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The map label for this gene is sucC

Identifier: 11499135

GI number: 11499135

Start: 1388629

End: 1389780

Strand: Reverse

Name: sucC

Synonym: AF1540

Alternate gene names: 11499135

Gene position: 1389780-1388629 (Counterclockwise)

Preceding gene: 11499136

Following gene: 11499134

Centisome position: 63.8

GC content: 52.69

Gene sequence:

>1152_bases
ATGATGCGCCTTCACGAGCATCAGGCAAAGCAGATATTTGCAAAGCACGGAATTAGGGTTCCGCGGGGCGAGGTTGCTAC
ATCACCTGAAGAGGCGGAGAAAATTGCGGAAAAACTTGGAGGCAGGGTTGTGGTTAAGGCCCAGATTTTGGTTGGTGGAA
GGGGCAAGGCGGGGGGTGTTAAGAAGGCAAACAGCCCGGAAGAGGCAAAGGAAGTGGCAAAGAAGATTCTCGGCATGACC
ATCAAAGGGCACAGGGTTGAGAAAGTGCTTGTGGAGGAGCAGCTCAATATGAGAAAGGAGTACTACGTGGGCTACGTCGT
TGACAAGTCGAGCAGGCTCCCCACAGTGATTTTCAGTCGGATGGGAGGTATGGATGTGGAGGAAATAGCTGCGAAGCACC
CCGATGCAATACACAGGATTTACTTCGACCCCCTTTGGGGGCTGAAGGATTACGAGGTTCGCAAGGCTCTGTTCAGAGCC
GGCTTTGAAGGAGAGGAGTTCAAGCAGATGTTTGACATAATCAAAAAACTTGTCGATATCGCATTTGCCTACGAAGCTGA
GCTGACGGAGATAAACCCCCTTGCGGTGACGGATGAGGGATTTTTGGCTGCCGACGCCCGATTGAACACCGATGACAACG
CCCTCTACCGCCATCCGGAGCTTGCAGAACTGAGGGAGGCAACGGAGGAGGACCCGCTTGAGAGGGAGGCGAGGCTGAAA
GGAATCAACTACGTCCACCTTGGCGGGAATGTGGGGGTAATTGCAAACGGTGCGGGCCTTGCAATGGCCACAATGGACAT
AATCAACCTGATGGGAGGAAAGCCGGCGAACTTCCTTGATACCGGAGGAGGCCTGGCTGACCCGGTTAAAATGAAAAATT
GCCTCCTTCACGTTCTCAAGGACCCGAATGTGAGGGTTGTTTTCATAAACATCTACGCAGAGATAACGAGGTGTGAAAAG
GTTGCTGAAGGAATCATTCTGGCACTGGACGAAGCTCCGAGAAAGGTTCCGCTTGTCGTAAAGCTTGCGGGCACAAATGA
GGAAATCGGGAGGGAAATGCTTGAGAGGTACAGTTCGGAGAAGGGGGCGGAAATCCACTTCGTGGAGTCTATTGAAGAGG
GAGCCAGAAAGGCTGTTGAGCTTGCGGGGTGA

Upstream 100 bases:

>100_bases
TATATTGAAAAATTGAGAATGTTAAATCGAACTTAAAAGGTGGTTGGATGTGCAGGCAGAATGGCGGAAGTCCTTTTGGT
TTCGTTGAAAATGGGGTGGT

Downstream 100 bases:

>100_bases
TGGATGTGGCGATTCTTGTTGATGAAAACACCCGTGTTATTGTGCAGGGAATAACCGGATTTCAGGGAAGTTTCCAGGCA
AAGAGAATGCTCGATTACGG

Product: succinyl-CoA synthetase subunit beta

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit beta-1; SCS-beta-1 [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MMRLHEHQAKQIFAKHGIRVPRGEVATSPEEAEKIAEKLGGRVVVKAQILVGGRGKAGGVKKANSPEEAKEVAKKILGMT
IKGHRVEKVLVEEQLNMRKEYYVGYVVDKSSRLPTVIFSRMGGMDVEEIAAKHPDAIHRIYFDPLWGLKDYEVRKALFRA
GFEGEEFKQMFDIIKKLVDIAFAYEAELTEINPLAVTDEGFLAADARLNTDDNALYRHPELAELREATEEDPLEREARLK
GINYVHLGGNVGVIANGAGLAMATMDIINLMGGKPANFLDTGGGLADPVKMKNCLLHVLKDPNVRVVFINIYAEITRCEK
VAEGIILALDEAPRKVPLVVKLAGTNEEIGREMLERYSSEKGAEIHFVESIEEGARKAVELAG

Sequences:

>Translated_383_residues
MMRLHEHQAKQIFAKHGIRVPRGEVATSPEEAEKIAEKLGGRVVVKAQILVGGRGKAGGVKKANSPEEAKEVAKKILGMT
IKGHRVEKVLVEEQLNMRKEYYVGYVVDKSSRLPTVIFSRMGGMDVEEIAAKHPDAIHRIYFDPLWGLKDYEVRKALFRA
GFEGEEFKQMFDIIKKLVDIAFAYEAELTEINPLAVTDEGFLAADARLNTDDNALYRHPELAELREATEEDPLEREARLK
GINYVHLGGNVGVIANGAGLAMATMDIINLMGGKPANFLDTGGGLADPVKMKNCLLHVLKDPNVRVVFINIYAEITRCEK
VAEGIILALDEAPRKVPLVVKLAGTNEEIGREMLERYSSEKGAEIHFVESIEEGARKAVELAG
>Mature_383_residues
MMRLHEHQAKQIFAKHGIRVPRGEVATSPEEAEKIAEKLGGRVVVKAQILVGGRGKAGGVKKANSPEEAKEVAKKILGMT
IKGHRVEKVLVEEQLNMRKEYYVGYVVDKSSRLPTVIFSRMGGMDVEEIAAKHPDAIHRIYFDPLWGLKDYEVRKALFRA
GFEGEEFKQMFDIIKKLVDIAFAYEAELTEINPLAVTDEGFLAADARLNTDDNALYRHPELAELREATEEDPLEREARLK
GINYVHLGGNVGVIANGAGLAMATMDIINLMGGKPANFLDTGGGLADPVKMKNCLLHVLKDPNVRVVFINIYAEITRCEK
VAEGIILALDEAPRKVPLVVKLAGTNEEIGREMLERYSSEKGAEIHFVESIEEGARKAVELAG

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI11321583, Length=397, Percent_Identity=37.0277078085642, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI157779135, Length=369, Percent_Identity=37.3983739837398, Blast_Score=241, Evalue=8e-64,
Organism=Homo sapiens, GI294862256, Length=360, Percent_Identity=37.7777777777778, Blast_Score=238, Evalue=8e-63,
Organism=Escherichia coli, GI1786948, Length=387, Percent_Identity=42.1188630490956, Blast_Score=285, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI17567829, Length=398, Percent_Identity=36.6834170854271, Blast_Score=234, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI17539378, Length=398, Percent_Identity=36.1809045226131, Blast_Score=234, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6321683, Length=400, Percent_Identity=35.5, Blast_Score=244, Evalue=1e-65,
Organism=Drosophila melanogaster, GI161078106, Length=397, Percent_Identity=37.7833753148615, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24645208, Length=397, Percent_Identity=37.7833753148615, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI281361397, Length=398, Percent_Identity=37.4371859296482, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI281361395, Length=398, Percent_Identity=37.4371859296482, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI21356231, Length=398, Percent_Identity=36.4321608040201, Blast_Score=219, Evalue=4e-57,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102 [H]

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 42337; Mature: 42337

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS50975 ATP_GRASP ; PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRLHEHQAKQIFAKHGIRVPRGEVATSPEEAEKIAEKLGGRVVVKAQILVGGRGKAGGV
CCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCC
KKANSPEEAKEVAKKILGMTIKGHRVEKVLVEEQLNMRKEYYVGYVVDKSSRLPTVIFSR
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHEEEEEEEECCCCCHHHHHHH
MGGMDVEEIAAKHPDAIHRIYFDPLWGLKDYEVRKALFRAGFEGEEFKQMFDIIKKLVDI
CCCCCHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
AFAYEAELTEINPLAVTDEGFLAADARLNTDDNALYRHPELAELREATEEDPLEREARLK
HHHHHCCCCCCCCEEECCCCCEEECCCCCCCCCCEECCCCHHHHHHHHCCCCHHHHHHHC
GINYVHLGGNVGVIANGAGLAMATMDIINLMGGKPANFLDTGGGLADPVKMKNCLLHVLK
CCCEEEECCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
DPNVRVVFINIYAEITRCEKVAEGIILALDEAPRKVPLVVKLAGTNEEIGREMLERYSSE
CCCEEEEEEEHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHCCC
KGAEIHFVESIEEGARKAVELAG
CCCEEEEHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMRLHEHQAKQIFAKHGIRVPRGEVATSPEEAEKIAEKLGGRVVVKAQILVGGRGKAGGV
CCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCC
KKANSPEEAKEVAKKILGMTIKGHRVEKVLVEEQLNMRKEYYVGYVVDKSSRLPTVIFSR
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHEEEEEEEECCCCCHHHHHHH
MGGMDVEEIAAKHPDAIHRIYFDPLWGLKDYEVRKALFRAGFEGEEFKQMFDIIKKLVDI
CCCCCHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
AFAYEAELTEINPLAVTDEGFLAADARLNTDDNALYRHPELAELREATEEDPLEREARLK
HHHHHCCCCCCCCEEECCCCCEEECCCCCCCCCCEECCCCHHHHHHHHCCCCHHHHHHHC
GINYVHLGGNVGVIANGAGLAMATMDIINLMGGKPANFLDTGGGLADPVKMKNCLLHVLK
CCCEEEECCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
DPNVRVVFINIYAEITRCEKVAEGIILALDEAPRKVPLVVKLAGTNEEIGREMLERYSSE
CCCEEEEEEEHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHCCC
KGAEIHFVESIEEGARKAVELAG
CCCEEEEHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]