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The map label for this gene is gyaR [H]

Identifier: 115351033

GI number: 115351033

Start: 1068960

End: 1069949

Strand: Direct

Name: gyaR [H]

Synonym: Bamb_0979

Alternate gene names: 115351033

Gene position: 1068960-1069949 (Clockwise)

Preceding gene: 115351032

Following gene: 115351034

Centisome position: 30.06

GC content: 69.29

Gene sequence:

>990_bases
ATGCAGAAGATCCTGGTCGCACGTCCGATCTTTCCGGACGTGATCGAACGGCTCGAGCAGTATTTCGAAGTCGACTGGAA
CAACGGCGACGCGCTCGCCCCCGATGCGCTTGCCGCGCGTCTCGCCGACAAGGACGGCGCGCTCACCGCGGGCGACCCGA
TCGGCGCGGCCACGCTGGCGGCGGCGCCGCGCCTGCGCGTCGTGTCGAACATGGCGGTCGGCTACAACAACTTCGACATG
GCCGCGTTCAACGCGGCGAACGTGCTCGGCACCAACACGCCCGACGTGCTGAACGAGTCCACCGCGGATTTCGGCTGGGC
GCTGATGATGGCGGCCGCGCGCCGGATCGCCGAATCCGAGCACTGGCTGCGCGCCGGGCACTGGCGGAAGTGGGCGTACG
ACGGTTTCCTCGGCAGCGACATTTATGGCTCGACGCTCGGCGTCATCGGCATGGGGCGCATCGGCCAGGCACTCGCACGC
CGCGCGCGCGGCTTCGGGATGCAGGTGATCTATCACAACCGCTCGCGGGTCGCCCCCGAGATCGAGGCCGAGCTGAACGC
CGAATACGTGGCGAAGGACGCGCTGCTCGCGCGCGCCGATCACGTCGTGCTCGTGCTGCCGTACACGAAAGAGAACCATC
ATACGATCGGCGCGGCCGAGCTCGCGAAGATGAAGCCGACCGCGACGCTGACCAACATCGCGCGCGGCGGCATCGTCGAC
GACGCGGCACTGGCTGCCGCGCTGCGCGACGGGACGATCGCCGCGGCCGGCCTCGACGTGTACGAAGGCGAGCCGAACGT
CCATCCGGCGCTGCTCGAAGTGCCGAACGTCGTGCTGACGCCGCACATCGCGAGCGCGACTGAAAAGACGCGCCGCGCGA
TGGCCAACCTCGCGGCCGACAACCTGATCGCCGCACTGGGCGTGGGGCCGCGCGCGGGGCAGCCGCCGAATCCGATCAAC
CCGGACGTGATCGGGAAGCCGCGCGCATGA

Upstream 100 bases:

>100_bases
GCTTTTCTTCCCGGCGTAGGCTGATTATTTTCAACCAAGCGCGGACGGTTCCGGCGGCGCACGATGCGCCGCGTTCCGGC
CGCGGCATGCGGAGATGGCG

Downstream 100 bases:

>100_bases
CGACGATGTTGTTGCTGGCGGCGGTCGTCGTGCTGGCCGTCGCGCTCGCGGTGGCGATCGTCGCGCTCGTGCGCGGCGGC
GGCCGCCACGACGATGCGGC

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MQKILVARPIFPDVIERLEQYFEVDWNNGDALAPDALAARLADKDGALTAGDPIGAATLAAAPRLRVVSNMAVGYNNFDM
AAFNAANVLGTNTPDVLNESTADFGWALMMAAARRIAESEHWLRAGHWRKWAYDGFLGSDIYGSTLGVIGMGRIGQALAR
RARGFGMQVIYHNRSRVAPEIEAELNAEYVAKDALLARADHVVLVLPYTKENHHTIGAAELAKMKPTATLTNIARGGIVD
DAALAAALRDGTIAAAGLDVYEGEPNVHPALLEVPNVVLTPHIASATEKTRRAMANLAADNLIAALGVGPRAGQPPNPIN
PDVIGKPRA

Sequences:

>Translated_329_residues
MQKILVARPIFPDVIERLEQYFEVDWNNGDALAPDALAARLADKDGALTAGDPIGAATLAAAPRLRVVSNMAVGYNNFDM
AAFNAANVLGTNTPDVLNESTADFGWALMMAAARRIAESEHWLRAGHWRKWAYDGFLGSDIYGSTLGVIGMGRIGQALAR
RARGFGMQVIYHNRSRVAPEIEAELNAEYVAKDALLARADHVVLVLPYTKENHHTIGAAELAKMKPTATLTNIARGGIVD
DAALAAALRDGTIAAAGLDVYEGEPNVHPALLEVPNVVLTPHIASATEKTRRAMANLAADNLIAALGVGPRAGQPPNPIN
PDVIGKPRA
>Mature_329_residues
MQKILVARPIFPDVIERLEQYFEVDWNNGDALAPDALAARLADKDGALTAGDPIGAATLAAAPRLRVVSNMAVGYNNFDM
AAFNAANVLGTNTPDVLNESTADFGWALMMAAARRIAESEHWLRAGHWRKWAYDGFLGSDIYGSTLGVIGMGRIGQALAR
RARGFGMQVIYHNRSRVAPEIEAELNAEYVAKDALLARADHVVLVLPYTKENHHTIGAAELAKMKPTATLTNIARGGIVD
DAALAAALRDGTIAAAGLDVYEGEPNVHPALLEVPNVVLTPHIASATEKTRRAMANLAADNLIAALGVGPRAGQPPNPIN
PDVIGKPRA

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=249, Percent_Identity=39.3574297188755, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI23308577, Length=292, Percent_Identity=28.7671232876712, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI145580578, Length=251, Percent_Identity=35.4581673306773, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI4557499, Length=251, Percent_Identity=35.4581673306773, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI145580575, Length=253, Percent_Identity=35.5731225296443, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI4557497, Length=250, Percent_Identity=33.2, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI61743967, Length=250, Percent_Identity=33.2, Blast_Score=120, Evalue=1e-27,
Organism=Escherichia coli, GI87082289, Length=325, Percent_Identity=42.4615384615385, Blast_Score=238, Evalue=3e-64,
Organism=Escherichia coli, GI1787645, Length=252, Percent_Identity=28.968253968254, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789279, Length=313, Percent_Identity=29.073482428115, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI87081824, Length=173, Percent_Identity=31.7919075144509, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=306, Percent_Identity=31.6993464052288, Blast_Score=151, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI25147481, Length=254, Percent_Identity=29.1338582677165, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=246, Percent_Identity=34.1463414634146, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6320925, Length=315, Percent_Identity=27.6190476190476, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6322116, Length=315, Percent_Identity=27.3015873015873, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321253, Length=307, Percent_Identity=24.4299674267101, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=144, Percent_Identity=30.5555555555556, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574284, Length=318, Percent_Identity=38.6792452830189, Blast_Score=188, Evalue=4e-48,
Organism=Drosophila melanogaster, GI45552429, Length=318, Percent_Identity=38.6792452830189, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI45551003, Length=318, Percent_Identity=38.6792452830189, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24585514, Length=318, Percent_Identity=38.6792452830189, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI28574282, Length=318, Percent_Identity=38.6792452830189, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI28574286, Length=258, Percent_Identity=40.3100775193798, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI28571528, Length=311, Percent_Identity=36.3344051446945, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24585516, Length=262, Percent_Identity=34.7328244274809, Blast_Score=151, Evalue=7e-37,
Organism=Drosophila melanogaster, GI19921140, Length=330, Percent_Identity=30.6060606060606, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI62472511, Length=253, Percent_Identity=34.3873517786561, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646446, Length=253, Percent_Identity=34.3873517786561, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646448, Length=253, Percent_Identity=34.3873517786561, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646452, Length=253, Percent_Identity=34.3873517786561, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646450, Length=253, Percent_Identity=34.3873517786561, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35001; Mature: 35001

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKILVARPIFPDVIERLEQYFEVDWNNGDALAPDALAARLADKDGALTAGDPIGAATLA
CCCEEEECCCCHHHHHHHHHHHEECCCCCCCCCHHHHHHHHCCCCCCEECCCCCCHHHHH
AAPRLRVVSNMAVGYNNFDMAAFNAANVLGTNTPDVLNESTADFGWALMMAAARRIAESE
HCCHHHHHHHHHCCCCCCCHHHCCCCHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHH
HWLRAGHWRKWAYDGFLGSDIYGSTLGVIGMGRIGQALARRARGFGMQVIYHNRSRVAPE
HHHHHCCCCEEECCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCEEEEEECCCCCCCH
IEAELNAEYVAKDALLARADHVVLVLPYTKENHHTIGAAELAKMKPTATLTNIARGGIVD
HHHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHCCCCCH
DAALAAALRDGTIAAAGLDVYEGEPNVHPALLEVPNVVLTPHIASATEKTRRAMANLAAD
HHHHHHHHCCCCEEEECCEEECCCCCCCHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
NLIAALGVGPRAGQPPNPINPDVIGKPRA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQKILVARPIFPDVIERLEQYFEVDWNNGDALAPDALAARLADKDGALTAGDPIGAATLA
CCCEEEECCCCHHHHHHHHHHHEECCCCCCCCCHHHHHHHHCCCCCCEECCCCCCHHHHH
AAPRLRVVSNMAVGYNNFDMAAFNAANVLGTNTPDVLNESTADFGWALMMAAARRIAESE
HCCHHHHHHHHHCCCCCCCHHHCCCCHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHH
HWLRAGHWRKWAYDGFLGSDIYGSTLGVIGMGRIGQALARRARGFGMQVIYHNRSRVAPE
HHHHHCCCCEEECCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCEEEEEECCCCCCCH
IEAELNAEYVAKDALLARADHVVLVLPYTKENHHTIGAAELAKMKPTATLTNIARGGIVD
HHHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHCCCCCH
DAALAAALRDGTIAAAGLDVYEGEPNVHPALLEVPNVVLTPHIASATEKTRRAMANLAAD
HHHHHHHHCCCCEEEECCEEECCCCCCCHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
NLIAALGVGPRAGQPPNPINPDVIGKPRA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA