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The map label for this gene is sucD-1

Identifier: 11499134

GI number: 11499134

Start: 1387757

End: 1388632

Strand: Reverse

Name: sucD-1

Synonym: AF1539

Alternate gene names: 11499134

Gene position: 1388632-1387757 (Counterclockwise)

Preceding gene: 11499135

Following gene: 11499133

Centisome position: 63.75

GC content: 52.4

Gene sequence:

>876_bases
GTGATGGATGTGGCGATTCTTGTTGATGAAAACACCCGTGTTATTGTGCAGGGAATAACCGGATTTCAGGGAAGTTTCCA
GGCAAAGAGAATGCTCGATTACGGAACCAAAGTTGTAGGAGGGGTGACACCCGGAAAGGGCGGTAGTGAAGTGCACGGAA
TACCCGTTTACAATACTGTGGAGGAGGCAGTAGCAGAAACAAATGCAGACACATCGATAATTTACGTTCCCGCACGCTTT
GCAACCGACGCCATTTTTGAGGCCTTCGACGCAGGGCTGAGGCTTGTTGTGTGCGTTACTGAGGGCATACCTCTCTACGA
CGAGATGCTCATTCACAGGAAGCTCAGGGAAGTGAAATCCATGCTCCTTGGCCCTAACTGCCCCGGTGTTATAAGTCCGG
GGAGGTCCAAGGTAGGTCTTCTGCCCGACAGAAGCTTTACACAGGGCAATCTCGGTGTAGTTTCGAGAAGCGGAACTCTT
ACCTATCAAATCTGCGAGAATCTTACAAAGGCAGGGATTGGCCAGTCCACAGTTGTGGGGATTGGGGGCGACCCGATGCC
TGGATTGACCTTTGTTGACGTTCTCAAAATGTTTGAGGAGGACGAAGAGACCAAAGCTGTTCTGCTGGTTGGTGAAATAG
GTGGAACAGCCGAGGAAAAGGCTGCGGAGTTCATAAAGCAAATGTCAAAGCCTGTCGTGGCATTCATTGCCGGAAGGACG
GCACCACCGGGGAAGAGAATGGGGCATGCCGGCGCAATAATCGAGGGGAGTACGGGGACTGCAGAGGCGAAAATGGCTGC
ACTACGCGATGCAGGGGCGAGGGTTGCGGAAACTTTGCTGGATGTGGTGAAGGAGGTCAGAAGAGTGCTGGAGTGA

Upstream 100 bases:

>100_bases
GGAGGGAAATGCTTGAGAGGTACAGTTCGGAGAAGGGGGCGGAAATCCACTTCGTGGAGTCTATTGAAGAGGGAGCCAGA
AAGGCTGTTGAGCTTGCGGG

Downstream 100 bases:

>100_bases
GCTGTTTTAAGCTTTGTTCTCTTTTATTTATTTGATTGTTGAGATTATGGGGTAGCTGAAATTTTGGTTTGTTTTGTTTG
ATTGCAGATTTGCACTTTAG

Product: succinyl-CoA synthetase, alpha subunit (sucD-1)

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha 1; SCS-alpha 1

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MMDVAILVDENTRVIVQGITGFQGSFQAKRMLDYGTKVVGGVTPGKGGSEVHGIPVYNTVEEAVAETNADTSIIYVPARF
ATDAIFEAFDAGLRLVVCVTEGIPLYDEMLIHRKLREVKSMLLGPNCPGVISPGRSKVGLLPDRSFTQGNLGVVSRSGTL
TYQICENLTKAGIGQSTVVGIGGDPMPGLTFVDVLKMFEEDEETKAVLLVGEIGGTAEEKAAEFIKQMSKPVVAFIAGRT
APPGKRMGHAGAIIEGSTGTAEAKMAALRDAGARVAETLLDVVKEVRRVLE

Sequences:

>Translated_291_residues
MMDVAILVDENTRVIVQGITGFQGSFQAKRMLDYGTKVVGGVTPGKGGSEVHGIPVYNTVEEAVAETNADTSIIYVPARF
ATDAIFEAFDAGLRLVVCVTEGIPLYDEMLIHRKLREVKSMLLGPNCPGVISPGRSKVGLLPDRSFTQGNLGVVSRSGTL
TYQICENLTKAGIGQSTVVGIGGDPMPGLTFVDVLKMFEEDEETKAVLLVGEIGGTAEEKAAEFIKQMSKPVVAFIAGRT
APPGKRMGHAGAIIEGSTGTAEAKMAALRDAGARVAETLLDVVKEVRRVLE
>Mature_291_residues
MMDVAILVDENTRVIVQGITGFQGSFQAKRMLDYGTKVVGGVTPGKGGSEVHGIPVYNTVEEAVAETNADTSIIYVPARF
ATDAIFEAFDAGLRLVVCVTEGIPLYDEMLIHRKLREVKSMLLGPNCPGVISPGRSKVGLLPDRSFTQGNLGVVSRSGTL
TYQICENLTKAGIGQSTVVGIGGDPMPGLTFVDVLKMFEEDEETKAVLLVGEIGGTAEEKAAEFIKQMSKPVVAFIAGRT
APPGKRMGHAGAIIEGSTGTAEAKMAALRDAGARVAETLLDVVKEVRRVLE

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family

Homologues:

Organism=Homo sapiens, GI109452591, Length=277, Percent_Identity=55.2346570397112, Blast_Score=260, Evalue=8e-70,
Organism=Homo sapiens, GI38569421, Length=256, Percent_Identity=29.6875, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI38569423, Length=256, Percent_Identity=29.6875, Blast_Score=99, Evalue=3e-21,
Organism=Escherichia coli, GI1786949, Length=289, Percent_Identity=55.0173010380623, Blast_Score=331, Evalue=3e-92,
Organism=Escherichia coli, GI1786729, Length=181, Percent_Identity=26.5193370165746, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1786513, Length=237, Percent_Identity=24.4725738396624, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17550194, Length=277, Percent_Identity=53.7906137184115, Blast_Score=279, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17553126, Length=279, Percent_Identity=52.3297491039427, Blast_Score=275, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17551266, Length=316, Percent_Identity=27.8481012658228, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17557344, Length=253, Percent_Identity=28.0632411067194, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324716, Length=283, Percent_Identity=46.9964664310954, Blast_Score=252, Evalue=4e-68,
Organism=Drosophila melanogaster, GI21356559, Length=274, Percent_Identity=48.9051094890511, Blast_Score=271, Evalue=3e-73,
Organism=Drosophila melanogaster, GI28574296, Length=292, Percent_Identity=48.2876712328767, Blast_Score=248, Evalue=3e-66,
Organism=Drosophila melanogaster, GI281363477, Length=243, Percent_Identity=31.2757201646091, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI281363475, Length=243, Percent_Identity=31.2757201646091, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI281363473, Length=243, Percent_Identity=31.2757201646091, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SUCD1_ARCFU (O28733)

Other databases:

- EMBL:   AE000782
- PIR:   B69442
- RefSeq:   NP_070368.1
- ProteinModelPortal:   O28733
- SMR:   O28733
- GeneID:   1484767
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF1539
- NMPDR:   fig|224325.1.peg.1529
- TIGR:   AF_1539
- HOGENOM:   HBG615372
- OMA:   ANDMVAT
- ProtClustDB:   CLSK541780
- BioCyc:   AFUL224325:AF_1539-MONOMER
- BRENDA:   6.2.1.5
- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:3.40.50.261
- PIRSF:   PIRSF001553
- PRINTS:   PR01798
- SMART:   SM00881
- TIGRFAMs:   TIGR01019

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA; SSF52210 CoA_ligase

EC number: =6.2.1.5

Molecular weight: Translated: 30796; Mature: 30796

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS01216 SUCCINYL_COA_LIG_1; PS00399 SUCCINYL_COA_LIG_2

Important sites: ACT_SITE 249-249

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDVAILVDENTRVIVQGITGFQGSFQAKRMLDYGTKVVGGVTPGKGGSEVHGIPVYNTV
CCEEEEEEECCCEEEEEECCCCCCCHHHHHHHHHCCHHCCCCCCCCCCCCCCCCCCHHHH
EEAVAETNADTSIIYVPARFATDAIFEAFDAGLRLVVCVTEGIPLYDEMLIHRKLREVKS
HHHHHHCCCCCEEEEECHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
MLLGPNCPGVISPGRSKVGLLPDRSFTQGNLGVVSRSGTLTYQICENLTKAGIGQSTVVG
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCEEEE
IGGDPMPGLTFVDVLKMFEEDEETKAVLLVGEIGGTAEEKAAEFIKQMSKPVVAFIAGRT
CCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCC
APPGKRMGHAGAIIEGSTGTAEAKMAALRDAGARVAETLLDVVKEVRRVLE
CCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MMDVAILVDENTRVIVQGITGFQGSFQAKRMLDYGTKVVGGVTPGKGGSEVHGIPVYNTV
CCEEEEEEECCCEEEEEECCCCCCCHHHHHHHHHCCHHCCCCCCCCCCCCCCCCCCHHHH
EEAVAETNADTSIIYVPARFATDAIFEAFDAGLRLVVCVTEGIPLYDEMLIHRKLREVKS
HHHHHHCCCCCEEEEECHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
MLLGPNCPGVISPGRSKVGLLPDRSFTQGNLGVVSRSGTLTYQICENLTKAGIGQSTVVG
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCEEEE
IGGDPMPGLTFVDVLKMFEEDEETKAVLLVGEIGGTAEEKAAEFIKQMSKPVVAFIAGRT
CCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCC
APPGKRMGHAGAIIEGSTGTAEAKMAALRDAGARVAETLLDVVKEVRRVLE
CCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475