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The map label for this gene is mltA [H]

Identifier: 115350497

GI number: 115350497

Start: 494048

End: 495280

Strand: Direct

Name: mltA [H]

Synonym: Bamb_0443

Alternate gene names: 115350497

Gene position: 494048-495280 (Clockwise)

Preceding gene: 115350496

Following gene: 115350503

Centisome position: 13.89

GC content: 68.86

Gene sequence:

>1233_bases
ATGAAGATCAGCAGGGCGAGCGCTACGAAAGCTTCGAGCGCGAAGATGAGCATCGGATATTGGTCGAGAAAATCTGACAT
GGCGGTTTCCATCAAGAACGGACATTGTATGTGGTTTGGGCCCCGGCTGGCCGGCTGGATTGCGGCGGCCGCGACGGCCG
CACTGCTTGCCGCGTGCGGCGGCGCGCCGACGCGGACGTCGACGCTCAAGCCGCCGACCGGCACGGCGATCGTGCCGGGG
CAGATCGCCGCGAAGCGGCTGACGCCGGTCGCCTGGCAGCAGGTGCCCGGCTGGCAGGACGATTCGCTGATCGGCGCGGC
GGCCGCGCTGCGGCAGAACTGCGTGCGGCTCGCGCGCCAGCCGGCGTGGCAGCGCGCGTGCGCGGCGGCCGATCGCCTCG
ACGAACTCGACGTTAGCGGCGCGCGTGCATTCTTCGAAACGTATTTCACGCCGTTCCAGCTGGCGAACACCGACGGCACG
CTCGACGGGCTCGTGACCGGCTATTACGAGCCGCTGCTGCACGGCTCGCGCGTGCGTCGCGGTCCTTACCAGTACGCGCT
GTACCGCTGGCCGGCAGGCTATCGCGCCGGCGCCGCGCTGCCCGCTCGCGCGCAGCTCGAGCGCGCCGGCATCCTGAACG
GCAACGAACTCGTGTGGGTCGACGATCCGATCGAGGCGTTCTTCCTGCAGGTGCAGGGTTCCGGACGCGTGCTGCTCGAC
GACGGCTCGGTGATGCGGGTCGGTTTCGGCGGGACCAACAACCAGCCGTACCGTTCGATCGGCAAGTGGCTGCTCGATCG
CGGCGAGTTGACGCCTGCACAGGCGACGATGCAGGGCATCAAGGCGTGGGCGAAGGCGAACCCGACTCGCGTCGACGCGT
TGCTCGACACGAATCCGCGCTTCGTGTTCTTCCGTGACATGCCGACCAAGGAAGATGCGCCGCACGGCGGCGCGGACGGC
CCGATCGGCGCGCTCGGCGTGCCGCTCACGCCCGAGCGTTCGATCGCGGTCGATCCGTCGTCGATCCCGCTCGGCACGCC
CGTGTTCCTGCAGACCACGCGTCCGTTGACGAATACGCCGATGAACCGGCTCGTGTTCGCGCAGGATACGGGCTCCGCGA
TCCGGGGCGGCGTGCGGGCCGACTATTTCTGGGGGCTCGGCGACGACGCCGGCGATCAGGCCGGGCGGATGAAGCAGACC
GGCCGGATGTGGCTGCTGTTCCCGAATTCGTGA

Upstream 100 bases:

>100_bases
CATGCCGCGCACGCTGCATTGAGCGTGCGAGGGCGGTCAGCGCGGCTGGCGGTCGTTGCCGCGGGCGTGCTTCTTCCTGC
CCGACGACGTCCACACGACG

Downstream 100 bases:

>100_bases
TGCGCGGCGGTGCCGGCGTGCACGTGTAGCCGGGCATCGAACGAAACAGCCCGATCGGTTTGGTGGCCGGTCGGACTGTT
TTTTTGTGCAAGCGATTCCT

Product: MltA domain-containing protein

Products: Muramic Acid Residue [C]

Alternate protein names: Mlt38; Murein hydrolase A [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MKISRASATKASSAKMSIGYWSRKSDMAVSIKNGHCMWFGPRLAGWIAAAATAALLAACGGAPTRTSTLKPPTGTAIVPG
QIAAKRLTPVAWQQVPGWQDDSLIGAAAALRQNCVRLARQPAWQRACAAADRLDELDVSGARAFFETYFTPFQLANTDGT
LDGLVTGYYEPLLHGSRVRRGPYQYALYRWPAGYRAGAALPARAQLERAGILNGNELVWVDDPIEAFFLQVQGSGRVLLD
DGSVMRVGFGGTNNQPYRSIGKWLLDRGELTPAQATMQGIKAWAKANPTRVDALLDTNPRFVFFRDMPTKEDAPHGGADG
PIGALGVPLTPERSIAVDPSSIPLGTPVFLQTTRPLTNTPMNRLVFAQDTGSAIRGGVRADYFWGLGDDAGDQAGRMKQT
GRMWLLFPNS

Sequences:

>Translated_410_residues
MKISRASATKASSAKMSIGYWSRKSDMAVSIKNGHCMWFGPRLAGWIAAAATAALLAACGGAPTRTSTLKPPTGTAIVPG
QIAAKRLTPVAWQQVPGWQDDSLIGAAAALRQNCVRLARQPAWQRACAAADRLDELDVSGARAFFETYFTPFQLANTDGT
LDGLVTGYYEPLLHGSRVRRGPYQYALYRWPAGYRAGAALPARAQLERAGILNGNELVWVDDPIEAFFLQVQGSGRVLLD
DGSVMRVGFGGTNNQPYRSIGKWLLDRGELTPAQATMQGIKAWAKANPTRVDALLDTNPRFVFFRDMPTKEDAPHGGADG
PIGALGVPLTPERSIAVDPSSIPLGTPVFLQTTRPLTNTPMNRLVFAQDTGSAIRGGVRADYFWGLGDDAGDQAGRMKQT
GRMWLLFPNS
>Mature_410_residues
MKISRASATKASSAKMSIGYWSRKSDMAVSIKNGHCMWFGPRLAGWIAAAATAALLAACGGAPTRTSTLKPPTGTAIVPG
QIAAKRLTPVAWQQVPGWQDDSLIGAAAALRQNCVRLARQPAWQRACAAADRLDELDVSGARAFFETYFTPFQLANTDGT
LDGLVTGYYEPLLHGSRVRRGPYQYALYRWPAGYRAGAALPARAQLERAGILNGNELVWVDDPIEAFFLQVQGSGRVLLD
DGSVMRVGFGGTNNQPYRSIGKWLLDRGELTPAQATMQGIKAWAKANPTRVDALLDTNPRFVFFRDMPTKEDAPHGGADG
PIGALGVPLTPERSIAVDPSSIPLGTPVFLQTTRPLTNTPMNRLVFAQDTGSAIRGGVRADYFWGLGDDAGDQAGRMKQT
GRMWLLFPNS

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=381, Percent_Identity=29.6587926509186, Blast_Score=136, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 44180; Mature: 44180

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISRASATKASSAKMSIGYWSRKSDMAVSIKNGHCMWFGPRLAGWIAAAATAALLAACG
CCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCEEEEECHHHHHHHHHHHHHHHHHHHC
GAPTRTSTLKPPTGTAIVPGQIAAKRLTPVAWQQVPGWQDDSLIGAAAALRQNCVRLARQ
CCCCCCCCCCCCCCCEEECCHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHC
PAWQRACAAADRLDELDVSGARAFFETYFTPFQLANTDGTLDGLVTGYYEPLLHGSRVRR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCC
GPYQYALYRWPAGYRAGAALPARAQLERAGILNGNELVWVDDPIEAFFLQVQGSGRVLLD
CCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCEEEEEEECCCCEEEEE
DGSVMRVGFGGTNNQPYRSIGKWLLDRGELTPAQATMQGIKAWAKANPTRVDALLDTNPR
CCCEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCC
FVFFRDMPTKEDAPHGGADGPIGALGVPLTPERSIAVDPSSIPLGTPVFLQTTRPLTNTP
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEECCCCCCCC
MNRLVFAQDTGSAIRGGVRADYFWGLGDDAGDQAGRMKQTGRMWLLFPNS
CHHEEEEECCCHHHHCCCCEEEEECCCCCCCCCCCCHHHCCCEEEEECCC
>Mature Secondary Structure
MKISRASATKASSAKMSIGYWSRKSDMAVSIKNGHCMWFGPRLAGWIAAAATAALLAACG
CCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCEEEEECHHHHHHHHHHHHHHHHHHHC
GAPTRTSTLKPPTGTAIVPGQIAAKRLTPVAWQQVPGWQDDSLIGAAAALRQNCVRLARQ
CCCCCCCCCCCCCCCEEECCHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHC
PAWQRACAAADRLDELDVSGARAFFETYFTPFQLANTDGTLDGLVTGYYEPLLHGSRVRR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCC
GPYQYALYRWPAGYRAGAALPARAQLERAGILNGNELVWVDDPIEAFFLQVQGSGRVLLD
CCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCEEEEEEECCCCEEEEE
DGSVMRVGFGGTNNQPYRSIGKWLLDRGELTPAQATMQGIKAWAKANPTRVDALLDTNPR
CCCEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCC
FVFFRDMPTKEDAPHGGADGPIGALGVPLTPERSIAVDPSSIPLGTPVFLQTTRPLTNTP
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEECCCCCCCC
MNRLVFAQDTGSAIRGGVRADYFWGLGDDAGDQAGRMKQTGRMWLLFPNS
CHHEEEEECCCHHHHCCCCEEEEECCCCCCCCCCCCHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]