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Identifier: 11499353

GI number: 11499353

Start: 1582678

End: 1583151

Strand: Reverse

Name: Not Available

Synonym: AF1764

Alternate gene names: 11499353

Gene position: 1583151-1582678 (Counterclockwise)

Preceding gene: 11499354

Following gene: 11499351

Centisome position: 72.67

GC content: 52.32

Gene sequence:

>474_bases
ATGAAGAGGCCCACGCTCGATGAGTACTTCATGGAAATCGCCTCGGTTGTGGCGAAGCGCTCCACCTGTCTTAGACAGCA
CGTCGGGGCCGTCATAGTCAAGGACAAGCGCATTCTTGCCACGGGCTACAACGGAGCGCCTTCAGGCCTGCCACACTGCG
AAGAGGTGGGATGCCTGAGGGACAGGATGTCCGTGCCGAGCGGGGAAAGGCAGGAGCTTTGCAGAGGGGTGCATGCGGAG
CAAAATGCAATAATACAGGCGGCTAAGTTCGGGATAAGTGTTGATGGTGGTACTCTTTACTCAACTCACTGCCCCTGCAT
CACGTGTGCGAAAATCATCATCAACGCGGGGATAAAGAGAGTTGTTTACGGGAAGGAGTATGCCGATAAGAACGGTTTGA
AGCTTCTGGAGGAGGCAGGAGTGGAGATTGAGTTCTTTCCTTCTGATTCGCTTAGCAAAAAAGTAAAAAATTAA

Upstream 100 bases:

>100_bases
CGGTGGCGGAGGCTGCTGTAAAGATTGAGGAGGCTGTGGGCAGGGAGGAGATGGAGAAGGTTGCGAGGGAAAACGCCAGA
AAATTTTTGAGGGTGTTGGA

Downstream 100 bases:

>100_bases
ATGTAATCCGAAAACTGCACGATAATCGAGTGCCTGTCCGCAGACCATGCCGGGATGGTGAAGCTTTCCTCCCCACCGGT
TCTCGACTTCACAGCTATGC

Product: dCMP deaminase, putative

Products: dUMP; NH3

Alternate protein names: NA

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MKRPTLDEYFMEIASVVAKRSTCLRQHVGAVIVKDKRILATGYNGAPSGLPHCEEVGCLRDRMSVPSGERQELCRGVHAE
QNAIIQAAKFGISVDGGTLYSTHCPCITCAKIIINAGIKRVVYGKEYADKNGLKLLEEAGVEIEFFPSDSLSKKVKN

Sequences:

>Translated_157_residues
MKRPTLDEYFMEIASVVAKRSTCLRQHVGAVIVKDKRILATGYNGAPSGLPHCEEVGCLRDRMSVPSGERQELCRGVHAE
QNAIIQAAKFGISVDGGTLYSTHCPCITCAKIIINAGIKRVVYGKEYADKNGLKLLEEAGVEIEFFPSDSLSKKVKN
>Mature_157_residues
MKRPTLDEYFMEIASVVAKRSTCLRQHVGAVIVKDKRILATGYNGAPSGLPHCEEVGCLRDRMSVPSGERQELCRGVHAE
QNAIIQAAKFGISVDGGTLYSTHCPCITCAKIIINAGIKRVVYGKEYADKNGLKLLEEAGVEIEFFPSDSLSKKVKN

Specific function: Dispensable for transformability [H]

COG id: COG2131

COG function: function code F; Deoxycytidylate deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI61742819, Length=147, Percent_Identity=36.0544217687075, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI61742821, Length=145, Percent_Identity=35.8620689655172, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321938, Length=149, Percent_Identity=39.5973154362416, Blast_Score=117, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24667298, Length=147, Percent_Identity=38.7755102040816, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24667302, Length=147, Percent_Identity=38.7755102040816, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR013404
- InterPro:   IPR015517
- InterPro:   IPR016193
- InterPro:   IPR016473 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.12

Molecular weight: Translated: 17156; Mature: 17156

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
4.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRPTLDEYFMEIASVVAKRSTCLRQHVGAVIVKDKRILATGYNGAPSGLPHCEEVGCLR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCEEEEECCCCCCCCCCCHHHHHHHH
DRMSVPSGERQELCRGVHAEQNAIIQAAKFGISVDGGTLYSTHCPCITCAKIIINAGIKR
HHHCCCCCCHHHHHHHCCCHHHHHHHHHHHCEECCCCEEEECCCCHHHHHHHHHHHCHHH
VVYGKEYADKNGLKLLEEAGVEIEFFPSDSLSKKVKN
HHCCCHHCCCCCHHHHHHCCCEEEEECCCHHHHHCCC
>Mature Secondary Structure
MKRPTLDEYFMEIASVVAKRSTCLRQHVGAVIVKDKRILATGYNGAPSGLPHCEEVGCLR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCEEEEECCCCCCCCCCCHHHHHHHH
DRMSVPSGERQELCRGVHAEQNAIIQAAKFGISVDGGTLYSTHCPCITCAKIIINAGIKR
HHHCCCCCCHHHHHHHCCCHHHHHHHHHHHCEECCCCEEEECCCCHHHHHHHHHHHCHHH
VVYGKEYADKNGLKLLEEAGVEIEFFPSDSLSKKVKN
HHCCCHHCCCCCHHHHHHCCCEEEEECCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dCMP; H2O

Specific reaction: dCMP + H2O = dUMP + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]