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The map label for this gene is alaS

Identifier: 115351339

GI number: 115351339

Start: 1407381

End: 1410005

Strand: Direct

Name: alaS

Synonym: Bamb_1286

Alternate gene names: 115351339

Gene position: 1407381-1410005 (Clockwise)

Preceding gene: 115351337

Following gene: 115351340

Centisome position: 39.57

GC content: 66.7

Gene sequence:

>2625_bases
ATGAAAGCTGCCGAAATCCGCGAGAAATTCCTCAAATTCTTCGAATCGAAGGGCCACACGATCGTCCGCTCGTCGAGCCT
CGTGCCCGGTAACGACCCCACGCTGATGTTCACGAACTCGGGCATGGTCCAGTTCAAGGACGTATTCCTCGGCACGGACC
CGCGTCCGTACTCGCGCGCCACGACGGCGCAGCGCAGCGTGCGCGCGGGCGGCAAGCACAACGACCTCGAGAACGTCGGC
TACACGGCGCGCCACCACACGTTCTTCGAGATGCTCGGCAACTTCTCGTTCGGCGACTACTTCAAGCACGACGCGATCCG
CTTCGCGTGGGAGCTGCTGACCACGGTCTACCAGCTGCCGAAGGAAAAACTGTGGGTCACCGTCTACCAGGAAGACGACG
AAGCCTACGACATCTGGGCGAAGGAAGTCGGCGTGCCGACCGAGCGGATCATCCGGATCGGCGACAACAAGGGCGCGCGC
TACGCGTCGGACAACTTCTGGACGATGGGCGACACCGGCCCGTGCGGCCCGTGCACGGAAATCTTCTACGACCACGGCCC
GGACGTGTGGGGCGGCCCGCCGGGGTCGCCTGAGGAAGACGGCGACCGCTACATCGAGATCTGGAACCTCGTGTTCATGC
AGTTCAACCGCGACGCGCAGGGCAACATGACGCGCCTGCCGAAGCAGTCGGTCGACACCGGCATGGGCCTCGAGCGCCTC
GCCGCGGTGCTGCAGCACGTGCACAGCAACTACGAGATCGACCTGTTCCAGAACCTGATCAAGGCCGCCGCGCGCGTGAC
CGAGATCAGCGACCTCACCAACAACTCGCTGAAGGTGATCGCCGATCACATCCGCGCGTGCTCGTTCCTGATCGTCGACG
GCGTGATTCCGGGCAACGAAGGACGCGGCTACGTGCTGCGCCGGATCGTGCGCCGCGCGATCCGCCACGGCTACAAGCTC
GGCCGCAAGGGCTCGTTCTTCCACAAGCTGGTGGCCGACCTCGTCGCCGAGATGGGCGCGGCCTATCCGGAGCTGAAGGA
AGCCGAGCAGCGCGTGACCGACGTGCTGCGCCAGGAAGAAGAGCGCTTCTTCGAAACCATCGAGCACGGGATGTCGATCC
TCGAGGCGGCACTCGCCGACGTCGAGGCGAAGGGCGGCAAGGTGCTCGACGGCGAGCTCGCGTTCAAGCTGCACGACACC
TACGGCTTCCCGCTCGACCTCACGGCCGACGTGTGCCGCGAGCGCGGGATGACGGTCGACGAGCCGGCATTCGACGACGC
GATGGCGCGCCAGCGCGAGCAGGCGCGCGCGGCCGGCAAGTTCAAGGCCACGCAGGGGCTCGAATACTCGGGCGCGAAAA
CCACGTTCCACGGTTACGAGGAAATCGCGTTCGACGACGCGAAGGTCGTCGCGCTGTACGTCGACGGTTCGGCCGTCAAC
GAAGTGAAGGCCGGCCAGGATGCGGTCGTGGTGCTCGACCACACGCCGTTCTACGCGGAATCGGGCGGCCAGGTCGGCGA
CCAGGGCGTGCTCGCGAACGCCGCGACGCGCTTCGCGGTGGCCGACACGCTGAAGGTGCAGGCCGACGTGGTCGGCCATC
ACGGCACGCTGGAGCAGGGCACGCTGAAGATCGGCGACGTGCTGCGCGCGGAAATCGACGCGCACCGCCGCGCCCGCACG
CAGCGCAACCACTCGGCCACCCATCTGATGCACAAGGCGCTGCGTGAAGTGCTCGGCGCGCACGTGCAGCAGAAGGGTTC
GCTCGTCGATGCGGAGAAAACCCGTTTCGACTTCGCGCACAACGCGCCGATGACCGACGACGAAATCCGTCGCGTCGAGC
AGATCGTCAACAACGAAATCCTCGCGAACGCGCCGGGCATCGTGCGCGTGATGCCGTATGACGAAGCGGTGAAGGGCGGC
GCGATGGCGCTGTTCGGCGAGAAGTACGGCGACGAAGTGCGCGTGCTCGATCTTGGCTTCTCGCGCGAACTGTGCGGCGG
CACGCACGTGCATCGCACCGGCGACATCGGCTTCTTCAAGATCGTCGTCGAAGGCGGCGTCGCGGCCGGCATCCGCCGGG
TCGAGGCGATCACCGGCGACAACGCGGTGCGTTACGTGCAGGAACTCGATGCGCGCGTGAACGAAGCCGCGGCCGCGCTG
AAGGCGCAACCGTCGGAACTCACGCAGCGCATCGCGCAGGTGCAGGACCAGGTGAAGTCGCTCGAGAAGGAACTGGGCGC
GCTGAAGTCGAAGCTCGCGTCGAGCCAGGGCGACGAGCTCGCGCAGCAGGCCACCGAAATCGGCGGCGTGTATGTGCTGG
CCGCGACACTCGACGGCGCGGACGCGAAGACGCTGCGCGAGACGGTCGACAAGCTGAAGGACAAGCTGAAGAGCGCGGCG
ATCGTGCTGGCGGCCGTCGAAGGCGGCAAGGTCAGCCTGATCGCGGGCGTCACGCCGGATGCGAGCAAGAAGGTCAAGGC
CGGCGAGCTCGTGAACTTCGTCGCGCAGCAGGTGGGCGGCAAGGGCGGCGGCCGTCCCGATATGGCGCAGGCGGGCGGCA
CCGAACCGGCGAACCTGCCGGGTGCGCTGGCCGGCGTGAAGGGCTGGGTCGAAGAGCGGTTGTAA

Upstream 100 bases:

>100_bases
TCGGTATCGTATAATCGATCGTTTACGATATTTGCCCGCCGTGCGTCCGCGAGGACGGCCGGCGTTTGAAGCCGTCTCAG
CCAGACATTCCCCGCACGCC

Downstream 100 bases:

>100_bases
TCAGAACGACGACGGCGCCGTGCAACGCGGCGCCGTCGCCCGATGCCGGCGATGTTCGGTTCTCCCCCGGCATCGCGGCG
GTTTTGCTGACGTTCGGCGC

Product: alanyl-tRNA synthetase

Products: NA

Alternate protein names: Alanine--tRNA ligase; AlaRS [H]

Number of amino acids: Translated: 874; Mature: 874

Protein sequence:

>874_residues
MKAAEIREKFLKFFESKGHTIVRSSSLVPGNDPTLMFTNSGMVQFKDVFLGTDPRPYSRATTAQRSVRAGGKHNDLENVG
YTARHHTFFEMLGNFSFGDYFKHDAIRFAWELLTTVYQLPKEKLWVTVYQEDDEAYDIWAKEVGVPTERIIRIGDNKGAR
YASDNFWTMGDTGPCGPCTEIFYDHGPDVWGGPPGSPEEDGDRYIEIWNLVFMQFNRDAQGNMTRLPKQSVDTGMGLERL
AAVLQHVHSNYEIDLFQNLIKAAARVTEISDLTNNSLKVIADHIRACSFLIVDGVIPGNEGRGYVLRRIVRRAIRHGYKL
GRKGSFFHKLVADLVAEMGAAYPELKEAEQRVTDVLRQEEERFFETIEHGMSILEAALADVEAKGGKVLDGELAFKLHDT
YGFPLDLTADVCRERGMTVDEPAFDDAMARQREQARAAGKFKATQGLEYSGAKTTFHGYEEIAFDDAKVVALYVDGSAVN
EVKAGQDAVVVLDHTPFYAESGGQVGDQGVLANAATRFAVADTLKVQADVVGHHGTLEQGTLKIGDVLRAEIDAHRRART
QRNHSATHLMHKALREVLGAHVQQKGSLVDAEKTRFDFAHNAPMTDDEIRRVEQIVNNEILANAPGIVRVMPYDEAVKGG
AMALFGEKYGDEVRVLDLGFSRELCGGTHVHRTGDIGFFKIVVEGGVAAGIRRVEAITGDNAVRYVQELDARVNEAAAAL
KAQPSELTQRIAQVQDQVKSLEKELGALKSKLASSQGDELAQQATEIGGVYVLAATLDGADAKTLRETVDKLKDKLKSAA
IVLAAVEGGKVSLIAGVTPDASKKVKAGELVNFVAQQVGGKGGGRPDMAQAGGTEPANLPGALAGVKGWVEERL

Sequences:

>Translated_874_residues
MKAAEIREKFLKFFESKGHTIVRSSSLVPGNDPTLMFTNSGMVQFKDVFLGTDPRPYSRATTAQRSVRAGGKHNDLENVG
YTARHHTFFEMLGNFSFGDYFKHDAIRFAWELLTTVYQLPKEKLWVTVYQEDDEAYDIWAKEVGVPTERIIRIGDNKGAR
YASDNFWTMGDTGPCGPCTEIFYDHGPDVWGGPPGSPEEDGDRYIEIWNLVFMQFNRDAQGNMTRLPKQSVDTGMGLERL
AAVLQHVHSNYEIDLFQNLIKAAARVTEISDLTNNSLKVIADHIRACSFLIVDGVIPGNEGRGYVLRRIVRRAIRHGYKL
GRKGSFFHKLVADLVAEMGAAYPELKEAEQRVTDVLRQEEERFFETIEHGMSILEAALADVEAKGGKVLDGELAFKLHDT
YGFPLDLTADVCRERGMTVDEPAFDDAMARQREQARAAGKFKATQGLEYSGAKTTFHGYEEIAFDDAKVVALYVDGSAVN
EVKAGQDAVVVLDHTPFYAESGGQVGDQGVLANAATRFAVADTLKVQADVVGHHGTLEQGTLKIGDVLRAEIDAHRRART
QRNHSATHLMHKALREVLGAHVQQKGSLVDAEKTRFDFAHNAPMTDDEIRRVEQIVNNEILANAPGIVRVMPYDEAVKGG
AMALFGEKYGDEVRVLDLGFSRELCGGTHVHRTGDIGFFKIVVEGGVAAGIRRVEAITGDNAVRYVQELDARVNEAAAAL
KAQPSELTQRIAQVQDQVKSLEKELGALKSKLASSQGDELAQQATEIGGVYVLAATLDGADAKTLRETVDKLKDKLKSAA
IVLAAVEGGKVSLIAGVTPDASKKVKAGELVNFVAQQVGGKGGGRPDMAQAGGTEPANLPGALAGVKGWVEERL
>Mature_874_residues
MKAAEIREKFLKFFESKGHTIVRSSSLVPGNDPTLMFTNSGMVQFKDVFLGTDPRPYSRATTAQRSVRAGGKHNDLENVG
YTARHHTFFEMLGNFSFGDYFKHDAIRFAWELLTTVYQLPKEKLWVTVYQEDDEAYDIWAKEVGVPTERIIRIGDNKGAR
YASDNFWTMGDTGPCGPCTEIFYDHGPDVWGGPPGSPEEDGDRYIEIWNLVFMQFNRDAQGNMTRLPKQSVDTGMGLERL
AAVLQHVHSNYEIDLFQNLIKAAARVTEISDLTNNSLKVIADHIRACSFLIVDGVIPGNEGRGYVLRRIVRRAIRHGYKL
GRKGSFFHKLVADLVAEMGAAYPELKEAEQRVTDVLRQEEERFFETIEHGMSILEAALADVEAKGGKVLDGELAFKLHDT
YGFPLDLTADVCRERGMTVDEPAFDDAMARQREQARAAGKFKATQGLEYSGAKTTFHGYEEIAFDDAKVVALYVDGSAVN
EVKAGQDAVVVLDHTPFYAESGGQVGDQGVLANAATRFAVADTLKVQADVVGHHGTLEQGTLKIGDVLRAEIDAHRRART
QRNHSATHLMHKALREVLGAHVQQKGSLVDAEKTRFDFAHNAPMTDDEIRRVEQIVNNEILANAPGIVRVMPYDEAVKGG
AMALFGEKYGDEVRVLDLGFSRELCGGTHVHRTGDIGFFKIVVEGGVAAGIRRVEAITGDNAVRYVQELDARVNEAAAAL
KAQPSELTQRIAQVQDQVKSLEKELGALKSKLASSQGDELAQQATEIGGVYVLAATLDGADAKTLRETVDKLKDKLKSAA
IVLAAVEGGKVSLIAGVTPDASKKVKAGELVNFVAQQVGGKGGGRPDMAQAGGTEPANLPGALAGVKGWVEERL

Specific function: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction:alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editin

COG id: COG0013

COG function: function code J; Alanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI109148542, Length=977, Percent_Identity=37.2569089048106, Blast_Score=531, Evalue=1e-150,
Organism=Homo sapiens, GI38569417, Length=944, Percent_Identity=33.2627118644068, Blast_Score=446, Evalue=1e-125,
Organism=Escherichia coli, GI1789048, Length=875, Percent_Identity=62.4, Blast_Score=1095, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17506981, Length=975, Percent_Identity=36.1025641025641, Blast_Score=531, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17536681, Length=752, Percent_Identity=32.5797872340425, Blast_Score=369, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6324911, Length=966, Percent_Identity=36.4389233954451, Blast_Score=556, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24582809, Length=960, Percent_Identity=36.5625, Blast_Score=542, Evalue=1e-154,
Organism=Drosophila melanogaster, GI45552267, Length=960, Percent_Identity=36.5625, Blast_Score=542, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24658214, Length=789, Percent_Identity=31.8124207858048, Blast_Score=342, Evalue=9e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002318
- InterPro:   IPR018162
- InterPro:   IPR018165
- InterPro:   IPR018164
- InterPro:   IPR023033
- InterPro:   IPR003156
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF02272 DHHA1; PF01411 tRNA-synt_2c; PF07973 tRNA_SAD [H]

EC number: =6.1.1.7 [H]

Molecular weight: Translated: 95557; Mature: 95557

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00087 SOD_CU_ZN_1 ; PS50860 AA_TRNA_LIGASE_II_ALA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAEIREKFLKFFESKGHTIVRSSSLVPGNDPTLMFTNSGMVQFKDVFLGTDPRPYSRA
CCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEECCCCEEEEEEEECCCCCCCCHH
TTAQRSVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKHDAIRFAWELLTTVYQLP
HHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCC
KEKLWVTVYQEDDEAYDIWAKEVGVPTERIIRIGDNKGARYASDNFWTMGDTGPCGPCTE
CCCEEEEEEECCCCHHHHHHHHHCCCHHHEEEECCCCCCCCCCCCCEECCCCCCCCHHHH
IFYDHGPDVWGGPPGSPEEDGDRYIEIWNLVFMQFNRDAQGNMTRLPKQSVDTGMGLERL
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHCCCCHHHH
AAVLQHVHSNYEIDLFQNLIKAAARVTEISDLTNNSLKVIADHIRACSFLIVDGVIPGNE
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEECCCCCCC
GRGYVLRRIVRRAIRHGYKLGRKGSFFHKLVADLVAEMGAAYPELKEAEQRVTDVLRQEE
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
ERFFETIEHGMSILEAALADVEAKGGKVLDGELAFKLHDTYGFPLDLTADVCRERGMTVD
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECEEEEEEECCCCCCCCCCHHHHHHCCCCCC
EPAFDDAMARQREQARAAGKFKATQGLEYSGAKTTFHGYEEIAFDDAKVVALYVDGSAVN
CCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCEECCHHHHCCCCCEEEEEEECCCHHH
EVKAGQDAVVVLDHTPFYAESGGQVGDQGVLANAATRFAVADTLKVQADVVGHHGTLEQG
HHCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC
TLKIGDVLRAEIDAHRRARTQRNHSATHLMHKALREVLGAHVQQKGSLVDAEKTRFDFAH
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCC
NAPMTDDEIRRVEQIVNNEILANAPGIVRVMPYDEAVKGGAMALFGEKYGDEVRVLDLGF
CCCCCHHHHHHHHHHHCCCCEECCCCEEEECCCHHHHCCCEEEEECCCCCCEEEEEECCC
SRELCGGTHVHRTGDIGFFKIVVEGGVAAGIRRVEAITGDNAVRYVQELDARVNEAAAAL
CHHHCCCCCEEECCCCEEEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
KAQPSELTQRIAQVQDQVKSLEKELGALKSKLASSQGDELAQQATEIGGVYVLAATLDGA
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEECCCC
DAKTLRETVDKLKDKLKSAAIVLAAVEGGKVSLIAGVTPDASKKVKAGELVNFVAQQVGG
CHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
KGGGRPDMAQAGGTEPANLPGALAGVKGWVEERL
CCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKAAEIREKFLKFFESKGHTIVRSSSLVPGNDPTLMFTNSGMVQFKDVFLGTDPRPYSRA
CCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEECCCCEEEEEEEECCCCCCCCHH
TTAQRSVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKHDAIRFAWELLTTVYQLP
HHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCC
KEKLWVTVYQEDDEAYDIWAKEVGVPTERIIRIGDNKGARYASDNFWTMGDTGPCGPCTE
CCCEEEEEEECCCCHHHHHHHHHCCCHHHEEEECCCCCCCCCCCCCEECCCCCCCCHHHH
IFYDHGPDVWGGPPGSPEEDGDRYIEIWNLVFMQFNRDAQGNMTRLPKQSVDTGMGLERL
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHCCCCHHHH
AAVLQHVHSNYEIDLFQNLIKAAARVTEISDLTNNSLKVIADHIRACSFLIVDGVIPGNE
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEECCCCCCC
GRGYVLRRIVRRAIRHGYKLGRKGSFFHKLVADLVAEMGAAYPELKEAEQRVTDVLRQEE
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
ERFFETIEHGMSILEAALADVEAKGGKVLDGELAFKLHDTYGFPLDLTADVCRERGMTVD
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECEEEEEEECCCCCCCCCCHHHHHHCCCCCC
EPAFDDAMARQREQARAAGKFKATQGLEYSGAKTTFHGYEEIAFDDAKVVALYVDGSAVN
CCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCEECCHHHHCCCCCEEEEEEECCCHHH
EVKAGQDAVVVLDHTPFYAESGGQVGDQGVLANAATRFAVADTLKVQADVVGHHGTLEQG
HHCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC
TLKIGDVLRAEIDAHRRARTQRNHSATHLMHKALREVLGAHVQQKGSLVDAEKTRFDFAH
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCC
NAPMTDDEIRRVEQIVNNEILANAPGIVRVMPYDEAVKGGAMALFGEKYGDEVRVLDLGF
CCCCCHHHHHHHHHHHCCCCEECCCCEEEECCCHHHHCCCEEEEECCCCCCEEEEEECCC
SRELCGGTHVHRTGDIGFFKIVVEGGVAAGIRRVEAITGDNAVRYVQELDARVNEAAAAL
CHHHCCCCCEEECCCCEEEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
KAQPSELTQRIAQVQDQVKSLEKELGALKSKLASSQGDELAQQATEIGGVYVLAATLDGA
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEECCCC
DAKTLRETVDKLKDKLKSAAIVLAAVEGGKVSLIAGVTPDASKKVKAGELVNFVAQQVGG
CHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
KGGGRPDMAQAGGTEPANLPGALAGVKGWVEERL
CCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA