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The map label for this gene is hdrA-2

Identifier: 11498973

GI number: 11498973

Start: 1228180

End: 1230159

Strand: Reverse

Name: hdrA-2

Synonym: AF1377

Alternate gene names: 11498973

Gene position: 1230159-1228180 (Counterclockwise)

Preceding gene: 11498974

Following gene: 11498972

Centisome position: 56.47

GC content: 51.11

Gene sequence:

>1980_bases
ATGAAAATTGGCGTTTACGTGTGTCACTGCGGTGAGAACATCTCTTCAAACGTCGATATTGATGAGCTGGTGGAGTTTGC
GAAGAGCAGTGAGGGGGTTAGCGTTGTCAGGGATCACCTCTTCATGTGCTCCGAAATTGCGCAGGAGATGATTAGGGACG
ATATAAAGTCGGGAAAGGTTGATAGGGTGGTTATTGCCGCCTGTTCCCCAAAAAATCACGAGAAGTTTTTCAGAGCAACT
CTTGAGAAGGCCGGGATATCAAAATACATGCTTGAGATTGCCAACATCAGAGAGCAGTGCAGCTGGGTGCATGAGAAGAA
TGCGACCGAAAAAGCCAAGAGTTTGCTGGCATCGTCGATAGCCAAGGCGAGAAAGCTCCAGCCTCTTGAGGAGCTGTGTC
TGGATGTTAACGATAGTGCTCTGGTTATTGGCGGGGGTGTGGCGGGCATAACTGCGGCCATTGAGCTCTCAAAAATGGGG
TTTAAGGTTTATCTGGTTGAGAAGGAGCCATCCATAGGCGGAAAGATGATGAAGTTTGATCGGATTTTCCCGATGAACGA
CTGCTCTTCCTGTGTCCTTTATCCTCTTATTTCAGAGGTTTCATCGAGCCCCTTAGTCGAGCTGATTACTTATGCGGAAG
TTGAGGAGGTTAAAGGCTCTGTGGGGAATTTTCAGGTGAAAATCAGGAAGAAGCAGACTTATGTTGACTGGGACAAGTGC
ATAGGCTGTGGGGCGTGTGTTGAGGCCTGCCCTCCAAGAGCGGTTACTGAGGATGAGTTCAATGAGGGCTTAACGAAGAG
AAGGGCAATGTACATCGCTTCTCCCTACGCAATACCGAGGAAGGCCGTTCACGACCCAAAAAGCTGTGTGAACTGCGGGA
AGAAGACGCTTGGCACGAGAAGATTTTTGAGAGGAGGGAAGGAGTACCTCGCCCCATGTGAGAAAGCCTGCCCTACGGGG
GCGATAAACAGGTCGTTAGAGTGGAATCCGGAGGGCGAGATTGTTGAGGTTAACGTTGGTGCAATAGTTGTTGCCGTTGG
CTACGAGGTTATGAAAAAGCAGAACTTCAAGGAGTACCTCCCTCCCTCTCCCAACGTGATTACAGCGTTGCAGTTTGAGA
GAATTCTTTCCCCCACGGGCCCCACAGCTGGGAAGGTTCTCAGGCCATCCGACATGAAGAAGCCTGAAACTGTGTCGTTC
ATTTCATGCGTGGGAAGCAGGGACGTGAGGTACCACACCTACTGCTCCAAAGTTTGCTGCATGTACATGCTCAAGCAGGC
TAGGCTAATTAAAGAAAGAAACCCGGAAATTGACGTTTACATACACATGATTGACGTCAGGGCTCCGGGGAAGGACTTGG
AGGAGTACTACACCCAGTCGAGGCAGATGGGGATTAAGATTATCAGGGGCAAGGTGGGGGGAATTGAGGAGCTTCCAGAT
GGCAGGCTTAGAGTTCTCGGATTTGATGCTGACATCGGCACTCCTGTGGAAGTTGAGGCGGATTTGGTTGTCCTCGCAAC
TGCTATAGAGCTGAGTGAGGATGCAAGGAAGCTGGCAAAGAATCTTGGAATCTCCGTTGACACCTCAGGATTCCTGAAGG
AAGACCACCCCAAGCTGAGGTCGGTTGAGAGCTGGCTTGACGGGATTTTTATCGCCGGATGCTGTCAGGGGCCAAAGGAC
ATTTCCGAGACTGTTTCTCAGGCAAAGGCGGCTGCCGCGGGAGCAGCGGCAATTCTCGGAAGGGACTTCATACAGCTTGA
GCCCTTTTTGGCTACTGTTGATGAAAAACTCTGCACGGGGTGCGGTATATGCGCGAGCGCCTGTCCTTACGAGGCCATAT
CCGTTAACGGGAGGGCTGAGGTTGACACGAGAAGGTGCAAGGGGTGCGGAATCTGCAGCTCCGTCTGCCCTGCCAACGCT
GTTGATTTAGCTGGATTCACAAGAGAGCAAATTCTCTCCCAGCTGGAGGCGATATTATGA

Upstream 100 bases:

>100_bases
AAAAATTGCACAATTTTTCATGCATCTATTAACTTTTACAATTTTTCATGTATGTAATTATTTATAAAATGATTTAAAGC
TGGAATTCAAATGAATTTGG

Downstream 100 bases:

>100_bases
GAGTTGTGAGGCTGCCAAGGCATGATGACGTTGTGGAGGAGGTTTCAAAGTTTGGTGGGGAAGGAATTGGGAGATGCATC
CAGTGCGGAGCGTGCATGTC

Product: heterodisulfide reductase, subunit A (hdrA-2)

Products: N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine; dihydromethanophenazine

Alternate protein names: NA

Number of amino acids: Translated: 659; Mature: 659

Protein sequence:

>659_residues
MKIGVYVCHCGENISSNVDIDELVEFAKSSEGVSVVRDHLFMCSEIAQEMIRDDIKSGKVDRVVIAACSPKNHEKFFRAT
LEKAGISKYMLEIANIREQCSWVHEKNATEKAKSLLASSIAKARKLQPLEELCLDVNDSALVIGGGVAGITAAIELSKMG
FKVYLVEKEPSIGGKMMKFDRIFPMNDCSSCVLYPLISEVSSSPLVELITYAEVEEVKGSVGNFQVKIRKKQTYVDWDKC
IGCGACVEACPPRAVTEDEFNEGLTKRRAMYIASPYAIPRKAVHDPKSCVNCGKKTLGTRRFLRGGKEYLAPCEKACPTG
AINRSLEWNPEGEIVEVNVGAIVVAVGYEVMKKQNFKEYLPPSPNVITALQFERILSPTGPTAGKVLRPSDMKKPETVSF
ISCVGSRDVRYHTYCSKVCCMYMLKQARLIKERNPEIDVYIHMIDVRAPGKDLEEYYTQSRQMGIKIIRGKVGGIEELPD
GRLRVLGFDADIGTPVEVEADLVVLATAIELSEDARKLAKNLGISVDTSGFLKEDHPKLRSVESWLDGIFIAGCCQGPKD
ISETVSQAKAAAAGAAAILGRDFIQLEPFLATVDEKLCTGCGICASACPYEAISVNGRAEVDTRRCKGCGICSSVCPANA
VDLAGFTREQILSQLEAIL

Sequences:

