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The map label for this gene is cobB [H]

Identifier: 115350857

GI number: 115350857

Start: 888731

End: 889552

Strand: Direct

Name: cobB [H]

Synonym: Bamb_0803

Alternate gene names: 115350857

Gene position: 888731-889552 (Clockwise)

Preceding gene: 115350856

Following gene: 115350859

Centisome position: 24.99

GC content: 70.92

Gene sequence:

>822_bases
TTGCCGGCGCATCTGGTCGCGTCCGCCGTCGACGCGCTCGCGCGCGCCGATGCGCTGCTGGTGACGGCCGGCGCCGGCAT
CGGCGTCGATTCGGGGCTGCCCGATTTTCGCGGCACGGACGGCTTCTGGCGCGCGTATCCGGCGCTGCGCCACGAACGTT
TCGCGTTCCACGAAATCGCGTCGCCGCACGCGTTCCGCGCGCATCCGCAGCTTGCGTGGGGATTCTATGGGCATCGTCTC
GCGCTCTATCGGGAGACGGTGCCGCACGCGGGCTTCGCGATCCTGCGGCGCTGGATGGACGCGATGCCGAACGGCGGCTT
CGTGCTGACGAGCAATGTCGACGGTCAGTTCCAGAAGGCGGGTTTCGATCCGGCGCACGTCGTCGAGATCCACGGTTCGA
TTCATTCGATGCAGTGCCTGCGACCGTGCTCGGACGACACCTGGGACGCCGCGCCGTTCACGCCCGACGTCGACGCAGCC
GCGTGCCGGCTGGTCGGCGAGCTGCCGCGCTGCTCGCGTTGCGGCGGTCTGGCGCGGCCGAACATCCTGATGTTCGGCGA
CGATGGCTGGCTCGGCGAACGCTACGACGCGCAGGAGCGGGCGCTGCAGGACTGGATCGCACGGGCAGGACGGGTGAGCG
TCGTCGAGATCGGCGCGGGCACCGCGATTCCGACCGTGCGGCTGCTGAGCGAACGCCTCGGCGCCGACGTGATCCGCATC
AACGCACGCGAAGCCCATGCGCGCCGCACGGACGTGATCGGGCTGCAGGGCGGCGCGCTCGCGACGCTGACCGCGCTCGA
TCGCGCGTGGCGGGGCGGCTGA

Upstream 100 bases:

>100_bases
CACCGTTCGACGCCACCACCGCTCCATCATGCCGTTTTCCGATTCAGCCGATTTACCCGATTCCCACGGCCCCACCGATT
CCAGCGCTGCTGGCGCGCAA

Downstream 100 bases:

>100_bases
GCGCCGCGCGACGAACCGGCCGGTTGCCGCGCGGTTACGGCTGTCCGACGAGCGCCTGGACGAGCGCCGGCGCGATCGGC
GAGCCGAGGCCCGTCACATA

Product: silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MPAHLVASAVDALARADALLVTAGAGIGVDSGLPDFRGTDGFWRAYPALRHERFAFHEIASPHAFRAHPQLAWGFYGHRL
ALYRETVPHAGFAILRRWMDAMPNGGFVLTSNVDGQFQKAGFDPAHVVEIHGSIHSMQCLRPCSDDTWDAAPFTPDVDAA
ACRLVGELPRCSRCGGLARPNILMFGDDGWLGERYDAQERALQDWIARAGRVSVVEIGAGTAIPTVRLLSERLGADVIRI
NAREAHARRTDVIGLQGGALATLTALDRAWRGG

Sequences:

>Translated_273_residues
MPAHLVASAVDALARADALLVTAGAGIGVDSGLPDFRGTDGFWRAYPALRHERFAFHEIASPHAFRAHPQLAWGFYGHRL
ALYRETVPHAGFAILRRWMDAMPNGGFVLTSNVDGQFQKAGFDPAHVVEIHGSIHSMQCLRPCSDDTWDAAPFTPDVDAA
ACRLVGELPRCSRCGGLARPNILMFGDDGWLGERYDAQERALQDWIARAGRVSVVEIGAGTAIPTVRLLSERLGADVIRI
NAREAHARRTDVIGLQGGALATLTALDRAWRGG
>Mature_272_residues
PAHLVASAVDALARADALLVTAGAGIGVDSGLPDFRGTDGFWRAYPALRHERFAFHEIASPHAFRAHPQLAWGFYGHRLA
LYRETVPHAGFAILRRWMDAMPNGGFVLTSNVDGQFQKAGFDPAHVVEIHGSIHSMQCLRPCSDDTWDAAPFTPDVDAAA
CRLVGELPRCSRCGGLARPNILMFGDDGWLGERYDAQERALQDWIARAGRVSVVEIGAGTAIPTVRLLSERLGADVIRIN
AREAHARRTDVIGLQGGALATLTALDRAWRGG

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=219, Percent_Identity=29.6803652968037, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI6912664, Length=232, Percent_Identity=30.6034482758621, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI13787215, Length=232, Percent_Identity=30.6034482758621, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI308199517, Length=171, Percent_Identity=26.9005847953216, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 29567; Mature: 29436

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAHLVASAVDALARADALLVTAGAGIGVDSGLPDFRGTDGFWRAYPALRHERFAFHEIA
CCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
SPHAFRAHPQLAWGFYGHRLALYRETVPHAGFAILRRWMDAMPNGGFVLTSNVDGQFQKA
CCCCCCCCCCEEEHHHHHHHEEHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHC
GFDPAHVVEIHGSIHSMQCLRPCSDDTWDAAPFTPDVDAAACRLVGELPRCSRCGGLARP
CCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHCCCCCCC
NILMFGDDGWLGERYDAQERALQDWIARAGRVSVVEIGAGTAIPTVRLLSERLGADVIRI
CEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEE
NAREAHARRTDVIGLQGGALATLTALDRAWRGG
ECHHHHHHHCCEEEECCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PAHLVASAVDALARADALLVTAGAGIGVDSGLPDFRGTDGFWRAYPALRHERFAFHEIA
CHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
SPHAFRAHPQLAWGFYGHRLALYRETVPHAGFAILRRWMDAMPNGGFVLTSNVDGQFQKA
CCCCCCCCCCEEEHHHHHHHEEHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHC
GFDPAHVVEIHGSIHSMQCLRPCSDDTWDAAPFTPDVDAAACRLVGELPRCSRCGGLARP
CCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHCCCCCCC
NILMFGDDGWLGERYDAQERALQDWIARAGRVSVVEIGAGTAIPTVRLLSERLGADVIRI
CEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEE
NAREAHARRTDVIGLQGGALATLTALDRAWRGG
ECHHHHHHHCCEEEECCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]