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The map label for this gene is hps-2

Identifier: 11498903

GI number: 11498903

Start: 1164092

End: 1165276

Strand: Reverse

Name: hps-2

Synonym: AF1305

Alternate gene names: 11498903

Gene position: 1165276-1164092 (Counterclockwise)

Preceding gene: 11498904

Following gene: 11498902

Centisome position: 53.49

GC content: 51.9

Gene sequence:

>1185_bases
ATGGAGTTCAGAATAGGTGAGGCTCTTATCGGAGAGGGTTTTGAAGTGGCTCACGTTGATTTGATAATTGGCACGAAGGA
CAGCCCCGCCGGAATTGCCTTCGCCAACGCTCTTGCCAACCTTTCTGCAGGCCACACACCGCTTCTCGCGGTTCTCAGAC
CAAACCTGATAACCAAGCCGCCTGCTGTGATAGTCCCAAAGGTAACGGTCAAGGACATGCATCAGGCTGAGCTTATTTTC
GGTCCGGCTCAAGCTGCAGTGGCGAAGGCTGTTGCGGATGCGGTTGAGGAGGGAATAATCCCAAGGGAGAGGGCGGACGA
GTACGTTGTTGTTGCAAGCGTTTTCATCCACCCAAACGCCAAAAACAAGCACAAGATTTACTACTACAACTATGGCGCCA
CAAAGCTCGCAATAAAGAGGGCGATGCAGAACTTCCCGGATGTTGATACCGTGCTTTACGAGAAGGACCGCAGTTTCCAC
CCGTTTGTTGGAAGAAAGCTCACGAAGCTCTGGGACCCGCCATATCTGCAGATTGCCATCGACATTCCAGATCTGGGTGA
GGTGCTGAAGGTTCTTGAGCAGATTCCTGACAGCGACCACATCGTTTTCGAGGTTGGAACGCCTTTGGCAAAGAGATACG
GCTGTGAGGTAATCCTGAAGCTCAGAGAGGTGAAGCCCGATGCGTTTTACATCCTCGACCTGAAGACGCTCGATGTTGGC
AATCTCGAAGCGAGAATGGCTGCAGACGCTACCGCAAACGCGGTTGTGATTTCGGGACTCGCGCCCACAAGCACAATCGT
TAAGGGGATAAGGGAAGCGGAGAAAACAGGAATTTTGAGCTACGTGGACATGATGAACGTCGATGATCCGATTAAAAGGC
TTGAAGAGATTCAGAAGGCTGGAGTTTTACCAAACGTCGTTGAGCTTCACAGAGCGATAGACAGCGAGGACAAAGAGCCT
CCGTGGATGCTTGCCGGAAAGATAAAGGAGAAGTTCAGCGTCCTCGTCGCCGTTGCAGGTGGGATAAGGCCAGAAAACGT
TGAGGAGGTAATTGCCGCTGGAGCGGACATCATAGTTGTCGGCAGAGCTGTAACGAAGGCCAGAGACGTTGAGGGAGCTG
TAAGGAAATTCATGAGCCACATGAAGCCCGACACAGACCAGTTCCGCATTATGACGGACTTTTGA

Upstream 100 bases:

>100_bases
CAAGTTCTTGGGAAGGCTCGGAATTTAAAGGAAAATTGAGTTTGGCAAATCAATTCGGCGAACTCCAAAAAATTTATTAC
ATATCCGGAGACGTAAGGCC

Downstream 100 bases:

>100_bases
GGTGAGAAAAATGGGGGTTGTGATAATAAACTTCAAGGCGTATAAGGAGGGATTTGGAAAAAGGGCGCTTGAGCTGGCGA
AGATTGCCGAAAACGTGGCG

Product: bifunctional formaldehyde-activating enzyme/3-hexulose-6-phosphate synthase

Products: NA

Alternate protein names: Formaldehyde-activating enzyme; Fae; 3-hexulose-6-phosphate synthase; HPS; D-arabino-3-hexulose-6-phosphate formaldehyde lyase

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MEFRIGEALIGEGFEVAHVDLIIGTKDSPAGIAFANALANLSAGHTPLLAVLRPNLITKPPAVIVPKVTVKDMHQAELIF
GPAQAAVAKAVADAVEEGIIPRERADEYVVVASVFIHPNAKNKHKIYYYNYGATKLAIKRAMQNFPDVDTVLYEKDRSFH
PFVGRKLTKLWDPPYLQIAIDIPDLGEVLKVLEQIPDSDHIVFEVGTPLAKRYGCEVILKLREVKPDAFYILDLKTLDVG
NLEARMAADATANAVVISGLAPTSTIVKGIREAEKTGILSYVDMMNVDDPIKRLEEIQKAGVLPNVVELHRAIDSEDKEP
PWMLAGKIKEKFSVLVAVAGGIRPENVEEVIAAGADIIVVGRAVTKARDVEGAVRKFMSHMKPDTDQFRIMTDF

Sequences:

>Translated_394_residues
MEFRIGEALIGEGFEVAHVDLIIGTKDSPAGIAFANALANLSAGHTPLLAVLRPNLITKPPAVIVPKVTVKDMHQAELIF
GPAQAAVAKAVADAVEEGIIPRERADEYVVVASVFIHPNAKNKHKIYYYNYGATKLAIKRAMQNFPDVDTVLYEKDRSFH
PFVGRKLTKLWDPPYLQIAIDIPDLGEVLKVLEQIPDSDHIVFEVGTPLAKRYGCEVILKLREVKPDAFYILDLKTLDVG
NLEARMAADATANAVVISGLAPTSTIVKGIREAEKTGILSYVDMMNVDDPIKRLEEIQKAGVLPNVVELHRAIDSEDKEP
PWMLAGKIKEKFSVLVAVAGGIRPENVEEVIAAGADIIVVGRAVTKARDVEGAVRKFMSHMKPDTDQFRIMTDF
>Mature_394_residues
MEFRIGEALIGEGFEVAHVDLIIGTKDSPAGIAFANALANLSAGHTPLLAVLRPNLITKPPAVIVPKVTVKDMHQAELIF
GPAQAAVAKAVADAVEEGIIPRERADEYVVVASVFIHPNAKNKHKIYYYNYGATKLAIKRAMQNFPDVDTVLYEKDRSFH
PFVGRKLTKLWDPPYLQIAIDIPDLGEVLKVLEQIPDSDHIVFEVGTPLAKRYGCEVILKLREVKPDAFYILDLKTLDVG
NLEARMAADATANAVVISGLAPTSTIVKGIREAEKTGILSYVDMMNVDDPIKRLEEIQKAGVLPNVVELHRAIDSEDKEP
PWMLAGKIKEKFSVLVAVAGGIRPENVEEVIAAGADIIVVGRAVTKARDVEGAVRKFMSHMKPDTDQFRIMTDF

Specific function: Catalyzes the formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate

COG id: COG0269

COG function: function code G; 3-hexulose-6-phosphate synthase and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FAEHP_ARCFU (O28964)

Other databases:

- EMBL:   AE000782
- PIR:   H69412
- RefSeq:   NP_070134.1
- ProteinModelPortal:   O28964
- SMR:   O28964
- GeneID:   1484531
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF1305
- NMPDR:   fig|224325.1.peg.1295
- TIGR:   AF_1305
- HOGENOM:   HBG541183
- OMA:   YNYGATK
- ProtClustDB:   PRK13307
- BioCyc:   AFUL224325:AF_1305-MONOMER
- HAMAP:   MF_01268
- InterPro:   IPR013785
- InterPro:   IPR020868
- InterPro:   IPR014826
- InterPro:   IPR001754
- InterPro:   IPR020568
- InterPro:   IPR000056
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- Gene3D:   G3DSA:3.30.230.60
- PANTHER:   PTHR11749
- SMART:   SM00934
- TIGRFAMs:   TIGR03126

Pfam domain/function: PF08714 Fae; PF00215 OMPdecase; SSF54211 Ribosomal_S5_D2-typ_fold; SSF51366 RibP_bind_barrel

EC number: =4.1.2.43

Molecular weight: Translated: 43201; Mature: 43201

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: ACT_SITE 18-18 BINDING 20-20 BINDING 49-49 BINDING 67-67 BINDING 69-69 BINDING 84-84

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFRIGEALIGEGFEVAHVDLIIGTKDSPAGIAFANALANLSAGHTPLLAVLRPNLITKP
CCCCCCCHHHCCCCEEEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCC
PAVIVPKVTVKDMHQAELIFGPAQAAVAKAVADAVEEGIIPRERADEYVVVASVFIHPNA
CCEEECCCHHHCCCCHHEEECCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCC
KNKHKIYYYNYGATKLAIKRAMQNFPDVDTVLYEKDRSFHPFVGRKLTKLWDPPYLQIAI
CCCEEEEEEECCHHHHHHHHHHHHCCCHHHHHEECCCCCCCHHHHHHHHHCCCCEEEEEE
DIPDLGEVLKVLEQIPDSDHIVFEVGTPLAKRYGCEVILKLREVKPDAFYILDLKTLDVG
ECCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHCHHHHHHHHHCCCCEEEEEEEEEECCC
NLEARMAADATANAVVISGLAPTSTIVKGIREAEKTGILSYVDMMNVDDPIKRLEEIQKA
CCHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
GVLPNVVELHRAIDSEDKEPPWMLAGKIKEKFSVLVAVAGGIRPENVEEVIAAGADIIVV
CCCCHHHHHHHHHCCCCCCCCEEEHHHHHHHHHEEEEHCCCCCCCCHHHHHHCCCCEEEE
GRAVTKARDVEGAVRKFMSHMKPDTDQFRIMTDF
CCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
>Mature Secondary Structure
MEFRIGEALIGEGFEVAHVDLIIGTKDSPAGIAFANALANLSAGHTPLLAVLRPNLITKP
CCCCCCCHHHCCCCEEEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCC
PAVIVPKVTVKDMHQAELIFGPAQAAVAKAVADAVEEGIIPRERADEYVVVASVFIHPNA
CCEEECCCHHHCCCCHHEEECCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCC
KNKHKIYYYNYGATKLAIKRAMQNFPDVDTVLYEKDRSFHPFVGRKLTKLWDPPYLQIAI
CCCEEEEEEECCHHHHHHHHHHHHCCCHHHHHEECCCCCCCHHHHHHHHHCCCCEEEEEE
DIPDLGEVLKVLEQIPDSDHIVFEVGTPLAKRYGCEVILKLREVKPDAFYILDLKTLDVG
ECCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHCHHHHHHHHHCCCCEEEEEEEEEECCC
NLEARMAADATANAVVISGLAPTSTIVKGIREAEKTGILSYVDMMNVDDPIKRLEEIQKA
CCHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
GVLPNVVELHRAIDSEDKEPPWMLAGKIKEKFSVLVAVAGGIRPENVEEVIAAGADIIVV
CCCCHHHHHHHHHCCCCCCCCEEEHHHHHHHHHEEEEHCCCCCCCCHHHHHHCCCCEEEE
GRAVTKARDVEGAVRKFMSHMKPDTDQFRIMTDF
CCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475