>Translated_659_residues
MKIGVYVCHCGENISSNVDIDELVEFAKSSEGVSVVRDHLFMCSEIAQEMIRDDIKSGKVDRVVIAACSPKNHEKFFRAT
LEKAGISKYMLEIANIREQCSWVHEKNATEKAKSLLASSIAKARKLQPLEELCLDVNDSALVIGGGVAGITAAIELSKMG
FKVYLVEKEPSIGGKMMKFDRIFPMNDCSSCVLYPLISEVSSSPLVELITYAEVEEVKGSVGNFQVKIRKKQTYVDWDKC
IGCGACVEACPPRAVTEDEFNEGLTKRRAMYIASPYAIPRKAVHDPKSCVNCGKKTLGTRRFLRGGKEYLAPCEKACPTG
AINRSLEWNPEGEIVEVNVGAIVVAVGYEVMKKQNFKEYLPPSPNVITALQFERILSPTGPTAGKVLRPSDMKKPETVSF
ISCVGSRDVRYHTYCSKVCCMYMLKQARLIKERNPEIDVYIHMIDVRAPGKDLEEYYTQSRQMGIKIIRGKVGGIEELPD
GRLRVLGFDADIGTPVEVEADLVVLATAIELSEDARKLAKNLGISVDTSGFLKEDHPKLRSVESWLDGIFIAGCCQGPKD
ISETVSQAKAAAAGAAAILGRDFIQLEPFLATVDEKLCTGCGICASACPYEAISVNGRAEVDTRRCKGCGICSSVCPANA
VDLAGFTREQILSQLEAIL
>Mature_659_residues
MKIGVYVCHCGENISSNVDIDELVEFAKSSEGVSVVRDHLFMCSEIAQEMIRDDIKSGKVDRVVIAACSPKNHEKFFRAT
LEKAGISKYMLEIANIREQCSWVHEKNATEKAKSLLASSIAKARKLQPLEELCLDVNDSALVIGGGVAGITAAIELSKMG
FKVYLVEKEPSIGGKMMKFDRIFPMNDCSSCVLYPLISEVSSSPLVELITYAEVEEVKGSVGNFQVKIRKKQTYVDWDKC
IGCGACVEACPPRAVTEDEFNEGLTKRRAMYIASPYAIPRKAVHDPKSCVNCGKKTLGTRRFLRGGKEYLAPCEKACPTG
AINRSLEWNPEGEIVEVNVGAIVVAVGYEVMKKQNFKEYLPPSPNVITALQFERILSPTGPTAGKVLRPSDMKKPETVSF
ISCVGSRDVRYHTYCSKVCCMYMLKQARLIKERNPEIDVYIHMIDVRAPGKDLEEYYTQSRQMGIKIIRGKVGGIEELPD
GRLRVLGFDADIGTPVEVEADLVVLATAIELSEDARKLAKNLGISVDTSGFLKEDHPKLRSVESWLDGIFIAGCCQGPKD
ISETVSQAKAAAAGAAAILGRDFIQLEPFLATVDEKLCTGCGICASACPYEAISVNGRAEVDTRRCKGCGICSSVCPANA
VDLAGFTREQILSQLEAIL

Specific function: Has oxidoreductase activity. The Hdl and Mvh subunits may together mediate electron transfer from hydrogen to an unidentified electron acceptor on the cytoplasmic side of the membrane [H]

COG id: COG1148

COG function: function code C; Heterodisulfide reductase, subunit A and related polyferredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 3 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO; PF00037 Fer4 [H]

