIKGKSIADCTSLEISDLLIFIRTIDSEAIATVLTAIVER
LEQMRAIGLDYLSLGRETASLSGGESQRVKMVRHLGSSLADIAYIFDEPSVGLHPSDVHQLNTLLRSLRDKGNTVLVVEH
DPDVIAIADHVVDMGPGAGKDGGHVVYQGDYAGLQQADTLTGRCLQRVAPMKREPRSATGQIALQRLSLHNLRDVSVSIP
TGVLTVVTGVAGSGKSTLVNRLLLRHCPDAILIDQRGLGGTRRSSVSSYIGVLDKIRSGFAQASDQPASLFSNNAQGACP
ACKGLGLVQTDLAFMDSVETPCDACSTTGFNEAARAITWMGCNIAQVLAFSAEQALRHFQSCQDIVEPLHRLSNVGLGYL
ALGQRLNTLSGGERQRLKLASRLAEVSSLYVLDEPTSGLHMSDVDRLLAILDDLTQRGATVIVVEHNLDVMAHADWLIEM
GPGAGKKGGKVIFEGLPTAMISAPESVTGPFLWRHLNGQL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=698, Percent_Identity=35.243553008596, Blast_Score=378, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR003593
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 82615; Mature: 82484

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPVHTPYQDMEIIGARNNNLRSVTVKVPKHCITVFTGVSGSGKSSLVFDTIAAESQRQL
CCCCCCCCCCCEEEECCCCCEEEEEEECCHHEEHHEECCCCCCCCCEEEHHHHHHHHHHH
NESHSAFVRHRLPHYGQPQADALRNLPASIVVDQKPLGGNARSTVGTATDIQPLLRLLFS
HHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
RLGEPFVGYSNVFSFNHPQGMCPTCQGLGMVDELDLDLLFDRNRSLNQGAIRFPTFARGT
HCCCCCCCHHHCEECCCCCCCCCCCCCCCCHHHCCCEEEECCCCCCCCCCEECCCCCCCH
FRWKRYAYSGLFDCDKPLADYTSDEWQILLYADDLAVSNPLPGWPSSARFQGVVPRFRRA
HHHHHHHHCCCCCCCCCHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHH
YLDHEPSRLTQAEREGLAHVITRQRCQACGGTRLNPTILSCKIKGKSIADCTSLEISDLL
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHH
IFIRTIDSEAIATVLTAIVERLEQMRAIGLDYLSLGRETASLSGGESQRVKMVRHLGSSL
HHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHCCCCCCHHHHHHHHHHCHHH
ADIAYIFDEPSVGLHPSDVHQLNTLLRSLRDKGNTVLVVEHDPDVIAIADHVVDMGPGAG
HHHHHEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHHHHHCCCCCC
KDGGHVVYQGDYAGLQQADTLTGRCLQRVAPMKREPRSATGQIALQRLSLHNLRDVSVSI
CCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEC
PTGVLTVVTGVAGSGKSTLVNRLLLRHCPDAILIDQRGLGGTRRSSVSSYIGVLDKIRSG
CCHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
FAQASDQPASLFSNNAQGACPACKGLGLVQTDLAFMDSVETPCDACSTTGFNEAARAITW
HHHCCCCCHHHHCCCCCCCCHHHCCCCCHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHH
MGCNIAQVLAFSAEQALRHFQSCQDIVEPLHRLSNVGLGYLALGQRLNTLSGGERQRLKL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHH
ASRLAEVSSLYVLDEPTSGLHMSDVDRLLAILDDLTQRGATVIVVEHNLDVMAHADWLIE
HHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCEEEE
MGPGAGKKGGKVIFEGLPTAMISAPESVTGPFLWRHLNGQL
ECCCCCCCCCEEEECCCCHHHHCCCCCCCCHHHHHHCCCCC
>Mature Secondary Structure 
SPVHTPYQDMEIIGARNNNLRSVTVKVPKHCITVFTGVSGSGKSSLVFDTIAAESQRQL
CCCCCCCCCCEEEECCCCCEEEEEEECCHHEEHHEECCCCCCCCCEEEHHHHHHHHHHH
NESHSAFVRHRLPHYGQPQADALRNLPASIVVDQKPLGGNARSTVGTATDIQPLLRLLFS
HHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
RLGEPFVGYSNVFSFNHPQGMCPTCQGLGMVDELDLDLLFDRNRSLNQGAIRFPTFARGT
HCCCCCCCHHHCEECCCCCCCCCCCCCCCCHHHCCCEEEECCCCCCCCCCEECCCCCCCH
FRWKRYAYSGLFDCDKPLADYTSDEWQILLYADDLAVSNPLPGWPSSARFQGVVPRFRRA
HHHHHHHHCCCCCCCCCHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHH
YLDHEPSRLTQAEREGLAHVITRQRCQACGGTRLNPTILSCKIKGKSIADCTSLEISDLL
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHH
IFIRTIDSEAIATVLTAIVERLEQMRAIGLDYLSLGRETASLSGGESQRVKMVRHLGSSL
HHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHCCCCCCHHHHHHHHHHCHHH
ADIAYIFDEPSVGLHPSDVHQLNTLLRSLRDKGNTVLVVEHDPDVIAIADHVVDMGPGAG
HHHHHEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHHHHHCCCCCC
KDGGHVVYQGDYAGLQQADTLTGRCLQRVAPMKREPRSATGQIALQRLSLHNLRDVSVSI
CCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEC
PTGVLTVVTGVAGSGKSTLVNRLLLRHCPDAILIDQRGLGGTRRSSVSSYIGVLDKIRSG
CCHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
FAQASDQPASLFSNNAQGACPACKGLGLVQTDLAFMDSVETPCDACSTTGFNEAARAITW
HHHCCCCCHHHHCCCCCCCCHHHCCCCCHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHH
MGCNIAQVLAFSAEQALRHFQSCQDIVEPLHRLSNVGLGYLALGQRLNTLSGGERQRLKL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHH
ASRLAEVSSLYVLDEPTSGLHMSDVDRLLAILDDLTQRGATVIVVEHNLDVMAHADWLIE
HHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCEEEE
MGPGAGKKGGKVIFEGLPTAMISAPESVTGPFLWRHLNGQL
ECCCCCCCCCEEEECCCCHHHHCCCCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]