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The map label for this gene is dmlR [H]

Identifier: 115351768

GI number: 115351768

Start: 1898596

End: 1899537

Strand: Direct

Name: dmlR [H]

Synonym: Bamb_1717

Alternate gene names: 115351768

Gene position: 1898596-1899537 (Clockwise)

Preceding gene: 115351764

Following gene: 115351769

Centisome position: 53.38

GC content: 71.87

Gene sequence:

>942_bases
ATGAGTGCCGATCCGATTCCGGCCCCCGACAAGCCGCTCGACCTGCTCGACGTCGGCCTGTTCGTGCGCGCCGCGCTGCT
CGCGAACGTGACGGCCGCCGGGCGCGAGTTCGGCGTGTCGGCCGCGGTCGCCAGCGCGCGCATCGCGCAGCTCGAGCGCC
AGCTCGGCGCGCGATTGCTGCACCGCACCACCCGCCGCATCAGCCTCACGCAGGACGGCGAGGTCTTCATGGCCCGGGCC
GAGGCGCTGCTGTCGGCCGCCGACGCCGCGCGGGCGTCGGTCGGCCACGGCCGCAGCGAGCCGTATGGACGGCTGAAGGT
GTCGATGTCGTCGTCGTTCGGCCGCCAGCACGTCGCGCCCGTGATTCCCGCGTTCCTGCGCCGCTACCCGTCCGTGTCGC
TGGACCTGCGGCTCTCCGACGAGATCGTCGATCTCGTCGACGACGGCTACGACGTCGCGATCCGCCTCGGCGCGCTGAAG
GATTCGACGCTGGTCGCGCGCAAGCTCGCCGCGAACCGGCGCGTGCTGTGTTGCTCGCCCGCGTATCTCGCCGAACACGG
GACGCCGCGCCATCCTGCCGACCTCGCGCAGCACGAATGCGTGATCCTCGGCGACCAGCGCGACTGGTCGTTCGTCACGC
CGCAGGGCCCGCTCACCGTGCGGGTCGGCGGCCGGCTCGTCGCGAGCAACGGCGAGGCGATCCGCGAAGCGCTCGTCGAC
GGCTTCGGCATCGCGATCAAGTCGACCTGGGACGTCGGCCCGCTGCTCGCGGACGGCACGCTCGTCACCGTGCTCGACGA
CTACCCGTTCGCGCAGGACGTCGCGATCTGGGCCGTCTACCCGAGCCGCGCGCACGTGCCGCTGAAGACGCTCGCGTTCA
TCGCGTTCCTGGCCGAACACTTCGGCGATCCACCCTACTGGGATCGCGCGGACGAACGCTGA

Upstream 100 bases:

>100_bases
GGCGGGCCGCGGCGCAGCCCCCATGCATGCCATCGTAGGCCGCCCGATCCTTCGAGAAAACCGCTATATTTCCTGAAACA
TTTTCAGGAATTTCAGAACA

Downstream 100 bases:

>100_bases
ACGCCGTCCGGCGAGCGGCGCTGGCGGCGGCGCTGGCCGGCCATCCGCGGCGATCCGGCCGCGAGCGGATACCAACCGGC
TACAATGGCGCGTTCGCGAC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: D-malate degradation protein R [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MSADPIPAPDKPLDLLDVGLFVRAALLANVTAAGREFGVSAAVASARIAQLERQLGARLLHRTTRRISLTQDGEVFMARA
EALLSAADAARASVGHGRSEPYGRLKVSMSSSFGRQHVAPVIPAFLRRYPSVSLDLRLSDEIVDLVDDGYDVAIRLGALK
DSTLVARKLAANRRVLCCSPAYLAEHGTPRHPADLAQHECVILGDQRDWSFVTPQGPLTVRVGGRLVASNGEAIREALVD
GFGIAIKSTWDVGPLLADGTLVTVLDDYPFAQDVAIWAVYPSRAHVPLKTLAFIAFLAEHFGDPPYWDRADER

Sequences:

>Translated_313_residues
MSADPIPAPDKPLDLLDVGLFVRAALLANVTAAGREFGVSAAVASARIAQLERQLGARLLHRTTRRISLTQDGEVFMARA
EALLSAADAARASVGHGRSEPYGRLKVSMSSSFGRQHVAPVIPAFLRRYPSVSLDLRLSDEIVDLVDDGYDVAIRLGALK
DSTLVARKLAANRRVLCCSPAYLAEHGTPRHPADLAQHECVILGDQRDWSFVTPQGPLTVRVGGRLVASNGEAIREALVD
GFGIAIKSTWDVGPLLADGTLVTVLDDYPFAQDVAIWAVYPSRAHVPLKTLAFIAFLAEHFGDPPYWDRADER
>Mature_312_residues
SADPIPAPDKPLDLLDVGLFVRAALLANVTAAGREFGVSAAVASARIAQLERQLGARLLHRTTRRISLTQDGEVFMARAE
ALLSAADAARASVGHGRSEPYGRLKVSMSSSFGRQHVAPVIPAFLRRYPSVSLDLRLSDEIVDLVDDGYDVAIRLGALKD
STLVARKLAANRRVLCCSPAYLAEHGTPRHPADLAQHECVILGDQRDWSFVTPQGPLTVRVGGRLVASNGEAIREALVDG
FGIAIKSTWDVGPLLADGTLVTVLDDYPFAQDVAIWAVYPSRAHVPLKTLAFIAFLAEHFGDPPYWDRADER

Specific function: Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87081978, Length=294, Percent_Identity=38.7755102040816, Blast_Score=195, Evalue=3e-51,
Organism=Escherichia coli, GI1789440, Length=297, Percent_Identity=31.6498316498317, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI1786401, Length=293, Percent_Identity=32.4232081911263, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1789639, Length=288, Percent_Identity=29.5138888888889, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1787128, Length=291, Percent_Identity=28.1786941580756, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI145693193, Length=284, Percent_Identity=30.9859154929577, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1787589, Length=279, Percent_Identity=25.089605734767, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1789173, Length=276, Percent_Identity=27.8985507246377, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1786448, Length=280, Percent_Identity=26.4285714285714, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788706, Length=192, Percent_Identity=29.6875, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI157672245, Length=207, Percent_Identity=28.9855072463768, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33835; Mature: 33704

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADPIPAPDKPLDLLDVGLFVRAALLANVTAAGREFGVSAAVASARIAQLERQLGARLL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHCHHHHHHHHHHHHHHHHHHHHHH
HRTTRRISLTQDGEVFMARAEALLSAADAARASVGHGRSEPYGRLKVSMSSSFGRQHVAP
HHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHH
VIPAFLRRYPSVSLDLRLSDEIVDLVDDGYDVAIRLGALKDSTLVARKLAANRRVLCCSP
HHHHHHHHCCCCEEEEEECHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEECC
AYLAEHGTPRHPADLAQHECVILGDQRDWSFVTPQGPLTVRVGGRLVASNGEAIREALVD
HHHHCCCCCCCCHHHCCCCEEEEECCCCCCEECCCCCEEEEECCEEEECCCHHHHHHHHC
GFGIAIKSTWDVGPLLADGTLVTVLDDYPFAQDVAIWAVYPSRAHVPLKTLAFIAFLAEH
CCCEEEECCCCCCCEEECCEEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
FGDPPYWDRADER
CCCCCCCCCCCCC
>Mature Secondary Structure 
SADPIPAPDKPLDLLDVGLFVRAALLANVTAAGREFGVSAAVASARIAQLERQLGARLL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHCHHHHHHHHHHHHHHHHHHHHHH
HRTTRRISLTQDGEVFMARAEALLSAADAARASVGHGRSEPYGRLKVSMSSSFGRQHVAP
HHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHH
VIPAFLRRYPSVSLDLRLSDEIVDLVDDGYDVAIRLGALKDSTLVARKLAANRRVLCCSP
HHHHHHHHCCCCEEEEEECHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEECC
AYLAEHGTPRHPADLAQHECVILGDQRDWSFVTPQGPLTVRVGGRLVASNGEAIREALVD
HHHHCCCCCCCCHHHCCCCEEEEECCCCCCEECCCCCEEEEECCEEEECCCHHHHHHHHC
GFGIAIKSTWDVGPLLADGTLVTVLDDYPFAQDVAIWAVYPSRAHVPLKTLAFIAFLAEH
CCCEEEECCCCCCCEEECCEEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
FGDPPYWDRADER
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]