EC number: 1.8.98.1

Molecular weight: Translated: 72069; Mature: 72069

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGVYVCHCGENISSNVDIDELVEFAKSSEGVSVVRDHLFMCSEIAQEMIRDDIKSGKV
CCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DRVVIAACSPKNHEKFFRATLEKAGISKYMLEIANIREQCSWVHEKNATEKAKSLLASSI
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
AKARKLQPLEELCLDVNDSALVIGGGVAGITAAIELSKMGFKVYLVEKEPSIGGKMMKFD
HHHHHCCCHHHHHCCCCCCEEEEECCHHHHHHHHHHHHCCEEEEEEECCCCCCCCEEHHC
RIFPMNDCSSCVLYPLISEVSSSPLVELITYAEVEEVKGSVGNFQVKIRKKQTYVDWDKC
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHH
IGCGACVEACPPRAVTEDEFNEGLTKRRAMYIASPYAIPRKAVHDPKSCVNCGKKTLGTR
CCCHHHHHCCCCCCCCHHHHHHHHHHHHEEEEECCCCCCHHHHCCCHHHHHHHHHHHHHH
RFLRGGKEYLAPCEKACPTGAINRSLEWNPEGEIVEVNVGAIVVAVGYEVMKKQNFKEYL
HHHHCCHHHHCCHHHCCCCCCCCCCCCCCCCCCEEEEECCEEEEEHHHHHHHHCCHHHHC
PPSPNVITALQFERILSPTGPTAGKVLRPSDMKKPETVSFISCVGSRDVRYHTYCSKVCC
CCCCCEEEHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHH
MYMLKQARLIKERNPEIDVYIHMIDVRAPGKDLEEYYTQSRQMGIKIIRGKVGGIEELPD
HHHHHHHHHHHHCCCCEEEEEEEEEECCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCC
GRLRVLGFDADIGTPVEVEADLVVLATAIELSEDARKLAKNLGISVDTSGFLKEDHPKLR
CCEEEEEECCCCCCCCEECCCEEEEEHHHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHH
SVESWLDGIFIAGCCQGPKDISETVSQAKAAAAGAAAILGRDFIQLEPFLATVDEKLCTG
HHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
CGICASACPYEAISVNGRAEVDTRRCKGCGICSSVCPANAVDLAGFTREQILSQLEAIL
CCHHHHCCCCCEEECCCCCCCCHHHCCCCCCHHHCCCCCCHHHCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MKIGVYVCHCGENISSNVDIDELVEFAKSSEGVSVVRDHLFMCSEIAQEMIRDDIKSGKV
CCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DRVVIAACSPKNHEKFFRATLEKAGISKYMLEIANIREQCSWVHEKNATEKAKSLLASSI
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
AKARKLQPLEELCLDVNDSALVIGGGVAGITAAIELSKMGFKVYLVEKEPSIGGKMMKFD
HHHHHCCCHHHHHCCCCCCEEEEECCHHHHHHHHHHHHCCEEEEEEECCCCCCCCEEHHC
RIFPMNDCSSCVLYPLISEVSSSPLVELITYAEVEEVKGSVGNFQVKIRKKQTYVDWDKC
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHH
IGCGACVEACPPRAVTEDEFNEGLTKRRAMYIASPYAIPRKAVHDPKSCVNCGKKTLGTR
CCCHHHHHCCCCCCCCHHHHHHHHHHHHEEEEECCCCCCHHHHCCCHHHHHHHHHHHHHH
RFLRGGKEYLAPCEKACPTGAINRSLEWNPEGEIVEVNVGAIVVAVGYEVMKKQNFKEYL
HHHHCCHHHHCCHHHCCCCCCCCCCCCCCCCCCEEEEECCEEEEEHHHHHHHHCCHHHHC
PPSPNVITALQFERILSPTGPTAGKVLRPSDMKKPETVSFISCVGSRDVRYHTYCSKVCC
CCCCCEEEHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHH
MYMLKQARLIKERNPEIDVYIHMIDVRAPGKDLEEYYTQSRQMGIKIIRGKVGGIEELPD
HHHHHHHHHHHHCCCCEEEEEEEEEECCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCC
GRLRVLGFDADIGTPVEVEADLVVLATAIELSEDARKLAKNLGISVDTSGFLKEDHPKLR
CCEEEEEECCCCCCCCEECCCEEEEEHHHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHH
SVESWLDGIFIAGCCQGPKDISETVSQAKAAAAGAAAILGRDFIQLEPFLATVDEKLCTG
HHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
CGICASACPYEAISVNGRAEVDTRRCKGCGICSSVCPANAVDLAGFTREQILSQLEAIL
CCHHHHCCCCCEEECCCCCCCCHHHCCCCCCHHHCCCCCCHHHCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: coenzyme B; coenzyme M; methanophenazine

Specific reaction: coenzyme B + coenzyme M + methanophenazine = N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine + dihydromethanophenazine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA