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The map label for this gene is hisB

Identifier: 115350400

GI number: 115350400

Start: 389766

End: 390353

Strand: Direct

Name: hisB

Synonym: Bamb_0345

Alternate gene names: 115350400

Gene position: 389766-390353 (Clockwise)

Preceding gene: 115350399

Following gene: 115350401

Centisome position: 10.96

GC content: 63.95

Gene sequence:

>588_bases
ATGCGTGTGGCGGAAGTCGTTCGCAATACCAGCGAAACGCAGATCCGTGTGAAGCTCGATCTCGACGGTACGGGCCGGCA
GAAGCTGGCCACCGGCGTGCCGTTTCTCGACCATATGCTCGATCAGATCGCGCGCCATGGTCTGATCGATCTCGAGGTCG
AAGCGCATGGCGATACGCATATCGACGACCACCACACGGTCGAGGACGTCGGTATCACGCTCGGCCAGGCCGTCGCGAAG
GCAATCGGCGACAAGAAGGGCATTCGCCGCTACGGCCATTCGTACGTGCCGCTCGACGAGGCGCTGTCGCGCGTCGTGAT
CGACTTCTCGGGCCGGCCGGGTCTCGAATTCCACGTGCCGTTCACGCGAGCGCGGATCGGTACGTTCGACGTCGACCTGT
CGATCGAATTCTTCCGCGGGTTCGTGAACCACGCGGGCGTCACGCTGCATATCGACAACCTGCGCGGGATCAACGCGCAC
CATCAACTCGAAACGGTGTTCAAGGCCTTCGGCCGGGCGCTGCGTGCGGCGGTGGAGCTCGACGAGCGCGCGGCGGGGCA
GATTCCGTCGACGAAGGGCAGCCTCTAA

Upstream 100 bases:

>100_bases
TGCTGGCTGCCTTGAAACTCGCGCTGCCCGGTTGAGCCCAGGGCGCGGCGGCGCGCGACGATCAATCCCCATTTACATCA
GACTCAATCAAGGAATTGCC

Downstream 100 bases:

>100_bases
CCTTCCGGACGGGCGCACGCCCAGGACAACCTCACGGCTTCGGCGCGGCGCGCCGGCTTGCGATGGATCTGCTCAAATCG
TTCATTTCGCTGCTGGCGCT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MRVAEVVRNTSETQIRVKLDLDGTGRQKLATGVPFLDHMLDQIARHGLIDLEVEAHGDTHIDDHHTVEDVGITLGQAVAK
AIGDKKGIRRYGHSYVPLDEALSRVVIDFSGRPGLEFHVPFTRARIGTFDVDLSIEFFRGFVNHAGVTLHIDNLRGINAH
HQLETVFKAFGRALRAAVELDERAAGQIPSTKGSL

Sequences:

>Translated_195_residues
MRVAEVVRNTSETQIRVKLDLDGTGRQKLATGVPFLDHMLDQIARHGLIDLEVEAHGDTHIDDHHTVEDVGITLGQAVAK
AIGDKKGIRRYGHSYVPLDEALSRVVIDFSGRPGLEFHVPFTRARIGTFDVDLSIEFFRGFVNHAGVTLHIDNLRGINAH
HQLETVFKAFGRALRAAVELDERAAGQIPSTKGSL
>Mature_195_residues
MRVAEVVRNTSETQIRVKLDLDGTGRQKLATGVPFLDHMLDQIARHGLIDLEVEAHGDTHIDDHHTVEDVGITLGQAVAK
AIGDKKGIRRYGHSYVPLDEALSRVVIDFSGRPGLEFHVPFTRARIGTFDVDLSIEFFRGFVNHAGVTLHIDNLRGINAH
HQLETVFKAFGRALRAAVELDERAAGQIPSTKGSL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=50, Blast_Score=187, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6324776, Length=216, Percent_Identity=39.3518518518519, Blast_Score=151, Evalue=8e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_BURA4 (B1YRV7)

Other databases:

- EMBL:   CP001025
- RefSeq:   YP_001807071.1
- ProteinModelPortal:   B1YRV7
- SMR:   B1YRV7
- GeneID:   6178349
- GenomeReviews:   CP001025_GR
- KEGG:   bac:BamMC406_0354
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   PRK00951
- BioCyc:   BAMB398577:BAMMC406_0354-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21501; Mature: 21501

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVAEVVRNTSETQIRVKLDLDGTGRQKLATGVPFLDHMLDQIARHGLIDLEVEAHGDTH
CCHHHHHCCCCCCEEEEEEECCCCCCHHHHHCCCHHHHHHHHHHHCCEEEEEEECCCCCC
IDDHHTVEDVGITLGQAVAKAIGDKKGIRRYGHSYVPLDEALSRVVIDFSGRPGLEFHVP
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHEEEECCCCCCCEEECC
FTRARIGTFDVDLSIEFFRGFVNHAGVTLHIDNLRGINAHHQLETVFKAFGRALRAAVEL
HHHHCCCEEEEEEHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DERAAGQIPSTKGSL
HHHHCCCCCCCCCCC
>Mature Secondary Structure
MRVAEVVRNTSETQIRVKLDLDGTGRQKLATGVPFLDHMLDQIARHGLIDLEVEAHGDTH
CCHHHHHCCCCCCEEEEEEECCCCCCHHHHHCCCHHHHHHHHHHHCCEEEEEEECCCCCC
IDDHHTVEDVGITLGQAVAKAIGDKKGIRRYGHSYVPLDEALSRVVIDFSGRPGLEFHVP
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHEEEECCCCCCCEEECC
FTRARIGTFDVDLSIEFFRGFVNHAGVTLHIDNLRGINAHHQLETVFKAFGRALRAAVEL
HHHHCCCEEEEEEHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DERAAGQIPSTKGSL
HHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA