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The map label for this gene is gdhA [H]

Identifier: 115350617

GI number: 115350617

Start: 631685

End: 632971

Strand: Direct

Name: gdhA [H]

Synonym: Bamb_0563

Alternate gene names: 115350617

Gene position: 631685-632971 (Clockwise)

Preceding gene: 115350616

Following gene: 115350618

Centisome position: 17.76

GC content: 65.42

Gene sequence:

>1287_bases
ATGTCTTCGCAACTGCAGTCCATCCCGTCCTACCTGCACGCCGACGATCTCGGCCCGTGGGGCAACTACCTTCAGCAGGT
CGATCGCGTCGCACCGTACCTCGGTTCGCTGTCGCGCTGGCTCGAAACGCTGAAGCGTCCGAAGCGCATCCTGATCGTCG
ACTGCCCCATCGAGCTCGACAACGGCACCGTCGCGCACTTCGAAGGCTATCGCGTGCAGCACAACGTGTCGCGCGGTCCG
GGCAAGGGCGGTGTGCGTTACCACCAGGACGTGACGCTGTCGGAAGTGATGGCGCTGTCGGCATGGATGTCGGTGAAGAA
CGCGGCCGTGAACGTGCCGTACGGCGGCGCGAAGGGCGGCATCCGCGTCGACCCGCGCAAGCTCTCGCGCGGTGAGCTCG
AGCGCGTGACGCGCCGCTACACCAGCGAAATCGGCATCATCATCGGACCGAACACCGACATTCCGGCGCCGGACGTCAAC
ACCAACGAACAGGTGATGGCGTGGATGATGGATACCTACTCGATGAACCAGGGCCAGACGTCGACCGGCGTCGTGACCGG
CAAGCCGATCTCGCTCGGCGGTTCGCTCGGCCGCAAGGAAGCGACGGGCCGCGGCGTGTTCGTCGTCGGCTGCGAAGCGG
CGAAGAAGAAGGGCCTGGAAATCGAAGGCGCGCGCATCGCGGTGCAGGGCTTCGGCAACGTCGGCGGCATCGCGGCGAAG
CTGTTCCAGGAAGCGGGTGCGAAGGTGATCGTGGTGCAGGATCACACGGGCACGATCTACCGGCCGGCCGGCCTCGATTC
GAACAAGCTGCTCGACCACGTGGCACGCACGGGCGGCGTCGCGGGCTTCGAAGGCGCCGAACCGATGCCGAACGACGAGT
TCTGGACGGTCGAGACCGACATCCTGATCCCGGCGGCACTGGAAAACCAGATCACCGAGAAGAACGCATCGAAGATCCGC
ACGAAGATCATCGTCGAAGGCGCGAACGGCCCGACGACGACGGCGGCCGACGACATCCTGAGCGCGAACGGCGTGCTCGT
GATCCCGGACGTGATCGCGAACGCGGGCGGCGTGACCGTGTCGTACTTCGAGTGGGTGCAGGACTTCTCGAGCTTCTTCT
GGACGGAAGACGAGATCAACCACCGTCTCGAGCGCGTGATGCGCGAAGCGTTCGCCGGCGTGTGGGCGGTTTCGGAAGAG
CACAAGGTGTCGGTGCGTACGGCGGCGTTCATCGTCGCGTGCAAGCGCATCCTGATGGCGCGCGAAATGCGCGGCCTGTA
CCCCTGA

Upstream 100 bases:

>100_bases
CGATCATGCAAGAAACGCATAATCGAATAAGCAAACGGCATTGGATAAAAAAAATGGGTTTTTCGACAATGTGCGCAATC
CGTTGAACGTTGGAGCATCC

Downstream 100 bases:

>100_bases
TCGGGCGTCGCCGATCGGCCATTGCCGATCGGCGATCGGTTGACTACGATCACAGCGTGACGCAATCCACCGATTGCGTG
CATGATCCCTCGCGGGCGGT

Product: Glu/Leu/Phe/Val dehydrogenase, C terminal

Products: NA

Alternate protein names: GDH [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSSQLQSIPSYLHADDLGPWGNYLQQVDRVAPYLGSLSRWLETLKRPKRILIVDCPIELDNGTVAHFEGYRVQHNVSRGP
GKGGVRYHQDVTLSEVMALSAWMSVKNAAVNVPYGGAKGGIRVDPRKLSRGELERVTRRYTSEIGIIIGPNTDIPAPDVN
TNEQVMAWMMDTYSMNQGQTSTGVVTGKPISLGGSLGRKEATGRGVFVVGCEAAKKKGLEIEGARIAVQGFGNVGGIAAK
LFQEAGAKVIVVQDHTGTIYRPAGLDSNKLLDHVARTGGVAGFEGAEPMPNDEFWTVETDILIPAALENQITEKNASKIR
TKIIVEGANGPTTTAADDILSANGVLVIPDVIANAGGVTVSYFEWVQDFSSFFWTEDEINHRLERVMREAFAGVWAVSEE
HKVSVRTAAFIVACKRILMAREMRGLYP

Sequences:

>Translated_428_residues
MSSQLQSIPSYLHADDLGPWGNYLQQVDRVAPYLGSLSRWLETLKRPKRILIVDCPIELDNGTVAHFEGYRVQHNVSRGP
GKGGVRYHQDVTLSEVMALSAWMSVKNAAVNVPYGGAKGGIRVDPRKLSRGELERVTRRYTSEIGIIIGPNTDIPAPDVN
TNEQVMAWMMDTYSMNQGQTSTGVVTGKPISLGGSLGRKEATGRGVFVVGCEAAKKKGLEIEGARIAVQGFGNVGGIAAK
LFQEAGAKVIVVQDHTGTIYRPAGLDSNKLLDHVARTGGVAGFEGAEPMPNDEFWTVETDILIPAALENQITEKNASKIR
TKIIVEGANGPTTTAADDILSANGVLVIPDVIANAGGVTVSYFEWVQDFSSFFWTEDEINHRLERVMREAFAGVWAVSEE
HKVSVRTAAFIVACKRILMAREMRGLYP
>Mature_427_residues
SSQLQSIPSYLHADDLGPWGNYLQQVDRVAPYLGSLSRWLETLKRPKRILIVDCPIELDNGTVAHFEGYRVQHNVSRGPG
KGGVRYHQDVTLSEVMALSAWMSVKNAAVNVPYGGAKGGIRVDPRKLSRGELERVTRRYTSEIGIIIGPNTDIPAPDVNT
NEQVMAWMMDTYSMNQGQTSTGVVTGKPISLGGSLGRKEATGRGVFVVGCEAAKKKGLEIEGARIAVQGFGNVGGIAAKL
FQEAGAKVIVVQDHTGTIYRPAGLDSNKLLDHVARTGGVAGFEGAEPMPNDEFWTVETDILIPAALENQITEKNASKIRT
KIIVEGANGPTTTAADDILSANGVLVIPDVIANAGGVTVSYFEWVQDFSSFFWTEDEINHRLERVMREAFAGVWAVSEEH
KVSVRTAAFIVACKRILMAREMRGLYP

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=371, Percent_Identity=42.8571428571429, Blast_Score=284, Evalue=1e-76,
Organism=Homo sapiens, GI4885281, Length=371, Percent_Identity=42.0485175202156, Blast_Score=277, Evalue=1e-74,
Organism=Escherichia coli, GI1788059, Length=366, Percent_Identity=34.1530054644809, Blast_Score=186, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17544676, Length=392, Percent_Identity=40.5612244897959, Blast_Score=271, Evalue=6e-73,
Organism=Saccharomyces cerevisiae, GI6319256, Length=402, Percent_Identity=29.3532338308458, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324951, Length=377, Percent_Identity=29.973474801061, Blast_Score=138, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45553475, Length=362, Percent_Identity=42.5414364640884, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI45549226, Length=354, Percent_Identity=43.2203389830509, Blast_Score=278, Evalue=4e-75,
Organism=Drosophila melanogaster, GI24649283, Length=358, Percent_Identity=43.5754189944134, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24649460, Length=301, Percent_Identity=43.5215946843854, Blast_Score=234, Evalue=7e-62,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.3 [H]

Molecular weight: Translated: 46483; Mature: 46351

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSQLQSIPSYLHADDLGPWGNYLQQVDRVAPYLGSLSRWLETLKRPKRILIVDCPIELD
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEECC
NGTVAHFEGYRVQHNVSRGPGKGGVRYHQDVTLSEVMALSAWMSVKNAAVNVPYGGAKGG
CCEEEEEECEEEEECCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCEEECCCCCCCCC
IRVDPRKLSRGELERVTRRYTSEIGIIIGPNTDIPAPDVNTNEQVMAWMMDTYSMNQGQT
EEECHHHCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
STGVVTGKPISLGGSLGRKEATGRGVFVVGCEAAKKKGLEIEGARIAVQGFGNVGGIAAK
CCCEEECCCEECCCCCCCCCCCCCEEEEEECHHHHHCCCEECCCEEEEEECCCCHHHHHH
LFQEAGAKVIVVQDHTGTIYRPAGLDSNKLLDHVARTGGVAGFEGAEPMPNDEFWTVETD
HHHHCCCEEEEEECCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEC
ILIPAALENQITEKNASKIRTKIIVEGANGPTTTAADDILSANGVLVIPDVIANAGGVTV
EEECHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCHHHHHCCCCEEEECHHHCCCCCCCH
SYFEWVQDFSSFFWTEDEINHRLERVMREAFAGVWAVSEEHKVSVRTAAFIVACKRILMA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEECCCCEEHHHHHHHHHHHHHHHHH
REMRGLYP
HHHHCCCC
>Mature Secondary Structure 
SSQLQSIPSYLHADDLGPWGNYLQQVDRVAPYLGSLSRWLETLKRPKRILIVDCPIELD
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEECC
NGTVAHFEGYRVQHNVSRGPGKGGVRYHQDVTLSEVMALSAWMSVKNAAVNVPYGGAKGG
CCEEEEEECEEEEECCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCEEECCCCCCCCC
IRVDPRKLSRGELERVTRRYTSEIGIIIGPNTDIPAPDVNTNEQVMAWMMDTYSMNQGQT
EEECHHHCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
STGVVTGKPISLGGSLGRKEATGRGVFVVGCEAAKKKGLEIEGARIAVQGFGNVGGIAAK
CCCEEECCCEECCCCCCCCCCCCCEEEEEECHHHHHCCCEECCCEEEEEECCCCHHHHHH
LFQEAGAKVIVVQDHTGTIYRPAGLDSNKLLDHVARTGGVAGFEGAEPMPNDEFWTVETD
HHHHCCCEEEEEECCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEC
ILIPAALENQITEKNASKIRTKIIVEGANGPTTTAADDILSANGVLVIPDVIANAGGVTV
EEECHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCHHHHHCCCCEEEECHHHCCCCCCCH
SYFEWVQDFSSFFWTEDEINHRLERVMREAFAGVWAVSEEHKVSVRTAAFIVACKRILMA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEECCCCEEHHHHHHHHHHHHHHHHH
REMRGLYP
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9680336; 10360571; 9135121; 9654452; 10366510 [H]